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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Subject term DNA methylation Remove constraint Subject term: DNA methylation Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Mechanistic insights into glucose induced vascular epigenetic reprogramming in type 2 diabetes

Author:
Priyal Dhawan; Sampara Vasishta; Aswath Balakrishnan; Manjunath B. Joshi
Source:
Life sciences 2022 v.298 pp. 120490
ISSN:
0024-3205
Subject:
DNA methylation; angiogenesis; epigenetics; epigenome; glucose; histones; hyperglycemia; inflammation; morbidity; mortality; noninsulin-dependent diabetes mellitus; pathogenesis; therapeutics; thrombosis; vasoconstriction
Abstract:
... Endothelial cells lining the vessel wall regulate thrombosis, inflammation, angiogenesis and balance between vasoconstriction and vasodilatory functions. Subjects with Type 2 diabetes (T2D) accrue a multitude of vasculopathies causing high morbidity and mortality across the globe. High glucose and its modified products such as advanced glycation end products lead to a bidirectional activation of i ...
DOI:
10.1016/j.lfs.2022.120490

2. Offspring from trained male mice inherit improved muscle mitochondrial function through PPAR co-repressor modulation

Author:
Ricardo Freitas-Dias; Tanes I. Lima; Jose Maria Costa-Junior; Luciana M. Gonçalves; Hygor N. Araujo; Flavia M.M. Paula; Gustavo J. Santos; Renato Chaves Souto Branco; Kristy Ou; Klaus H. Kaestner; Leonardo R. Silveira; Camila A.M. Oliveira; Antonio C. Boschero; Claudio C. Zoppi; Everardo M. Carneiro
Source:
Life sciences 2022 v.291 pp. 120239
ISSN:
0024-3205
Subject:
DNA methylation; epigenetics; exercise; fatigue strength; glucose tolerance; glycemic control; insulin resistance; males; mitochondria; muscles; oxygen consumption; peroxisome proliferator-activated receptors; progeny; skeletal muscle; spermatozoa
Abstract:
... Aim Investigate whether inheritance of improved skeletal muscle mitochondrial function and its association with glycemic control are multigenerational benefits of exercise. Male Swiss mice were subjected to 8 weeks of endurance training and mated with untrained females. Trained fathers displayed typical endurance training-induced adaptations. Remarkably, offspring from trained fathers also exhibit ...
DOI:
10.1016/j.lfs.2021.120239

3. Cancer-driving mutations and variants of components of the membrane trafficking core machinery

Author:
Cheryl Qian Ying Yong; Bor Luen Tang
Source:
Life sciences 2021 v.264 pp. 118662
ISSN:
0024-3205
Subject:
DNA methylation; autophagy; cell membranes; cell movement; cell proliferation; epigenetics; genes; humans; microRNA; physiological transport
Abstract:
... The core machinery for vesicular membrane trafficking broadly comprises of coat proteins, RABs, tethering complexes and SNAREs. As cellular membrane traffic modulates key processes of mitogenic signaling, cell migration, cell death and autophagy, its dysregulation could potentially results in increased cell proliferation and survival, or enhanced migration and invasion. Changes in the levels of so ...
DOI:
10.1016/j.lfs.2020.118662

4. Crosstalk between lncRNAs and miRNAs in gastrointestinal cancer drug resistance

Author:
Negin Raei; Reza Safaralizadeh; Mohammadali Hesseinpourfeizi; Abbas Yazdanbod; Farhad Pourfarzi; Saeid Latifi-Navid
Source:
Life sciences 2021 v.284 pp. 119933
ISSN:
0024-3205
Subject:
DNA methylation; apoptosis; biomarkers; carcinogenesis; cell division; chromatin; cisplatin; drug therapy; epigenetics; fluorouracil; gastrointestinal neoplasms; gastrointestinal system; histones; methotrexate; microRNA; multiple drug resistance; paclitaxel; platinum; prognosis
Abstract:
... Gastrointestinal cancers are one of the most prevalent malignancies worldwide. Dysregulation of lncRNAs by epigenetic alteration is crucial in gastrointestinal carcinogenesis. Epigenetic alteration includes DNA methylation, chromatin remodeling, histone modifications, and deregulated-gene expression by miRNAs. LncRNAs are involved in biological processes, including, uncontrolled cell division, mig ...
DOI:
10.1016/j.lfs.2021.119933

