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1. Acetyl-11-keto-β-boswellic acid regulates the repair of rat sciatic nerve injury by promoting the proliferation of Schwann cells

Author:
Jiang, Xiaowen; Wang, Yao; Zhang, Binqing; Fei, Xue; Guo, Xu; Jia, Yongzhen; Yu, Wenhui
Source:
Life sciences 2020 v.254 pp. 116887
ISSN:
0024-3205
Subject:
Schwann cells; drugs; genes; immunohistochemistry; mitogen-activated protein kinase; models; myelin sheath; myelination; nerve tissue; peripheral nerves; phosphorylation; protein synthesis; proteins; rats; signal transduction; staining
Abstract:
... This study aimed to study the effects of acetyl-11-keto-β-boswellic acid (AKBA) on the regeneration of injured peripheral nerves and the ability of the extracellular signal-regulated kinase (ERK) signaling pathway to regulate the proliferation of Schwann cells and the formation of myelin.A sciatic nerve crush injury model rats were randomly divided into the model control, low-, medium-, and high-d ...
DOI:
10.1016/j.lfs.2019.116887

2. Brn4 promotes the differentiation of radial glial cells into neurons by inhibiting CtBP2

Author:
Zhang, Lei; Zhang, Xinhua; Zhang, Ye; Xu, Naijuan; Wang, Jue; Zhu, Yuanyuan; Xia, Chunlin
Source:
Life sciences 2020 v.254 pp. 116866
ISSN:
0024-3205
Subject:
Lentivirus; binding proteins; brain damage; cell differentiation; cerebral cortex; gene overexpression; genes; humans; neural stem cells; neurodegenerative diseases; neuroglia; neurons; rats; therapeutics; transcription (genetics); transcription factors
Abstract:
... Neural stem cells (NSCs) are pluripotent cells that are capable of differentiating into neurons and considered as the most promising cell source for cell replacement therapy. However, the difficulty in inducing neuronal differentiation and maturation from NSCs is a major challenge for their clinical application. Clarifying the molecular mechanisms underlying the neuronal differentiation of NSCs ca ...
DOI:
10.1016/j.lfs.2019.116866

3. DDX11-AS1 contributes to osteosarcoma progression via stabilizing DDX11

Author:
Zhang, Hui; Lin, Jiangtao; Chen, Junjun; Gu, Wenqi; Mao, Yanjie; Wang, Haixia; Zhang, Yahui; Liu, Wanjun
Source:
Life sciences 2020 v.254 pp. 117392
ISSN:
0024-3205
Subject:
carcinogenesis; cell proliferation; genes; loss-of-function mutation; messenger RNA; metastasis; non-coding RNA; osteosarcoma
Abstract:
... Increasing evidence has uncovered that long noncoding RNAs (lncRNAs) play extremely important roles in numerous steps of gene regulation concerning the progression of tumors. Defined as a kind of lncRNA, DDX11-AS1 has been considered to be closely related to the tumorigenesis of malignancies. Nevertheless, the underlying regulatory role of it in osteosarcoma remains to be analyzed and elucidated. ...
DOI:
10.1016/j.lfs.2020.117392

4. High salt diet elevates the mean arterial pressure of SLC14α1 gene depletion mice

Author:
Wang, Song; Liu, Jinshu; Cai, Hongwei; Liu, Keyuan; He, Yayu; Liu, Shuxiang; Guo, Yingze; Guo, Lirong
Source:
Life sciences 2020 v.254 pp. 117751
ISSN:
0024-3205
Subject:
blood; blood pressure; brain; cerebrospinal fluid; choroid plexus; diet; genes; hypertension; males; mice; reverse transcriptase polymerase chain reaction; sodium; urea
Abstract:
... Urea transporter B (UTB) is encoded by the SLC14α1 gene, and exerts its activity in the choroid plexus (CP) by regulating [Na⁺] in the cerebrospinal fluid (CSF) and maintaining normal blood pressure in mice fed on high salt diet. The aim of this study is to investigate the effect of high salt diet on the mean arterial pressure (MAP) in SLC14α1 depletion mice and its possible molecular mechanism.Ad ...
DOI:
10.1016/j.lfs.2020.117751

5. LncRNA MALAT1 mediates proliferation of LPS treated-articular chondrocytes by targeting the miR-146a-PI3K/Akt/mTOR axis

Author:
Li, Hongxi; Xie, Shujuan; Li, Huazhe; Zhang, Rui; Zhang, Hanjun
Source:
Life sciences 2020 v.254 pp. 116801
ISSN:
0024-3205
Subject:
adenocarcinoma; apoptosis; bioinformatics; bioluminescence assay; cell proliferation; chondrocytes; collagen; gene expression; genes; inflammation; interleukin-6; lipopolysaccharides; lungs; messenger RNA; metabolism; metastasis; models; non-coding RNA; osteoarthritis; patients; phosphatidylinositol 3-kinase; prediction; prostaglandin synthase; quantitative polymerase chain reaction; rapamycin; rats; transfection
Abstract:
... The study aimed to investigate the regulation of long noncoding RNA (lncRNA), Metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in osteoarthritis (OA) development. Isolated rat chondrocytes treated with lipopolysaccharide (LPS) were used as OA cell model. Results from quantitative real-time PCR (Q-PCR) showed that, in OA patients and OA cell model, the expression of MALAT1 and PI3K w ...
DOI:
10.1016/j.lfs.2019.116801

