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- Author:
- Priyal Dhawan; Sampara Vasishta; Aswath Balakrishnan; Manjunath B. Joshi
- Source:
- Life sciences 2022 v.298 pp. 120490
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; angiogenesis; epigenetics; epigenome; glucose; histones; hyperglycemia; inflammation; morbidity; mortality; noninsulin-dependent diabetes mellitus; pathogenesis; therapeutics; thrombosis; vasoconstriction
- Abstract:
- ... Endothelial cells lining the vessel wall regulate thrombosis, inflammation, angiogenesis and balance between vasoconstriction and vasodilatory functions. Subjects with Type 2 diabetes (T2D) accrue a multitude of vasculopathies causing high morbidity and mortality across the globe. High glucose and its modified products such as advanced glycation end products lead to a bidirectional activation of i ...
- DOI:
- 10.1016/j.lfs.2022.120490
- https://doi.org/10.1016/j.lfs.2022.120490
- Author:
- Ricardo Freitas-Dias; Tanes I. Lima; Jose Maria Costa-Junior; Luciana M. Gonçalves; Hygor N. Araujo; Flavia M.M. Paula; Gustavo J. Santos; Renato Chaves Souto Branco; Kristy Ou; Klaus H. Kaestner; Leonardo R. Silveira; Camila A.M. Oliveira; Antonio C. Boschero; Claudio C. Zoppi; Everardo M. Carneiro
- Source:
- Life sciences 2022 v.291 pp. 120239
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; epigenetics; exercise; fatigue strength; glucose tolerance; glycemic control; insulin resistance; males; mitochondria; muscles; oxygen consumption; peroxisome proliferator-activated receptors; progeny; skeletal muscle; spermatozoa
- Abstract:
- ... Aim Investigate whether inheritance of improved skeletal muscle mitochondrial function and its association with glycemic control are multigenerational benefits of exercise. Male Swiss mice were subjected to 8 weeks of endurance training and mated with untrained females. Trained fathers displayed typical endurance training-induced adaptations. Remarkably, offspring from trained fathers also exhibit ...
- DOI:
- 10.1016/j.lfs.2021.120239
- https://doi.org/10.1016/j.lfs.2021.120239
- Author:
- Cheryl Qian Ying Yong; Bor Luen Tang
- Source:
- Life sciences 2021 v.264 pp. 118662
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; autophagy; cell membranes; cell movement; cell proliferation; epigenetics; genes; humans; microRNA; physiological transport
- Abstract:
- ... The core machinery for vesicular membrane trafficking broadly comprises of coat proteins, RABs, tethering complexes and SNAREs. As cellular membrane traffic modulates key processes of mitogenic signaling, cell migration, cell death and autophagy, its dysregulation could potentially results in increased cell proliferation and survival, or enhanced migration and invasion. Changes in the levels of so ...
- DOI:
- 10.1016/j.lfs.2020.118662
- https://doi.org/10.1016/j.lfs.2020.118662
- Author:
- Negin Raei; Reza Safaralizadeh; Mohammadali Hesseinpourfeizi; Abbas Yazdanbod; Farhad Pourfarzi; Saeid Latifi-Navid
- Source:
- Life sciences 2021 v.284 pp. 119933
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; apoptosis; biomarkers; carcinogenesis; cell division; chromatin; cisplatin; drug therapy; epigenetics; fluorouracil; gastrointestinal neoplasms; gastrointestinal system; histones; methotrexate; microRNA; multiple drug resistance; paclitaxel; platinum; prognosis
- Abstract:
- ... Gastrointestinal cancers are one of the most prevalent malignancies worldwide. Dysregulation of lncRNAs by epigenetic alteration is crucial in gastrointestinal carcinogenesis. Epigenetic alteration includes DNA methylation, chromatin remodeling, histone modifications, and deregulated-gene expression by miRNAs. LncRNAs are involved in biological processes, including, uncontrolled cell division, mig ...
- DOI:
- 10.1016/j.lfs.2021.119933
- https://doi.org/10.1016/j.lfs.2021.119933
- Author:
- Ana C.R. Ribeiro; Fay M. Jahr; Elisa Hawkins; Mohamad M. Kronfol; Rabha M. Younis; Joseph L. McClay; Laxmikant S. Deshpande
- Source:
- Life sciences 2021 v.281 pp. 119765
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; acetylation; chromatin; chromatin immunoprecipitation; elevated plus-maze test; enzyme activity; epigenetics; forced swimming test; hippocampus; histones; organophosphorus compounds; rats; valproic acid
- Abstract:
- ... Deployment-related exposures to organophosphate (OP) compounds are implicated for Gulf War Illness (GWI) development in First GW veterans. However, reasons for the persistence of GWI are not fully understood. Epigenetic modifications to chromatin are regulatory mechanisms that can adaptively or maladaptively respond to external stimuli. These include DNA methylation and histone acetylation. DNA me ...
- DOI:
- 10.1016/j.lfs.2021.119765
- https://doi.org/10.1016/j.lfs.2021.119765
- Author:
- Genki Mizuno; Hiroya Yamada; Eiji Munetsuna; Yoshitaka Ando; Atsushi Teshigawara; Manaka Ito; Itsuki Kageyama; Yuki Nouchi; Takuya Wakasugi; Tomohide Sakakibara; Mirai Yamazaki; Ryosuke Fujii; Hiroaki Ishikawa; Koji Suzuki; Shuji Hashimoto; Koji Ohashi
- Source:
- Life sciences 2022 v.301 pp. 120638
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; adolescence; adulthood; animal models; carnitine palmitoyltransferase; childhood; epigenetics; fatty-acid synthase; gene expression; genes; high fructose corn syrup; high-throughput nucleotide sequencing; lipid metabolism; lipids; peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor gamma; quantitative polymerase chain reaction; young adults
- Abstract:
- ... This study aimed to analyze differences in sensitivity to hepatic lipid metabolism at different ages, through DNA methylation, using an experimental rat model of high-fructose corn syrup (HFCS) intake. The experimental was divided into three periods: childhood and adolescence (postnatal day (PD) 21–60), young adulthood (PD61–100), and adulthood (PD101–140). Rats in the different age groups were as ...
