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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Publication year rev 7981-2019 Remove constraint Publication year rev: 7981-2019 Source 2019 v.229 Remove constraint Source: 2019 v.229
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1. Carbenoxolone enhances peripheral insulin sensitivity and GLUT4 expression in skeletal muscle of obese rats: Potential participation of UBC9 protein

Author:
Rosana Cristina Mori; Thaís Poças da Silva; Raquel Saldanha Campello; Ubiratan Fabres Machado
Source:
Life sciences 2019 v.229 pp. 157-165
ISSN:
0024-3205
Subject:
adipose tissue; animal disease models; glucose; glucose transporters; hyperinsulinemia; insulin; insulin resistance; insulin tolerance test; liver; messenger RNA; monosodium glutamate; muscles; obesity; rats; skeletal muscle; solutes; sterols; transcription (genetics)
Abstract:
... This study investigates the insulin sensitizer effect of carbenoxolone (CBX) and potentially involved peripheral mechanisms.Taking glucose transporter 4 (GLUT4) as a marker of glucose disposal, we investigated the CBX effects on whole-body insulin sensitivity and solute carrier 2a4 (Slc2a4)/GLUT4 expression in visceral (VAT) and subcutaneous (SAT) adipose tissues and soleus muscle of monosodium gl ...
DOI:
10.1016/j.lfs.2019.05.017

2. Chromatin remodeling factor BAZ1A regulates cellular senescence in both cancer and normal cells

Author:
Xueping Li; Dong Ding; Jun Yao; Bin Zhou; Ting Shen; Yun Qi; Ting Ni; Gang Wei
Source:
Life sciences 2019 v.229 pp. 225-232
ISSN:
0024-3205
Subject:
Lentivirus; cell lines; cell senescence; chromatin; gene expression regulation; genes; humans; immunotherapy; models; neoplasm cells; neoplasms; phenotype; small interfering RNA; staining; transcription (genetics)
Abstract:
... Cellular senescence is a well-known cancer prevention mechanism, inducing cancer cells to senescence can enhance cancer immunotherapy. However, how cellular senescence is regulated is not fully understood. Dynamic chromatin changes have been discovered during cellular senescence, while the causality remains elusive. BAZ1A, a gene coding the accessory subunit of ATP-dependent chromatin remodeling c ...
DOI:
10.1016/j.lfs.2019.05.023

3. FGF-2 targets sclerostin in bone and myostatin in skeletal muscle to mitigate the deleterious effects of glucocorticoid on musculoskeletal degradation

Author:
Sulekha Adhikary; Dharmendra Choudhary; Ashish Kumar Tripathi; Anirudha Karvande; Naseer Ahmad; Priyanka Kothari; Ritu Trivedi
Source:
Life sciences 2019 v.229 pp. 261-276
ISSN:
0024-3205
Subject:
Western blotting; adverse effects; antagonists; biomechanics; bone formation; cell lines; dexamethasone; fibroblast growth factor 2; histology; mice; muscles; muscular atrophy; myoblasts; myostatin; osteoblasts; quantitative polymerase chain reaction; skeletal muscle; strength (mechanics)
Abstract:
... Myokines are associated with regulation of bone and muscle mass. However, limited information is available regarding the impact of myokines on glucocorticoid (GC) mediated adverse effects on the musculoskeletal system. This study investigates the role of myokine fibroblast growth factor-2 (FGF-2) in regulating GC-induced deleterious effects on bone and skeletal muscle.Primary osteoblast cells and ...
DOI:
10.1016/j.lfs.2019.05.022

4. Gene polymorphism and risk of idiopathic membranous nephropathy

Author:
Dongwei Liu; Jiahui Zhang; Yan Shi; Zhangsuo Liu
Source:
Life sciences 2019 v.229 pp. 124-131
ISSN:
0024-3205
Subject:
genes; genetic factors; genetic polymorphism; kidney diseases; pathogenesis; patients; risk
Abstract:
... Membranous nephropathy (MN) is the most common primary glomerular disease (PGD) in the world. Currently, MN still lacks specific diagnostic markers and effective treatment strategy. It is speculated that the occurrence of MN is mainly related to environmental and genetic factors. The pathological manifestations of MN patients are diverse, significant differences in response to treatment options, a ...
DOI:
10.1016/j.lfs.2019.05.010

