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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Subject demethylation Remove constraint Subject: demethylation Subject term DNA methylation Remove constraint Subject term: DNA methylation
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1. Epigenetic modulation of glycoprotein VI gene expression by DNA methylation

Author:
Shuibo Gao; Yongjun Han; Xiaohui Chen; Liping Dai; Haixia Gao; Zhen Lei; Xinzhou Wang; Zhentao Wang; Hong Wu
Source:
Life sciences 2020 v.241 pp. 117103
ISSN:
0024-3205
Subject:
DNA methylation; Western blotting; biomarkers; coronary disease; demethylation; epigenetics; flow cytometry; gene expression; gene expression regulation; genes; glycoproteins; leukocytes; luciferase; messenger RNA; patients; phosphorylation; promoter regions; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:
... Glycoprotein VI (GPVI) is an important platelet membrane receptor. The expression of GPVI on platelet membranes is increased in patients with coronary heart disease (CHD). DNA methylation is one of the most common post-replication and pre-transcriptional modifications and plays a critical role in the regulation of gene expression. Here, we aimed to reveal how methylation regulates GPVI expression. ...
DOI:
10.1016/j.lfs.2019.117103

2. Dynamic decreased expression and hypermethylation of secreted frizzled-related protein 1 and 4 over the course of pulmonary fibrosis in mice

Author:
Junfei Zhou; Zheng Yi; Qiang Fu
Source:
Life sciences 2019 v.218 pp. 241-252
ISSN:
0024-3205
Subject:
DNA; DNA methylation; antagonists; demethylation; epigenetics; fibrosis; gene expression regulation; messenger RNA; methyltransferases; mice; polymerase chain reaction; protein synthesis; proteins; signal transduction
Abstract:
... Aberrantly activated Wnt signaling pathway and dysregulation of extracellular antagonists of Wnt signaling have been revealed in pulmonary fibrosis. In this study we evaluated the expression of secreted frizzled-related proteins (SFRPs) and their aberrant promoter methylation to investigate the involvement of epigenetic regulation in pulmonary fibrosis. The pulmonary fibrosis induced by intratrach ...
DOI:
10.1016/j.lfs.2018.12.041

3. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044