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You searched for: Journal name Life sciences Remove constraint Journal name: Life sciences Subject term bisphenol A Remove constraint Subject term: bisphenol A
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1. Antifibrotic effect of curcumin, N-acetyl cysteine and propolis extract against bisphenol A-induced hepatotoxicity in rats: Prophylaxis versus co-treatment

Author:
Sahar El-Sayed Elswefy; Fatma Rizk Abdallah; Alaa Samir Wahba; Rehab Abdallah Hasan; Hebatallah Husseini Atteia
Source:
Life sciences 2020 v.260 pp. 118245
ISSN:
0024-3205
Subject:
B-cell lymphoma; antioxidants; bisphenol A; caspase-3; curcumin; cysteine; disease prevention; extracellular matrix; fibrosis; gelatinase A; gelatinase B; hepatocytes; hepatoprotective effect; hepatotoxicity; liver cirrhosis; males; models; propolis; therapeutics
Abstract:
... Bisphenol A (BPA) has been shown to induce liver fibrosis in rodents. Therefore, this study examined the protective effect of a triple combination of curcumin (Cur), N-acetyl cysteine (NAC) and propolis (Prp) extract against BPA-induced hepatic fibrosis.100 Wistar male rats were equally assigned into 10 groups; one group was designated as control. 10 rats were gavaged with BPA (50 mg/kg/day) for 8 ...
DOI:
10.1016/j.lfs.2020.118245

2. Bisphenol A exposure disturbs the bone metabolism: An evolving interest towards an old culprit

Author:
Zar Chi Thent; Gabriele Ruth Anisah Froemming; Suhaila Muid
Source:
Life sciences 2018 v.198 pp. 1-7
ISSN:
0024-3205
Subject:
alkaline phosphatase; apoptosis; bisphenol A; bone resorption; calcitonin; calcium; endocrine-disrupting chemicals; environmental exposure; humans; osteoblasts; osteoclasts; propane; secretion; signal transduction; toxicity
Abstract:
... Bisphenol A (BPA) (2,2,-bis (hydroxyphenyl) propane), a well-known endocrine disruptor (ED), is the exogenous chemical that mimic the natural endogenous hormone like oestrogen. Due to its extensive exposure to humans, BPA is considered to be a major toxicological agent for general population. Environmental exposure of BPA results in adverse health outcomes including bone loss. BPA disturbs the bon ...
DOI:
10.1016/j.lfs.2018.02.013

3. Bisphenol A exposure induces metastatic aggression in low metastatic MCF-7 cells via PGC-1α mediated mitochondrial biogenesis and epithelial-mesenchymal plasticity

Author:
Mohammad Imran Ansari; Nuzhat Bano; KM Kainat; Vipendra Kumar Singh; Pradeep Kumar Sharma
Source:
Life sciences 2022 v.302 pp. 120649
ISSN:
0024-3205
Subject:
actin; aggression; biogenesis; bisphenol A; breast neoplasms; breasts; cadherins; carcinogenesis; carcinogenicity; energy metabolism; estrogen receptors; humans; metastasis; mitochondria; muscles; peroxisome proliferator-activated receptor gamma; slugs; vimentin
Abstract:
... The frequency of estrogen receptor alpha (ERα)-positive breast cancers and their metastatic progression is prevalent in females globally. Aberrant interaction of estrogen-like endocrine-disrupting chemicals (EDCs) is highly implicated in breast carcinogenesis. Studies have shown that single or acute exposures of weak EDCs such as bisphenol A (BPA) may not have a substantial pro-carcinogenic/metast ...
DOI:
10.1016/j.lfs.2022.120649

4. Bisphenol A reduces differentiation and stimulates apoptosis of osteoclasts and osteoblasts

Author:
Jin Kyung Hwang; Kwan Hee Min; Kyoung Hee Choi; You Cheol Hwang; In-Kyung Jeong; Kyu Jeung Ahn; Ho-Yeon Chung; Jae Suk Chang
Source:
Life sciences 2013 v.93 no.9-11 pp. 367-372
ISSN:
0024-3205
Subject:
Western blotting; apoptosis; bisphenol A; caspases; cell culture; cell differentiation; coatings; dose response; endocrine-disrupting chemicals; epoxides; estrogen receptors; macrophages; mitogen-activated protein kinase; osteoblasts; osteoclasts; protein synthesis; resins
Abstract:
... AIMS: Bisphenol A (BPA), a major component of epoxy resins used in protective coatings, is a known endocrine-disrupting chemical. BPA has the ability of binding to estrogen receptors. In the current paper, we examine the direct effects of bisphenol A on in vitro osteoclast and osteoblast culture systems. MAIN METHODS: We evaluated the effects of BPA on osteoclast formation using bone marrow-derive ...
DOI:
10.1016/j.lfs.2013.07.020

