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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018
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1. 3-Nitroacridine derivatives arrest cell cycle at G0/G1 phase and induce apoptosis in human breast cancer cells may act as DNA-target anticancer agents

Author:
Qian Zhou; Chaoqun You; Cong Zheng; Yawen Gu; Hongchao Gu; Rui Zhang; Hongshuai Wu; Baiwang Sun
Source:
Life sciences 2018 v.206 pp. 1-9
ISSN:
0024-3205
Subject:
DNA; DNA damage; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; bacteriophages; binding capacity; bioavailability; breast neoplasms; cell cycle checkpoints; cell growth; cell proliferation; circular dichroism spectroscopy; dose response; enzyme inhibition; fluorescence microscopes; growth retardation; humans; interphase; mechanism of action; neoplasm cells; therapeutics; ultraviolet-visible spectroscopy
Abstract:
... DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer ...
DOI:
10.1016/j.lfs.2018.05.010

2. 3H-1,2-dithiole-3-thione protects PC12 cells against amyloid beta 1–42 (Aβ1–42) induced apoptosis via activation of the ERK1/2 pathway

Author:
Chunyan Zhang; Linsen Xie; Fangxia Guan; Yuanbo Cui
Source:
Life sciences 2018 v.213 pp. 74-81
ISSN:
0024-3205
Subject:
Alzheimer disease; Western blotting; amyloid; apoptosis; calcium; caspase-3; cell viability; flow cytometry; lactate dehydrogenase; neurons; neuroprotective effect; phosphatidylinositol 3-kinase; protein content; protein kinases; rats; reactive oxygen species
Abstract:
... Increasing evidence displays that deposition of aggregated β-amyloid (Aβ) leads to neuronal cell apoptosis, thus aggravates the pathological progression of Alzheimer's disease (AD). 3H-1,2-dithiole-3-thione (D3T) has been proved to exert neuroprotective effects. However, the effect of D3T on protecting against Aβ-induced apoptosis and the underlying mechanism are unknown.MTT, DCFH-DA assay, LDH re ...
DOI:
10.1016/j.lfs.2018.10.025

3. A meta-analysis of dysregulated miRNAs in coronary heart disease

Author:
Si-Si Wang; Li-Juan Wu; Jia-Jiang-Hui Li; Huan-Bo Xiao; Yan He; Yu-Xiang Yan
Source:
Life sciences 2018 v.215 pp. 170-181
ISSN:
0024-3205
Subject:
Internet; bioinformatics; biomarkers; blood sampling; blood serum; coronary disease; databases; gene expression regulation; meta-analysis; microRNA; models; myocardial infarction; odds ratio; tissues
Abstract:
... To combine the results of dysregulated miRNAs in individual coronary heart disease (CHD) studies and to identify potential miRNA biomarkers.MiRNA profiling studies of CHD were extracted from Pubmed, Embase, Web of Science and China National Knowledge Internet (CNKI) databases if they met the inclusion criteria. The meta-analysis was conducted using a random effects model to identify the effect of ...
DOI:
10.1016/j.lfs.2018.11.016

4. A new hypoglycemic mechanism of catalpol revealed by enhancing MyoD/MyoG-mediated myogenesis

Author:
Dengqiu Xu; Lu Wang; Zhenzhou Jiang; Guolin Zhao; Hozeifa M. Hassan; Lixin Sun; Sisi Fan; Zhixing Zhou; Luyong Zhang; Tao Wang
Source:
Life sciences 2018 v.209 pp. 313-323
ISSN:
0024-3205
Subject:
blood glucose; blood serum; catalpol; genes; glucose; glycemic effect; histology; insulin resistance; metformin; mice; muscle development; myogenin; myosin heavy chains; noninsulin-dependent diabetes mellitus; phosphatidylinositol 3-kinase; protein synthesis; skeletal muscle; small interfering RNA; therapeutics
Abstract:
... Enhancing myogenesis has been identified as a possible target to improve insulin sensitivity and protect against metabolic diseases. Catalpol, an iridoid glycoside, has been shown to exert a hypoglycaemic effect by improvement of insulin sensitivity; however, the underlying mechanism remains unknown. In this study, we tested whether catalpol has the potential to improve insulin sensitivity by augm ...
DOI:
10.1016/j.lfs.2018.08.028