- DOI:
- 10.1016/j.lfs.2022.120638
- https://doi.org/10.1016/j.lfs.2022.120638
- Author:
- Varalakshmi Velagacherla; Chetan Hasmukh Mehta; Yogendra Nayak; Usha Yogendra Nayak
- Source:
- Life sciences 2022 v.291 pp. 120283
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; drugs; epigenetics; etiology; genetic predisposition to disease; histones; humans; longevity; lung neoplasms; microRNA; nucleosomes; pulmonary fibrosis; telomerase; transcription (genetics); tyrosine
- Abstract:
- ... Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with unknown etiological factors that can progress to other dangerous diseases like lung cancer. Environmental and genetic predisposition are the two major etiological or risk factors involved in the pathology of the IPF. Among the environmental risk factors, smoking is one of the major causes for the development of IPF. Epigenetic pathwa ...
- DOI:
- 10.1016/j.lfs.2021.120283
- https://doi.org/10.1016/j.lfs.2021.120283
- Author:
- Yuansheng Zheng; Yiwei Huang; Guoshu Bi; Yajing Du; Jiaqi Liang; Mengnan Zhao; Zhencong Chen; Cheng Zhan; Junjie Xi; Qun Wang
- Source:
- Life sciences 2021 v.270 pp. 119081
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; databases; drugs; gene expression; genes; glycolysis; microRNA; microsatellite repeats; models; multiomics; neoplasms; prediction; somatic mutation; therapeutics
- Abstract:
- ... To establish a microsatellite instability (MSI) predictive model in pan-cancer and compare the multi-omics characterization of MSI-related molecular features.We established a 15-gene signature for predicting MSI status and performed a systematic assessment of MSI-related molecular features including gene and miRNA expression, DNA methylation, and somatic mutation, in approximately 10,000 patients ...
- DOI:
- 10.1016/j.lfs.2021.119081
- https://doi.org/10.1016/j.lfs.2021.119081
- Author:
- Shushan Jia; Guihua Wei; Jamie Bono; Zhiqiang Pan; Bixin Zheng; Bing Wang; Adejuyigbe Adaralegbe; Christopher Tenorio; Alex Bekker; Yuan-Xiang Tao
- Source:
- Life sciences 2022 v.297 pp. 120486
- ISSN:
- 0024-3205
- Subject:
- 5-methylcytosine; DNA demethylation; DNA methylation; Western blotting; analgesic effect; chromatin immunoprecipitation; cold; ganglia; genes; heat; herpes simplex; hypersensitivity; males; pain; potassium channels; promoter regions; somatosensory disorders; transcription (genetics); viruses
- Abstract:
- ... Paclitaxel-induced downregulation of two-pore domain K+ channel 1.1 (K₂ₚ1.1) caused by increasing DNA methylation within its gene promoter in the dorsal root ganglion (DRG) contributes to neuropathic pain. Given that ten-eleven translocation methylcytosine dioxygenase 1 (TET1) promotes DNA demethylation and gene transcription, the present study investigated whether DRG overexpression of TET1 produ ...
- DOI:
- 10.1016/j.lfs.2022.120486
- https://doi.org/10.1016/j.lfs.2022.120486
- Author:
- Min Yang; Mingming Zhu; Kang Song; Tanna Wuren; Jun Yan; Ri-Li Ge; Linhua Ji; Sen Cui
- Source:
- Life sciences 2021 v.266 pp. 118873
- ISSN:
- 0024-3205
- Subject:
- DNA methyltransferase; animal models; bisulfites; bone marrow; eosin; epigenetics; genes; hyperplasia; hypoxia; immunohistochemistry; pathogenesis; polycythemia; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Hypoxia-inducible factors (HIFs) play important roles in the pathogenesis of erythrocytosis in chronic mountain sickness (CMS). von Hippel-Lindau (VHL) is a key regulator of hypoxia that can direct the poly-ubiquitylation and degradation of HIFs. Epigenetic mechanisms are believed to contribute toward adaption to chronic hypoxia. Here, we investigated the contribution and mechanism of VHL methylat ...
- DOI:
- 10.1016/j.lfs.2020.118873
- https://doi.org/10.1016/j.lfs.2020.118873
- Author:
- Lei Xu; Jian He; Qihang Cai; Menglong Li; Xuemei Pu; Yanzhi Guo
- Source:
- Life sciences 2020 v.243 pp. 117289
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; biomarkers; carcinoma; disease progression; gender; gene expression; genes; human diseases; messenger RNA; models; patients; prediction; regression analysis; risk assessment; risk factors; transcription (genetics)
- Abstract:
- ... Currently, using clinicopathological risk factors only is not far from effective to evaluate the risk of disease progression in renal clear cell carcinoma (KIRC) patients. Molecular biomarkers might improve risk stratification of KIRC. DNA methylation occurs the whole process of tumor development and transcriptional disorders are also one of the important characteristics of tumor. Hence, this stud ...
- DOI:
- 10.1016/j.lfs.2020.117289
- https://doi.org/10.1016/j.lfs.2020.117289
- Author:
- Mohammad Amini; Khodayar Ghorban; Ahad Mokhtarzadeh; Maryam Dadmanesh; Behzad Baradaran
- Source:
- Life sciences 2020 v.254 pp. 117774
- ISSN:
- 0024-3205
- Subject:
- DNA hypermethylation; biomarkers; biopsy; breasts; databases; diagnostic techniques; epigenetics; gene expression; genes; humans; immune response; microarray technology; neoplasm progression; prognosis; stomach neoplasms
- Abstract:
- ... Gastric cancer (GC) remains one of the deadliest malignancies worldwide due to its poor prognosis. DNA methylation changes, as an early event during tumor progression, constitute attractive markers for cancer diagnostics. In the current study, CD40 DNA methylation was investigated in GC as a novel epigenetic biomarker.We first analyzed DNA methylation microarrays from the Gene Expression Omnibus d ...
