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Life sciences
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7982-2018
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2018 v.206
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- Author:
- Qian Zhou; Chaoqun You; Cong Zheng; Yawen Gu; Hongchao Gu; Rui Zhang; Hongshuai Wu; Baiwang Sun
- Source:
- Life sciences 2018 v.206 pp. 1-9
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA damage; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; bacteriophages; binding capacity; bioavailability; breast neoplasms; cell cycle checkpoints; cell growth; cell proliferation; circular dichroism spectroscopy; dose response; enzyme inhibition; fluorescence microscopes; growth retardation; humans; interphase; mechanism of action; neoplasm cells; therapeutics; ultraviolet-visible spectroscopy
- Abstract:
- ... DNA is considered to be one of the most promising targets for anticancer agents. Acridine analogues have anticancer activity based on DNA binding and topoisomerases inhibition. However, due to the side effects, resistance and low bioavailability, a few have entered into clinical usage and the mechanisms of action are not fully understood. Novel acridine derivatives are needed for effective cancer ...
- DOI:
- 10.1016/j.lfs.2018.05.010
- https://doi.org/10.1016/j.lfs.2018.05.010
2. Alamandine attenuates sepsis-associated cardiac dysfunction via inhibiting MAPKs signaling pathways
- Author:
- Peng Li; Xi-Ru Chen; Fei Xu; Chi Liu; Chang Li; Hui Liu; Hui Wang; Wei Sun; Yan-Hui Sheng; Xiang-Qing Kong
- Source:
- Life sciences 2018 v.206 pp. 106-116
- ISSN:
- 0024-3205
- Subject:
- adenosine monophosphate; apoptosis; autophagy; blood pressure; calcium-binding proteins; cardiomyocytes; cyclic AMP; death; endothelial nitric oxide synthase; inducible nitric oxide synthase; inflammation; lipopolysaccharides; mice; mitogen-activated protein kinase; myosin; sepsis (infection); signal transduction
- Abstract:
- ... Sepsis-induced myocardial dysfunction represents a major cause of death. Alamandine is an important biologically active peptide. The present study evaluated whether alamandine improves cardiac dysfunction, inflammation, and apoptosis, and affects the signaling pathways involved in these events. Experiments were carried out in mice treated with lipopolysaccharide (LPS) or alamandine, and in neonata ...
- DOI:
- 10.1016/j.lfs.2018.04.010
- https://doi.org/10.1016/j.lfs.2018.04.010
- Author:
- Vaishali V. Kasture; Deepali P. Sundrani; Sadhana R. Joshi
- Source:
- Life sciences 2018 v.206 pp. 61-69
- ISSN:
- 0024-3205
- Subject:
- angiogenesis; apoptosis; carbon cycle; carbon metabolism; fetal development; folic acid; free radicals; growth factors; homocysteine; long chain polyunsaturated fatty acids; maternal nutrition; oxidative stress; placenta; pre-eclampsia; pregnancy outcome; proteins; signal transduction; vitamin B12; women
- Abstract:
- ... Adequate maternal nutrition is critical for a healthy pregnancy outcome and poor maternal nutrition is known to be associated with pregnancy complications like preeclampsia. We have earlier demonstrated that there is an imbalance in the levels of micronutrients (folate and vitamin B12) along with low levels of long chain polyunsaturated fatty acids (LCPUFA) and high homocysteine levels in women wi ...