5. A pan-cancer study of copy number gain and up-regulation in human oncogenes

Author:
YongKiat Wee; TianFang Wang; Yining Liu; Xiaoyan Li; Min Zhao
Source:
Life sciences 2018 v.211 pp. 206-214
ISSN:
0024-3205
Subject:
carcinogenesis; databases; gene expression; gene expression regulation; guanosinetriphosphatase; humans; mitogen-activated protein kinase; neoplasms; oncogenes; signal transduction; somatic mutation
Abstract:
... There has been limited research on CNVs in oncogenes and we conducted a systematic pan-cancer analysis of CNVs and their gene expression changes. The aim of the present study was to provide an insight into the relationships between gene expression and oncogenesis.We collected all the oncogenes from ONGene database and overlapped with CNVs TCGA tumour samples from Catalogue of Somatic Mutations in ...
DOI:
10.1016/j.lfs.2018.09.032

6. Acetyl-11-keto-β-boswellic acid inhibits the secretion of cytokines by dendritic cells via the TLR7/8 pathway in an imiquimod-induced psoriasis mouse model and in vitro

Author:
Ming-Xing Wang; Jing-Xia Zhao; Yu-Jiao Meng; Ting-ting Di; Xiao-long Xu; Xiang-Jiang Xie; Yan Lin; Lu Zhang; Ning Wang; Ping Li; Yan Wang
Source:
Life sciences 2018 v.207 pp. 90-104
ISSN:
0024-3205
Subject:
T-lymphocytes; Toll-like receptor 8; Western blotting; animal models; anti-inflammatory activity; dendritic cells; flow cytometry; gene expression; inflammation; interleukin-12; interleukin-23; messenger RNA; methotrexate; mice; psoriasis; reverse transcriptase polymerase chain reaction; secretion; signal transduction; skin lesions; staining; transcription (genetics)
Abstract:
... Psoriasis vulgaris is mediated by T and dendritic cells. This study aimed to investigate the effects of acetyl-11-keto-β-boswellic acid (AKBA) on activated dendritic cells (DCs) using an imiquimod (IMQ)-induced psoriasis-like mouse model and murine bone marrow–derived dendritic cells (BMDCs) stimulated with resiquimod (R848) in vitro.The mice were treated with IMQ and intragastrically administered ...
DOI:
10.1016/j.lfs.2018.05.044

7. Activation of AMPK prevents monocrotaline-induced pulmonary arterial hypertension by suppression of NF-κB-mediated autophagy activation

Author:
Cui Zhai; Wenhua Shi; Wei Feng; Yanting Zhu; Jian Wang; Shaojun Li; Xin Yan; Qingting Wang; Qianqian Zhang; Limin Chai; Cong Li; Pengtao Liu; Manxiang Li
Source:
Life sciences 2018 v.208 pp. 87-95
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; autophagy; cytosol; heart diseases; human diseases; hypertension; hypertrophy; immunoblotting; metformin; models; monocrotaline; neoplasms; protein content; pulmonary artery; rats; transcription factor NF-kappa B
Abstract:
... It has been shown that activation of autophagy is involved in the development of pulmonary arterial hypertension (PAH). Meanwhile, activation of nuclear factor-kappaB (NF-κB) has been found to induce autophagy in several types of human diseases including cancer and cardiac diseases. However, it is still unknown whether NF-κB mediates autophagy activation in PAH, and whether activation of adenosine ...
DOI:
10.1016/j.lfs.2018.07.018

8. Acute exercise alters homocysteine plasma concentration in an intensity-dependent manner due increased methyl flux in liver of rats

Author:
Diogo Farias Riberio; Paola Sanchez Cella; Lilian Eslaine Costa Mendes da Silva; Alceu Afonso Jordao; Rafael Deminice
Source:
Life sciences 2018 v.196 pp. 63-68
ISSN:
0024-3205
Subject:
S-adenosylmethionine; blood; blood sampling; body weight; caudal vein; exercise; genes; homocysteine; liver; messenger RNA; metabolism; rats; sulfurtransferases; swimming; tail
Abstract:
... We aimed to determine the effects of different intensities of acute exercise on Hcy plasma levels, and the exercise-induced changes in Hcy liver metabolism.First, thirty-two Wistar rats were randomly submitted to an acute bout of swimming exercise carrying a load of 2% (n=8), 4% (n=8) and 6% (n=8) of their total body weight attached in their tail. Control rats remained rested (n=8). Blood samples ...
DOI:
10.1016/j.lfs.2018.01.003