- DOI:
- 10.1016/j.lfs.2020.117774
- https://doi.org/10.1016/j.lfs.2020.117774
- Author:
- Lu Tan; Ting Qiu; Rong Xiang; Cheng Cao; Yuqin Deng; Zezhang Tao; Yu Xu
- Source:
- Life sciences 2020 v.241 pp. 117101
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; T-lymphocytes; allergic rhinitis; chromatin; flow cytometry; gene expression regulation; genes; messenger RNA; patients; precipitin tests; protein binding; quantitative polymerase chain reaction; sequence analysis; spleen
- Abstract:
- ... Ten-eleven-translocation (Tet) proteins are 5-methylcytosine oxidases and have profound impact on DNA methylation and genes expression. This study aimed to investigate the role of Tet2 and its association with Foxp3 DNA methylation in regulatory T (Treg) cell of allergic rhinitis (AR). CD4⁺CD25⁺Treg cells were sorted from peripheral blood lymphocytes drawn from AR patients and spleen lymphocytes d ...
- DOI:
- 10.1016/j.lfs.2019.117101
- https://doi.org/10.1016/j.lfs.2019.117101
- Author:
- Ajinath Kale; Himanshu Sankrityayan; Hans-Joachim Anders; Anil Bhanudas Gaikwad
- Source:
- Life sciences 2021 v.264 pp. 118644
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; acute kidney injury; albumins; biomarkers; brain; cytokines; diabetic nephropathy; epigenetics; fibrosis; histones; kidneys; microRNA; pancreas; physiology; reactive oxygen species; renin; therapeutics
- Abstract:
- ... Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest expression levels in the kidney. Klotho sustains normal kidney physiology but Klotho regulation also contributes to the progression of kidney disease. Systemic and intrarenal levels of Klotho fall drastically during acute ...
- DOI:
- 10.1016/j.lfs.2020.118644
- https://doi.org/10.1016/j.lfs.2020.118644
- Author:
- Shuibo Gao; Yongjun Han; Xiaohui Chen; Liping Dai; Haixia Gao; Zhen Lei; Xinzhou Wang; Zhentao Wang; Hong Wu
- Source:
- Life sciences 2020 v.241 pp. 117103
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; Western blotting; biomarkers; coronary disease; demethylation; epigenetics; flow cytometry; gene expression; gene expression regulation; genes; glycoproteins; leukocytes; luciferase; messenger RNA; patients; phosphorylation; promoter regions; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
- Abstract:
- ... Glycoprotein VI (GPVI) is an important platelet membrane receptor. The expression of GPVI on platelet membranes is increased in patients with coronary heart disease (CHD). DNA methylation is one of the most common post-replication and pre-transcriptional modifications and plays a critical role in the regulation of gene expression. Here, we aimed to reveal how methylation regulates GPVI expression. ...
- DOI:
- 10.1016/j.lfs.2019.117103
- https://doi.org/10.1016/j.lfs.2019.117103
- Author:
- Xuping Li; Ying Yang; Sixuan Chen; Jiuyao Zhou; Jingyan Li; Yuanyuan Cheng
- Source:
- Life sciences 2021 v.271 pp. 119186
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; collagen; epigenetics; extracellular matrix; fibroblasts; fibrosis; heart failure; histone code; mortality; myocardium; therapeutics
- Abstract:
- ... Myocardial fibrosis (MF) is a reactive remodeling process in response to myocardial injury. It is mainly manifested by the proliferation of cardiac muscle fibroblasts and secreting extracellular matrix (ECM) proteins to replace damaged tissue. However, the excessive production and deposition of extracellular matrix, and the rising proportion of type I and type III collagen lead to pathological fib ...
- DOI:
- 10.1016/j.lfs.2021.119186
- https://doi.org/10.1016/j.lfs.2021.119186
- Author:
- Lin Xiang; La-Mei Chen; Yu-Jia Zhai; Wei-Juan Sun; Jie-Ru Yang; Yu-Chen Fan; Kai Wang
- Source:
- Life sciences 2021 v.270 pp. 119061
- ISSN:
- 0024-3205
- Subject:
- Hepatitis B virus; antagonists; biomarkers; chronic hepatitis B; disease diagnosis; females; gene expression; genes; hepatoma; methylation
- Abstract:
- ... For patients with hepatocellular carcinoma (HCC), early detection is critical to improve survival. Secreted frizzled-related protein 2 (SFRP2) is a candidate tumor suppressor as Wnt antagonist and SFRP2 promoter has been found hypermethylated in various malignancies. This study aimed to investigate the methylation status of SFRP2 promoter in hepatitis B virus (HBV) associated HCC and estimate its ...
- DOI:
- 10.1016/j.lfs.2021.119061
- https://doi.org/10.1016/j.lfs.2021.119061
- Author:
- Xiaoshuai Wang; Yueyin Han; Jia Li; Dongchun Hong; Zhicheng Xue; Haoyang Huang; Zefeng Du; Yingdong Hou; Hongbo Li; Hongyi Li; Hongyi Liao; Xianbiao Xie; Changhai Ding
- Source:
- Life sciences 2021 v.265 pp. 118734
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; RNA; biomarkers; carcinogenesis; cell lines; copy number variation; diploidy; drugs; inhibitory concentration 50; leiomyosarcoma; mast cells; multiomics; patients; prognosis; tissues
- Abstract:
- ... RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation (CNV) is a frequent characteristic in soft tissue sarcomas (STS). However, little is known regarding their possible roles in STS.RNA sequence profiles and CNV data of 255 STS patients were downloaded from the Cancer Genome Atlas (TCGA). The correlation analysis involved CNVs of R ...
- DOI:
- 10.1016/j.lfs.2020.118734
- https://doi.org/10.1016/j.lfs.2020.118734
- Author:
- Sadegh Fattahi; Fatemeh Amjadi-Moheb; Reza Tabaripour; Gholam Hossein Ashrafi; Haleh Akhavan-Niaki
- Source:
- Life sciences 2020 v.262 pp. 118513
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; Helicobacter pylori; Human gammaherpesvirus 4; apoptosis; autophagy; cancer therapy; carcinogenesis; epigenetics; histones; humans; metastasis; prognosis; stomach neoplasms
- Abstract:
- ... PI3K/AKT/mTOR pathway is one of the most important signaling pathways involved in normal cellular processes. Its aberrant activation modulates autophagy, epithelial-mesenchymal transition, apoptosis, chemoresistance, and metastasis in many human cancers. Emerging evidence demonstrates that some infections as well as epigenetic regulatory mechanisms can control PI3K/AKT/mTOR signaling pathway. In t ...