- DOI:
- 10.1016/j.lfs.2018.05.029
- https://doi.org/10.1016/j.lfs.2018.05.029
- Author:
- Michel Kendy Souza; Rodrigo Vanerson Passos Neves; Thiago Santos Rosa; Marcos Antônio Cenedeze; Simone Costa A. Arias; Clarice Kazue Fujihara; Reury Frank Pereira Bacurau; Niels Olsen Saraiva Câmara; Milton Rocha Moraes; Alvaro Pacheco e Silva Filho
- Source:
- Life sciences 2018 v.206 pp. 93-97
- ISSN:
- 0024-3205
- Subject:
- carrying capacity; creatine kinase; fibrosis; inflammation; interleukin-10; interleukin-4; interleukin-6; kidney diseases; males; messenger RNA; models; muscle strength; muscles; patients; protocols; rats; strength training
- Abstract:
- ... Patients with chronic kidney disease (CKD) have progressive renal fibrosis, inflammation, and reduced muscle mass and strength. Resistance training (RT) has been suggested to mitigate the loss of muscle mass, of strength and the inflammation in CKD, but the mechanisms are unknown. The aim of this study was to evaluate the influence of RT on renal fibrosis, renal cytokine expression, creatine kinas ...
- DOI:
- 10.1016/j.lfs.2018.05.034
- https://doi.org/10.1016/j.lfs.2018.05.034
- Author:
- Christiano R.R. Alves; Daniele de P. Faria; Camila de G. Carneiro; Alexandre T. Garcez; Vanessa P. Gutierrez; Willian das Neves; Ney R. de Almeida; Yara Cury; Roger Chammas; Patricia C. Brum
- Source:
- Life sciences 2018 v.206 pp. 29-34
- ISSN:
- 0024-3205
- Subject:
- animal models; computed tomography; diphosphonates; disease course; femur; image analysis; longitudinal studies; neoplasm cells; neoplasms; photons; positron-emission tomography; rats; somatosensory disorders; tracer techniques
- Abstract:
- ... Noninvasive imaging using positron emission tomography/computed tomography (PET/CT) and single photon emission computed tomography/computed tomography (SPECT/CT) are considered revolutionized approaches to detect bone cancer. Both PET/CT and SPECT/CT technologies have advanced to permit miniaturization, which has provided the advantage of including animals as their own controls in longitudinal stu ...
- DOI:
- 10.1016/j.lfs.2018.05.030
- https://doi.org/10.1016/j.lfs.2018.05.030
- Author:
- Xiao Lei; Bo-da Zhang; Ji-gang Ren; Fang-li Luo
- Source:
- Life sciences 2018 v.206 pp. 77-83
- ISSN:
- 0024-3205
- Subject:
- Western blotting; albuminuria; animal disease models; apoptosis; astragalosides; diabetic nephropathy; enzyme-linked immunosorbent assay; glucose; luciferase; messenger RNA; quantitative polymerase chain reaction; rats; reverse transcriptase polymerase chain reaction; signal transduction; staining; streptozotocin; transfection; transferases; tumor necrosis factors
- Abstract:
- ... Apoptosis of podocytes plays a crucial role in diabetic nephropathy (DN) development, and astragaloside (AS-IV) has a significant impact on podocyte apoptosis. This study aims to explore the effect of AS-IV on diabetic nephropathy progression.The diabetic nephropathy model was established in rats with streptozotocin (STZ) injection. The albuminuria was examined by using the enzyme linked immunosor ...
- DOI:
- 10.1016/j.lfs.2018.05.037
- https://doi.org/10.1016/j.lfs.2018.05.037
- Author:
- Helga Caputo Nunes; Wellerson Rodrigo Scarano; Elenice Deffune; Sérgio Luis Felisbino; Immacolata Porreca; Flávia Karina Delella
- Source:
- Life sciences 2018 v.206 pp. 22-28
- ISSN:
- 0024-3205
- Subject:
- adipogenesis; adipose tissue; adults; allografting; bisphenol A; clinical trials; endocrine-disrupting chemicals; homeostasis; humans; medicine; mesenchymal stromal cells; obesity; stem cells; surveys
- Abstract:
- ... Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem ...
