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1. CRTC2 suppresses BMP2-induced osteoblastic differentiation via Smurf1 expression in MC3T3-E1 cells

Author:
Kim, Kyeong-Min; Jeon, Wan-Jin; Kim, Eun-Jung; Jang, Won-Gu
Source:
Life sciences 2018 v.214 pp. 70-76
ISSN:
0024-3205
Subject:
Western blotting; alizarin; alkaline phosphatase; bone formation; cyclic AMP; extracellular matrix; gene overexpression; genes; gluconeogenesis; luciferase; messenger RNA; mineralization; mothers against decapentaplegic homolog proteins; osteoblasts; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; staining; transcription (genetics); tumor necrosis factor-alpha
Abstract:
... CREB (cAMP response element-binding protein)-regulated transcription coactivator (CRTC2) has been reported to act as a coactivator of CREB during gluconeogenesis. The role of CRTC2 in osteoblastic differentiation has not yet been elucidated. The aim of this study is to identify the mechanism of CRTC2 in osteoblast differentiation.The mRNA expression was determined by RT-PCR and qPCR. Protein level ...
DOI:
10.1016/j.lfs.2018.10.052