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You searched for: Journal Life sciences Remove constraint Journal: Life sciences Publication Year 2016 Remove constraint Publication Year: 2016 Source 2016 v.147 Remove constraint Source: 2016 v.147
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1. ALDH2 gene polymorphism in different types of cancers and its clinical significance

Author:
Li, Rui; Zhao, Zihan; Sun, Mingyang; Luo, Jiachi; Xiao, Yechen
Source:
Life sciences 2016 v.147 pp. 59-66
ISSN:
0024-3205
Subject:
aldehyde dehydrogenase; biomarkers; colorectal neoplasms; esophageal neoplasms; ethanol; genes; genotype; humans; liver neoplasms; metabolism; mitochondria; mutants; patients; prognosis; risk; screening; single nucleotide polymorphism
Abstract:
... Aldehyde dehydrogenase 2 (ALDH2), an important mitochondrial enzyme governing ethanol metabolism, displays polymorphism in human. Recent evidence suggested that genetic polymorphism in ALDH2 gene may be significantly correlated with the susceptibility to cancer, such as colorectal cancer, esophageal cancer, and liver cancer. To investigate the correlation between ALDH2 mutant gene and the risk of ...
DOI:
10.1016/j.lfs.2016.01.028

2. Amygdalin delays cell cycle progression and blocks growth of prostate cancer cells in vitro

Author:
Makarević, Jasmina; Tsaur, Igor; Juengel, Eva; Borgmann, Hendrik; Nelson, Karen; Thomas, Christian; Bartsch, Georg; Haferkamp, Axel; Blaheta, Roman A.
Source:
Life sciences 2016 v.147 pp. 137-142
ISSN:
0024-3205
Subject:
alternative medicine; amygdalin; antineoplastic activity; apoptosis; cell growth; cell lines; cyclins; drug resistance; flow cytometry; interphase; neoplasm cells; prostatic neoplasms
Abstract:
... Despite impressive survival benefits from new agents to treat metastasized prostate cancer (PCa), progressive drug resistance hinders long-term response and restricts the efficacy of subsequent therapy. Due to reported antitumor activity of amygdalin and growing popularity for complementary and alternative medicine the potential of this natural, widely used substance to exert antineoplastic effect ...
DOI:
10.1016/j.lfs.2016.01.039

3. Effect of ipragliflozin, an SGLT2 inhibitor, on progression of diabetic microvascular complications in spontaneously diabetic Torii fatty rats

Author:
Takakura, Shoji; Toyoshi, Tohru; Hayashizaki, Yuka; Takasu, Toshiyuki
Source:
Life sciences 2016 v.147 pp. 125-131
ISSN:
0024-3205
Subject:
blood glucose; cataract; diabetic complications; electroretinography; glucose; glycohemoglobin; histopathology; hyperglycemia; kidney diseases; males; motor neurons; peripheral nervous system diseases; rats; retinal diseases; symporters; urinalysis
Abstract:
... We investigated the effect of the selective sodium-dependent glucose cotransporter 2 inhibitor ipragliflozin on the simultaneous progression of diabetic microvascular complications of retinopathy, nephropathy and neuropathy in individual Spontaneously Diabetic Torii (SDT) fatty rats.Ipragliflozin was administered to male SDT fatty rats for 12weeks. Male Sprague–Dawley rats of the same age were use ...
DOI:
10.1016/j.lfs.2016.01.042

4. Global profiling of the signaling network of papillary thyroid carcinoma

Author:
Huang, Kaijun; Cui, Miao; Ye, Fei; Li, Yanbing; Zhang, David
Source:
Life sciences 2016 v.147 pp. 9-14
ISSN:
0024-3205
Subject:
carcinoma; gene expression regulation; glutamate-ammonia ligase; lymph nodes; metastasis; phosphoproteins; regulatory proteins; signal transduction; tissues; United States
Abstract:
... Thyroid carcinoma is one of the most fast rising cancer diagnoses in the US. Papillary thyroid carcinoma (PTC) comprises 80% of thyroid carcinoma. The goal of our study is to identify regulatory proteins and signaling pathways altered in PTC.Protein Pathway Array (PPA) was applied to screen 65 signaling proteins and phosphoproteins in 27 pairs of PTC and surrounding benign tissues. Ingenuity Pathw ...
DOI:
10.1016/j.lfs.2016.01.005

5. Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis

Author:
Liu, Wentao; Li, Jing; Cai, Yan; Wu, Qiong; Pan, Yue; Chen, Yang; Chen, Yujing; Zheng, Xiao; Li, Wei; Zhang, Xuewen; E, Changyong
Source:
Life sciences 2016 v.147 pp. 97-102
ISSN:
0024-3205
Subject:
blood serum; carbon tetrachloride; enzyme-linked immunosorbent assay; histology; hospitals; humans; insulin; insulin-like growth factor I; insulin-like growth factor I receptor; intraperitoneal injection; liver; liver cirrhosis; liver neoplasms; mice; models; parenchyma (animal tissue); patients; signal transduction; staining; tau-protein kinase; tissue banks; China
Abstract:
... Liver cirrhosis is the common pathological histology manifest among a number of chronic liver diseases and liver cancer. Circulating levels of insulin growth factor-1 (IGF-1) have been recently linked to liver cirrhosis and the development of liver cancer. Herein, we hypothesized that IGF-1R overexpression combining the activation of GSK-3β and FOXO3a were involved in the development of human and ...
DOI:
10.1016/j.lfs.2016.01.037

6. Improvement of depressive behavior by Sweetme Sweet Pumpkin™ and its active compound, β-carotene

Author:
Kim, Na-Rae; Kim, Hee-Yun; Kim, Min-Ho; Kim, Hyung-Min; Jeong, Hyun-Ja
Source:
Life sciences 2016 v.147 pp. 39-45
ISSN:
0024-3205
Subject:
Cucurbita moschata; serotonin; brain; interleukin-6; forced swimming test; Western blotting; estrogens; beta-carotene; tumor necrosis factor-alpha; norepinephrine; patients; active ingredients; oral administration; mitogen-activated protein kinase; Korean Peninsula
Abstract:
... Sweetme Sweet Pumpkin™ (SSP, baked Cucurbita moschata Duch.) has been used to treat patients with depression in Korea. However, the role of SSP in improving depression has not been elucidated yet. Thus, we assessed the antidepressant-like effect of SSP and its active compound, β-carotene, with the forced swimming test (FST).SSP and β-carotene were orally administered once a day for 28days. The lev ...
DOI:
10.1016/j.lfs.2016.01.036

7. Lactate calcium salt affects the viability of colorectal cancer cells via betaine homeostasis

Author:
Jang, Yeong-Su; Jo, Young-Kwon; Sim, Jae Jun; Ji, Eunhee; Jeong, Keun-Yeong; Kim, Hwan Mook
Source:
Life sciences 2016 v.147 pp. 71-76
ISSN:
0024-3205
Subject:
animals; antineoplastic activity; betaine; calcium; cell viability; colorectal neoplasms; gamma-aminobutyric acid; homeostasis; lactic acid; models; neoplasm cells; risk reduction; therapeutics
Abstract:
... Betaine plays an important role in cellular homeostasis. However, the physiological roles of betaine-γ-aminobutyric acid (GABA) transporter (BGT-1) are still being disputed in cancer. In this study, we tried to find the possibility of the antitumor effect on colorectal cancer (CRC) cell via lactate calcium salt (CaLa)-induced BGT-1 downregulation.The CRC cell viability and clonogenic assay was per ...
DOI:
10.1016/j.lfs.2016.01.030

8. Low-dose occupational exposure to benzene and signal transduction pathways involved in the regulation of cellular response to oxidative stress

Author:
Fenga, Concettina; Gangemi, Silvia; Giambò, Federica; Tsitsimpikou, Christina; Golokhvast, Kirill; Tsatsakis, Aristidis; Costa, Chiara
Source:
Life sciences 2016 v.147 pp. 67-70
ISSN:
0024-3205
Subject:
antioxidants; apoptosis; benzene; cell proliferation; chronic exposure; fruits; gasoline; males; men; metabolism; mitogen-activated protein kinase; mononuclear leukocytes; occupational exposure; office workers; oxidative stress; quantitative analysis; signal transduction; transactivators; transcription factor NF-kappa B; vegetables; Sicily
Abstract:
... Benzene metabolism seems to modulate NF-κB, p38-MAPK (mitogen-activated protein kinase) and signal transducer and activator of transcription 3 (STAT3) signalling pathways via the production of reactive oxygen species. This study aims to evaluate the effects of low-dose, long-term exposure on NF-κB, STAT3, p38-MAPK and stress-activated protein kinase/Jun amino-terminal kinase (SAPK/JNK) signal tran ...
DOI:
10.1016/j.lfs.2015.12.025