9. Acyclovir induces cell cycle perturbation and apoptosis in Jurkat leukemia cells, and enhances chemotherapeutic drug cytotoxicity

Author:
Serena Benedetti; Simona Catalani; Francesco Palma; Barbara Canonico; Francesca Luchetti; Rossella Galati; Stefano Papa; Serafina Battistelli
Source:
Life sciences 2018 v.215 pp. 80-85
ISSN:
0024-3205
Subject:
DNA fragmentation; T-lymphocytes; antiviral agents; apoptosis; caspase-3; cell lines; cisplatin; cytotoxicity; drug therapy; flow cytometry; fluorouracil; interphase; neoplasm cells; neoplasms; nuclear genome
Abstract:
... Many antiviral agents have been reported to present direct cytotoxic activity in cancer, showing antiproliferative and proapoptotic effects through different mechanisms. In the present study, we took into account the cytotoxic action of the antiviral drug acyclovir (ACV) on leukemia cells, by investigating cell cycle perturbations and apoptosis induction upon drug administration to three still une ...
DOI:
10.1016/j.lfs.2018.11.002

10. Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis

Author:
Lei Li; Zhongwei Sun; Caiming Xu; Jun Wu; Geliang Liu; Hongzhang Cui; Hailong Chen
Source:
Life sciences 2018 v.202 pp. 167-174
ISSN:
0024-3205
Subject:
Adenoviridae; amylases; animal models; anti-inflammatory activity; apoptosis; blood serum; carboxylic ester hydrolases; cardiac output; cardioprotective effect; caudal vein; creatine kinase; genes; green fluorescent protein; heart; histology; inflammation; interleukins; intravenous injection; isozymes; lactate dehydrogenase; pancreas; pancreatitis; rats; sodium; tissues; troponin T
Abstract:
... Severe acute pancreatitis (SAP) is a serious disease associated with systematic inflammation and multiple organs dysfunction. Soluble ST2 (sST2), a member of the Toll interleukin (IL)-1 receptor (TIR) superfamily, has been demonstrated to exert immune-regulatory and anti-inflammatory properties in several inflammation-related diseases. In this study, we investigated whether transfer of sST2 gene b ...
DOI:
10.1016/j.lfs.2018.04.008

11. Akt modulation by miR-145 during exercise-induced VSMC phenotypic switching in hypertension

Author:
Jingwen Liao; Yanyan Zhang; Ying Wu; Fanxing Zeng; Lijun Shi
Source:
Life sciences 2018 v.199 pp. 71-79
ISSN:
0024-3205
Subject:
animal disease models; arterioles; exercise; histology; hypertension; insulin receptor substrate proteins; insulin-like growth factor I receptor; mesenteric arteries; messenger RNA; myocytes; non-specific serine/threonine protein kinase; osteopontin; phenotype; phosphorylation; rats; smooth muscle; transfection
Abstract:
... This study investigated whether long-term exercise can influence vascular smooth muscle cells (VSMCs) phenotypic switching in mesenteric arteries of hypertensive rats, with a focus on the modulation of protein kinase B (PKB/Akt) signaling by microRNA-145 (miR-145). In the exercise intervention experiment, mesenteric arteries from 3-month-old spontaneously hypertensive rats (SHR) and Wistar Kyoto r ...
DOI:
10.1016/j.lfs.2018.03.011

12. Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways

Author:
Peng Li; Xi-Ru Chen; Fei Xu; Chi Liu; Chang Li; Hui Liu; Hui Wang; Wei Sun; Yan-Hui Sheng; Xiang-Qing Kong
Source:
Life sciences 2018 v.206 pp. 106-116
ISSN:
0024-3205
Subject:
adenosine monophosphate; apoptosis; autophagy; blood pressure; calcium-binding proteins; cardiomyocytes; cyclic AMP; death; endothelial nitric oxide synthase; inducible nitric oxide synthase; inflammation; lipopolysaccharides; mice; mitogen-activated protein kinase; myosin; sepsis (infection); signal transduction
Abstract:
... Sepsis-induced myocardial dysfunction represents a major cause of death. Alamandine is an important biologically active peptide. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonata ...
DOI:
10.1016/j.lfs.2018.04.010

