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- Wedel, Johannes; Weij, Michel; Oosten, Annemieke Smit-van; Hillebrands, Jan-Luuk
- Laboratory animals 2014 v.48 no.4 pp. 338-341
- bioavailability; catheters; intravenous injection; jugular vein; laboratory animals; physical activity; pumps; rats; risk; weight gain
- ... Subcutaneous osmotic pump implantation connected to a venous catheter is a well-established method for delivering compounds intravenously for an intermediate duration (approximately two weeks). When prolonged release is desired (approximately four weeks) reduced flow rate is needed with a similar pump volume. With a fixed intra-pump compound concentration, reduced flow rate results in unwanted red ...