Jump to Main Content
- de los Santos, Teresa; Diaz-San Segundo, Fayna; Zhu, James; Koster, Marla; Dias, Camila C.A.; Grubman, Marvin J.
- Journal of virology 2009 v.83 no.4 pp. 1800
- Foot-and-mouth disease virus; proteinases; mutants; phenotype; host-pathogen relationships; cytopathogenicity; virus replication; immunocytochemistry; proteolysis; cultured cells
- ... The leader proteinase (Lpro) of foot-and-mouth disease virus (FMDV) is involved in antagonizing the innate immune response by blocking the expression of interferon (IFN) and by reducing the immediate-early induction of kIFN-kβ mRNA and IFN-stimulated genes. In addition to its role in shutting off cap-dependent host mRNA translation, Lpro is associated with the degradation of the p65/RelA subunit o ...
- PubMed Central: