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- Ma, Yanchao; Wang, Zhuoya; Zhang, Aiping; Xu, Fenghuang; Zhao, Nannan; Xue, Jiangnan; Zhang, Hongqin; Luan, Xiying
- Life sciences 2018 v.214 pp. 98-105
- T-lymphocytes; animal models; body weight; cell differentiation; coculture; flow cytometry; humans; inflammation; interleukin-17; interleukin-6; intestines; ligands; liver; lungs; mesenchymal stromal cells; mice; phosphates; placenta; severe combined immunodeficiency; spleen; transforming growth factor beta; weight loss
- ... To examine whether human placenta mesenchymal stem/stromal cells (hpMSCs) mitigate graft-versus-host-disease (GVHD) via regulation of Th17 and Tr1.hpMSCs or phosphate buffered saline (PBS, as a control) were injected into humanized xeno-GVHD NOD/SCID mouse model. Effects on body weights and survival times were determined. In addition, various assays, including flow cytometry (FCM) and HE stain, we ...