- DOI:
- 10.1016/j.lfs.2018.05.023
- https://doi.org/10.1016/j.lfs.2018.05.023
- Author:
- Shathiswaran N. Andy; Vijayapandi Pandy; Zazali Alias; Habsah Abdul Kadir
- Source:
- Life sciences 2018 v.206 pp. 45-60
- ISSN:
- 0024-3205
- Subject:
- Alzheimer disease; Elephantopus scaber; analysis of variance; animal models; apoptosis; caspase-3; chemokines; cognition; hippocampus; inducible nitric oxide synthase; lipopolysaccharides; memory disorders; neurodegenerative diseases; neuroglia; rats; therapeutics
- Abstract:
- ... Neuroinflammation is a critical pathogenic mechanism of most neurodegenerative disorders especially, Alzheimer's disease (AD). Lipopolysaccharides (LPS) are known to induce neuroinflammation which is evident from significant upsurge of pro-inflammatory mediators in in vitro BV-2 microglial cells and in vivo animal models. In present study, we investigated anti-neuroinflammatory properties of deoxy ...
- DOI:
- 10.1016/j.lfs.2018.05.035
- https://doi.org/10.1016/j.lfs.2018.05.035
- Author:
- Adrián Plaza; Beatriz Merino; Andrés Sánchez-Pernaute; Antonio J. Torres-García; Miguel A. Rubio-Herrera; Mariano Ruiz-Gayo
- Source:
- Life sciences 2018 v.206 pp. 98-105
- ISSN:
- 0024-3205
- Subject:
- adipocytes; antagonists; autocrine signaling; cholecystokinin; gene expression; humans; mesenchymal stromal cells; non-specific serine/threonine protein kinase; phosphorylation; protein synthesis; rats; receptors; reverse transcriptase polymerase chain reaction; triacylglycerols; white adipose tissue
- Abstract:
- ... Cholecystokinin (CCK) participates in the storage of dietary triglycerides in white adipose tissue (WAT). Our goal was to characterize, both in subcutaneous (Sc-WAT) and visceral WAT (Vis-WAT), the functional expression of the two known CCK receptors, CCK-1 (CCK-1R) and CCK-2 (CCK-2R), as well as of CCK.Gene and protein expression was assessed in different cell types of rat and human WAT by means ...
- DOI:
- 10.1016/j.lfs.2018.05.036
- https://doi.org/10.1016/j.lfs.2018.05.036
- Author:
- Liangsheng Kong; Jingyuan Li; Yongli Liu; Zhiwei Sun; Shixia Zhou; Junling Tang; Ting Ye; Jianyu Wang; H. Rosie Xing
- Source:
- Life sciences 2018 v.206 pp. 70-76
- ISSN:
- 0024-3205
- Subject:
- Western blotting; cell lines; in vitro studies; lung neoplasms; mice; neoplasm cells; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; small interfering RNA; stem cells; therapeutics
- Abstract:
- ... Asymmetric division (ASD), the unique characteristic of normal stem cells, is regarded as a stemness marker when applied to the study of cancer stem cells (CSCs). However, the role of ASD in the self-renewal of CSCs and its regulation remain largely unknown. Here, we first established a mouse Lewis lung carcinoma CSC cell line that could undergo asymmetric division (LLC-ASD cells) derived from the ...
- DOI:
- 10.1016/j.lfs.2018.05.033
- https://doi.org/10.1016/j.lfs.2018.05.033
- Author:
- Xiaolin Peng; Zhengming Wang; Yang Liu; Xin Peng; Yao Liu; Shan Zhu; Zhe Zhang; Yuling Qiu; Meihua Jin; Ran Wang; Qingying Zhang; Dexin Kong
- Source:
- Life sciences 2018 v.206 pp. 35-44
- ISSN:
- 0024-3205
- Subject:
- Oxytropis; Western blotting; agar; antineoplastic agents; apoptosis; cell proliferation; cyclins; enzyme activity; flow cytometry; gelatin; humans; inhibitory concentration 50; interphase; melanoma; metalloproteinases; metastasis; mitogen-activated protein kinase; proteolysis; synergism; therapeutics; tissue repair; viability
- Abstract:
- ... Melanoma remains to be one of the most incurable cancers. Discovery of novel antitumor agent for melanoma therapy is expected. We recently isolated Oxyfadichalcone C from Oxytropis falcate and investigated the anti-proliferative and anti-metastatic activity on human melanoma A375 cells in vitro.Cell viability was determined using MTT assay and soft agar cloning formation assay. The effect of Oxyfa ...