13. Alpha pinene modulates UVA-induced oxidative stress, DNA damage and apoptosis in human skin epidermal keratinocytes

Author:
Ramasamy Karthikeyan; Govindasamy Kanimozhi; Nagarajan Rajendra Prasad; Balupillai Agilan; Muthusamy Ganesan; Gunaseelan Srithar
Source:
Life sciences 2018 v.212 pp. 150-158
ISSN:
0024-3205
Subject:
DNA; DNA damage; DNA repair; alpha-pinene; antioxidant activity; apoptosis; cytotoxicity; essential oils; fluorescence emission spectroscopy; fluorescence microscopy; inflammation; interleukin-6; keratinocytes; lipid peroxidation; membrane potential; mitochondrial membrane; oxidative stress; protective effect; skin (animal); transcription factor NF-kappa B; tumor necrosis factor-alpha; ultraviolet radiation
Abstract:
... This study aims to evaluate the protective effect of alpha pinene (AP), an essential oil monoterpene, against ultraviolet-A (UVA; 320–400 nm) induced cellular damages in human skin epidermal keratinocytes (HaCaT cells).In this study, HaCaT cells were subjected to single UVA-irradiation (10 J/cm²) in the presence and absence of AP (30 μM) then different cellular end points were analyzed. The protec ...
DOI:
10.1016/j.lfs.2018.10.004

14. Alpha-tocopherol succinate increases cyclooxygenase-2 activity: Tissue-specific action in pregnant rat uterus in vitro

Author:
Anna Kothencz; Judit Hajagos-Tóth; Adrienn Csányi; Róbert Gáspár
Source:
Life sciences 2018 v.192 pp. 199-204
ISSN:
0024-3205
Subject:
alpha-tocopherol; diclofenac; enzyme activity; enzyme inhibitors; lipids; myometrium; prostaglandin synthase; rats; risk; succinic acid
Abstract:
... Lipid soluble vitamin E plays a role in several physiological mechanisms, however, the mechanism of this action is controversial. We investigated how tocopherol (α-tocopherol acid succinate) influences the effects of cyclooxygenase inhibitors (COXi) in the smooth muscles.The contractility of the samples from 22-day-pregnant myometrium and non-pregnant myometrium and trachea was determined in an is ...
DOI:
10.1016/j.lfs.2017.11.048

15. Altered expression of Aquaporin-2 in one-kidney, one-clip hypertension

Author:
Maria Florencia Albertoni Borghese; Sandra Hope; Maria del Carmen Ortiz; Magalí Barchuk; Camila Kessler; Carlos Davio; Marcelo Vatta; Mónica Majowicz
Source:
Life sciences 2018 v.208 pp. 72-78
ISSN:
0024-3205
Subject:
cyclic AMP; cytosol; excretion; fluorescent antibody technique; hypertension; immunohistochemistry; kidneys; models; patients; quantitative polymerase chain reaction; rats; vasopressin
Abstract:
... The aim of the present study was to evaluate the regulation of Aquaporin-2 (AQP2) water channel in the kidney of one-kidney, one-clip rats (Goldblatt-1 model). In addition, some mechanisms that underlie the role of AQP2 in the Goldblatt-1 model were evaluated.Sprague-Dawley rats were divided in three groups: control two-kidney, no clip (C, 2 K-NC); nephrectomized one-kidney, no clip (N, 1 K-NC) an ...
DOI:
10.1016/j.lfs.2018.07.020

16. Analysis of heart rate variability-related indexes in the interictal period in patients with focal epilepsy

Author:
Yun-Li Yu; Na-Na Li; Meng-Ting Shi; Hong-Juan Lu
Source:
Life sciences 2018 v.209 pp. 403-408
ISSN:
0024-3205
Subject:
anticonvulsants; drug therapy; epilepsy; heart; heart rate; patients
Abstract:
... Changes in cardiac autonomic nervous function have been evaluated by studying the related indexes of heart rate variability (HRV) in patients with focal epilepsy (FE) in the interictal period.A total of 30 FE patients who were treated in our department from July 2015 to May 2017, were included into this study. These patients were divided into three pairs of groups: less frequent seizure group and ...
DOI:
10.1016/j.lfs.2018.08.033