5. Bisphenol A suppresses proliferation and induces apoptosis in colonic epithelial cells through mitochondrial and MAPK/AKT pathways

Author:
Wei Qu; Zhenguo Zhao; Sijin Chen; Lijin Zhang; Danlian Wu; Zhigao Chen
Source:
Life sciences 2018 v.208 pp. 167-174
ISSN:
0024-3205
Subject:
apoptosis; bisphenol A; cell proliferation; colorectal neoplasms; epithelial cells; epithelium; gene expression; gene expression regulation; humans; hydrogen peroxide; malondialdehyde; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; pathogens; signal transduction; toxicity; viability
Abstract:
... Bisphenol A (BPA) can act as pathogenic agent on mammalian cells. However, whether BPA induces colonic epithelial cell damage remains unexplored. We used HCT116 cells as a model to investigate the negative effect of BPA on human colon cancer cells and explore the potential mechanism. Our results suggest that BPA decreased viability of HCT116 cells. BPA also caused serious oxidative damage to the c ...
DOI:
10.1016/j.lfs.2018.07.040

6. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

7. Bisphenol a and mesenchymal stem cells: Recent insights

Author:
Helga Caputo Nunes; Wellerson Rodrigo Scarano; Elenice Deffune; Sérgio Luis Felisbino; Immacolata Porreca; Flávia Karina Delella
Source:
Life sciences 2018 v.206 pp. 22-28
ISSN:
0024-3205
Subject:
adipogenesis; adipose tissue; adults; allografting; bisphenol A; clinical trials; endocrine-disrupting chemicals; homeostasis; humans; medicine; mesenchymal stromal cells; obesity; stem cells; surveys
Abstract:
... Mesenchymal stem cells (MSCs) are found in all adult mesenchymal tissues. They play a role in the maintenance of tissue homeostasis and repair by allowing renewal of the cellular stock. MSCs can be isolated from both human and animal sources. These cells are important in regenerative medicine and cell therapy, thus adipose tissue is a rich and promising source of these cells. Adipose-derived stem ...
DOI:
10.1016/j.lfs.2018.05.023

8. Bisphenol-A exposure worsens hepatic steatosis in ovariectomized mice fed on a high-fat diet: Role of endoplasmic reticulum stress and fibrogenic pathways

Author:
Letícia S. Figueiredo; Kênia M. Oliveira; Israelle N. Freitas; Joel A. Silva; Juliana N. Silva; Bianca C. Favero-Santos; Maria Lúcia Bonfleur; Everardo M. Carneiro; Rosane A. Ribeiro
Source:
Life sciences 2020 v.256 pp. 118012
ISSN:
0024-3205
Subject:
adiposity; bisphenol A; collagen; endocrine-disrupting chemicals; endoplasmic reticulum; endoplasmic reticulum stress; fatty liver; females; glucose; high fat diet; homeostasis; insulin resistance; lipogenesis; liver; mitochondria; ovariectomy; postmenopause; risk
Abstract:
... Bisphenol (BP)-A exposure can impair glucose and lipid metabolism. However, it is unclear whether this endocrine disruptor (ED) modulates these processes in postmenopause, a period with organic changes that increase the risk for metabolic diseases. Herein, we evaluated the effects of BPA exposure on adiposity, glucose homeostasis and hepatic steatosis in ovariectomized (OVX) mice fed on a high-fat ...
DOI:
10.1016/j.lfs.2020.118012

9. Effects of maternal bisphenol A on behavior, sex steroid and thyroid hormones levels in the adult rat offspring

Author:
B.S. Silva; I.M. Bertasso; C.B. Pietrobon; B.P. Lopes; T.R. Santos; N. Peixoto-Silva; J.C. Carvalho; S. Claudio-Neto; A.C. Manhães; S.S. Cabral; G.E.G. Kluck; G.C. Atella; E. Oliveira; E.G. Moura; P.C. Lisboa
Source:
Life sciences 2019 v.218 pp. 253-264
ISSN:
0024-3205
Subject:
adulthood; adults; bisphenol A; cholesterol; endocrine-disrupting chemicals; estradiol; euthanasia; females; food intake; homeostasis; hyperinsulinemia; hyperlipidemia; laboratory animals; lactation; males; milk; obesity; placenta; pregnancy; progeny; progesterone; pups; rats; testosterone; thyroid hormones; triacylglycerols; visceral fat; weaning
Abstract:
... Bisphenol A (BPA), an endocrine disruptor used in industrial applications, has been detected in both placenta and milk. We studied the effects of BPA exposure during pregnancy and lactation on body composition, palatable food intake, biochemical, hormonal and behavioral profiles of young and adult Wistar rat offspring.Female rats were divided into: control, BPA10 (10 μg/kg/day) and BPA50 (50 μg/kg ...
DOI:
10.1016/j.lfs.2018.12.039

