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1. Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling

Author:
Wang, Xuliang; Lyu, Jia; Ji, Alin; Zhang, Qi; Liao, Guodong
Source:
Life sciences 2019 v.230 pp. 162-168
ISSN:
0024-3205
Subject:
Western blotting; apoptosis; bladder; carcinogenesis; catalytic activity; cell growth; chromatin; disease course; flow cytometry; gene expression regulation; methylation; precipitin tests; reverse transcriptase polymerase chain reaction; tissues; transfection; urinary bladder neoplasms
Abstract:
... Jumonji AT-rich interactive domain 2 (Jarid2) is an interacting component of PRC2 which catalyzes methylation of H3K27 (H3K27me3) and causes the downregulation of PTEN. In the present study, we aimed to explore whether Jarid2 could interact with H3K27me3 to regulate PTEN expression in bladder cancer.Jarid2 expression in bladder cancer tissues and cells were determined by western blotting and RT-PC ...
DOI:
10.1016/j.lfs.2019.05.053

2. Lysosomal dysfunction induced by changes in albumin's tertiary structure: Potential key factor in protein toxicity during diabetic nephropathy

Author:
Medina-Navarro, Rafael; Torres-Ramos, Yessica Dorin; Guzmán-Grenfell, Alberto Martin; Díaz-Flores, Margarita; León-Reyes, Guadalupe; Hicks G., Juan José
Source:
Life sciences 2019 v.230 pp. 197-207
ISSN:
0024-3205
Subject:
Western blotting; albumins; apoptosis; cadherins; cathepsin B; cell viability; diabetic nephropathy; endoplasmic reticulum stress; enzyme activity; fibrosis; flow cytometry; humans; lysosomes; models; patients; proteolysis; toxicity; vimentin
Abstract:
... Increased amounts of protein, in particular albumin within renal tubular cells (TBCs), induce the expression of inflammatory and fibrogenic mediators, which are adverse prognostic factors in tubulointerstitial fibrosis and diabetic nephropathy (DN). We sought to assess the participation of the thiol-linked tertiary structure of albumin in the mechanism of protein toxicity in a model of TBCs.Cultur ...
DOI:
10.1016/j.lfs.2019.05.069

3. MiR-223 regulates proliferation and apoptosis of IL-22-stimulated HaCat human keratinocyte cell lines via the PTEN/Akt pathway

Author:
Wang, Rui; Wang, Fei-fei; Cao, Hong-wei; Yang, Jun-ya
Source:
Life sciences 2019 v.230 pp. 28-34
ISSN:
0024-3205
Subject:
apoptosis; bioluminescence assay; enzymes; flow cytometry; genes; human cell lines; humans; immune response; keratinocytes; messenger RNA; mononuclear leukocytes; patients; protein synthesis; psoriasis
Abstract:
... Psoriasis, a chronic inflammatory skin disorder disease, is closely associated with hyperproliferation of keratinocytes. Upregulated miR-223 has been found in peripheral blood mononuclear cells from patients with psoriasis and from psoriatic skin. However, its role in keratinocytes remains unknown. We thus aimed to investigate the function of miR-223 in psoriasis. Interleukin-22 (IL-22) is a cruci ...
DOI:
10.1016/j.lfs.2019.05.045

4. Paracrine action of human placental trophoblast cells attenuates cisplatin-induced acute kidney injury

Author:
Liu, Pengfei; Feng, Yetong; Chen, Xin; Wang, Guangsuo; Nawaz, Imran; Hu, Lifu; Zhao, Lei
Source:
Life sciences 2019 v.230 pp. 45-54
ISSN:
0024-3205
Subject:
apoptosis; caspase-3; chemokine CCL5; cisplatin; flow cytometry; genes; humans; inflammation; interleukin-10; kidneys; mice; models; patients; renal function; renoprotective effect; therapeutics; tissues; trophoblast
Abstract:
... The action of cell-based therapy against acute kidney injury (AKI) has been demonstrated by different groups for years. However, which kind of cells hold best therapeutic effect remains unclear. In this study, we mainly explored whether human placental trophoblast cells hold the potential to be applied in AKI therapy.To study the renoprotective effect, the trophoblast cells were isolated from huma ...
DOI:
10.1016/j.lfs.2019.05.054