- DOI:
- 10.1016/j.lfs.2020.118513
- https://doi.org/10.1016/j.lfs.2020.118513
- Author:
- Rohan Gupta; Rashmi K. Ambasta; Pravir Kumar
- Source:
- Life sciences 2020 v.243 pp. 117278
- ISSN:
- 0024-3205
- Subject:
- DNA damage; DNA methylation; apoptosis; brain; cell cycle; chromatin; clinical trials; epigenetics; gene expression; histone code; histone deacetylase; histones; homeostasis; inflammation; models; neurodegenerative diseases; neurons; neuroprotective effect; post-translational modification; protein-protein interactions; tau-protein kinase; therapeutics; transcription (genetics)
- Abstract:
- ... Reversal of aging symptoms and related disorders are the challenging task where epigenetic is a crucial player that includes DNA methylation, histone modification; chromatin remodeling and regulation that are linked to the progression of various neurodegenerative disorders (NDDs). Overexpression of various histone deacetylase (HDACs) can activate Glycogen synthase kinase 3 which promotes the hyper ...
- DOI:
- 10.1016/j.lfs.2020.117278
- https://doi.org/10.1016/j.lfs.2020.117278
- Author:
- Xuejiao Bian; Qin Xie; Yuxiao Zhou; Haibo Wu; Junqi Cui; Liling Jia; Lun Suo
- Source:
- Life sciences 2021 v.264 pp. 118654
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; GATA transcription factors; cell cycle; data collection; follicular development; gene expression; immune system; metabolism; mice; oocytes; sequence analysis; transcription (genetics); transcriptome; variance
- Abstract:
- ... Folliculogenesis contains gonadotropin-independent and -dependent stage. Disruption in any of this process would induce failure in retrieving capable oocytes during clinical treatment. However, there is still limited understanding of the molecular components specifically regulating this process.Ovaries of P3, P20 and exogenous gonadotropin-treated P22 mice were sampled and underwent RNA-seq to inv ...
- DOI:
- 10.1016/j.lfs.2020.118654
- https://doi.org/10.1016/j.lfs.2020.118654
- Author:
- Vinay Koshy Varghese; Vaibhav Shukla; Padacherri Vethil Jishnu; Shama Prasada Kabekkodu; Deeksha Pandey; Krishna Sharan; Kapaettu Satyamoorthy
- Source:
- Life sciences 2019 v.232 pp. 116668
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; apoptosis; bisulfites; carcinogenesis; cell proliferation; cervix; epigenetics; epithelium; genes; humans; luciferase; metastasis; microRNA; neoplasm progression; pathophysiology; sequence analysis; squamous cell carcinoma; uterine cervical neoplasms
- Abstract:
- ... Gene regulatory mechanisms determine the multistep carcinogenesis process. Two aspects of epigenetics are microRNA (miRNAs) and DNA methylation that regulate distinct biological mechanisms such as metastasis, apoptosis cell proliferation and induction of senescence. Although critical, the interplay between these two epigenetic mechanisms is yet to be completely understood, particularly in cervical ...
- DOI:
- 10.1016/j.lfs.2019.116668
- https://doi.org/10.1016/j.lfs.2019.116668
- Author:
- Donghui Cao; Zhifang Jia; Yanhua Wu; Tongrong Su; Dan Zhao; Menghui Wu; Tetsuya Tsukamoto; Masanobu Oshima; Jing Jiang; Xueyuan Cao
- Source:
- Life sciences 2020 v.263 pp. 118580
- ISSN:
- 0024-3205
- Subject:
- DNA demethylation; carcinogenesis; cell cycle; cell viability; curcumin; hydrogen; methylation; stomach neoplasms; therapeutics; tumor suppressor genes
- Abstract:
- ... Aberrant methylation of promoter CpG islands (CGIs) can inactivate the expression of many tumor suppressor genes and play an important role in the carcinogenesis of gastric cancer. The tumor suppressor gene RB1, which encodes a cell cycle regulator, is hypermethylated and downregulated in multiple kinds of cancer. Activation of RB1 expression through DNA demethylation is a potential strategy for t ...
- DOI:
- 10.1016/j.lfs.2020.118580
- https://doi.org/10.1016/j.lfs.2020.118580
- Author:
- Armita Mahdavi Gorabi; Peter E. Penson; Maciej Banach; Morteza Motallebnezhad; Tannaz Jamialahmadi; Amirhossein Sahebkar
- Source:
- Life sciences 2020 v.253 pp. 117682
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; arteries; atherosclerosis; endothelial cells; epigenetics; foam cells; genes; histone code; inflammation; microRNA; myocytes; oxidative stress; physiology; smooth muscle; therapeutics
- Abstract:
- ... Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, in ...
- DOI:
- 10.1016/j.lfs.2020.117682
- https://doi.org/10.1016/j.lfs.2020.117682
- Author:
- Ruijie Wang; Ya Li; Peipei Du; Xiaoan Zhang; Xiaofu Li; Guomei Cheng
- Source:
- Life sciences 2019 v.233 pp. 116708
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; antisense RNA; bioinformatics; data collection; genes; immunologic factors; messenger RNA; metastasis; non-coding RNA; nutritional status; prognosis; sequence analysis; statistical analysis; uterine cervical neoplasms; women; women's health
- Abstract:
- ... Cervical cancer seriously affects women's health. The function of methylated alterations in the long non-coding RNAs (lncRNAs) promote the progression and metastasis of cancer. Our study aims to identify the functional effects of lncRNA methylation in cervical carcinogenesis.Genome-wide DNA methylation of 6 samples was assessed using the Illumina Infinium MethylationEPIC BeadChip. RNA sequencing ( ...
- DOI:
- 10.1016/j.lfs.2019.116708
- https://doi.org/10.1016/j.lfs.2019.116708
- Author:
- Donghui Cao; Dan Zhao; Zhifang Jia; Tongrong Su; Yangyu Zhang; Yanhua Wu; Menghui Wu; Tetsuya Tsukamoto; Masanobu Oshima; Jing Jiang; Xueyuan Cao
- Source:
- Life sciences 2020 v.242 pp. 117214
- ISSN:
- 0024-3205
- Subject:
- DNA demethylation; DNA methylation; Glycyrrhiza; bioactive compounds; carcinogenesis; exons; gastric acid; gene silencing; genetically modified organisms; genomic islands; models; precipitin tests; promoter regions; protons; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; secretion; stomach; stomach neoplasms; therapeutics; tissues; transcriptome; tumor suppressor genes
- Abstract:
- ... Accumulating evidence suggests that aberrant DNA methylation and gene silencing of tumor suppressors are pervasive in gastric malignancies, supporting reactivation of tumor suppressors through DNA demethylation as a potential therapeutic opportunity. Atp4a is an important tumor suppressor gene, encoding H⁺, K⁺-ATPase, and mediating gastric acid secretion in the stomach. Using transgenic gastric ca ...
- DOI:
- 10.1016/j.lfs.2019.117214
- https://doi.org/10.1016/j.lfs.2019.117214
- Author:
- Peihua Liu; Longxiang Wu; Harripersaud Chand; Chao Li; Xiheng Hu; Yangle Li
- Source:
- Life sciences 2020 v.261 pp. 118311
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; DNA methyltransferase; RNA; Western blotting; cell growth; cell viability; genes; luciferase; precipitin tests; therapeutics; urinary bladder neoplasms
- Abstract:
- ... Bladder cancer (BCa) is one of the most commonly occurring urological malignancy. DNA methylation mediated by DNA methyltransferase 1 (DNMT1) plays a crucial role in the physiological and pathological processes of cancer. However, the role of upstream regulatory factors and downstream target genes of DNA methylation mediated by DNMT1 needs further study in BCa. We aim to discover the upstream regu ...
- DOI:
- 10.1016/j.lfs.2020.118311
- https://doi.org/10.1016/j.lfs.2020.118311
- Author:
- Kunal Singh; Niraj Kumar Jha; Abhimanyu Thakur
- Source:
- Life sciences 2019 v.221 pp. 377-391
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA-directed RNA polymerase; acetylation; acetyltransferases; chromatin; circadian rhythm; enzyme activity; epigenetics; genes; histone deacetylase; histones; metabolic diseases; methylation; microRNA; neoplasms; protein composition; protein products; regulatory sequences; selection pressure; stoichiometry; transcription (genetics); transcriptome
- Abstract:
- ... Over the course of evolution, nature has forced organisms under selection pressure to hardwire an internal time keeping device that defines 24 h of a daily cycle of physiological and behavioral rhythms, known as circadian rhythms. At the cellular level, the cycle is governed by significant fractions of transcriptomes, which are under the control of transcriptional and translational feedback loop o ...
- DOI:
- 10.1016/j.lfs.2019.02.006
- https://doi.org/10.1016/j.lfs.2019.02.006
- Author:
- Guangchao Yang; Yuanfei Yao; Dehai Wu; Hongrui Guo; Shuo Zhou; Dan Sun; Xinyu Guo; Tongsen Zheng; Jiabei Wang; Shugeng Zhang; Yan Wang; Ruipeng Song; Shanjia Ke; Yao Liu; Fanzheng Meng; Yingjian Liang; Zhaoyang Lu; Lianxin Liu
- Source:
- Life sciences 2020 v.263 pp. 118576
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; cell cycle; data collection; databases; gene expression; genome; hepatoma; immunohistochemistry; microarray technology; multivariate analysis; neoplasm progression; protein synthesis; risk factors
- Abstract:
- ... To investigate the role and prognostic value of mH2A1 in the progression of hepatocellular carcinoma (HCC).Basing on the Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC) and GEO datasets, the gene expression of mH2A1 and relative clinical characteristics were analyzed to assess the prognostic significant of mH2A1 in HCC. The protein expression of mH2A1 was measured by immunohistochem ...
- DOI:
- 10.1016/j.lfs.2020.118576
- https://doi.org/10.1016/j.lfs.2020.118576
- Author:
- Dan Jiang; Min Sun; Linna You; Kai Lu; Lei Gao; Chunxiao Hu; Shiyong Wu; Guanglei Chang; Hongmei Tao; Dongying Zhang
- Source:
- Life sciences 2019 v.224 pp. 241-248
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; atherosclerosis; coronary artery disease; elderly; enzyme-linked immunosorbent assay; gene expression regulation; genes; humans; immunohistochemistry; mononuclear leukocytes; patients; risk factors; staining
- Abstract:
- ... DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and 5-hmC levels associated with CHD remain controversial. In the present study, we aimed ...
- DOI:
- 10.1016/j.lfs.2019.03.021
- https://doi.org/10.1016/j.lfs.2019.03.021
- Author:
- Ioanna Papathanasiou; Varvara Trachana; Evanthia Mourmoura; Aspasia Tsezou
- Source:
- Life sciences 2019 v.228 pp. 274-284
- ISSN:
- 0024-3205
- Subject:
- DNA hypermethylation; binding capacity; bisulfites; chondrocytes; gene expression regulation; genes; interleukin-6; microRNA; osteoarthritis; pathogenesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sequence analysis; transcription (genetics); transcription factor NF-kappa B; transfection
- Abstract:
- ... Previous studies have demonstrated that transcriptional silencing of miRNAs due to DNA hypermethylation is associated with different pathologies. It has also been reported that abnormal expression of miR-140-5p and miR-146a is linked to osteoarthritis (OA) progression. In this study, we investigated the role of DNA methylation on miR-140-5p and miR-146a expression in OA.miR-140-5p and miR-146a exp ...
- DOI:
- 10.1016/j.lfs.2019.05.018
- https://doi.org/10.1016/j.lfs.2019.05.018
- Author:
- Junfei Zhou; Zheng Yi; Qiang Fu
- Source:
- Life sciences 2019 v.218 pp. 241-252
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; antagonists; demethylation; epigenetics; fibrosis; gene expression regulation; messenger RNA; methyltransferases; mice; polymerase chain reaction; protein synthesis; proteins; signal transduction
- Abstract:
- ... Aberrantly activated Wnt signaling pathway and dysregulation of extracellular antagonists of Wnt signaling have been revealed in pulmonary fibrosis. In this study we evaluated the expression of secreted frizzled-related proteins (SFRPs) and their aberrant promoter methylation to investigate the involvement of epigenetic regulation in pulmonary fibrosis. The pulmonary fibrosis induced by intratrach ...
- DOI:
- 10.1016/j.lfs.2018.12.041
- https://doi.org/10.1016/j.lfs.2018.12.041
- Author:
- Ayappa V.Subramaniam; Ashwaq Hamid Salem Yehya; Wei kang Cheng; Xiaomeng Wang; Chern Ein Oon
- Source:
- Life sciences 2019 v.232 pp. 116652
- ISSN:
- 0024-3205
- Subject:
- DNA; angiogenesis; blood vessels; endothelial cells; epigenetics; genes; histones; methylation; microRNA; neoplasms; nutrients; oxygen; protein synthesis; sprouting; therapeutics
- Abstract:
- ... The development of new blood vessels from pre-existing vasculature is called angiogenesis. The growth of tumors depends on a network of supplying vessels that provide them with oxygen and nutrients. Pro-angiogenic factors that are secreted by tumors will trigger the sprouting of nearby existing blood vessels towards themselves and therefore researchers have developed targeted therapy towards these ...
- DOI:
- 10.1016/j.lfs.2019.116652
- https://doi.org/10.1016/j.lfs.2019.116652
- Author:
- Shanshan Li; Yu Chen; Yanyan Zhang; Huirong Zhang; Ying Wu; Hui He; Lijing Gong; Fanxing Zeng; Lijun Shi
- Source:
- Life sciences 2019 v.231 pp. 116576
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; Western blotting; animal disease models; bisulfites; blood pressure; epigenetics; exercise; gene expression; gene expression regulation; genes; hypertension; males; mesenteric arteries; messenger RNA; myocytes; norepinephrine; pregnancy; progeny; promoter regions; protein synthesis; rats; reverse transcriptase polymerase chain reaction; sequence analysis; smooth muscle; swimming
- Abstract:
- ... Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects and underlying mechanisms of exercise during pregnancy on CaV1.2 channel functional remodeling in hypertensive offspring. Exercise groups were subjected to ...
- DOI:
- 10.1016/j.lfs.2019.116576
- https://doi.org/10.1016/j.lfs.2019.116576
- Author:
- Mengshu Zhang; Likui Lu; Yingying Zhang; Xiang Li; Xiaorong Fan; Xueyi Chen; Jiaqi Tang; Bing Han; Min Li; Jianying Tao; Qinqin Gao; Zhice Xu; Miao Sun
- Source:
- Life sciences 2019 v.234 pp. 116792
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; Western blotting; angiotensin II; antagonists; bisulfites; fetus; gene expression; genes; humans; in vitro fertilization; messenger RNA; pregnancy; progeny; quantitative polymerase chain reaction; sequence analysis; umbilical cord; umbilical veins; vasoconstriction
- Abstract:
- ... Assisted reproductive technologies (ART) have been widely used to treat infertility, which may impact on fetuses and offspring. This study investigated the effects of in vitro fertilization-embryo transfer (IVF-ET) on angiotensin II (AII)-mediated vasoconstrictions in umbilical cord vein, and explored possible reprogrammed methylation mechanism.Human umbilical cords were randomly divided into ordi ...
- DOI:
- 10.1016/j.lfs.2019.116792
- https://doi.org/10.1016/j.lfs.2019.116792
- Author:
- Xiaoshan Yu; Bin Zhao; Yanhua Su; Yan Zhang; Jianghui Chen; Wenhui Wu; Qijun Cheng; Xiaorong Guo; Zeyu Zhao; Xiayi Ke; Wangmu Danzeng; Benhua Zhao; Qilin Ma
- Source:
- Life sciences 2018 v.200 pp. 81-86
- ISSN:
- 0024-3205
- Subject:
- DDT (pesticide); DNA methylation; blood; epigenetics; gene expression; genes; maternal exposure; public health; tumor suppressor proteins
- Abstract:
- ... To investigate whether intrauterine organochlorine pesticide (OCP)-dichlorodiphenyltrichloroethane (DDT) exposure could lead to epigenetic alterations by DNA methylation with possible important lifetime health consequences for offspring.We used Illumina Infinium HumanMethylation 450 K BeadChip to explore the pattern of genome-wide DNA methylation containing >485,000 gene sites in cord blood of 24 ...
- DOI:
- 10.1016/j.lfs.2018.03.030
- https://doi.org/10.1016/j.lfs.2018.03.030
- Author:
- Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
- Source:
- Life sciences 2018 v.214 pp. 136-144
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
- Abstract:
- ... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
- DOI:
- 10.1016/j.lfs.2018.10.044
- https://doi.org/10.1016/j.lfs.2018.10.044
- Author:
- Juan Chen; Qiu-Yun Li; Yong-Heng Luo; En-Hua Xiao
- Source:
- Life sciences 2018 v.215 pp. 57-63
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; albumins; bone marrow; epidermal growth factor; genes; glycogen; hepatocyte growth factor; mesenchymal stromal cells; messenger RNA; protein synthesis; rabbits; urea
- Abstract:
- ... To investigate the effect of zebularine, a stable inhibitor of DNA methylation, on hepatic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) under liver-specific factors induction in vitro.BM-MSCs were isolated from the mononuclear cell fraction of rabbit bone marrow samples. The identification of these cells was carried out by immunophenotype analysis. The three hepatic diff ...
- DOI:
- 10.1016/j.lfs.2018.10.049
- https://doi.org/10.1016/j.lfs.2018.10.049
- Author:
- liling Yang; Qian Zhang; Qiong Wu; Yi Wei; Jiawei Yu; Jiao Mu; Jun Zhang; Wei Zeng; Bing Feng
- Source:
- Life sciences 2018 v.207 pp. 127-137
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; bioactive properties; biomedical research; cell proliferation; cortex; diabetic nephropathy; gene expression; genomic islands; glucose; hyperglycemia; kidneys; mice; pathogenesis; patients; phenotype; small interfering RNA; therapeutics; transforming growth factor beta 1
- Abstract:
- ... Transforming growth factor β1 (TGFβ1) plays a pivotal role in the pathogenesis of diabetic nephropathy (DN). However, the mechanism of its expression and activation induced by high glucose (HG) is still unclear. We mainly explored the role of ten-eleven translocation enzyme-2 (TET2) in regulating TGFβ1 expression in the process of DN.Human mesangial cells (HMCs) and db/db mice were used to analyze ...
- DOI:
- 10.1016/j.lfs.2018.04.044
- https://doi.org/10.1016/j.lfs.2018.04.044
- Author:
- Ying-xue Ding; Hong Cui
- Source:
- Life sciences 2017 v.179 pp. 60-65
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; animal models; blood sampling; brain; epigenetics; gene expression; genes; gestational age; humans; immunomodulation; infants; loci; malnutrition; microarray technology; neoplasms; perinatal period; promoter regions; protein metabolism; sugars
- Abstract:
- ... Intrauterine growth restriction (IUGR), a serious complication of perinatal period, results in metabolic and brain disorders. However, the exact cause of IUGR remains unclear. Recently, some evidences indicated that epigenetic modification plays an important role in IUGR. Hence, in this study the methylation status and gene expression profiles of IUGR were compared to investigate the changes in ep ...
- DOI:
- 10.1016/j.lfs.2017.04.020
- https://doi.org/10.1016/j.lfs.2017.04.020
- Author:
- Chang-Lin Hsieh; Hon-Ping Ma; Chih-Ming Su; Yu-Jia Chang; Wan-Yu Hung; Yuan-Soon Ho; Wei-Jan Huang; Ruo-Kai Lin
- Source:
- Life sciences 2016 v.151 pp. 7-14
- ISSN:
- 0024-3205
- Subject:
- adverse effects; breast neoplasms; breasts; carcinogenesis; cell movement; data collection; disease course; drugs; gene expression; genome; histone deacetylase; histones; messenger RNA; patients; prognosis; promoter regions; tissue repair
- Abstract:
- ... Alterations in histone proteins can lead to breast tumorigenesis. Selective histone deacetylase 8 (HDAC8) inhibitors with fewer adverse effects have been developed. A more comprehensive study of alterations and its mechanisms in HDAC8 is required. In this study, we investigated mechanisms of dysregulation of HDAC8 expression and its biological role and pathways in breast cancer.Alterations in HDAC ...
- DOI:
- 10.1016/j.lfs.2016.02.092
- https://doi.org/10.1016/j.lfs.2016.02.092
- Author:
- Faheem Maqbool; Sara Mostafalou; Haji Bahadar; Mohammad Abdollahi
- Source:
- Life sciences 2016 v.145 pp. 265-273
- ISSN:
- 0024-3205
- Subject:
- Alzheimer disease; DNA methylation; breast neoplasms; breasts; carcinoma; diabetes; endocrine-disrupting chemicals; epidemiological studies; estrogen receptors; food composition; fuels; human diseases; humans; industrial wastes; industry; models; mutation; nerve tissue; obesity; ovarian neoplasms; packaging; pesticides; plasticizers; plastics; risk; schizophrenia; signal transduction; testes; toxic substances; toxicity; xenobiotics
- Abstract:
- ... Endocrine disrupting chemicals (EDC) are released into environment from different sources. They are mainly used in packaging industries, pesticides and food constituents. Clinical evidence, experimental models, and epidemiological studies suggest that EDC have major risks for human by targeting different organs and systems in the body. Multiple mechanisms are involved in targeting the normal syste ...
- DOI:
- 10.1016/j.lfs.2015.10.022
- https://doi.org/10.1016/j.lfs.2015.10.022
- Author:
- Haniyeh Eyvani; Farima Moghaddaskho; Majid Kabuli; Ali Zekri; Majid Momeny; Javad Tavakkoly-Bazzaz; Kamran Alimoghaddam; Ardeshir Ghavamzadeh; Seyed H. Ghaffari
- Source:
- Life sciences 2016 v.167 pp. 67-77
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; carcinogenesis; cell cycle checkpoints; colorectal neoplasms; cyclins; epigenetics; flow cytometry; gene expression; methyltransferases; neoplasm cells; promoter regions; quantitative polymerase chain reaction; regulator genes; transcription (genetics)
- Abstract:
- ... Cell cycle dysregulation is important in tumorigenesis. Transcriptional silencing of cell cycle regulatory genes, due to DNA methylation, is a common epigenetic event in malignancies. As2O3 has been shown to induce cell cycle arrest and also to be a potential hypomethylating agent. Our study aimed to investigate DNA methylation patterns of cell cycle regulatory genes promoters, the effects of Arse ...
- DOI:
- 10.1016/j.lfs.2016.10.020
- https://doi.org/10.1016/j.lfs.2016.10.020
- Author:
- Cindy M. Anderson; Jody L. Ralph; LuAnn Johnson; Angela Scheett; Michelle L. Wright; Jacquelyn Y. Taylor; Joyce E. Ohm; Eric Uthus
- Source:
- Life sciences 2015 v.129 pp. 10-15
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; animal tissues; blood serum; calcitriol receptors; epigenetics; food frequency questionnaires; food intake; genes; placenta; pre-eclampsia; prospective studies; protein synthesis; vitamin D; vitamin status; women
- Abstract:
- ... As maternal vitamin D status has been associated with preeclampsia, the purpose of this study was to determine variations in DNA methylation patterns and associated protein expression in placental genes regulating vitamin D metabolism.A convenience sample of 48 pregnant nulliparous women, including 11 later diagnosed with preeclampsia, were recruited in this prospective study. Using a case–control ...