5. Ginsenoside Rb1 promotes the growth of mink hair follicle via PI3K/AKT/GSK-3β signaling pathway

Author:
Haihua Zhang; Yongmei Su; Jiantao Wang; Ying Gao; Fuhe Yang; Guangyu Li; Qiumei Shi
Source:
Life sciences 2019 v.229 pp. 210-218
ISSN:
0024-3205
Subject:
Western blotting; cell cycle; cell movement; cell proliferation; flow cytometry; fluorescent antibody technique; gene expression; ginsenosides; hair follicles; messenger RNA; mink; proteins; quantitative polymerase chain reaction; signal transduction; staining; tissue repair; transforming growth factor beta 1; vascular endothelial growth factor A; vascular endothelial growth factor receptors
Abstract:
... Hair follicles play a critical role in the process of hair growth. The dermal papilla cells (DPCs) are an important component in the hair follicle regeneration and growth. This study investigated the effects of ginsenoside Rb1 on the growth of cultured mink hair follicles and DPCs.The mink hair follicles were treated with ginsenoside Rb1 for 9 days and their lengths were measured every three days. ...
DOI:
10.1016/j.lfs.2019.05.033

6. HIV-1 Nef-GCC185 interaction regulates assembly of cellular protein complexes at TGN targeting MHC-I downregulation

Author:
Sushila Kumari; Manjeet Kumar; Richa Verma; Jimut Kanti Ghosh; Raj Kamal Tripathi
Source:
Life sciences 2019 v.229 pp. 13-20
ISSN:
0024-3205
Subject:
Human immunodeficiency virus 1; T-lymphocytes; confocal microscopy; mutants; peptides; phosphatidylinositol 3-kinase; precipitin tests; proteins; small interfering RNA
Abstract:
... HIV-1 Nef downregulates surface MHC-I to protect the infected cells from CTLs-mediated killing. Although MHC-I downregulation has been extensively studied, the Nef-dependent assembly of the multi-protein complex and subsequent pathways activation has not yet been well explored. The present study is aimed for the identification of Nef-mediated sequential recruitment of cellular proteins that consti ...
DOI:
10.1016/j.lfs.2019.04.008

7. Hyperbaric oxygen therapy reduces apoptosis and dendritic/synaptic degeneration via the BDNF/TrkB signaling pathways in SCI rats

Author:
Xinwang Ying; Wenzhan Tu; Sisi Li; Qiaoyun Wu; Xiaolong Chen; Ye Zhou; Jie Hu; Guanhu Yang; Songhe Jiang
Source:
Life sciences 2019 v.229 pp. 187-199
ISSN:
0024-3205
Subject:
Western blotting; animal injuries; apoptosis; dendrites; drugs; fluorescent antibody technique; models; nervous system diseases; oxygen; protective effect; protein synthesis; rats; reverse transcriptase polymerase chain reaction; signal transduction; spinal cord; staining; synapse; therapeutics
Abstract:
... Spinal cord injury (SCI) is a serious neurological disease without efficacious drugs. Anti-apoptosis and suppressing dendritic/synaptic degeneration in the anterior horn are essential targets after SCI. Previous studies found that hyperbaric oxygen therapy (HBOT) significantly protected rats after SCI. However, its potential effects and mechanisms remain unknown. The BDNF/TrkB signaling pathways e ...
DOI:
10.1016/j.lfs.2019.05.029

8. MMP targeting in the battle for vision: Recent developments and future prospects in the treatment of diabetic retinopathy

Author:
Justyna Drankowska; Michał Kos; Andrzej Kościuk; Paweł Marzęda; Anna Boguszewska-Czubara; Magdalena Tylus; Anna Święch-Zubilewicz
Source:
Life sciences 2019 v.229 pp. 149-156
ISSN:
0024-3205
Subject:
Alzheimer disease; atherosclerosis; blindness; diabetic retinopathy; disease course; enzyme inhibitors; extracellular matrix; metalloproteinases; neoplasms; therapeutics; vision
Abstract:
... Matrix metalloproteinases (MMPs) are enzymes capable of degrading nearly all types of extracellular matrix. They perform a wide range of roles in physiological processes, which is the reason for their strict regulation by numerous mechanisms including natural tissue inhibitors of metalloproteinases (TIMP). Research only started to shed light on more troublesome aspects of MMPs function, like cance ...
DOI:
10.1016/j.lfs.2019.05.038

9. Moxibustion improves ovary function by suppressing apoptosis events and upregulating antioxidant defenses in natural aging ovary

