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1. WITHDRAWN: A meta-analysis on associations of CDKN2B-AS variants with atherosclerotic cardio-cerebral vascular diseases

Author:
Huang, Yupeng; Jin, Hongyan; Yang, Guokang
Source:
Life sciences 2018
ISSN:
0024-3205
Subject:
Asians; Whites; coronary artery disease; cyclin-dependent kinase; meta-analysis; myocardial infarction; patients; statistical analysis; stroke
Abstract:
... This article has been withdrawn at the request of the editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal. ...
DOI:
10.1016/j.lfs.2018.12.047

2. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity

Author:
Benedetti, Serena; Catalani, Simona; Palma, Francesco; Canonico, Barbara; Luchetti, Francesca; Galati, Rossella; Papa, Stefano; Battistelli, Serafina
Source:
Life sciences 2018 v.215 pp. 80-85
ISSN:
0024-3205
Subject:
DNA fragmentation; T-lymphocytes; antiviral agents; apoptosis; caspase-3; cell lines; cisplatin; cytotoxicity; drug therapy; flow cytometry; fluorouracil; interphase; neoplasm cells; neoplasms; nuclear genome
Abstract:
... Many antiviral agents have been reported to present direct cytotoxic activity in cancer, showing antiproliferative and proapoptotic effects through different mechanisms. In the present study, we took into account the cytotoxic action of the antiviral drug acyclovir (ACV) on leukemia cells, by investigating cell cycle perturbations and apoptosis induction upon drug administration to three still une ...
DOI:
10.1016/j.lfs.2018.11.002

3. ALDH2 attenuates early-stage STZ-induced aged diabetic rats retinas damage via Sirt1/Nrf2 pathway

Author:
He, Mengshan; Long, Pan; Yan, Weiming; Chen, Tao; Guo, Lunfeng; Zhang, Zouming; Wang, Siwang
Source:
Life sciences 2018 v.215 pp. 227-235
ISSN:
0024-3205
Subject:
acetaldehyde dehydrogenase; animal disease models; dark adaptation; diabetic retinopathy; dimethyl sulfoxide; electroretinography; interleukin-6; intraperitoneal injection; laboratory animals; males; neurodegenerative diseases; rats; retina; streptozotocin; stroke; superoxide dismutase; tomography; tumor necrosis factor-alpha; vascular endothelial growth factors
Abstract:
... Acetaldehyde dehydrogenase 2 (ALDH2) was reported for its protective properties on myocardial damage, stroke and neurodegeneration disease, but the effects and mechanisms of ALDH2 in the modulation of diabetic retinopathy remain unclear. The present study evaluated the protection effects of ALDH2 on streptozocin (STZ)-induced aged diabetic rats retinas damage.24 aged male diabetic Sprague-Dawley ( ...
DOI:
10.1016/j.lfs.2018.10.019

4. Alogliptin abates memory injuries of hepatic encephalopathy induced by acute paracetamol intoxication via switching-off autophagy-related apoptosis

Author:
Saad, Muhammed A.; Rastanawi, Alyasaa A.; El-Yamany, Muhammed F.
Source:
Life sciences 2018 v.215 pp. 11-21
ISSN:
0024-3205
Subject:
acetaminophen; acetylcholine; acetylcholinesterase; actin; alanine transaminase; alkaline phosphatase; ammonia; apoptosis; aspartate transaminase; autophagy; bioavailability; blood; caspase-3; cytochrome c; dopamine; encephalopathy; enzyme activity; gamma-aminobutyric acid; glutamic acid; hepatocytes; hepatotoxicity; hippocampus; histopathology; inflammation; ligands; liver; memory; memory disorders; muscles; neurotransmitters; norepinephrine; poisoning; rats; serotonin; transforming growth factor beta 1; tumor necrosis factor-alpha
Abstract:
... Hepatic encephalopathy (HE) is a complex neuropsychiatric syndrome. Paracetamol (APAP) causes, in high doses, a hepatic injury. Alogliptin (ALO), with its 100% oral bioavailability, may be able to reverse the acute hepatic injury and memory impairments.Forty rats were divided into four groups as follows; Normal Control Group, APAP intoxicated group, ALO and SIL groups. Behavioral tests (Morris wat ...
DOI:
10.1016/j.lfs.2018.10.069

