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1. Epigenetic control of atherosclerosis via DNA methylation: A new therapeutic target?

Author:
Gorabi, Armita Mahdavi; Penson, Peter E.; Banach, Maciej; Motallebnezhad, Morteza; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
Source:
Life sciences 2020 v.253 pp. 117682
ISSN:
0024-3205
Subject:
DNA methylation; arteries; atherosclerosis; endothelial cells; epigenetics; foam cells; genes; histone code; inflammation; microRNA; myocytes; oxidative stress; physiology; smooth muscle; therapeutics
Abstract:
... Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, in ...
DOI:
10.1016/j.lfs.2020.117682

2. An effective seven-CpG-based signature to predict survival in renal clear cell carcinoma by integrating DNA methylation and gene expression

Author:
Xu, Lei; He, Jian; Cai, Qihang; Li, Menglong; Pu, Xuemei; Guo, Yanzhi
Source:
Life sciences 2020 v.243 pp. 117289
ISSN:
0024-3205
Subject:
DNA methylation; biomarkers; carcinoma; disease progression; gender; gene expression; genes; human diseases; messenger RNA; models; patients; prediction; regression analysis; risk assessment; risk factors; transcription (genetics)
Abstract:
... Currently, using clinicopathological risk factors only is not far from effective to evaluate the risk of disease progression in renal clear cell carcinoma (KIRC) patients. Molecular biomarkers might improve risk stratification of KIRC. DNA methylation occurs the whole process of tumor development and transcriptional disorders are also one of the important characteristics of tumor. Hence, this stud ...
DOI:
10.1016/j.lfs.2020.117289

3. Down-regulation of Tet2 is associated with Foxp3 TSDR hypermethylation in regulatory T cell of allergic rhinitis

Author:
Tan, Lu; Qiu, Ting; Xiang, Rong; Cao, Cheng; Deng, Yuqin; Tao, Zezhang; Xu, Yu
Source:
Life sciences 2020 v.241 pp. 117101
ISSN:
0024-3205
Subject:
DNA; DNA methylation; T-lymphocytes; allergic rhinitis; chromatin; flow cytometry; gene expression regulation; genes; messenger RNA; patients; precipitin tests; protein binding; quantitative polymerase chain reaction; sequence analysis; spleen
Abstract:
... Ten-eleven-translocation (Tet) proteins are 5-methylcytosine oxidases and have profound impact on DNA methylation and genes expression. This study aimed to investigate the role of Tet2 and its association with Foxp3 DNA methylation in regulatory T (Treg) cell of allergic rhinitis (AR).CD4⁺CD25⁺Treg cells were sorted from peripheral blood lymphocytes drawn from AR patients and spleen lymphocytes dr ...
DOI:
10.1016/j.lfs.2019.117101

4. Epigenetic modulation of glycoprotein VI gene expression by DNA methylation

Author:
Gao, Shuibo; Han, Yongjun; Chen, Xiaohui; Dai, Liping; Gao, Haixia; Lei, Zhen; Wang, Xinzhou; Wang, Zhentao; Wu, Hong
Source:
Life sciences 2020 v.241 pp. 117103
ISSN:
0024-3205
Subject:
DNA methylation; Western blotting; biomarkers; coronary disease; demethylation; epigenetics; flow cytometry; gene expression; gene expression regulation; genes; glycoproteins; leukocytes; luciferase; messenger RNA; patients; phosphorylation; promoter regions; protein content; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:
... Glycoprotein VI (GPVI) is an important platelet membrane receptor. The expression of GPVI on platelet membranes is increased in patients with coronary heart disease (CHD). DNA methylation is one of the most common post-replication and pre-transcriptional modifications and plays a critical role in the regulation of gene expression. Here, we aimed to reveal how methylation regulates GPVI expression. ...
DOI:
10.1016/j.lfs.2019.117103

5. Methylation-reprogrammed AGTR1 results in increased vasoconstriction by angiotensin II in human umbilical cord vessel following in vitro fertilization-embryo transfer