Author:
Xiaoting Yang; Wanqiu Wang; Yan Zhang; Jintao Wang; Fengjie Huang
Source:
Life sciences 2019 v.229 pp. 166-172
ISSN:
0024-3205
Subject:
Oriental traditional medicine; Western blotting; animal ovaries; antioxidant activity; apoptosis; blood serum; enzyme-linked immunosorbent assay; females; fibrosis; follicle-stimulating hormone; follicular atresia; genes; messenger RNA; oocytes; oxidative stress; protein synthesis; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; secretion; therapeutics
Abstract:
... Ovarian aging is a natural physiological phenomenon accompanied by follicular atresia as well as the decline of oocyte quality. Moxibustion is a form of traditional Chinese medicine therapy which has been reported to treat many aging-related problems and improve immune defense.Moxibustion treatment was applied to the 10-month female rats for 2 or 6 months to evaluate whether moxibustion could dela ...
DOI:
10.1016/j.lfs.2019.05.040

10. Myocardial hypothermia induced after reperfusion does not prevent adverse left ventricular remodeling nor improve cardiac function

Author:
Jianru Shi; Wangde Dai; Juan Carreno; Sharon L. Hale; Robert A. Kloner; Gregory L. Kay
Source:
Life sciences 2019 v.229 pp. 98-103
ISSN:
0024-3205
Subject:
cardiac output; cold; coronary vessels; heart; hypothermia; infarction; lungs; models; myocardial ischemia; rats; therapeutics
Abstract:
... The purpose of the study was to determine whether late therapeutic hypothermia (LTH), administered after reperfusion, could prevent adverse left ventricular (LV) remodeling and improve cardiac function in the rat myocardial ischemia/reperfusion model.Rats were randomized to normothermia (n = 10) or LTH (initiated at 1 min after coronary artery reperfusion, n = 10) and subjected to 30 min of corona ...
DOI:
10.1016/j.lfs.2019.04.026

11. Neurolymphatic biomarkers of brain endothelial inflammatory activation: Implications for multiple sclerosis diagnosis

Author:
J.W. Yun; U. Cvek; P.C.S.R. Kilgore; I. Tsunoda; S. Omura; F. Sato; R. Zivadinov; M. Ramanathan; A. Minagar; J.S. Alexander
Source:
Life sciences 2019 v.229 pp. 116-123
ISSN:
0024-3205
Subject:
biomarkers; blood serum; brain; endothelial cells; humans; interferons; patients; protein content; protein synthesis; proteins; sclerosis; therapeutics; tumor necrosis factor-alpha; young adults
Abstract:
... Multiple sclerosis (MS) is the leading cause of non-traumatic neurological disability in young adults, and its diagnosis is often delayed due to the lack of diagnostic markers. Initiation of disease -modifying therapy in the early stages of MS is especially critical because currently available therapy mostly target relapsing-remitting MS, and is less effective as disease progresses into the more c ...
DOI:
10.1016/j.lfs.2019.05.021

12. Pharmacological modulation of autophagy as a novel potential target in the successful implementation of in vitro fertilization

Author:
Xue Bai; Chun-Yang Zheng; Ming Ma
Source:
Life sciences 2019 v.229 pp. 93-97
ISSN:
0024-3205
Subject:
apoptosis; autophagy; blastocyst; endoplasmic reticulum; fetal development; free radicals; granulosa cells; homeostasis; in vitro fertilization; oocytes; viability; women
Abstract:
... Autophagy is an important intracellular process to maintain homeostasis and studies have shown the key role of autophagy in modulating the functions of reproductive system. Alongside with it, the activation of autophagy has also been found to regulate a number of important processes involved in in vitro fertilization including degeneration of granulosa cells and oocyte defects in obese and aging w ...
DOI:
10.1016/j.lfs.2019.05.032

13. Physical & mental activities enhance the neuroprotective effect of vinpocetine & coenzyme Q10 combination against Alzheimer & bone remodeling in rats

Author:
Azza A. Ali; Dina M. Abo El-Ella; Soad Z. El-Emam; Amal S. Shahat; Rehab M. El-Sayed
Source:
Life sciences 2019 v.229 pp. 21-35
ISSN:
0024-3205
Subject:
Alzheimer disease; aluminum chloride; antioxidant activity; antioxidants; blood serum; bone density; bone resorption; brain; brain damage; chitinase; coenzyme Q10; cognition; drugs; histopathology; minerals; models; monoamines; neurodegenerative diseases; neuroprotective effect; oxidants; rats
Abstract:
... Alzheimer's disease is a neurodegenerative disorder characterized by a progressive decline of cognitive abilities as well as bone loss. Physical and mental activities maintain cognitive functions as well as increase bone mass by inhibiting bone resorption. VIN and CoQ10 are neuroprotective drugs that possess anti-inflammatory and antioxidant properties.To study the effect of PH&M on enhancing the ...
DOI:
10.1016/j.lfs.2019.05.006

14. RAP-8 ameliorates liver fibrosis by modulating cell cycle and oxidative stress

Author:
Hongjiao Xu; Sihua Hong; Zhibin Yan; Qian Zhao; Ying Shi; Nazi Song; Junqiu Xie; Xianxing Jiang
Source:
Life sciences 2019 v.229 pp. 200-209
ISSN:
0024-3205
Subject:
Western blotting; antioxidant activity; cell cycle checkpoints; flow cytometry; gene ontology; genes; liver; liver cirrhosis; messenger RNA; mice; mitosis; oxidation; oxidative stress; peptides; quantitative polymerase chain reaction; rapeseed protein; sequence analysis; therapeutics
Abstract:
... The rapeseed protein derived peptide DHNNPQIR (named as RAP-8) has been previously reported to possess antioxidant activity and alleviate liver fibrosis. The purpose of the present study was to investigate the potential crucial pathways involved in ameliorating liver fibrosis of RAP-8.Next-generation sequencing of messenger RNA (RNA-Seq) analysis of the fibrotic and RAP-8 treated mice was performe ...
DOI:
10.1016/j.lfs.2019.04.037

15. Sparc, an EPS-induced gene, modulates the extracellular matrix and mitochondrial function via ILK/AMPK pathways in C2C12 cells

Author:
Aicha Melouane; Mayumi Yoshioka; Makoto Kanzaki; Jonny St-Amand
Source:
Life sciences 2019 v.229 pp. 277-287
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; antibodies; collagen; cysteine; extracellular matrix; genes; glycogen (starch) synthase; mitochondria; muscles; myoblasts; peroxisome proliferator-activated receptor gamma; protein secretion; succinate dehydrogenase (quinone)
Abstract:
... Secreted protein acidic and rich in cysteine, (SPARC), is a matricellular protein implicated in the modulation of the extracellular matrix (ECM) and mitochondrial proteins expression.To study the mechanism through which SPARC is involved in the possible link between ECM and mitochondria, C2C12 myoblasts were cultured with/without the exogenous addition/inhibition of SPARC as well as activation/inh ...
DOI:
10.1016/j.lfs.2019.05.070

16. The alterations of bile acids in rats with high-fat diet/streptozotocin-induced type 2 diabetes and their negative effects on glucose metabolism

Author:
Fan Zhang; Wenzhen Yuan; Yuhui Wei; Dongmei Zhang; Yingting Duan; Boxia Li; Xiaohui Wang; Lili Xi; Yan Zhou; Xinan Wu
Source:
Life sciences 2019 v.229 pp. 80-92
ISSN:
0024-3205
Subject:
animal models; bile acids; biomarkers; blood serum; colon; gene expression; gene expression regulation; glucose; high fat diet; insulin secretion; liver; messenger RNA; metabolism; noninsulin-dependent diabetes mellitus; pancreas; rats; streptozotocin
Abstract:
... Bile acids (BAs) as a kind of endogenous and signaling molecules altered under the circumstance of T2DM, which could impact on the relevant pathways to further affect the glucose metabolism and insulin secretion and might be associated with the T2DM development and restoration. However, the potential mechanisms still need more various and multifaceted studies. Here, we explored the alterations of ...
DOI:
10.1016/j.lfs.2019.05.031

17. The effects of prenatal androgen exposure on cardiac function and tolerance to ischemia/reperfusion injury in male and female rats during adulthood