9. Methylmercury affects cerebrovascular reactivity to angiotensin II and acetylcholine via Rho-kinase and nitric oxide pathways in mice

Author:
Islam, Md. Zahorul; Van Dao, Cuong; Shiraishi, Mitsuya; Miyamoto, Atsushi
Source:
Life sciences 2016 v.147 pp. 30-38
ISSN:
0024-3205
Subject:
acetylcholine; angiotensin II; arteries; bioavailability; blood pressure; drinking water; endothelial cells; enzyme activity; hypertension; methylmercury compounds; mice; nitric oxide; risk
Abstract:
... Methylmercury (MeHg) exposure results in increased risk of hypertension and cardiovascular diseases. In this study, we aimed to investigate whether the in vivo exposure of MeHg in mice affects blood pressure and basilar arterial responses to angiotensin II (Ang II) and acetylcholine (ACh), which are important modulators of cerebrovascular autoregulation.Mice were exposed to MeHg (40ppm) in drinkin ...
DOI:
10.1016/j.lfs.2016.01.033

10. MicroRNA-103/107 is involved in hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by targeting HIF-1β

Author:
Deng, Bi; Du, Jie; Hu, Rong; Wang, Ai-Ping; Wu, Wei-Hua; Hu, Chang-Ping; Li, Yuan-Jian; Li, Xiao-Hui
Source:
Life sciences 2016 v.147 pp. 117-124
ISSN:
0024-3205
Subject:
Western blotting; gain-of-function mutation; hypertension; hypoxia; hypoxia-inducible factor 1; loss-of-function mutation; microRNA; models; myocytes; pulmonary artery; quantitative polymerase chain reaction; rats; smooth muscle
Abstract:
... Activation of hypoxia inducible factor-1 (HIF) is a hallmark in hypoxia-induced pulmonary hypertension (HPH). microRNAs play a significant role in regulating proliferation of pulmonary arterial smooth muscle cells (PASMCs) in pulmonary hypertension. Previous studies have shown that HIF-1β is a target of miR-103/107. In this present study, we aimed to investigate whether miR-103/107 regulate vascul ...
DOI:
10.1016/j.lfs.2016.01.043

11. MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells

Author:
Li, Shufeng; Qiang, Qian; Shan, Haitao; Shi, Minke; Gan, Guangming; Ma, Fang; Chen, Baojun
Source:
Life sciences 2016 v.147 pp. 143-152
ISSN:
0024-3205
Subject:
autophagy; breast neoplasms; messenger RNA; microRNA; mutation; neoplasm cells; protein content; transmission electron microscopy
Abstract:
... RB1CC1/FIP200 was essential for autophagosome formation. Therefore, RB1CC1/FIP200 cellular levels are critical for the activation of the autophagy pathways. Following the screen of miRNAs affecting RB1CC1/FIP200 level and rapamycin-induced autophagy, we discovered miR-20a and miR-20b could regulate autophagy by targeting RB1CC1/FIP200.Inhibitory effect of miR-20a and 20b on basal and rapamycin-sti ...
DOI:
10.1016/j.lfs.2016.01.044

12. Molecular and biochemical evidence on the protective effects of embelin and carnosic acid in isoproterenol-induced acute myocardial injury in rats

Author:
Kocak, Cengiz; Kocak, Fatma Emel; Akcilar, Raziye; Isiklar, Ozben Ozden; Kocak, Havva; Bayat, Zeynep; Simsek, Hasan; Taser, Figen; Altuntas, Irfan
Source:
Life sciences 2016 v.147 pp. 15-23
ISSN:
0024-3205
Subject:
adults; albumins; antioxidants; apoptosis; blood serum; drugs; fatty acid-binding proteins; gene expression; glutathione peroxidase; heart; histopathology; isoproterenols; males; messenger RNA; mitogen-activated protein kinase; myocardial infarction; oxidants; protective effect; public health; rats; subcutaneous injection; superoxide dismutase; thiols; tissues; transcription factor NF-kappa B; troponin I; tumor necrosis factor-alpha
Abstract:
... Acute myocardial infarction is a serious acute cardiac disorder and heart disease is still a major public health problem in adults. We investigated the effects of embelin (EMB) and carnosic acid (CA) in animals with isoproterenol (ISO)-induced myocardial injury.Adult male Wistar–Albino rats were divided into four groups: control, ISO, ISO with EMB, and ISO with CA. Before myocardial injury was ind ...
DOI:
10.1016/j.lfs.2016.01.038