10. Employing different types of phytoestrogens improve bone mineralization in bisphenol A stimulated osteoblast

Author:
Zar Chi Thent; Gabriele Ruth Anisah Froemming; Aletza Binti Mohd Ismail; Syed Baharom Syed Ahmad Fuad; Suhaila Muid
Source:
Life sciences 2018 v.210 pp. 214-223
ISSN:
0024-3205
Subject:
agonists; alkaline phosphatase; antagonists; bisphenol A; bone mineralization; bones; calcium; daidzein; enzyme activity; genistein; mineralization; osteoblasts; osteocalcin; phosphates; plant estrogens; quantitative analysis; risk; xenoestrogens
Abstract:
... Phytoestrogens and xenoestrogens act as agonists/antagonists in bone formation and differentiation. Strong bones are depending of the ability of osteoblasts to form new tissue and to mineralize the newly formed tissue. Dysfunctional or loss of mineralization leads to weak bone and increased fracture risk. In this study, we reported the effect of different types of phytoestrogens (daidzein, geniste ...
DOI:
10.1016/j.lfs.2018.08.057

11. Endrin potentiates early-stage adipogenesis in 3T3-L1 cells by activating the mammalian target of rapamycin

Author:
Jo Woon Seok; Jae Yeo Park; Hyun Ki Park; Hyangkyu Lee
Source:
Life sciences 2022 v.288 pp. 120151
ISSN:
0024-3205
Subject:
adipocytes; adipogenesis; bisphenol A; cell lines; corticosterone; dose response; endocrine system; endrin; genes; humans; insulin; insulin resistance; lipogenesis; lipolysis; metabolic diseases; obesity; protein kinases; rapamycin; tolylfluanid; triacylglycerols
Abstract:
... Obesogens are a type of endocrine-disrupting chemicals (EDCs) that disrupt the human endocrine system, resulting in obesity and metabolic disease. Several obesogens, including bisphenol A, tolylfluanid, and some pesticides, have been identified and studied previously; however, the underlying molecular mechanisms by which obesogens interfere with adipogenesis and induce insulin resistance in adipoc ...
DOI:
10.1016/j.lfs.2021.120151

12. Fluorene-9-bisphenol exposure decreases locomotor activity and induces lipid-metabolism disorders by impairing fatty acid oxidation in zebrafish

Author:
Shuhui Zhang; Yixin Xu; Shaozhi Zhang; Chengtian Zhao; Daofu Feng; Xizeng Feng
Source:
Life sciences 2022 v.294 pp. 120379
ISSN:
0024-3205
Subject:
Danio rerio; beta oxidation; biochemical pathways; bisphenol A; cortisol; endocrine-disrupting chemicals; endoplasmic reticulum; fatty liver; growth retardation; homeostasis; inflammation; lipids; locomotion; mitochondria; obesity; toxicology
Abstract:
... Fluorene-9-bisphenol (BHPF), as a substitute for bisphenol A, is used in many industries in daily life. Many studies have clarified its effects as an endocrine disruptor on organisms, but its effect on lipid metabolism of zebrafish larvae is not clear. Patients with non-alcoholic fatty liver disease (NAFLD) are more susceptible to external pollutants. It is not clear how BHPF perturbs lipid metabo ...
DOI:
10.1016/j.lfs.2022.120379

13. Hormone receptor expression in aging mammary tissue and carcinoma from a rodent model after xenoestrogen disruption

Author:
Thalles Fernando Rocha Ruiz; Simone Jacovaci Colleta; Débora Aparecida Pires de Campos Zuccari; Patrícia Simone Leite Vilamaior; Ellen Cristina Rivas Leonel; Sebastião Roberto Taboga
Source:
Life sciences 2021 v.285 pp. 120010
ISSN:
0024-3205
Subject:
Meriones unguiculatus; androgens; animal models; bisphenol A; breast neoplasms; carcinogenesis; carcinoma; cytoplasm; epigenetics; females; hormone receptors; mammary glands; mammary neoplasms (animal); phenotype; pregnancy; progesterone; prognosis; prolactin
Abstract:
... Hormone receptors are the main markers applied for prognosis of breast cancer subtypes. Among modulators, exogenous chemical agents known as endocrine disruptors interact with certain receptors, triggering molecular pathways or increasing their expression. Bisphenol A (BPA), a xenoestrogen, interacts with several hormone receptors. Thus, our aim was to characterize the hormone receptor status in t ...
DOI:
10.1016/j.lfs.2021.120010