Author:
Zhang, Mengshu; Lu, Likui; Zhang, Yingying; Li, Xiang; Fan, Xiaorong; Chen, Xueyi; Tang, Jiaqi; Han, Bing; Li, Min; Tao, Jianying; Gao, Qinqin; Xu, Zhice; Sun, Miao
Source:
Life sciences 2019 v.234 pp. 116792
ISSN:
0024-3205
Subject:
DNA methylation; Western blotting; angiotensin II; antagonists; bisulfites; fetus; gene expression; genes; humans; in vitro fertilization; messenger RNA; pregnancy; progeny; quantitative polymerase chain reaction; sequence analysis; umbilical cord; umbilical veins; vasoconstriction
Abstract:
... Assisted reproductive technologies (ART) have been widely used to treat infertility, which may impact on fetuses and offspring. This study investigated the effects of in vitro fertilization-embryo transfer (IVF-ET) on angiotensin II (AII)-mediated vasoconstrictions in umbilical cord vein, and explored possible reprogrammed methylation mechanism.Human umbilical cords were randomly divided into ordi ...
DOI:
10.1016/j.lfs.2019.116792

6. Characterizing methylation regulated miRNA in carcinoma of the human uterine cervix

Author:
Varghese, Vinay Koshy; Shukla, Vaibhav; Jishnu, Padacherri Vethil; Kabekkodu, Shama Prasada; Pandey, Deeksha; Sharan, Krishna; Satyamoorthy, Kapaettu
Source:
Life sciences 2019 v.232 pp. 116668
ISSN:
0024-3205
Subject:
DNA methylation; apoptosis; bisulfites; carcinogenesis; cell proliferation; cervix; epigenetics; epithelium; genes; humans; luciferase; metastasis; microRNA; neoplasm progression; pathophysiology; sequence analysis; squamous cell carcinoma; uterine cervical neoplasms
Abstract:
... Gene regulatory mechanisms determine the multistep carcinogenesis process. Two aspects of epigenetics are microRNA (miRNAs) and DNA methylation that regulate distinct biological mechanisms such as metastasis, apoptosis cell proliferation and induction of senescence. Although critical, the interplay between these two epigenetic mechanisms is yet to be completely understood, particularly in cervical ...
DOI:
10.1016/j.lfs.2019.116668

7. Exercise during pregnancy enhances vascular function via epigenetic repression of CaV1.2 channel in offspring of hypertensive rats

Author:
Li, Shanshan; Chen, Yu; Zhang, Yanyan; Zhang, Huirong; Wu, Ying; He, Hui; Gong, Lijing; Zeng, Fanxing; Shi, Lijun
Source:
Life sciences 2019 v.231 pp. 116576
ISSN:
0024-3205
Subject:
DNA; DNA methylation; Western blotting; animal disease models; bisulfites; blood pressure; epigenetics; exercise; gene expression; gene expression regulation; genes; hypertension; males; mesenteric arteries; messenger RNA; myocytes; norepinephrine; pregnancy; progeny; promoter regions; protein synthesis; rats; reverse transcriptase polymerase chain reaction; sequence analysis; smooth muscle; swimming
Abstract:
... Studies suggest that cardiovascular function in offspring can be epigenetically programmed by environmental changes during pregnancy. CaV1.2 channel plays a major role in the regulation of the vascular tone. This study investigated the effects and underlying mechanisms of exercise during pregnancy on CaV1.2 channel functional remodeling in hypertensive offspring.Exercise groups were subjected to s ...
DOI:
10.1016/j.lfs.2019.116576

8. Hypomethylation of the lncRNA SOX21-AS1 has clinical prognostic value in cervical cancer

Author:
Wang, Ruijie; Li, Ya; Du, Peipei; Zhang, Xiaoan; Li, Xiaofu; Cheng, Guomei
Source:
Life sciences 2019 pp. 116708
ISSN:
0024-3205
Subject:
DNA; DNA methylation; antisense RNA; bioinformatics; data collection; genes; immunologic factors; messenger RNA; metastasis; non-coding RNA; nutritional status; prognosis; sequence analysis; statistical analysis; uterine cervical neoplasms; women; women's health
Abstract:
... Cervical cancer seriously affects women's health. The function of methylated alterations in the long non-coding RNAs (lncRNAs) promote the progression and metastasis of cancer. Our study aims to identify the functional effects of lncRNA methylation in cervical carcinogenesis.Genome-wide DNA methylation of 6 samples was assessed using the Illumina Infinium MethylationEPIC BeadChip. RNA sequencing ( ...
DOI:
10.1016/j.lfs.2019.116708

9. DNA methylation and hydroxymethylation are associated with the degree of coronary atherosclerosis in elderly patients with coronary heart disease

