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- Schwemmle, Martin, et al. Show all 8 Authors
- Journal of virology 2011 v.85 no.20 pp. 10691-10698
- Orthomyxoviridae; avian influenza; chickens; genes; glutamic acid; host range; hosts; lethal dose 50; lysine; mice; mutation; virulence; virus replication; viruses
- ... H5N1 highly pathogenic avian influenza viruses (HPAIV) of clade 2.2 spread from Southeast Asia to Europe. Intriguingly, in contrast to all common avian strains specifying glutamic acid at position 627 of the PB2 protein (PB2-627E), they carry a lysine at this position (PB2-627K), which is normally found only in human strains. To analyze the impact of this mutation on the host range of HPAIV H5N1, ...
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