14. Modulatory effect of methylsulfonylmethane against BPA/γ-radiation induced neurodegenerative alterations in rats: Influence of TREM-2/DAP-12/Syk pathway

Author:
Mohamed K. Abdel-Rafei; Noura M. Thabet
Source:
Life sciences 2020 v.260 pp. 118410
ISSN:
0024-3205
Subject:
Alzheimer disease; acetylcholinesterase; bisphenol A; cortex; fractionation; hippocampus; histopathology; humans; neurodegenerative diseases; neuroprotective effect; neurotoxicity; oxidative stress; poisoning; pollution; tumor necrosis factors
Abstract:
... Methylsulfonylmethane (MSM), is an organosulfur compound, has many health benefits. Bisphenol-A (BPA) and γ-radiation (R) are two risky environmental contaminants that human beings are exposed to in everyday life. This work aims at unveiling the modulatory role of MSM in combating BPA and R co-exposure induced neurodegenerative disorder (Alzheimer's (AD)-mimic neurotoxicity).Female rats were rando ...
DOI:
10.1016/j.lfs.2020.118410

15. Molecular interactions of thyroxine binding globulin and thyroid hormone receptor with estrogenic compounds 4-nonylphenol, 4-tert-octylphenol and bisphenol A metabolite (MBP)

Author:
Ishfaq A. Sheikh
Source:
Life sciences 2020 v.253 pp. 117738
ISSN:
0024-3205
Subject:
binding capacity; bisphenol A; chemical pollutants; globulins; human health; ligands; metabolites; pollution; thyroid hormone receptors; thyroid hormones; thyroxine
Abstract:
... Endocrine disruption due to environmental chemical contaminants is a global human health issue. The aim of present study was to investigate the structural binding aspects of possible interference of commonly detected environmental contaminants on thyroid function.Three compounds, 4-tert-octylphenol (4-tert-OP), 4-nonylphenol (4-NP), and 4-methyl-2,4-bis(4-hydroxypentyl)pent-1-ene (MBP) were subjec ...
DOI:
10.1016/j.lfs.2020.117738

16. Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway

Author:
Olufemi I. Oluranti; Babatunde A. Alabi; Olugbenga S. Michael; Alaba O. Ojo; Bosede P. Fatokun
Source:
Life sciences 2021 v.284 pp. 119878
ISSN:
0024-3205
Subject:
C-reactive protein; bisphenol A; catalase; dibutyl phthalate; glutathione; heart; human health; inflammation; lipid peroxidation; malondialdehyde; oral administration; oxidative stress; rutin; superoxide dismutase; transcription factor NF-kappa B
Abstract:
... Environmental pollutants such as plastic-component substances (phthalates and bisphenol A) that coexist in natural ecosystems have been linked to an increase in the occurrence of human health hazards, particularly cardiovascular health. This study was designed to investigate single and combined cardio-toxic effects of dibutyl phthalate and bisphenol-A and the possible interventional role of rutin. ...
DOI:
10.1016/j.lfs.2021.119878

17. Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts

Author:
Yasuhiro Miki; Shuko Hata; Shuji Nagasaki; Takashi Suzuki; Kiyoshi Ito; Hiroyuki Kumamoto; Hironobu Sasano
Source:
Life sciences 2016 v.155 pp. 29-35
ISSN:
0024-3205
Subject:
adults; bisphenol A; bone metabolism; bones; cell proliferation; coatings; collagen; endocrine-disrupting chemicals; enzyme activity; fetus; homeostasis; humans; medical equipment; osteoblasts; osteoclasts; plastics; receptors; skeletal development; xenobiotics
Abstract:
... Bisphenol A, one of the industrial chemicals used in plastics and in the coating of dishes and medical equipment, behaves as an endocrine disruptor in the human body. Bisphenol A can bind directly to several types of nuclear receptors, including steroid and xenobiotic receptor (SXR). SXR plays an important role in bone metabolism through the activation of osteoblasts in vitro, but SXR protein loca ...
DOI:
10.1016/j.lfs.2016.05.013