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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.263 Remove constraint Source: 2020 v.263
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1. Antioxidant and anti-inflammatory effects of piperine on UV-B-irradiated human HaCaT keratinocyte cells

Author:
Yamaratee Jaisin; Piyanee Ratanachamnong; Orapin Wongsawatkul; Atthaboon Watthammawut; Kittiya Malaniyom; Sutthibhon Natewong
Source:
Life sciences 2020 v.263 pp. 118607
ISSN:
0024-3205
Subject:
Western blotting; apoptosis; cytotoxicity; free radicals; humans; inflammation; keratinocytes; nitrogen; oxygen; quantitative polymerase chain reaction; radiation resistance; skin (animal); therapeutics; ultraviolet radiation
Abstract:
... The increase in intracellular reactive oxygen and nitrogen species plays a key role in ultraviolet B (UV-B)-induced inflammatory responses in the human skin. Piperine exhibits many pharmacological benefits. In the present study, the photoprotective effects and the possible underlying mechanisms of the anti-inflammatory effects of piperine on UV-B-irradiated keratinocytes were investigated. Piperin ...
DOI:
10.1016/j.lfs.2020.118607

2. Cell cycle re-entry of neurons and reactive neuroblastosis in Huntington's disease: Possibilities for neural-glial transition in the brain

Author:
Nivethitha Manickam; Risna Kanjirassery Radhakrishnan; Jemi Feiona Vergil Andrews; Divya Bharathi Selvaraj; Mahesh Kandasamy
Source:
Life sciences 2020 v.263 pp. 118569
ISSN:
0024-3205
Subject:
brain; cell cycle; cognitive disorders; exons; mutants; neonates; neuroglia
Abstract:
... Huntington's disease (HD) is an autosomal dominant pathogenic condition that causes progressive degeneration of GABAergic neurons in the brain. The abnormal expansion of the CAG repeats in the exon 1 of the Huntingtin gene (HTT gene) has been associated with the onset and progression of movement disorders, psychiatric disturbance and cognitive decline in HD. Microglial activation and reactive astr ...
DOI:
10.1016/j.lfs.2020.118569

3. Cellular plasticity and drug resistance in sarcoma

Author:
Zhengjun Lin; Zhihua Fan; Xianghong Zhang; Jia Wan; Tang Liu
Source:
Life sciences 2020 v.263 pp. 118589
ISSN:
0024-3205
Subject:
drug therapy; epigenetics; multiple drug resistance; plasticity; prognosis; radiotherapy; relapse; resection; sarcoma
Abstract:
... Sarcomas, originating from mesenchymal progenitor stem cells, are a group of rare malignant tumors with poor prognosis. Wide surgical resection, chemotherapy, and radiotherapy are the most common sarcoma treatments. However, sarcomas' response rates to chemotherapy are quite low and sarcoma cells can have intrinsic or acquired resistance after treatment with chemotherapeutics drugs, leading to the ...
DOI:
10.1016/j.lfs.2020.118589

4. Ceramide ratios are affected by cigarette smoke but not heat-not-burn or e-vapor aerosols across four independent mouse studies

Author:
Oksana Lavrynenko; Bjoern Titz; Sophie Dijon; Daniel Dos Santos; Catherine Nury; Thomas Schneider; Emmanuel Guedj; Justyna Szostak; Athanasios Kondylis; Blaine Phillips; Kim Ekroos; Florian Martin; Manuel C. Peitsch; Julia Hoeng; Nikolai V. Ivanov
Source:
Life sciences 2020 v.263 pp. 118753
ISSN:
0024-3205
Subject:
aorta; blood serum; cardiovascular diseases; ceramides; cigarettes; glucosylceramidase; hydrolysis; liver; mice; proteomics; respiratory tract diseases; risk assessment; risk factors; smoke; transcriptomics
Abstract:
... Smoking is an important risk factor for the development of chronic obstructive pulmonary disease and cardiovascular diseases. This study aimed to further elucidate the role of ceramides, as a key lipid class dysregulated in disease states.In this article we developed and validated LC–MS/MS method for ceramides (Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1(15Z)) for the abso ...
DOI:
10.1016/j.lfs.2020.118753

