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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term bisphenol A Remove constraint Subject term: bisphenol A
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1. Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit

Author:
Zar Chi Thent; Gabriele Ruth Anisah Froemming; Suhaila Muid
Source:
Life sciences 2018 v.198 pp. 1-7
ISSN:
0024-3205
Subject:
alkaline phosphatase; apoptosis; bisphenol A; bone resorption; calcitonin; calcium; endocrine-disrupting chemicals; environmental exposure; humans; osteoblasts; osteoclasts; propane; secretion; signal transduction; toxicity
Abstract:
... Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Environmental exposure of BPA results in adverse health outcomes including bone loss. BPA disturbs the bon ...
DOI:
10.1016/j.lfs.2018.02.013

2. Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways

Author:
Wei Qu; Zhenguo Zhao; Sijin Chen; Lijin Zhang; Danlian Wu; Zhigao Chen
Source:
Life sciences 2018 v.208 pp. 167-174
ISSN:
0024-3205
Subject:
apoptosis; bisphenol A; cell proliferation; colorectal neoplasms; epithelial cells; epithelium; gene expression; gene expression regulation; humans; hydrogen peroxide; malondialdehyde; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; pathogens; signal transduction; toxicity; viability
Abstract:
... Bisphenol A (BPA) can act as pathogenic agent on mammalian cells. However, whether BPA induces colonic epithelial cell damage remains unexplored. We used HCT116 cells as a model to investigate the negative effect of BPA on human colon cancer cells and explore the potential mechanism. Our results suggest that BPA decreased viability of HCT116 cells. BPA also caused serious oxidative damage to the c ...
DOI:
10.1016/j.lfs.2018.07.040

3. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

4. Bisphenol a and mesenchymal stem cells: Recent insights

Author:
Helga Caputo Nunes; Wellerson Rodrigo Scarano; Elenice Deffune; Sérgio Luis Felisbino; Immacolata Porreca; Flávia Karina Delella
Source:
Life sciences 2018 v.206 pp. 22-28
ISSN:
0024-3205
Subject:
adipogenesis; adipose tissue; adults; allografting; bisphenol A; clinical trials; endocrine-disrupting chemicals; homeostasis; humans; medicine; mesenchymal stromal cells; obesity; stem cells; surveys
Abstract:
... Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem ...
DOI:
10.1016/j.lfs.2018.05.023

5. Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblast

Author:
Zar Chi Thent; Gabriele Ruth Anisah Froemming; Aletza Binti Mohd Ismail; Syed Baharom Syed Ahmad Fuad; Suhaila Muid
Source:
Life sciences 2018 v.210 pp. 214-223
ISSN:
0024-3205
Subject:
agonists; alkaline phosphatase; antagonists; bisphenol A; bone mineralization; bones; calcium; daidzein; enzyme activity; genistein; mineralization; osteoblasts; osteocalcin; phosphates; plant estrogens; quantitative analysis; risk; xenoestrogens
Abstract:
... Phytoestrogens and xenoestrogens act as agonists/antagonists in bone formation and differentiation. Strong bones are depending of the ability of osteoblasts to form new tissue and to mineralize the newly formed tissue. Dysfunctional or loss of mineralization leads to weak bone and increased fracture risk. In this study, we reported the effect of different types of phytoestrogens (daidzein, geniste ...
DOI:
10.1016/j.lfs.2018.08.057