5. A meta-analysis of dysregulated miRNAs in coronary heart disease

Author:
Wang, Si-Si; Wu, Li-Juan; Li, Jia-Jiang-Hui; Xiao, Huan-Bo; He, Yan; Yan, Yu-Xiang
Source:
Life sciences 2018 v.215 pp. 170-181
ISSN:
0024-3205
Subject:
Internet; bioinformatics; biomarkers; blood sampling; blood serum; coronary disease; databases; gene expression regulation; meta-analysis; microRNA; models; myocardial infarction; odds ratio; tissues
Abstract:
... To combine the results of dysregulated miRNAs in individual coronary heart disease (CHD) studies and to identify potential miRNA biomarkers.MiRNA profiling studies of CHD were extracted from Pubmed, Embase, Web of Science and China National Knowledge Internet (CNKI) databases if they met the inclusion criteria. The meta-analysis was conducted using a random effects model to identify the effect of ...
DOI:
10.1016/j.lfs.2018.11.016

6. ApoA-1 accelerates regeneration of small-for-size fatty liver graft after transplantation

Author:
Li, Chang Xian; Chen, Lei Lei; Li, Xiang Cheng; Ng, Kevin Tak-Pan; Yang, Xin Xiang; Lo, Chung Mau; Guan, Xin Yuan; Man, Kwan
Source:
Life sciences 2018 v.215 pp. 128-135
ISSN:
0024-3205
Subject:
animal models; apolipoprotein A-I; energy metabolism; fatty liver; hepatectomy; hepatocytes; liver; liver regeneration; liver transplant; mice; mitochondria; oleic acid; rats
Abstract:
... Apolipoprotein A-1 (ApoA-1) is involved in regulating both lipid and energy metabolism, which may play important roles in liver regeneration, especially for the liver with steatosis. We here intended to investigate the role of ApoA-1 in regeneration of small-for-size fatty liver graft and to explore the underlying mechanism.The association of ApoA-1 expression with liver regeneration was studied i ...
DOI:
10.1016/j.lfs.2018.10.053

7. Assessment of PKA and PKC inhibitors on force and kinetics of non-failing and failing human myocardium

Author:
Saad, Nancy S.; Elnakish, Mohammad T.; Brundage, Elizabeth A.; Biesiadecki, Brandon J.; Kilic, Ahmet; Ahmed, Amany A.E.; Mohler, Peter J.; Janssen, Paul M.L.
Source:
Life sciences 2018 v.215 pp. 119-127
ISSN:
0024-3205
Subject:
cAMP-dependent protein kinase; cardiac output; dimethyl sulfoxide; heart failure; humans; inhibitory concentration 50; muscles; myocardium; protein kinase C; United States
Abstract:
... Heart failure (HF) is a prevalent disease that is considered the foremost reason for hospitalization in the United States. Most protein kinases (PK) are activated in heart disease and their inhibition has been shown to improve cardiac function in both animal and human studies. However, little is known about the direct impact of PKA and PKC inhibitors on human cardiac contractile function.We invest ...
DOI:
10.1016/j.lfs.2018.10.065
PubMed:
30399377
PubMed Central:
PMC6279240

8. Cardioprotective and anti-apoptotic effects of Potentilla reptans L. root via Nrf2 pathway in an isolated rat heart ischemia/reperfusion model

Author:
Enayati, Ayesheh; Yassa, Narguess; Mazaheri, Zohreh; Rajaei, Maryam; Pourabouk, Mona; Ghorghanlu, Sajjad; Basiri, Salar; Khori, Vahid
Source:
Life sciences 2018 v.215 pp. 216-226
ISSN:
0024-3205
Subject:
Potentilla reptans; antioxidant activity; antioxidants; apoptosis; arrhythmia; cardioprotective effect; caspase-3; catalase; ethyl acetate; heart; hemodynamics; immunohistochemistry; infarction; ischemia; laboratory animals; models; nitric oxide; proanthocyanidins; rats; staining; superoxide dismutase
Abstract:
... Previous studies have shown that proanthocyanidins have cardioprotective effects which are mediated via the release of nitric oxide (NO) ultimately resulting in increasing the antioxidant activity. We have investigated to show whether 1) the total extract and ethyl acetate fraction (Et) of Potentilla reptans root have an ischemic preconditioning (IPC) effect, 2) P. reptans has antioxidant and card ...
DOI:
10.1016/j.lfs.2018.11.021