Author:
Jiang, Dan; Sun, Min; You, Linna; Lu, Kai; Gao, Lei; Hu, Chunxiao; Wu, Shiyong; Chang, Guanglei; Tao, Hongmei; Zhang, Dongying
Source:
Life sciences 2019 v.224 pp. 241-248
ISSN:
0024-3205
Subject:
DNA methylation; atherosclerosis; coronary artery disease; elderly; enzyme-linked immunosorbent assay; gene expression regulation; genes; humans; immunohistochemistry; mononuclear leukocytes; patients; risk factors; staining
Abstract:
... DNA methylation and hydroxymethylation are significantly related to the occurrence and development of coronary heart disease (CHD) and atherosclerosis (AS). 5-Methylcytosine (5-mC) and 5-hydroxymethylcytosine (5-hmC) are used to assess DNA methylation and hydroxymethylation levels, respectively. However, 5-mC and 5-hmC levels associated with CHD remain controversial. In the present study, we aimed ...
DOI:
10.1016/j.lfs.2019.03.021

10. Continuous zebularine treatment enhances hepatic differentiation of mesenchymal stem cells under liver-specific factors induction in vitro

Author:
Chen, Juan; Li, Qiu-Yun; Luo, Yong-Heng; Xiao, En-Hua
Source:
Life sciences 2018 v.215 pp. 57-63
ISSN:
0024-3205
Subject:
DNA methylation; albumins; bone marrow; epidermal growth factor; genes; glycogen; hepatocyte growth factor; mesenchymal stromal cells; messenger RNA; protein synthesis; rabbits; urea
Abstract:
... To investigate the effect of zebularine, a stable inhibitor of DNA methylation, on hepatic differentiation of bone marrow-derived mesenchymal stem cells (BM-MSCs) under liver-specific factors induction in vitro.BM-MSCs were isolated from the mononuclear cell fraction of rabbit bone marrow samples. The identification of these cells was carried out by immunophenotype analysis. The three hepatic diff ...
DOI:
10.1016/j.lfs.2018.10.049

11. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Rahmani, Soheila; Pour Khalili, Nazila; Khan, Fazlullah; Hassani, Shokoufeh; Ghafour-Boroujerdi, Elmira; Abdollahi, Mohammad
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044

12. Association of prenatal organochlorine pesticide-dichlorodiphenyltrichloroethane exposure with fetal genome-wide DNA methylation

Author:
Yu, Xiaoshan; Zhao, Bin; Su, Yanhua; Zhang, Yan; Chen, Jianghui; Wu, Wenhui; Cheng, Qijun; Guo, Xiaorong; Zhao, Zeyu; Ke, Xiayi; Danzeng, Wangmu; Zhao, Benhua; Ma, Qilin
Source:
Life sciences 2018 v.200 pp. 81-86
ISSN:
0024-3205
Subject:
DDT (pesticide); DNA methylation; blood; epigenetics; gene expression; genes; maternal exposure; public health; tumor suppressor proteins
Abstract:
... To investigate whether intrauterine organochlorine pesticide (OCP)-dichlorodiphenyltrichloroethane (DDT) exposure could lead to epigenetic alterations by DNA methylation with possible important lifetime health consequences for offspring.We used Illumina Infinium HumanMethylation 450 K BeadChip to explore the pattern of genome-wide DNA methylation containing >485,000 gene sites in cord blood of 24 ...
DOI:
10.1016/j.lfs.2018.03.030

13. Integrated analysis of genome-wide DNA methylation and gene expression data provide a regulatory network in intrauterine growth restriction

Author:
Ding, Ying-xue; Cui, Hong
Source:
Life sciences 2017 v.179 pp. 60-65
ISSN:
0024-3205
Subject:
DNA; DNA methylation; animal models; blood sampling; brain; epigenetics; gene expression; genes; gestational age; humans; immunomodulation; infants; loci; malnutrition; microarray technology; neoplasms; perinatal period; promoter regions; protein metabolism; sugars
Abstract:
... Intrauterine growth restriction (IUGR), a serious complication of perinatal period, results in metabolic and brain disorders. However, the exact cause of IUGR remains unclear. Recently, some evidences indicated that epigenetic modification plays an important role in IUGR. Hence, in this study the methylation status and gene expression profiles of IUGR were compared to investigate the changes in ep ...
DOI:
10.1016/j.lfs.2017.04.020