5. Epigenetic histone acetylation and Bdnf dysregulation in the hippocampus of rats exposed to repeated, low-dose diisopropylfluorophosphate

Author:
Ana C.R. Ribeiro; Fay M. Jahr; Elisa Hawkins; Mohamad M. Kronfol; Rabha M. Younis; Joseph L. McClay; Laxmikant S. Deshpande
Source:
Life sciences 2021 v.281 pp. 119765
ISSN:
0024-3205
Subject:
DNA methylation; acetylation; chromatin; chromatin immunoprecipitation; elevated plus-maze test; enzyme activity; epigenetics; forced swimming test; hippocampus; histones; organophosphorus compounds; rats; valproic acid
Abstract:
... Deployment-related exposures to organophosphate (OP) compounds are implicated for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the persistence of GWI are not fully understood. Epigenetic modifications to chromatin are regulatory mechanisms that can adaptively or maladaptively respond to external stimuli. These include DNA methylation and histone acetylation. DNA me ...
DOI:
10.1016/j.lfs.2021.119765

6. Molecular pathways and role of epigenetics in the idiopathic pulmonary fibrosis

Author:
Varalakshmi Velagacherla; Chetan Hasmukh Mehta; Yogendra Nayak; Usha Yogendra Nayak
Source:
Life sciences 2022 v.291 pp. 120283
ISSN:
0024-3205
Subject:
DNA methylation; drugs; epigenetics; etiology; genetic predisposition to disease; histones; humans; longevity; lung neoplasms; microRNA; nucleosomes; pulmonary fibrosis; telomerase; transcription (genetics); tyrosine
Abstract:
... Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with unknown etiological factors that can progress to other dangerous diseases like lung cancer. Environmental and genetic predisposition are the two major etiological or risk factors involved in the pathology of the IPF. Among the environmental risk factors, smoking is one of the major causes for the development of IPF. Epigenetic pathwa ...
DOI:
10.1016/j.lfs.2021.120283

7. Multi-omics characterization and validation of MSI-related molecular features across multiple malignancies

Author:
Yuansheng Zheng; Yiwei Huang; Guoshu Bi; Yajing Du; Jiaqi Liang; Mengnan Zhao; Zhencong Chen; Cheng Zhan; Junjie Xi; Qun Wang
Source:
Life sciences 2021 v.270 pp. 119081
ISSN:
0024-3205
Subject:
DNA methylation; databases; drugs; gene expression; genes; glycolysis; microRNA; microsatellite repeats; models; multiomics; neoplasms; prediction; somatic mutation; therapeutics
Abstract:
... To establish a microsatellite instability (MSI) predictive model in pan-cancer and compare the multi-omics characterization of MSI-related molecular features.We established a 15-gene signature for predicting MSI status and performed a systematic assessment of MSI-related molecular features including gene and miRNA expression, DNA methylation, and somatic mutation, in approximately 10,000 patients ...
DOI:
10.1016/j.lfs.2021.119081

8. TET1 overexpression attenuates paclitaxel-induced neuropathic pain through rescuing K2p1.1 expression in primary sensory neurons of male rats

Author:
Shushan Jia; Guihua Wei; Jamie Bono; Zhiqiang Pan; Bixin Zheng; Bing Wang; Adejuyigbe Adaralegbe; Christopher Tenorio; Alex Bekker; Yuan-Xiang Tao
Source:
Life sciences 2022 v.297 pp. 120486
ISSN:
0024-3205
Subject:
5-methylcytosine; DNA demethylation; DNA methylation; Western blotting; analgesic effect; chromatin immunoprecipitation; cold; ganglia; genes; heat; herpes simplex; hypersensitivity; males; pain; potassium channels; promoter regions; somatosensory disorders; transcription (genetics); viruses
Abstract:
... Paclitaxel-induced downregulation of two-pore domain K+ channel 1.1 (K₂ₚ1.1) caused by increasing DNA methylation within its gene promoter in the dorsal root ganglion (DRG) contributes to neuropathic pain. Given that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) promotes DNA demethylation and gene transcription, the present study investigated whether DRG overexpression of TET1 produ ...
DOI:
10.1016/j.lfs.2022.120486