9. Carnosine improves functional recovery and structural regeneration after sciatic nerve crush injury in rats

Author:
Mirzakhani, Navideh; Farshid, Amir Abbas; Tamaddonfard, Esmaeal; Imani, Mehdi; Erfanparast, Amir; Noroozinia, Farahnaz
Source:
Life sciences 2018 v.215 pp. 22-30
ISSN:
0024-3205
Subject:
antioxidant activity; axons; carnosine; electron microscopes; histology; histopathology; malondialdehyde; muscles; muscular atrophy; myelin sheath; myelination; nerve regeneration; nerve tissue; normal values; oxidative stress; rats; superoxide dismutase; therapeutics; tumor necrosis factor-alpha
Abstract:
... Peripheral nerve injury represents a substantial clinical problem with insufficient or unsatisfactory treatment options. Current researches have extensively focused on the new approaches for the treatment of peripheral nerve injuries. Carnosine is a naturally occurring pleotropic dipeptide and has many biological functions such as antioxidant property. In the present study, we examined the regener ...
DOI:
10.1016/j.lfs.2018.10.043

10. CB2-deficiency is associated with a stronger hypertrophy and remodeling of the right ventricle in a murine model of left pulmonary artery occlusion

Author:
Duerr, Georg Daniel; Feißt, Andreas; Halbach, Katharina; Verfuerth, Luise; Gestrich, Christopher; Wenzel, Daniela; Zimmer, Andreas; Breuer, Johannes; Dewald, Oliver
Source:
Life sciences 2018 v.215 pp. 96-105
ISSN:
0024-3205
Subject:
animal models; apoptosis; cannabinoids; cardiomyocytes; collagen; enzymes; hemodynamics; hypertension; hypertrophy; immunohistochemistry; inflammation; interleukin-10; ischemia; long term effects; lungs; macrophages; messenger RNA; mice; myosin; organ transplantation; protective effect; pulmonary artery
Abstract:
... Pulmonary hypertension (PH) leads to right ventricular (RV) adaptation and remodeling and has deleterious long-term effects on RV function. The endocannabinoid receptor CB2 has been associated with protective effects in adaptation and remodeling of the left ventricle after ischemia. Therefore, we investigated the role of CB2 receptor in RV adaptation after occlusion of the left pulmonary artery (L ...
DOI:
10.1016/j.lfs.2018.11.003

11. Continuous zebularine treatment enhances hepatic differentiation of mesenchymal stem cells under liver-specific factors induction in vitro

Author:
Chen, Juan; Li, Qiu-Yun; Luo, Yong-Heng; Xiao, En-Hua
Source:
Life sciences 2018 v.215 pp. 57-63
ISSN:
0024-3205
Subject:
DNA methylation; albumins; bone marrow; epidermal growth factor; genes; glycogen; hepatocyte growth factor; mesenchymal stromal cells; messenger RNA; protein synthesis; rabbits; urea
Abstract:
... To investigate the effect of zebularine, a stable inhibitor of DNA methylation, on hepatic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) under liver-specific factors induction in vitro.BM-MSCs were isolated from the mononuclear cell fraction of rabbit bone marrow samples. The identification of these cells was carried out by immunophenotype analysis. The three hepatic diff ...
DOI:
10.1016/j.lfs.2018.10.049

12. Contribution of sulfate-reducing bacteria to homeostasis disruption during intestinal inflammation

Author:
Figliuolo, Vanessa Ribeiro; Coutinho-Silva, Robson; Coutinho, Claudia Mara Lara Melo
Source:
Life sciences 2018 v.215 pp. 145-151
ISSN:
0024-3205
Subject:
homeostasis; hydrogen production; hydrogen sulfide; immunosuppression; inflammation; inflammatory bowel disease; intestinal mucosa; metabolism; patients; sulfate-reducing bacteria
Abstract:
... Alteration in microbial populations and metabolism are key events associated with disruption of intestinal homeostasis and immune tolerance during intestinal inflammation. A substantial imbalance in bacterial populations in the intestine and their relationships with the host have been observed in patients with inflammatory bowel disease (IBD), believed to be part of an intricate mechanism of trigg ...
DOI:
10.1016/j.lfs.2018.11.009

