PubAg

Main content area

Search

1  Search Results

1 entry found
Number of results to display per page

Search Results

1. Hepatic IGF-1R overexpression combined with the activation of GSK-3β and FOXO3a in the development of liver cirrhosis

Author:
Chen, Yang,   et al.   ; Liu, Wentao; Li, Jing; Cai, Yan; Wu, Qiong; Pan, Yue; Chen, Yujing; Zheng, Xiao; Li, Wei; Zhang, Xuewen; E, Changyong;     Show all 11 Authors
Source:
Life sciences 2016 v.147 pp. 97-102
ISSN:
0024-3205
Subject:
blood serum; carbon tetrachloride; enzyme-linked immunosorbent assay; histology; hospitals; humans; insulin; insulin-like growth factor I; insulin-like growth factor I receptor; intraperitoneal injection; liver; liver cirrhosis; liver neoplasms; mice; models; parenchyma (animal tissue); patients; signal transduction; staining; tau-protein kinase; tissue banks; China
Abstract:
... Liver cirrhosis is the common pathological histology manifest among a number of chronic liver diseases and liver cancer. Circulating levels of insulin growth factor-1 (IGF-1) have been recently linked to liver cirrhosis and the development of liver cancer. Herein, we hypothesized that IGF-1R overexpression combining the activation of GSK-3β and FOXO3a were involved in the development of human and ...
DOI:
10.1016/j.lfs.2016.01.037