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- Kidani, Yukie; Miki, Yasuo; Nomimura, Nana; Minakawa, Shiori; Tanaka, Norifumi; Miyoshi, Hiroshi; Wakabayashi, Koichi; Kudo, Yoshiki
- Life sciences 2016 v.157 pp. 108-115
- umbilical cord, etc ; blood; brain; brain damage; encephalopathy; humans; intraperitoneal injection; medicine; mice; models; nerve tissue; severe combined immunodeficiency; stem cells; therapeutics; Show all 14 Subjects
- ... Brain damage at birth can cause lifelong neurodevelopmental deficits. Recently, stem cell therapies have been used in several fields of medicine. We previously reported that CD133⁺ cells, endothelial progenitor cells derived from human umbilical cord blood, induce nerve extension in an ex vivo hypoxic-ischemic encephalopathy model. Here, we used an in vivo model to examine the effect of CD133⁺ cel ...
- Zhao, Lei; Feng, Yetong; Chen, Xin; Yuan, Jing; Liu, Xiaobo; Chen, Yaoyu; Zhao, Yifan; Liu, Pengfei; Li, Yalan
- Life sciences 2016 v.151 pp. 93-101
- umbilical cord, etc ; RNA; astrocytes; clinical trials; gene expression regulation; genes; humans; insulin-like growth factor I; microarray technology; quantitative polymerase chain reaction; stem cells; therapeutics; Show all 12 Subjects
- ... Umbilical cord derived mesenchymal stem cells (UC-MSCs) have been demonstrated to hold the potential to be applied in the treatment of kinds of disease. In recent years, some scientists have differentiated the cells into neural progenitor cells (NPCs) successfully, providing a new cell source for neural disease therapy. However, the differentiation methods still need to be improved for the clinica ...