5. Changes in serum inflammatory cytokine levels and intestinal flora in a self-healing dextran sodium sulfate-induced ulcerative colitis murine model

Author:
Liu Jialing; Gao Yangyang; Zhou Jing; Tang Xiaoyi; Wang Ping; Shen Liwei; Chen Simin
Source:
Life sciences 2020 v.263 pp. 118587
ISSN:
0024-3205
Subject:
C-reactive protein; Lactobacillus; Streptococcus; animal models; blood serum; dextran; genes; histopathology; inflammation; interleukin-6; intestinal microorganisms; males; sodium; sodium sulfate; ulcerative colitis
Abstract:
... Whether dextran sodium sulfate (DSS)-induced ulcerative colitis (UC) animal models undergo self-healing remains unclear. Therefore, the study aim was to determine if these models have self-healing ability.UC was induced using 4% DSS in male KM mice. Histopathological and inflammatory cytokine were evaluated. Fecal samples were analyzed by 16S rDNA gene sequencing.Physiological and inflammatory cyt ...
DOI:
10.1016/j.lfs.2020.118587

6. DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1

Author:
Shuang Li; Anjing Zhu; Kai Ren; Shilin Li; Limin Chen
Source:
Life sciences 2020 v.263 pp. 118564
ISSN:
0024-3205
Subject:
DNA replication; Zika virus; cell communication; cell cycle; cell proliferation; coculture; exosomes; flow cytometry; humans; innate immunity; pathogenicity; public health; transcriptome; virus replication; viruses
Abstract:
... Zika virus (ZIKV) infection causes a public health concern because of its potential association with the development of microcephaly. During viral infections, the host innate immune response is mounted quickly to produce some endogenous functional molecules to limit virus replication and spread. Exosomes contain molecules from their cell of origin following virus infection and can enter recipient ...
DOI:
10.1016/j.lfs.2020.118564

7. Dexmedetomidine alleviates neurobehavioral impairments and myelination deficits following lipopolysaccharide exposure in early postnatal rats

Author:
Ziyi Wu; Hang Xue; Yahan Zhang; Ping Zhao
Source:
Life sciences 2020 v.263 pp. 118556
ISSN:
0024-3205
Subject:
Western blotting; adjuvants; anesthetics; brain; brain damage; dexmedetomidine; geotaxis; immunohistochemistry; inflammation; lipopolysaccharides; myelin sheath; myelination; neonates; pathogenesis; rats
Abstract:
... White matter injury (WMI) is the main form of brain injury in preterm neonate survivors, and perinatal inflammation is implicated in the pathogenesis of WMI. It has been demonstrated that dexmedetomidine, an anesthetic adjuvant, possesses neuroprotective effects in both preclinical and clinical trials. The present study was conducted to explore whether dexmedetomidine could protect against neurobe ...
DOI:
10.1016/j.lfs.2020.118556

8. Donepezil in the treatment of ischemic stroke: Review and future perspective

Author:
Arnavaz Hajizadeh Barfejani; Mahbod Jafarvand; Seyed Mohammad Seyedsaadat; Roozbeh Tarighati Rasekhi
Source:
Life sciences 2020 v.263 pp. 118575
ISSN:
0024-3205
Subject:
Alzheimer disease; acetylcholine; cholinesterase inhibitors; cognition; inflammation; ischemia; morbidity; mortality; stroke
Abstract:
... Ischemic stroke remains the leading cause of morbidity and the second most common cause of mortality worldwide. Over the past decade, endovascular thrombectomy (EVT) drastically changed the care of patients with ischemic stroke due to large vessel occlusion. Nevertheless, despite revascularization, many patients do not achieve a good functional outcome. Moreover, not all patients with ischemic str ...
DOI:
10.1016/j.lfs.2020.118575

