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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Publication year rev 7982-2018 Remove constraint Publication year rev: 7982-2018 Subject term demethylation Remove constraint Subject term: demethylation
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1. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

2. Hydrogen peroxide redistributes the localization of protein phosphatase methylesterase 1

Author:
Shen Tang; Cailing Lu; Laiming Mo; Xinhang Wang; Ziwei Liang; Fu Qin; Yinpin Liu; Yuyang Liu; Haiyan Huang; Yue Huang; Haiqing Cai; Deqiang Xiao; Songchao Guo; Yiqiang Ouyang; Bin Sun; Xiyi Li
Source:
Life sciences 2018 v.213 pp. 166-173
ISSN:
0024-3205
Subject:
Western blotting; catalytic activity; cell lines; cysteine; cytoplasm; demethylation; fibroblasts; fluorescent antibody technique; humans; hydrogen peroxide; leucine; methylation; methyltransferases; oxidative stress; phosphoprotein phosphatase; physiological transport; protein phosphatase methylesterase-1; protein synthesis; proteins
Abstract:
... Protein phosphatase methylesterase-1 (PME-1) is a serine hydrolase that catalyzes protein phosphatase 2A (PP2A) demethylation and negatively regulates its activity. PME-1 is compartmentalized within cells to precisely control the demethylation of PP2A. This study investigated the localization of PME-1 in human fibroblast cells (HDF) under oxidative stress.Alkaline demethylation and peptide competi ...
DOI:
10.1016/j.lfs.2018.10.029