Author:
Mahsa Noroozzadeh; Mohammad Reza Raoufy; Razieh Bidhendi Yarandi; Farzaneh Faraji Shahrivar; Fahimeh Ramezani Tehrani
Source:
Life sciences 2019 v.229 pp. 251-260
ISSN:
0024-3205
Subject:
adulthood; adults; cardiac output; females; heart; hyperandrogenism; ischemia; laboratory animals; males; pregnancy; progeny; rats; reperfusion injury; solvents; testosterone
Abstract:
... Cardiovascular diseases may originate from suboptimal intrauterine environments. We aimed to examine the effects of prenatal androgen exposure (PAE) on heart basal hemodynamic parameters and tolerance to ischemia/reperfusion (I/R) injury, in PAE adult females and males.Pregnant Wistar rats in the experimental group (n = 8) received 5 mg of testosterone (s.c. injection) on the 20th day of pregnancy ...
DOI:
10.1016/j.lfs.2019.05.044

18. IL- 17A-stimulated endothelial fatty acid β-oxidation promotes tumor angiogenesis

Author:
Ruirui Wang; Xiaohan Lou; Guang Feng; Jinfeng Chen; Linyu Zhu; Xiaomeng Liu; Xiaohan Yao; Pan Li; Jiajia Wan; Yi Zhang; Chen Ni; Zhihai Qin
Source:
Life sciences 2019 v.229 pp. 46-56
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; Western blotting; angiogenesis; beta oxidation; fatty acids; human cell lines; human umbilical vein endothelial cells; humans; interleukin-17; liquid chromatography; lung neoplasms; mass spectrometry; mitochondria; models; neoplasm cells; signal transduction; therapeutics
Abstract:
... Tumor growth is an angiogenesis-dependent process that requires sustained new vessel growth. Interleukin-17 (IL-17A) is a key cytokine that modulates tumor progression. However, whether IL-17A affects the metabolism of endothelial cells is unknown.A xenograft model was established by implanting H460 (human lung cancer cell line) cells transfected with IL-17A-expressing or control vector. The effec ...
DOI:
10.1016/j.lfs.2019.05.030

19. Anti-hyperalgesic and anti-inflammatory effects of citral with β-cyclodextrin and hydroxypropyl-β-cyclodextrin inclusion complexes in animal models

Author:
Caio A. Campos; Bruno S. Lima; Gabriela G.G. Trindade; Eloísa P.B.S.S. Souza; Débora S.A. Mota; Luana Heimfarth; Jullyana S.S. Quintans; Lucindo J. Quintans-Júnior; Eliana M. Sussuchi; Victor H.V. Sarmento; Flávio M.S. Carvalho; Ricardo N. Marreto; Roseane M.R. Costa; Rogéria S. Nunes; Adriano A.S. Araújo; Saravanan Shanmugam; Parimelazhagan Thangaraj
Source:
Life sciences 2019 v.229 pp. 139-148
ISSN:
0024-3205
Subject:
Cymbopogon citratus; Fourier transform infrared spectroscopy; X-ray diffraction; animal models; anti-inflammatory activity; beta-cyclodextrin; bioavailability; carrageenan; cell lines; cell viability; differential scanning calorimetry; differential thermal analysis; essential oils; freeze drying; geranial; high performance liquid chromatography; leukocytes; macrophages; mice; neral; pain; pleurisy; scanning electron microscopy; solubility; somatosensory disorders; stereoisomers; thermogravimetry; tumor necrosis factor-alpha; viability assays
Abstract:
... Citral (CIT) is a monoterpene formed by the geranial and neral stereoisomers. CIT is the major compound of Cymbopogon citratus essential oil, commonly known as “lemongrass”, and has demonstrated potential antihyperalgesic, anti-nociceptive and anti-inflammatory effects. However, CIT shows high volatility, low solubility in water and consequent low bioavailability, which limits its use. Therefore, ...
DOI:
10.1016/j.lfs.2019.05.026

20. Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models

Author:
Samaneh Bayat; Nafise Amiri; Elham Pishavar; Fatemeh Kalalinia; Jebrail Movaffagh; Maryam Hashemi
Source:
Life sciences 2019 v.229 pp. 57-66
ISSN:
0024-3205
Subject:
Ananas comosus; animal models; bromelains; burns (injuries); chitosan; cytotoxicity; histology; nanofibers; physicochemical properties; pineapples; rats; tissue repair; tissues; toxicity testing
Abstract:
... Bromelain is a mixture of proteolytic enzymes present in all tissues of pineapple (Ananas comosus). It is known as an efficient debriding agent in burn treatment. In this study, the efficiency of bromelain-loaded chitosan nanofibers for burn wounds repair was investigated in animal model. Chitosan nanofibers containing bromelain (2% and 4% w/v) were prepared by electrospinning method. The physicoc ...
DOI:
10.1016/j.lfs.2019.05.028