9. Effects of maternal protein restriction on central and peripheral renin-angiotensin systems in male rat offspring

Author:
Monique Assis de Vasconcelos Barros; José Luiz de Brito Alves; Rayssa Gabriella Nery Barros; Manuel Santana e Silva; Souad Nasser; Yves Tourneur; Carol Virgínia Gois Leandro; Hubert Vidal; Luciano Pirola; João Henrique Costa-Silva
Source:
Life sciences 2020 v.263 pp. 118574
ISSN:
0024-3205
Subject:
botulinum toxin; casein; gene expression; heart rate; hypertension; intravenous injection; lactation; low protein diet; males; mitogens; potassium; potassium cyanide; pregnancy; progeny; rats; renin; respiratory rate; spectral analysis
Abstract:
... We investigated the involvement of the renin angiotensin system (RAS) on the cardiorespiratory control in rats from dams fed with a low-protein diet.Male offspring were obtained from dams fed a normoprotein diet (NP, 17% casein) and low-protein diet (LP, 8% casein) during pregnancy and lactation. Direct measurements of arterial pressure (AP), heart rate (HR) and respiratory frequency (RF) were rec ...
DOI:
10.1016/j.lfs.2020.118574

10. Estrogen receptor agonists protect against acetaminophen-induced hepatorenal toxicity in rats

Author:
Türkan Koyuncuoğlu; Alper Yıldırım; Ekin K. Dertsiz; Meral Yüksel; Feriha Ercan; Berrak Ç. Yeğen
Source:
Life sciences 2020 v.263 pp. 118561
ISSN:
0024-3205
Subject:
acetaminophen; anesthesia; antioxidants; blood serum; chemiluminescence; creatinine; estrogen receptors; females; glutathione; histopathology; kidneys; liver; liver function; males; myeloperoxidase; nephrotoxicity; ovariectomy
Abstract:
... Acetaminophen-induced hepatorenal toxicity varies among sexes with controversial results among species. The aim was to compare the impact of sex and ovarian hormones on hepatorenal toxicity and to elucidate protective effects of estrogen and estrogen receptor (ER) agonists.Under anesthesia, female rats underwent ovariectomy (OVX) or sham-OVX. Starting at postsurgical 40th day, OVX-rats received su ...
DOI:
10.1016/j.lfs.2020.118561

11. Estrogen-regulated expression of SK3 channel in rat colonic smooth muscle contraction

Author:
Wenjie Xiong; Ya Jiang; Ting Yu; Yongping Zheng; Ling Jiang; Xiaoxue Shen; Yurong Tang; Lin Lin
Source:
Life sciences 2020 v.263 pp. 118549
ISSN:
0024-3205
Subject:
Western blotting; antagonists; blood serum; calcium; cattle; constipation; estrogen receptors; estrogens; females; genes; genomics; males; muscle contraction; protein synthesis; rats; reverse transcriptase polymerase chain reaction; silicone; smooth muscle; solvents
Abstract:
... Estrogen can induce inhibition of colonic smooth muscle contraction in male and female mice, which may lead to constipation; however, the mechanisms of inhibition are poorly understood. Hence, this study investigated the effect of estrogen on rat colonic smooth muscle contraction and role of small-conductance Ca²⁺-activated K⁺ 3 (SK3) and transcription factors (Sp1 and Sp3) in the underlying mecha ...
DOI:
10.1016/j.lfs.2020.118549

12. Evaluation of angiopoietin-like protein 3 (ANGPTL3) levels in polycystic ovary syndrome

Author:
Akram Vatannejad; Fouzieh Salimi; Nariman Moradi; Fatima Zahraa Fouani; Zahra Zandieh; Soheila Ansaripour; Asie Sadeghi; Reza Fadaei
Source:
Life sciences 2020 v.263 pp. 118595
ISSN:
0024-3205
Subject:
C-reactive protein; adiponectin; blood serum; homocysteine; hyperlipidemia; insulin; insulin resistance; lipid metabolism; pathogenesis; polycystic ovary syndrome; premenopause; triacylglycerols
Abstract:
... Angiopoietin-like protein 3 (ANGPTL3) is recognized as a regulator of lipid metabolism. However, little is known about its association with insulin resistance in polycystic ovary syndrome (PCOS) setting. The present study aimed to investigate the serum levels of ANGPTL3 and adiponectin in PCOS women compared to healthy controls.In this study, a total of 175 premenopausal women (117 PCOS and 58 non ...
DOI:
10.1016/j.lfs.2020.118595