13. Differential effects of maternal high-fat/high-caloric or isocaloric diet on offspring's skeletal muscle phenotype

Author:
Oliveira, Thaynan Raquel dos Prazeres; Manhães-de-Castro, Raul; Silva, Jacqueline Maria; Cadena-Burbano, Erika Vanesa; Cavalcanti, Carolina Cadete Lucena; Benjamim, Raquel Arruda Campos; Lago, Amanda Braz; Tourneur, Yves; Antonio-Santos, José; da Silva Aragão, Raquel
Source:
Life sciences 2018 v.215 pp. 136-144
ISSN:
0024-3205
Subject:
adenosinetriphosphatase; adults; body weight; glucose; glycolysis; high fat diet; laboratory animals; lactation; maternal nutrition; muscles; phenotype; pregnancy; progeny; pups; rats; skeletal muscle; staining; weaning
Abstract:
... AimThis study sought to investigate the effects of two different maternal high-fat diets, during gestation and lactation, on the morphology of the skeletal muscle of the adult offspring rats.Female Wistar rats were fed Control (C) or High-fat/high-caloric (HH) or High-fat/isocaloric (HI) diet during gestation and lactation. The somatic growth of the offspring was measured throughout lactation. Glu ...
DOI:
10.1016/j.lfs.2018.11.011

14. Elevated expression of Twinfilin-1 is correlated with inferior prognosis of lung adenocarcinoma

Author:
Kaishang, Zhang; Xue, Pan; Shaozhong, Zheng; Yingying, Fan; Yan, Zhang; Chanjun, Sun; Zhenzhen, Li; Xiangnan, Li
Source:
Life sciences 2018 v.215 pp. 159-169
ISSN:
0024-3205
Subject:
adenocarcinoma; cell movement; data collection; genome; graphs; immunoblotting; lung neoplasms; lungs; lymph nodes; meta-analysis; metastasis; patients; prediction; prognosis; regression analysis; squamous cell carcinoma; therapeutics; tissues
Abstract:
... Twinfilin-1 (TWF1) has been implicated in cell motility, invasion and migration. However, its exact role in lung cancer progression is still unclear. In the present study, we explored clinical and prognostic relevance of Twinfilin-1 (TWF1) levels for non-small cell lung carcinoma (NSCLC).The Cancer Genome Atlas (TCGA) dataset was analyzed for possible association between TWF1 expressions in NSCLC ...
DOI:
10.1016/j.lfs.2018.10.067

15. Energy and metabolic pathways in trefoil factor family member 2 (Tff2) KO mice beyond the protection from high-fat diet-induced obesity

Author:
Ghanemi, Abdelaziz; Melouane, Aicha; Mucunguzi, Octave; Yoshioka, Mayumi; St-Amand, Jonny
Source:
Life sciences 2018 v.215 pp. 190-197
ISSN:
0024-3205
Subject:
Western blotting; adipose tissue; biochemical pathways; blood glucose; blood serum; energy expenditure; energy metabolism; free fatty acids; genes; genomics; glucose; glycerol; high fat diet; liver; low fat diet; mice; obesity; proteins; skeletal muscle; sympathetic nervous system; triacylglycerols
Abstract:
... Trefoil factor family member 2 (TFF2) is a small gut peptide. We have previously shown that Tff2 knock out (KO) mice are protected from high-fat (HF) diet-induced obesity (De Giorgio et al., 2013a). Thus, exploring Tff2 KO-related pathways of mice at the genomic, proteinic and biochemical levels would allow us to elucidate the processes behind this protection from obesity.To explore the metabolic ...
DOI:
10.1016/j.lfs.2018.11.006

16. FTY720P inhibits the Na+/K+ ATPase in Caco-2 cells via S1PR2: PGE2 and NO are along the signaling pathway

Author:
Rida, Reem; Kreydiyyeh, Sawsan
Source:
Life sciences 2018 v.215 pp. 198-206
ISSN:
0024-3205
Subject:
Western blotting; adenosinetriphosphatase; agonists; cAMP-dependent protein kinase; diarrhea; electrolytes; enzyme activity; enzyme inhibitors; human cell lines; indomethacin; inflammatory bowel disease; models; nitric oxide; ouabain; phosphates; prostaglandin synthase; protein synthesis; receptors; signal transduction; sodium; sodium-potassium-exchanging ATPase
Abstract:
... Sphingosine-1-phosphate (S1P) has been implicated lately in inflammatory bowel disease which has diarrhea as one of its symptoms. Diarrhea is due to altered water movements as a result of altered electrolyte transport, and in particular sodium. Sodium movements are geared by the sodium gradient established by the Na+/K+ ATPase. The aim of this work was to investigate if S1P can modulate the activi ...
DOI:
10.1016/j.lfs.2018.11.026

17. Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma-aminobutyric acid and piperine in kidney epithelial cells

Author:
Lee, Yoon-Mi; Choi, Jun-Ha; Min, Wan-Kwon; Han, Jong-Kwon; Oh, Jae-Wook
Source:
Life sciences 2018 v.215 pp. 207-215
ISSN:
0024-3205
Subject:
cell viability; epithelial cells; erythropoietin; gamma-aminobutyric acid; gamma-aminobutyric acid receptors; gene expression; interleukin-10; kidneys; macrophages; messenger RNA; mitogen-activated protein kinase; protein synthesis; signal transduction; transcription factor NF-kappa B
Abstract:
... The aim of this study was to evaluate gamma-aminobutyric acid (GABA)- and piperine-induced erythropoietin (EPO) and EPO-receptor expression.The effect of GABA and piperine on cell viability was examined using kidney epithelial cells. Expression levels of EPO and EPO-R mRNA and protein were evaluated in response to GABA and piperine treatments. GABA- and piperine-mediated activation of the mitogen- ...
DOI:
10.1016/j.lfs.2018.11.024

18. Integrative proteomic analysis reveals potential high-frequency alternative open reading frame-encoded peptides in human colorectal cancer

Author:
Wang, Tianfang; Liu, Yining; Liu, Qi; Cummins, Scott; Zhao, Min
Source:
Life sciences 2018 v.215 pp. 182-189
ISSN:
0024-3205
Subject:
amino acids; biomarkers; colorectal neoplasms; disease course; genes; humans; mutation; patients; peptides; proteome; proteomics; spectral analysis; therapeutics
Abstract:
... Identification of alternative open reading frame-encoded peptides (AEPs) for the diagnosis of colorectal cancer at the proteome level is largely unexplored because of a lack of comprehensive proteomics data. Here, we performed a comprehensive integrative analysis of mass spectral data published by Clinical Proteomic Tumor Analysis Consortium and characterized 93 high-confident AEPs encoded within ...
DOI:
10.1016/j.lfs.2018.11.018

19. Knockdown of NRSF inhibits cell proliferation of ovarian cancer via activating Hippo pathway

Author:
Deng, Pengfei; Zuo, Yan; Feng, Shuxian; Li, Zongtao; Chen, Wan; Li, Huawen; Wang, Xiaoyu
Source:
Life sciences 2018 v.215 pp. 73-79
ISSN:
0024-3205
Subject:
Western blotting; animal ovaries; cell cycle; cell proliferation; flow cytometry; fluorescent antibody technique; immunohistochemistry; luciferase; neoplasm cells; ovarian neoplasms; patients; quantitative polymerase chain reaction; tissues
Abstract:
... Ovarian cancer is the most leading cause of deaths among gynecologic malignancies, and Neuron-restrictive silencer factor (NRSF) can be upregulated or downregulated according to the type of tumor. However, the expression and function of NRSF in ovarian cancer is still unknown.Expression of NRSF in normal ovary and ovarian cancer cells were evaluated by quantitative PCR (qPCR). NRSF expression in n ...
DOI:
10.1016/j.lfs.2018.10.070

20. MicroRNA-499-5p regulates skeletal myofiber specification via NFATc1/MEF2C pathway and Thrap1/MEF2C axis

Author:
Xu, Meng; Chen, Xiaoling; Chen, Daiwen; Yu, Bing; Li, Mingzhou; He, Jun; Huang, Zhiqing
Source:
Life sciences 2018 v.215 pp. 236-245
ISSN:
0024-3205
Subject:
Western blotting; cyclosporine; gene overexpression; genes; glycolysis; muscle fibers; muscles; quantitative polymerase chain reaction; small interfering RNA
Abstract:
... This study aimed to investigate the role of microRNA-499-5p (miR-499-5p) in the regulation of skeletal myofiber specification and its underlying mechanisms.Mouse C2C12 cells were used in this study. Cyclosporin A and siRNA targeting Thrap1 (si-Thrap1) were used to inhibit NFATc1/MEF2C pathway and knockdown Thrap1, respectively. The expressions of miR-499-5p and genes were evaluated by real-time qu ...
DOI:
10.1016/j.lfs.2018.11.020