9. VHL gene methylation contributes to excessive erythrocytosis in chronic mountain sickness rat model by upregulating the HIF-2α/EPO pathway

Author:
Min Yang; Mingming Zhu; Kang Song; Tanna Wuren; Jun Yan; Ri-Li Ge; Linhua Ji; Sen Cui
Source:
Life sciences 2021 v.266 pp. 118873
ISSN:
0024-3205
Subject:
DNA methyltransferase; animal models; bisulfites; bone marrow; eosin; epigenetics; genes; hyperplasia; hypoxia; immunohistochemistry; pathogenesis; polycythemia; reverse transcriptase polymerase chain reaction
Abstract:
... Hypoxia-inducible factors (HIFs) play important roles in the pathogenesis of erythrocytosis in chronic mountain sickness (CMS). von Hippel-Lindau (VHL) is a key regulator of hypoxia that can direct the poly-ubiquitylation and degradation of HIFs. Epigenetic mechanisms are believed to contribute toward adaption to chronic hypoxia. Here, we investigated the contribution and mechanism of VHL methylat ...
DOI:
10.1016/j.lfs.2020.118873

10. An effective seven-CpG-based signature to predict survival in renal clear cell carcinoma by integrating DNA methylation and gene expression

Author:
Lei Xu; Jian He; Qihang Cai; Menglong Li; Xuemei Pu; Yanzhi Guo
Source:
Life sciences 2020 v.243 pp. 117289
ISSN:
0024-3205
Subject:
DNA methylation; biomarkers; carcinoma; disease progression; gender; gene expression; genes; human diseases; messenger RNA; models; patients; prediction; regression analysis; risk assessment; risk factors; transcription (genetics)
Abstract:
... Currently, using clinicopathological risk factors only is not far from effective to evaluate the risk of disease progression in renal clear cell carcinoma (KIRC) patients. Molecular biomarkers might improve risk stratification of KIRC. DNA methylation occurs the whole process of tumor development and transcriptional disorders are also one of the important characteristics of tumor. Hence, this stud ...
DOI:
10.1016/j.lfs.2020.117289

11. CD40 DNA hypermethylation in primary gastric tumors; as a novel diagnostic biomarker

Author:
Mohammad Amini; Khodayar Ghorban; Ahad Mokhtarzadeh; Maryam Dadmanesh; Behzad Baradaran
Source:
Life sciences 2020 v.254 pp. 117774
ISSN:
0024-3205
Subject:
DNA hypermethylation; biomarkers; biopsy; breasts; databases; diagnostic techniques; epigenetics; gene expression; genes; humans; immune response; microarray technology; neoplasm progression; prognosis; stomach neoplasms
Abstract:
... Gastric cancer (GC) remains one of the deadliest malignancies worldwide due to its poor prognosis. DNA methylation changes, as an early event during tumor progression, constitute attractive markers for cancer diagnostics. In the current study, CD40 DNA methylation was investigated in GC as a novel epigenetic biomarker.We first analyzed DNA methylation microarrays from the Gene Expression Omnibus d ...
DOI:
10.1016/j.lfs.2020.117774

12. Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis

Author:
Lu Tan; Ting Qiu; Rong Xiang; Cheng Cao; Yuqin Deng; Zezhang Tao; Yu Xu
Source:
Life sciences 2020 v.241 pp. 117101
ISSN:
0024-3205
Subject:
DNA; DNA methylation; T-lymphocytes; allergic rhinitis; chromatin; flow cytometry; gene expression regulation; genes; messenger RNA; patients; precipitin tests; protein binding; quantitative polymerase chain reaction; sequence analysis; spleen
Abstract:
... Ten-eleven-translocation (Tet) proteins are 5-methylcytosine oxidases and have profound impact on DNA methylation and genes expression. This study aimed to investigate the role of Tet2 and its association with Foxp3 DNA methylation in regulatory T (Treg) cell of allergic rhinitis (AR). CD4⁺CD25⁺Treg cells were sorted from peripheral blood lymphocytes drawn from AR patients and spleen lymphocytes d ...
DOI:
10.1016/j.lfs.2019.117101

13. Epigenetic and non-epigenetic regulation of Klotho in kidney disease

Author:
Ajinath Kale; Himanshu Sankrityayan; Hans-Joachim Anders; Anil Bhanudas Gaikwad
Source:
Life sciences 2021 v.264 pp. 118644
ISSN:
0024-3205
Subject:
DNA methylation; acute kidney injury; albumins; biomarkers; brain; cytokines; diabetic nephropathy; epigenetics; fibrosis; histones; kidneys; microRNA; pancreas; physiology; reactive oxygen species; renin; therapeutics
Abstract:
... Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest expression levels in the kidney. Klotho sustains normal kidney physiology but Klotho regulation also contributes to the progression of kidney disease. Systemic and intrarenal levels of Klotho fall drastically during acute ...
DOI:
10.1016/j.lfs.2020.118644

14. Epigenetic modulation of glycoprotein VI gene expression by DNA methylation

Author:
Shuibo Gao; Yongjun Han; Xiaohui Chen; Liping Dai; Haixia Gao; Zhen Lei; Xinzhou Wang; Zhentao Wang; Hong Wu
Source:
Life sciences 2020 v.241 pp. 117103
ISSN:
0024-3205
Subject:
DNA methylation; Western blotting; biomarkers; coronary disease; demethylation; epigenetics; flow cytometry; gene expression; gene expression regulation; genes; glycoproteins; leukocytes; luciferase; messenger RNA; patients; phosphorylation; promoter regions; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:
... Glycoprotein VI (GPVI) is an important platelet membrane receptor. The expression of GPVI on platelet membranes is increased in patients with coronary heart disease (CHD). DNA methylation is one of the most common post-replication and pre-transcriptional modifications and plays a critical role in the regulation of gene expression. Here, we aimed to reveal how methylation regulates GPVI expression. ...
DOI:
10.1016/j.lfs.2019.117103

15. Epigenetics-based therapeutics for myocardial fibrosis

Author:
Xuping Li; Ying Yang; Sixuan Chen; Jiuyao Zhou; Jingyan Li; Yuanyuan Cheng
Source:
Life sciences 2021 v.271 pp. 119186
ISSN:
0024-3205
Subject:
DNA methylation; collagen; epigenetics; extracellular matrix; fibroblasts; fibrosis; heart failure; histone code; mortality; myocardium; therapeutics
Abstract:
... Myocardial fibrosis (MF) is a reactive remodeling process in response to myocardial injury. It is mainly manifested by the proliferation of cardiac muscle fibroblasts and secreting extracellular matrix (ECM) proteins to replace damaged tissue. However, the excessive production and deposition of extracellular matrix, and the rising proportion of type I and type III collagen lead to pathological fib ...
DOI:
10.1016/j.lfs.2021.119186

16. Hypermethylation of secreted frizzled related protein 2 gene promoter serves as a noninvasive biomarker for HBV-associated hepatocellular carcinoma

Author:
Lin Xiang; La-Mei Chen; Yu-Jia Zhai; Wei-Juan Sun; Jie-Ru Yang; Yu-Chen Fan; Kai Wang
Source:
Life sciences 2021 v.270 pp. 119061
ISSN:
0024-3205
Subject:
Hepatitis B virus; antagonists; biomarkers; chronic hepatitis B; disease diagnosis; females; gene expression; genes; hepatoma; methylation
Abstract:
... For patients with hepatocellular carcinoma (HCC), early detection is critical to improve survival. Secreted frizzled-related protein 2 (SFRP2) is a candidate tumor suppressor as Wnt antagonist and SFRP2 promoter has been found hypermethylated in various malignancies. This study aimed to investigate the methylation status of SFRP2 promoter in hepatitis B virus (HBV) associated HCC and estimate its ...
DOI:
10.1016/j.lfs.2021.119061

17. Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma

Author:
Xiaoshuai Wang; Yueyin Han; Jia Li; Dongchun Hong; Zhicheng Xue; Haoyang Huang; Zefeng Du; Yingdong Hou; Hongbo Li; Hongyi Li; Hongyi Liao; Xianbiao Xie; Changhai Ding
Source:
Life sciences 2021 v.265 pp. 118734
ISSN:
0024-3205
Subject:
DNA methylation; RNA; biomarkers; carcinogenesis; cell lines; copy number variation; diploidy; drugs; inhibitory concentration 50; leiomyosarcoma; mast cells; multiomics; patients; prognosis; tissues
Abstract:
... RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS.RNA sequence profiles and CNV data of 255 STS patients were downloaded from the Cancer Genome Atlas (TCGA). The correlation analysis involved CNVs of R ...
DOI:
10.1016/j.lfs.2020.118734

18. PI3K/AKT/mTOR signaling in gastric cancer: Epigenetics and beyond

Author:
Sadegh Fattahi; Fatemeh Amjadi-Moheb; Reza Tabaripour; Gholam Hossein Ashrafi; Haleh Akhavan-Niaki
Source:
Life sciences 2020 v.262 pp. 118513
ISSN:
0024-3205
Subject:
DNA methylation; Helicobacter pylori; Human gammaherpesvirus 4; apoptosis; autophagy; cancer therapy; carcinogenesis; epigenetics; histones; humans; metastasis; prognosis; stomach neoplasms
Abstract:
... PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved in normal cellular processes. Its aberrant activation modulates autophagy, epithelial-mesenchymal transition, apoptosis, chemoresistance, and metastasis in many human cancers. Emerging evidence demonstrates that some infections as well as epigenetic regulatory mechanisms can control PI3K/AKT/mTOR signaling pathway. In t ...
DOI:
10.1016/j.lfs.2020.118513

19. Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders

Author:
Rohan Gupta; Rashmi K. Ambasta; Pravir Kumar
Source:
Life sciences 2020 v.243 pp. 117278
ISSN:
0024-3205
Subject:
DNA damage; DNA methylation; apoptosis; brain; cell cycle; chromatin; clinical trials; epigenetics; gene expression; histone code; histone deacetylase; histones; homeostasis; inflammation; models; neurodegenerative diseases; neurons; neuroprotective effect; post-translational modification; protein-protein interactions; tau-protein kinase; therapeutics; transcription (genetics)
Abstract:
... Reversal of aging symptoms and related disorders are the challenging task where epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin remodeling and regulation that are linked to the progression of various neurodegenerative disorders (NDDs). Overexpression of various histone deacetylase (HDACs) can activate Glycogen synthase kinase 3 which promotes the hyper ...
DOI:
10.1016/j.lfs.2020.117278

20. Transcriptional changes of mouse ovary during follicle initial or cyclic recruitment mediated by extra hormone treatment

Author:
Xuejiao Bian; Qin Xie; Yuxiao Zhou; Haibo Wu; Junqi Cui; Liling Jia; Lun Suo
Source:
Life sciences 2021 v.264 pp. 118654
ISSN:
0024-3205
Subject:
DNA methylation; GATA transcription factors; cell cycle; data collection; follicular development; gene expression; immune system; metabolism; mice; oocytes; sequence analysis; transcription (genetics); transcriptome; variance
Abstract:
... Folliculogenesis contains gonadotropin-independent and -dependent stage. Disruption in any of this process would induce failure in retrieving capable oocytes during clinical treatment. However, there is still limited understanding of the molecular components specifically regulating this process.Ovaries of P3, P20 and exogenous gonadotropin-treated P22 mice were sampled and underwent RNA-seq to inv ...
DOI:
10.1016/j.lfs.2020.118654