13. Fingolimod suppressed the chronic unpredictable mild stress-induced depressive-like behaviors via affecting microglial and NLRP3 inflammasome activation

Author:
Yuanxin Guo; Xiaohong Gan; Houfeng Zhou; Hongjing Zhou; Shiyun Pu; Xia Long; Changyu Ren; Tao Feng; Hongmei Tang
Source:
Life sciences 2020 v.263 pp. 118582
ISSN:
0024-3205
Subject:
caspase-1; cognition; hippocampus; inflammasomes; inflammation; interleukin-10; interleukin-6; lifestyle; neurons; neuroprotective effect; oxidative stress; phenotype; sclerosis; sphingosine; sugars; therapeutics
Abstract:
... Depression is a common aspect of the modern lifestyle, and most patients are recalcitrant to the current antidepressants. Fingolimod (FTY720), a sphingosine analogue approved for the treatment of multiple sclerosis, has a significant neuroprotective effect on the central nervous system. The aim of this study was to determine the potential therapeutic effect of FTY720 on the behavior and cognitive ...
DOI:
10.1016/j.lfs.2020.118582

14. Genistin attenuates cellular growth and promotes apoptotic cell death breast cancer cells through modulation of ERalpha signaling pathway

Author:
Sun Tae Hwang; Min Hee Yang; Seung Ho Baek; Jae-Young Um; Kwang Seok Ahn
Source:
Life sciences 2020 v.263 pp. 118594
ISSN:
0024-3205
Subject:
DNA; angiogenesis; antineoplastic agents; apoptosis; breast neoplasms; cell cycle checkpoints; cell growth; cell viability; cytotoxicity; estrogen receptors; genistin; therapeutics
Abstract:
... Estrogen receptor alpha (ERα) is a vital molecular target in ER-positive breast cancer. Genistin (GS) is one of isoflavones that can exert diverse pharmacological effects including that of anti-proliferation, anti-tumor angiogenesis, induce cell cycle arrest and apoptosis. Here, we examined the efficacy of GS as an anti-cancer agent against breast cancer cells. We observed that GS exhibited more c ...
DOI:
10.1016/j.lfs.2020.118594

15. Initiation of PI3K/AKT pathway by IGF-1 decreases spinal cord injury-induced endothelial apoptosis and microvascular damage

Author:
Haibo Li; Renyi Kong; Bowen Wan; Lei Yang; Sheng Zhang; Xiaojian Cao; Hongtao Chen
Source:
Life sciences 2020 v.263 pp. 118572
ISSN:
0024-3205
Subject:
Lentivirus; animal injuries; apoptosis; cytokines; insulin-like growth factor I; mice; models; spinal cord; tight junctions; tissue repair; transfection
Abstract:
... Apoptosis of endothelial cells (ECs) is a crucial factor in blood-spinal cord barrier (BSCB) disruption post spinal cord injury (SCI). Insulin-like growth factor-1 (IGF-1) is a protective cytokine that plays an important role in multiple diseases, whereas the distinct role in SCI-induced remains critical questions to address. Here we designed to explore the role and underlying mechanism of IGF-1 i ...
DOI:
10.1016/j.lfs.2020.118572

16. Long-term exercise-secreted extracellular vesicles promote browning of white adipocytes by suppressing miR-191a-5p

Author:
Wenjuan Di; Nousayhah Amdanee; Wenling Zhang; Yichan Zhou
Source:
Life sciences 2020 v.263 pp. 118464
ISSN:
0024-3205
Subject:
Western blotting; body temperature; brown adipose tissue; exercise; heat production; high fat diet; luciferase; mice; models; obesity; transmission electron microscopes; triacylglycerols; weight control; white adipocytes; white adipose tissue
Abstract:
... The purpose of the study is to explore the mechanism of transdifferentiation from white adipose tissue (WAT) to Brown adipose tissue (BAT).In this study, we established a model of mouse obesity induced by a high-fat diet (HFD) before 30 days of forced exercise or sedentary mice. Then, we isolated extracellular vesicles (EVs) from plasma and identified them by transmission electron microscope, dyna ...
DOI:
10.1016/j.lfs.2020.118464