17. Angiogenic lncRNAs: A potential therapeutic target for ischaemic heart disease

Author:
Zhi-Meng Xu; Feng Huang; Wei-Qiang Huang
Source:
Life sciences 2018 v.211 pp. 157-171
ISSN:
0024-3205
Subject:
angiogenesis; biomarkers; clinical trials; endothelial cells; mesenchymal stromal cells; myocardial ischemia; myocytes; non-coding RNA; patients; prognosis; quality of life; smooth muscle; stem cells; therapeutics
Abstract:
... Long noncoding RNAs (LncRNAs) are involved in biological processes and the pathology of diseases and represent an important biomarker or therapeutic target for disease. Emerging evidence has suggested that lncRNAs modulate angiogenesis by regulating the angiogenic cell process—including vascular endothelial cells (VECs); stem cells, particularly bone marrow-derived stem cells, endothelial progenit ...
DOI:
10.1016/j.lfs.2018.09.022

18. Antibiotic-induced dysbiosis effects on the murine gastrointestinal tract and their systemic repercussions

Author:
Caio Pupin Rosa; Gustavo Andrade Brancaglion; Tatimara M. Miyauchi-Tavares; Patrícia Paiva Corsetti; Leonardo Augusto de Almeida
Source:
Life sciences 2018 v.207 pp. 480-491
ISSN:
0024-3205
Subject:
T-lymphocytes; animal models; antibiotics; bacteria; bacterial infections; drugs; dysbiosis; epidemiological studies; homeostasis; human health; humans; immunoglobulin A; intestinal mucosa; mice; microbiome; short chain fatty acids; translation (genetics)
Abstract:
... The gastrointestinal tract has become a focus of study recently. The crosstalk between microbiota, especially bacteria, and the intestinal mucosa has to be accurately balanced in order to maintain physiological homeostasis in the human body. This dynamic interaction results in different levels of short-chain fatty acids (SCFAs), IgA, and T cell lymphocyte subsets, which could lead the human body t ...
DOI:
10.1016/j.lfs.2018.06.030

19. Anticancer activity of two novel ruthenium compounds in gastric cancer cells

Author:
S. Ramírez-Rivera; S. Pizarro; M. Gallardo; F. Gajardo; A. Delgadillo; E. De La Fuente-Ortega; F.M. MacDonnell; G. Bernal
Source:
Life sciences 2018 v.213 pp. 57-65
ISSN:
0024-3205
Subject:
antineoplastic activity; apoptosis; caspases; cisplatin; confocal microscopy; cytotoxicity; enzyme activity; gene overexpression; genes; humans; neoplasm cells; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; ruthenium; stomach neoplasms
Abstract:
... Ruthenium (II) complexes are promising anticancer molecules due its pharmacological properties and selectivity to cells tumor. The aim of this work was to study the cytotoxic activity, and apoptosis induction of two new ruthenium complexes on a human gastric cancer cell line.Two ruthenium(II) complexes were synthesized: [(H₂pbbzim)Ru(tpy-Ph-COOCH₃)](Cl)₂ (Ru-UCN1), and [(tpy)Ru(tpy-Ph-bzH)](Cl)₂ ( ...
DOI:
10.1016/j.lfs.2018.10.024

20. Astragaloside IV improves vascular endothelial dysfunction by inhibiting the TLR4/NF-κB signaling pathway

Author:
Bin Leng; Futian Tang; Meili Lu; Zhen Zhang; Hongxin Wang; Yingjie Zhang
Source:
Life sciences 2018 v.209 pp. 111-121
ISSN:
0024-3205
Subject:
Astragalus membranaceus; Toll-like receptor 4; active ingredients; antioxidant activity; astragalosides; blood serum; diabetes; endothelial nitric oxide synthase; enzyme-linked immunosorbent assay; human umbilical vein endothelial cells; hyperglycemia; immunohistochemistry; intercellular adhesion molecule-1; interleukin-6; intraperitoneal injection; medicinal properties; models; nitrate reductase; nitric oxide; protective effect; signal transduction; streptozotocin; transcription factor NF-kappa B; tumor necrosis factor-alpha; vascular cell adhesion molecules
Abstract:
... Astragaloside IV (As-IV) is the major active ingredient of Astragalus membranaceus and has diverse pharmacological activities, including anti-inflammatory and antioxidant effects. However, the beneficial effect of As-IV on protecting vascular endothelial dysfunction is not completely understood. The aim of this study was to investigate the protective effect and mechanism of As-IV on vascular endot ...
DOI:
10.1016/j.lfs.2018.07.053