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- Mackenzie, Louise S.; Lione, Lisa
- Life sciences 2013 v.93 no.25-26 pp. 963-967
- agonists; clinical trials; diabetes; drugs; humans; in vitro studies; neoplasms; rodents; therapeutics; transcription factors
- ... Lipid mediators have complex effects on the cell; one of the key transcriptional factors that moderate proliferation and inflammatory effects is PPARβ/δ. Following highly successful clinical trials using the PPARβ/δ agonists GW501516 for treatment of diabetes, GSK announced that any further research would be discontinued due to preclinical trials in rodents which linked this drug to wide spread tu ...