17. Low-dose lixisenatide protects against early-onset nephropathy induced in diabetic rats

Author:
Rania G. Abdel-latif; Amira F. Ahmed; Gehan H. Heeba
Source:
Life sciences 2020 v.263 pp. 118592
ISSN:
0024-3205
Subject:
agonists; antioxidant activity; blood serum; creatinine; diabetic nephropathy; glucagon-like peptide 1; glucose; high fat diet; histology; insulin resistance; malondialdehyde; nephroprotective effect; urea
Abstract:
... Diabetic nephropathy (DN) is the most frequent cause of end-stage renal disease. This study was performed to investigate the possible protective effect of lixisenatide, a glucagon-like peptide-1 (GLP-1) receptor agonist, on early diabetic nephropathy induced in diabetic rats and explore the various mechanisms underlie this postulated effect.Early DN was induced after 3 weeks in diabetic rats fed w ...
DOI:
10.1016/j.lfs.2020.118592

18. Mechanistic insights into dimethyl cardamonin-mediated pharmacological effects: A double control of the AMPK-HMGB1 signaling axis

Author:
Christian Bailly; Gérard Vergoten
Source:
Life sciences 2020 v.263 pp. 118601
ISSN:
0024-3205
Subject:
COVID-19 infection; Syzygium nervosum; acute respiratory distress syndrome; chalcone; glycemic effect; nucleoproteins; secretion
Abstract:
... Dimethyl cardamonin (DMC) has been isolated from diverse plants, notably from Cleistocalyx operculatus. We have reviewed the pharmacological properties of this natural product which displays anti-inflammatory, anti-hyperglycemic and anti-cancer properties. The pharmacological activities essentially derive from the capacity of DMC to interact with the protein targets HMGB1 and AMPK. Upon binding to ...
DOI:
10.1016/j.lfs.2020.118601

19. Mesenchymal stem cell immunomodulation and regeneration therapeutics as an ameliorative approach for COVID-19 pandemics

Author:
Pooja Yadav; Ravina Vats; Afsareen Bano; Rashmi Bhardwaj
Source:
Life sciences 2020 v.263 pp. 118588
ISSN:
0024-3205
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; World Health Organization; acute respiratory distress syndrome; cytokines; epithelium; humans; immune response; immunomodulation; inflammation; lungs; mesenchymal stromal cells; pandemic; pneumonia; renin-angiotensin system; therapeutics; vaccines; viruses
Abstract:
... The severe acute respiratory syndrome-novel coronavirus mediated COVID-19 has been recently declared a pandemic by the World Health Organization. The primary target of the SARS-CoV-2 virus is the human lungs governed by the ACE-2 receptor of epithelial type II cells/endothelial cells, which promote modulation of the immune response of host cells through generating cytokine storm, inflammation, sev ...
DOI:
10.1016/j.lfs.2020.118588

20. Metabolomics study of the effect of smoking and high-fat diet on metabolic responses and related mechanism following myocardial infarction in mice

Author:
Zhe Zhao; Yaping Zhang; Liang Liu; Yu Chen; Di Wang; Xian Jin; Chengxing Shen
Source:
Life sciences 2020 v.263 pp. 118570
ISSN:
0024-3205
Subject:
arachidonic acid; cardiac output; echocardiography; energy metabolism; heart; high fat diet; inflammation; metabolomics; myocardial infarction; oxidative stress
Abstract:
... The present study aimed to evaluate the impact of chronic smoking and high fat diet on the post-MI metabolic features and inflammation resolution.Eight weeks old C57BL/6J mice were randomly divided into control(C), smoking(S), high-fat diet(H), and smoking plus high-fat diet(SH) groups for 16 weeks. MI was induced by permanent coronary ligation. Cardiac function was assessed by echocardiography at ...
DOI:
10.1016/j.lfs.2020.118570