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- Diaz-San Segundo, Fayna; Moraes, Mauro P.; de los Santos, Teresa; Dias, Camila C.A.; Grubman, Marvin J.
- Journal of virology 2010 v.84 no.4 pp. 2063
- swine; Foot-and-mouth disease virus; foot-and-mouth disease; immune response; interferons; gene expression; messenger RNA; blood; skin; lymph nodes; signs and symptoms (animals and humans); natural killer cells; dendritic cells; chemokines
- ... Previously, we demonstrated that type I interferon (IFN-/β) or a combination of IFN-/β and type II IFN (IFN-) delivered by a replication-defective human adenovirus 5 (Ad5) vector protected swine when challenged 1 day later with foot-and-mouth disease virus (FMDV). To gain a more comprehensive understanding of the mechanism of protection induced by IFNs, we inoculated groups of six swine with Ad5-v ...
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