14. First trimester vitamin D status and placental epigenomics in preeclampsia among Northern Plains primiparas

Author:
Anderson, Cindy M.; Ralph, Jody L.; Johnson, LuAnn; Scheett, Angela; Wright, Michelle L.; Taylor, Jacquelyn Y.; Ohm, Joyce E.; Uthus, Eric
Source:
Life sciences 2015 v.129 pp. 10-15
ISSN:
0024-3205
Subject:
DNA methylation; animal tissues; blood serum; calcitriol receptors; epigenetics; food frequency questionnaires; food intake; genes; placenta; pre-eclampsia; prospective studies; protein synthesis; vitamin D; vitamin status; women
Abstract:
... As maternal vitamin D status has been associated with preeclampsia, the purpose of this study was to determine variations in DNA methylation patterns and associated protein expression in placental genes regulating vitamin D metabolism.A convenience sample of 48 pregnant nulliparous women, including 11 later diagnosed with preeclampsia, were recruited in this prospective study. Using a case–control ...
DOI:
10.1016/j.lfs.2014.07.012

15. Proposing interactions between maternal phospholipids and the one carbon cycle: A novel mechanism influencing the risk for cardiovascular diseases in the offspring in later life

Author:
Khot, Vinita; Chavan-Gautam, Preeti; Joshi, Sadhana
Source:
Life sciences 2015 v.129 pp. 16-21
ISSN:
0024-3205
Subject:
DNA; DNA methylation; S-adenosylmethionine; adults; angiogenesis; biochemical pathways; carbon; carbon cycle; cardiovascular diseases; children; epigenetics; fetus; folic acid; genes; long chain polyunsaturated fatty acids; maternal nutrition; metabolism; moieties; mothers; phospholipids; pre-eclampsia; pregnancy outcome; risk; vitamin B12
Abstract:
... Studies have adequately demonstrated the importance of maternal nutrition, particularly, micronutrients (folic acid, vitamin B12) and long chain polyunsaturated fatty acids (LCPUFAs) in determining pregnancy outcome. Reports indicate that children born preterm or to mothers with preeclampsia are at increased risk of developing cardiovascular diseases (CVD) in later life although mechanisms are unc ...
DOI:
10.1016/j.lfs.2014.09.026

16. Genome-wide analysis of DNA methylation in UVB- and DMBA/TPA-induced mouse skin cancer models

Author:
Yang, Anne Yuqing; Lee, Jong Hun; Shu, Limin; Zhang, Chengyue; Su, Zheng-Yuan; Lu, Yaoping; Huang, Mou-Tuan; Ramirez, Christina; Pung, Douglas; Huang, Ying; Verzi, Michael; Hart, Ronald P.; Kong, Ah-Ng Tony
Source:
Life sciences 2014 v.113 no.1-2 pp. 45-54
ISSN:
0024-3205
Subject:
DNA; DNA methylation; G-protein coupled receptors; anthracenes; cAMP-dependent protein kinase; carcinogenesis; carcinogens; computer software; epigenetics; gene interaction; genes; genome-wide association study; high-throughput nucleotide sequencing; irradiation; metabolism; mice; models; precipitin tests; skin neoplasms; ultraviolet radiation; xenobiotics
Abstract:
... Ultraviolet irradiation and carcinogens have been reported to induce epigenetic alterations, which potentially contribute to the development of skin cancer. We aimed to study the genome-wide DNA methylation profiles of skin cancers induced by ultraviolet B (UVB) irradiation and 7,12-dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-1,3-acetate (TPA).Methylated DNA immunoprecipitation (MeD ...
DOI:
10.1016/j.lfs.2014.07.031
PubMed:
25093921
PubMed Central:
PMC5897904

17. Haloperidol induces demethylation and expression of the dual specificity phosphatase 6 gene in MIA PaCa-2 human pancreatic cancer cells

Author:
Kim, Se Hyun; Lee, Hee Young; Yi, Heesun; Ahn, Yong Min; Kim, Yong Sik
Source:
Life sciences 2012 v.91 no.25-26 pp. 1317-1322
ISSN:
0024-3205
Subject:
DNA methylation; acetylation; antipsychotics; carcinoma; cell proliferation; epigenetics; genes; haloperidol; histones; humans; mechanism of action; neoplasm cells; pancreatic neoplasms; sequence analysis; transcription (genetics)
Abstract:
... AIMS: The effects of antipsychotics on various gene expressions through change in DNA methylation have been reported. Dual-specificity phosphatase 6 (DUSP6) is an extracellular signal regulated kinase 1/2 (ERK1/2)-selective phosphatase, and its expression can be suppressed by intronic methylation. Antipsychotic agent haloperidol affects ERK1/2 activity and could induce changes in DNA methylation a ...
DOI:
10.1016/j.lfs.2012.10.002