- DOI:
- 10.1016/j.lfs.2018.05.032
- https://doi.org/10.1016/j.lfs.2018.05.032
- Author:
- Yichen Song; Ruoxi Sun; Zhouye Ji; Xiaoxi Li; Qiang Fu; Shiping Ma
- Source:
- Life sciences 2018 v.206 pp. 117-124
- ISSN:
- 0024-3205
- Subject:
- Perilla frutescens; Western blotting; aldehydes; animal models; antioxidant activity; caspase-1; cytokines; hippocampus; histopathology; locomotion; mental depression; proteins; rats; sucrose
- Abstract:
- ... Current evidence supports that inflammatory reaction in the hippocampus is a potential cause of major depressive disorder (MDD). Perilla aldehyde (PAH), a major constituent from Perilla frutescens, has been reported to have anti-inflammatory and anti-oxidant activity. The aim of this study is to explore the antidepressant-like effect and the underlying mechanism of PAH on the rats model induced by ...
- DOI:
- 10.1016/j.lfs.2018.05.038
- https://doi.org/10.1016/j.lfs.2018.05.038
- Author:
- Greeshma Tom; Sheena Philip; Rimal Isaac; P.K. Praseetha; S.G. Jiji; V.V. Asha
- Source:
- Life sciences 2018 v.206 pp. 10-21
- ISSN:
- 0024-3205
- Subject:
- Fourier transform infrared spectroscopy; Raman spectroscopy; Western blotting; X-ray diffraction; acute toxicity; adsorption; animal tissues; antineoplastic agents; apoptosis; autophagy; cytotoxicity; drug therapy; fluorescent antibody technique; hepatoma; human cell lines; hydrophobicity; iron oxides; laboratory animals; nanocarriers; nanoparticles; rats; staining; toxicity testing; transmission electron microscopy
- Abstract:
- ... Superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery vehicles, offer to eliminate the concerns associated with hydrophobic anti-cancer agents. The current study was intended to fabricate a SPION based delivery system for sorafenib that can simultaneously enable targeted delivery of sorafenib and expand its therapeutic index against hepatocellular carcinoma (HCC).Co-precipitation a ...
- DOI:
- 10.1016/j.lfs.2018.04.046
- https://doi.org/10.1016/j.lfs.2018.04.046
- Author:
- Xiufang Chen; Long Yi; Shiyu Song; Lei Wang; Qiao Liang; Yong Wang; Yongzheng Wu; Qian Gao
- Source:
- Life sciences 2018 v.206 pp. 84-92
- ISSN:
- 0024-3205
- Subject:
- Toll-like receptors; adenosine triphosphate; animals; biogenesis; enzymes; gene expression; inflammation; insulin; insulin resistance; membrane potential; mitochondria; mitochondrial membrane; mitophagy; myotubes; oxidative phosphorylation; oxidative stress; palmitates; saturated fatty acids; skeletal muscle
- Abstract:
- ... High level of saturated fatty acids leads to mitochondrial dysfunction and inflammation in the development of insulin resistance in skeletal muscle. We recently found that puerarin improved impaired insulin signaling in skeletal muscle in diabetic animals and in myotubes in vitro. However, whether puerarin can act directly on muscle cells to alleviate lipid-induced mitochondrial dysfunction and in ...
- DOI:
- 10.1016/j.lfs.2018.05.041
- https://doi.org/10.1016/j.lfs.2018.05.041