13. Morphological and morphometric study of protective effect of green tea in gentamicin-induced nephrotoxicity in rats

Author:
Veljković, Milica; Pavlović, Dragana R.; Stojiljković, Nenad; Ilić, Sonja; Petrović, Aleksandar; Jovanović, Ivan; Radenković, Mirjana
Source:
Life sciences 2016 v.147 pp. 85-91
ISSN:
0024-3205
Subject:
animal models; antioxidant activity; antioxidants; beverages; blood serum; catalase; creatinine; cytoplasm; gentamicin; green tea; health promotion; histology; histopathology; lipid peroxidation; monitoring; morphometry; necrosis; nephrotoxicity; oxidants; oxidative stress; protective effect; proximal tubules; rats; renal function; renoprotective effect; urea
Abstract:
... One of the most popular beverages worldwide, green tea, was investigated for its potential protective effect in a rat model of gentamicin-induced nephrotoxicity by monitoring functional and morphological changes in kidneys.The study was conducted on four groups of rats: control group (C), treated with only gentamicin (GM), treated with only green tea (GT) and treated with both gentamicin and green ...
DOI:
10.1016/j.lfs.2016.01.035

14. Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

Author:
An, Jing; Yang, Hao; Zhang, Qian; Liu, Cuicui; Zhao, Jingjing; Zhang, Lingling; Chen, Bo
Source:
Life sciences 2016 v.147 pp. 46-58
ISSN:
0024-3205
Subject:
Oriental traditional medicine; active ingredients; adverse effects; anthraquinones; bone density; bone formation; bone resorption; coumarins; developmental orthopedic disease; diterpenoids; flavonoids; glycosides; mitogen-activated protein kinase; monoterpenoids; nitric oxide; osteoblasts; osteoporosis; phenolic acids; phenols; research and development; sesquiterpenoids; signal transduction; transcription (genetics); transcription factors
Abstract:
... Osteoporosis is a systemic metabolic bone disease characterized by a reduction in bone mass, bone quality, and microarchitectural deterioration. An imbalance in bone remodeling that is caused by more osteoclast-mediated bone resorption than osteoblast-mediated bone formation results in such pathologic bone disorder. Traditional Chinese medicines (TCM) have long been used to prevent and treat osteo ...
DOI:
10.1016/j.lfs.2016.01.024

15. Obesity-induced p53 activation in insulin-dependent and independent tissues is inhibited by beta-adrenergic agonist in diet-induced obese rats

Author:
Zand, Hamid; Homayounfar, Reza; Cheraghpour, Makan; Jeddi-Tehrani, Mahmood; Ghorbani, Arman; Pourvali, Katayoun; Soltani, Sama Reza
Source:
Life sciences 2016 v.147 pp. 103-109
ISSN:
0024-3205
Subject:
Western blotting; adenosine monophosphate; adenylate cyclase; beta adrenergic receptors; beta-adrenergic agonists; cyclic AMP; diabetes; diet; forskolin; insulin; insulin resistance; isoproterenols; obesity; rats; reverse transcriptase polymerase chain reaction; tissues
Abstract:
... The purpose of this study was to assay the role of beta-adrenergic receptor signaling in the regulation of obesity-induced p53 in high fat feeding obese rats.The role of beta-adrenergic receptor/cyclic AMP in the regulation of p53 and its downstream mediators was evaluated by western blot and real-time quantitative RT-PCR among diet induced rats.Beta-adrenergic receptor agonist, isoproterenol, and ...
DOI:
10.1016/j.lfs.2016.01.040

16. Selective serotonin reuptake inhibitors increase sympathetic activity under heavy alcohol exposure in rat models

Author:
Hu, Tsung-Ming; Wu, Meng-Shien; Wu, Wen-Tien; Yang, Fwu-Lin; Lee, Ru-Ping
Source:
Life sciences 2016 v.147 pp. 92-96
ISSN:
0024-3205
Subject:
alcohol drinking; alcohols; animal models; antidepressants; blood serum; heart rate; patients; rats; serotonin; statistical analysis
Abstract:
... Self-medication with alcohol while being treated with antidepressants is a common problem in patients with depression. Both alcohol consumption and antidepressant administration can induce changes in the cardiac autonomic responses as indicated by heart rate variability (HRV). In this study, we examined cardiac autonomic responses induced by acute heavy alcohol exposure after SSRIs (selective sero ...
DOI:
10.1016/j.lfs.2016.01.021