- DOI:
- 10.1016/j.lfs.2014.07.012
- https://doi.org/10.1016/j.lfs.2014.07.012
- Author:
- Leonidas Raftopoulos; Vasiliki Katsi; Thomas Makris; Dimitrios Tousoulis; Christodoulos Stefanadis; Ioannis Kallikazaros
- Source:
- Life sciences 2015 v.129 pp. 22-26
- ISSN:
- 0024-3205
- Subject:
- DNA; epigenetics; hypertension; nucleotide sequences; phenotype; transcription (genetics)
- Abstract:
- ... Epigenetics refers to functional alterations in gene expression or phenotype without any change of the underlying DNA sequence. It is the study of the potential of a cell or organism to express different traits through functional regulation of its gene transcription. Though it is met as a necessary process in biology, epigenetics may often play a crucial part in the development of specific patholo ...
- DOI:
- 10.1016/j.lfs.2014.08.003
- https://doi.org/10.1016/j.lfs.2014.08.003
- Author:
- Anne Yuqing Yang; Jong Hun Lee; Limin Shu; Chengyue Zhang; Zheng-Yuan Su; Yaoping Lu; Mou-Tuan Huang; Christina Ramirez; Douglas Pung; Ying Huang; Michael Verzi; Ronald P. Hart; Ah-Ng Tony Kong
- Source:
- Life sciences 2014 v.113 no.1-2 pp. 45-54
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; G-protein coupled receptors; anthracenes; cAMP-dependent protein kinase; carcinogenesis; carcinogens; computer software; epigenetics; gene interaction; genes; genome-wide association study; high-throughput nucleotide sequencing; irradiation; metabolism; mice; models; precipitin tests; skin neoplasms; ultraviolet radiation; xenobiotics
- Abstract:
- ... Ultraviolet irradiation and carcinogens have been reported to induce epigenetic alterations, which potentially contribute to the development of skin cancer. We aimed to study the genome-wide DNA methylation profiles of skin cancers induced by ultraviolet B (UVB) irradiation and 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-1,3-acetate (TPA).Methylated DNA immunoprecipitation (MeD ...
- DOI:
- 10.1016/j.lfs.2014.07.031
- PubMed:
- 25093921
- PubMed Central:
- PMC5897904
- https://doi.org/10.1016/j.lfs.2014.07.031
- Author:
- Ana B. Crujeiras; Marcos C. Carreira; Begoña Cabia; Sara Andrade; Maria Amil; Felipe F. Casanueva
- Source:
- Life sciences 2015 v.140 pp. 57-63
- ISSN:
- 0024-3205
- Subject:
- appetite; energy expenditure; epigenetics; food intake; homeostasis; hypothalamus; leptin; neurons; obesity; pandemic; signal transduction; therapeutics
- Abstract:
- ... Leptin is an adipocyte-secreted hormone that inhibits food intake and stimulates energy expenditure through interactions with neuronal pathways in the brain, particularly pathways involving the hypothalamus. Intact functioning of the leptin route is required for body weight and energy homeostasis. Given its function, the discovery of leptin increased expectations for the treatment of obesity. Howe ...
- DOI:
- 10.1016/j.lfs.2015.05.003
- https://doi.org/10.1016/j.lfs.2015.05.003
- Author:
- Vinita Khot; Preeti Chavan-Gautam; Sadhana Joshi
- Source:
- Life sciences 2015 v.129 pp. 16-21
- ISSN:
- 0024-3205
- Subject:
- DNA; DNA methylation; S-adenosylmethionine; adults; angiogenesis; biochemical pathways; carbon; carbon cycle; cardiovascular diseases; children; epigenetics; fetus; folic acid; genes; long chain polyunsaturated fatty acids; maternal nutrition; metabolism; moieties; mothers; phospholipids; pre-eclampsia; pregnancy outcome; risk; vitamin B12
- Abstract:
- ... Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of developing cardiovascular diseases (CVD) in later life although mechanisms are unc ...
- DOI:
- 10.1016/j.lfs.2014.09.026
- https://doi.org/10.1016/j.lfs.2014.09.026
- Author:
- Sheng Chen; Nianhai He; Jialin Yu; Luquan Li; Ying Hu; Rui Deng; Shiming Zhong; Leilei Shen
- Source:
- Life sciences 2014 v.107 no.1-2 pp. 8-13
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; Western blotting; adults; animal models; bilirubin; encephalopathy; hepatocytes; jaundice; liver; messenger RNA; mice; neonates; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Jaundice, potentially fatal encephalopathy, is common in approximately two-thirds of all well term infants. It is largely due to low expression of constitutive androstane receptor (CAR) in newborns; however, the mechanisms for this low expression were poorly understood.Expression of miR-137 and CAR was compared between neonatal and adult mice and between healthy and a mouse model of obstructive ja ...
- DOI:
- 10.1016/j.lfs.2014.04.024
- https://doi.org/10.1016/j.lfs.2014.04.024
- Author:
- Se Hyun Kim; Hee Young Lee; Heesun Yi; Yong Min Ahn; Yong Sik Kim
- Source:
- Life sciences 2012 v.91 no.25-26 pp. 1317-1322
- ISSN:
- 0024-3205
- Subject:
- DNA methylation; acetylation; antipsychotics; carcinoma; cell proliferation; epigenetics; genes; haloperidol; histones; humans; mechanism of action; neoplasm cells; pancreatic neoplasms; sequence analysis; transcription (genetics)
- Abstract:
- ... AIMS: The effects of antipsychotics on various gene expressions through change in DNA methylation have been reported. Dual-specificity phosphatase 6 (DUSP6) is an extracellular signal regulated kinase 1/2 (ERK1/2)-selective phosphatase, and its expression can be suppressed by intronic methylation. Antipsychotic agent haloperidol affects ERK1/2 activity and could induce changes in DNA methylation a ...
- DOI:
- 10.1016/j.lfs.2012.10.002
- https://doi.org/10.1016/j.lfs.2012.10.002