17. Tactile learning in rodents: Neurobiology and neuropharmacology

Author:
Roohbakhsh, Ali; Shamsizadeh, Ali; Arababadi, Mohammad Kazemi; Ayoobi, Fateme; Fatemi, Iman; Allahtavakoli, Mohammad; Mohammad-Zadeh, Mohammad
Source:
Life sciences 2016 v.147 pp. 1-8
ISSN:
0024-3205
Subject:
animal models; memory; mice; rats; touch (sensation); vision
Abstract:
... Animal models of learning and memory have been the subject of considerable research. Rodents such as mice and rats are nocturnal animals with poor vision, and their survival depends on their sense of touch. Recent reports have shown that whisker somatosensation is the main channel through which rodents collect and process environmental information. This review describes tactile learning in rodents ...
DOI:
10.1016/j.lfs.2016.01.031

18. The responses of pulmonary and systemic circulation and airway to anaphylactic mediators in anesthetized BALB/c mice

Author:
Wang, Mofei; Shibamoto, Toshishige; Kuda, Yuhichi; Tanida, Mamoru; Zhang, Tao; Song, Jie; Kurata, Yasutaka
Source:
Life sciences 2016 v.147 pp. 77-84
ISSN:
0024-3205
Subject:
anaphylaxis; blood flow; histamine; mice; nitric oxide; platelet-activating factor; prostaglandins; pulmonary artery; serotonin; vasoconstriction; vasodilation
Abstract:
... Anaphylactic shock sometimes accompanies pulmonary vaso- and broncho-constriction. We previously reported the hemodynamic features of mouse anaphylaxis (Life Sci. 2014; 116: 98–105). However, the effects of anaphylactic chemical mediators on the hemodynamics of in vivo mice are not well known. Furthermore, it is uncertain whether the mediators exert the same directional actions. Therefore, we dete ...
DOI:
10.1016/j.lfs.2016.01.034

19. The role of nitric oxide in the epigenetic regulation of THP-1 induced by lipopolysaccharide

Author:
Rios, Ester Correia Sarmento; de Lima, Thais Martins; Moretti, Ana Iochabel Soares; Soriano, Francisco Garcia
Source:
Life sciences 2016 v.147 pp. 110-116
ISSN:
0024-3205
Subject:
acetylation; acetyltransferases; chromatin; epigenetics; gene expression; genes; histone deacetylase; histones; inflammation; interleukin-10; interleukin-6; lipopolysaccharides; nitric oxide; nitric oxide synthase; sepsis (infection)
Abstract:
... Changes in the gene expression are one of the molecular events involved in the Systemic of Inflammatory Response Syndrome during sepsis. The preconditioning with low doses of lipopolysaccharide (LPS) reduces the expression of pro-inflammatory genes leading to less tissue damage and better outcome. This hyporesponsive state called tolerance is associated to alterations in chromatin structure and ni ...
DOI:
10.1016/j.lfs.2016.01.041

20. Treatment of allergic rhinitis with intranasal infusion of botulinum toxin type A in mice

Author:
Aoishi, Kunihide; Takahashi, Hirotaka; Hato, Naohito; Gyo, Kiyofumi; Yokota, Makoto; Ozaki, Shinya; Suzuki, Motohiko
Source:
Life sciences 2016 v.147 pp. 132-136
ISSN:
0024-3205
Subject:
botulinum toxin; hemorrhage; histology; inflammation; intraperitoneal injection; mice; nasal cavity; nasal mucosa; ovalbumin; pain; rhinitis; therapeutics
Abstract:
... To determine whether intranasal infusion of botulinum toxin type A (BTX-A) relieves symptoms of ovalbumin (OVA)-induced allergic rhinitis (AR) and reduces nasal inflammation in mice.AR was induced via intraperitoneal injection of OVA followed by daily intranasal challenge with OVA. Five weeks after the initiation of OVA sensitization, nasal cavities were exposed to a single intranasal infusion of ...
DOI:
10.1016/j.lfs.2015.08.003