6. MiR-27b suppresses epithelial–mesenchymal transition and chemoresistance in lung cancer by targeting Snail1

Author:
Zhang, Jun; Hua, Xionghuai; Qi, Na; Han, Guangsen; Yu, Juan; Yu, Yongkui; Wei, Xiufeng; Li, Haomiao; Chen, Xiankai; Leng, Changsen; Liu, Qi; Lu, Yingmin; Li, Yin
Source:
Life sciences 2020 v.254 pp. 117238
ISSN:
0024-3205
Subject:
Western blotting; algorithms; cell movement; cisplatin; flow cytometry; gene expression; genes; luciferase; lung neoplasms; microRNA; neoplasm cells; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; therapeutics; tissues
Abstract:
... MicroRNA-27b (miR-27b) has been shown to play a role in the progression of many different forms of cancer, but its specific relevance in the context of non-small cell lung cancer (NSCLC) remains uncertain. As such, this study sought to explore the role of miR-27b in NSCLC and the mechanisms whereby it functions.We quantified miR-27b and target gene expression via quantitative real-time PCR (RT-qPC ...
DOI:
10.1016/j.lfs.2019.117238

7. Ursodeoxycholic acid abrogates gentamicin-induced hepatotoxicity in rats: Role of NF-κB-p65/TNF-α, Bax/Bcl-xl/Caspase-3, and eNOS/iNOS pathways

Author:
Ali, Fares E.M.; Hassanein, Emad H.M.; Bakr, Adel G.; El-Shoura, Ehab A.M.; El-Gamal, Dalia A.; Mahmoud, Amany R.; Abd-Elhamid, Tarek Hamdy
Source:
Life sciences 2020 v.254 pp. 117760
ISSN:
0024-3205
Subject:
adults; apoptosis; caspase-3; endothelial nitric oxide synthase; gene expression regulation; genes; hepatotoxicity; histology; histopathology; inducible nitric oxide synthase; inflammation; interleukin-10; males; mitochondria; oxidative stress; rats; signal transduction; tumor necrosis factor-alpha; ursodeoxycholic acid
Abstract:
... The present study focused on the possible underlying protective mechanisms of UDCA against GNT-induced hepatic injury.For achieving this goal, adult male rats were allocated into 4 groups: normal control (received vehicle), GNT (100 mg/kg, i.p. for 8 days), UDCA (60 mg/kg, P.O. for 15 days), and GNT + UDCA (received UDCA for 15 days and GNT started from the 7th day and lasted for 8 days).The resul ...
DOI:
10.1016/j.lfs.2020.117760

8. Whole-genome sequencing of prostate cancer reveals novel mutation-driven processes and molecular subgroups

Author:
Liang, Caixia; Niu, Lijuan; Xiao, Zejun; Zheng, Cuiling; Shen, Yinchen; Shi, Yuankai; Han, Xiaohong
Source:
Life sciences 2020 v.254 pp. 117218
ISSN:
0024-3205
Subject:
genes; genomics; men; mutation; patients; prostatic neoplasms; sequence analysis
Abstract:
... Prostate cancer (PCa) is the second most frequently diagnosed cancer in men. However, its genetic characteristics in the Chinese population have not been extensively profiled. Here we screened 27 Chinese patients and preformed whole-genome sequencing to dissect their genomic patterns. We found that 18.5% (5/27) tumors harbored non-protein coding mutations on FOXA1. Besides, novel focal amplificati ...
DOI:
10.1016/j.lfs.2019.117218

9. Epigenetic control of atherosclerosis via DNA methylation: A new therapeutic target?

Author:
Gorabi, Armita Mahdavi; Penson, Peter E.; Banach, Maciej; Motallebnezhad, Morteza; Jamialahmadi, Tannaz; Sahebkar, Amirhossein
Source:
Life sciences 2020 v.253 pp. 117682
ISSN:
0024-3205
Subject:
DNA methylation; arteries; atherosclerosis; endothelial cells; epigenetics; foam cells; genes; histone code; inflammation; microRNA; myocytes; oxidative stress; physiology; smooth muscle; therapeutics
Abstract:
... Atherosclerosis is a disease in which lipid-laden plaques are developed inside the vessel walls of arteries. The immune system is activated, resulting in inflammation and oxidative stress. Endothelial cells (ECs) are activated, arterial smooth muscle cells (SMCs) proliferate, macrophages are activated, and foam cells are developed, leading to dysfunctional ECs. Epigenetic regulatory mechanisms, in ...
DOI:
10.1016/j.lfs.2020.117682

10. Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress

Author:
Li, Dongdong; Zhao, Dandan; Du, Jinghua; Dong, Shiming; Aldhamin, Zaid; Yuan, Xiwei; Li, Wencong; Du, Huijuan; Zhao, Wen; Cui, Luyao; Liu, Lingdi; Fu, Na; Nan, Yuemin
Source:
Life sciences 2020 v.253 pp. 117678
ISSN:
0024-3205
Subject:
Western blotting; apoptosis; cholesterol; diet; endoplasmic reticulum; endoplasmic reticulum stress; fatty liver; genes; heme oxygenase (biliverdin-producing); immunohistochemistry; messenger RNA; mice; oxidative toxicity; patients; plasmids; proteins; protoporphyrin; quantitative polymerase chain reaction; staining; stress response; therapeutics; ultrastructure
Abstract:
... The endoplasmic reticulum (ER) stress response plays a crucial role in the development of nonalcoholic steatohepatitis (NASH). Heme oxygenase-1 (HO-1) exerts beneficial effects against oxidative injury in NASH. This study is aimed to clarify whether HO-1 is an effective therapeutic strategy for NASH via regulation of ER stress.The C57BL/6J mice were fed with methionine-choline deficient (MCD) for ...
DOI:
10.1016/j.lfs.2020.117678

11. Long-chain non-coding RNA HOTAIR promotes the progression of osteoarthritis via sponging miR-20b/PTEN axis

Author:
Chen, Yingchun; Zhang, Lin; Li, Ernan; Zhang, Genai; Hou, Yu; Yuan, Wei; Qu, Wei; Ding, Lixiang
Source:
Life sciences 2020 v.253 pp. 117685
ISSN:
0024-3205
Subject:
animal disease models; apoptosis; bioinformatics; cartilage; cell proliferation; chondrocytes; collagen; computer software; extracellular matrix; gene expression regulation; genes; interleukins; luciferase; messenger RNA; metalloproteinases; non-coding RNA; osteoarthritis; pathogenesis
Abstract:
... Cumulative evidence suggests that long-chain non-coding RNA (lncRNA) is involved in the pathogenesis of osteoarthritis (OA). The present study aimed to explore the regulatory role and related mechanisms of HOX transcript antisense intergenic RNA (HOTAIR) in OA.The OA mouse model was constructed by the medial meniscus (DMM) method, and Interleukin (IL)-1β-induced chondrocytes were used to simulate ...
DOI:
10.1016/j.lfs.2020.117685

12. Long noncoding RNA LCTS5 inhibits non-small cell lung cancer by interacting with INO80

Author:
Wang, Baozhong; Wang, Yanwen; Ma, Dan; Wang, Liping; Yang, Mengxiang
Source:
Life sciences 2020 v.253 pp. 117680
ISSN:
0024-3205
Subject:
genes; lung neoplasms; non-coding RNA; small interfering RNA; therapeutics; viability
Abstract:
... To investigate the effect of lncRNA LCTS5 in the non-small cell lung cancer (NSCLC).LncRNA profiling was used to identify the novel lncRNA LCTS5. Viability and migration assays were implemented to evaluate the in vitro effect of LCTS5. Transplantation study was designed to investigate the in vivo role. Short hairpin RNA (shRNA) and lentiviral vector were used to alter LCTS5 expression.We identifie ...
DOI:
10.1016/j.lfs.2020.117680

13. Mining database for the expression and gene regulation network of JAK2 in skin cutaneous melanoma

Author:
Zhang, Wancong; Zhao, Hanxing; Chen, Jiasheng; Zhong, Xiaoping; Zeng, Weiping; Li, Zhonglei; Zhou, Jianda; He, Zhihao; Tang, Shijie
Source:
Life sciences 2020 v.253 pp. 117600
ISSN:
0024-3205
Subject:
DNA; apoptosis; biomarkers; burden of disease; carcinogenesis; cell cycle checkpoints; databases; gene expression regulation; genes; melanoma; mortality; non-specific protein-tyrosine kinase; patients; prognosis; signal transduction
Abstract:
... Skin cutaneous melanoma (SKCM) is the most common subtype of skin malignancy, with ever-increasing incidence, mortality, and disease burden. Dysregulation of JAK-STATs signaling pathway is involved in the pathogenesis and progression of cancers, thus affecting the prognosis of cancer patients. The function of JAKs in SKCM is still not clarified.A total of five online portal (GEPIA, TIMER, GeneMANI ...
DOI:
10.1016/j.lfs.2020.117600

14. The biological function of BMAL1 in skeleton development and disorders

Author:
Chen, Guangjin; Tang, Qingming; Yu, Shaoling; Xie, Yanling; Sun, Jiwei; Li, Shue; Chen, Lili
Source:
Life sciences 2020 v.253 pp. 117636
ISSN:
0024-3205
Subject:
bone density; bone formation; bone resorption; cartilage; chondrocytes; circadian clocks; genes; homeostasis; osteoarthritis; osteoblasts; osteoclasts; osteoporosis; skeletal development; skeleton; teeth; therapeutics
Abstract:
... BMAL1 is a core component of the circadian clock loop, which directs the sophisticated circadian expression of clock-controlled genes. Skeletal Bone development is a complex biological process involving intramembranous ossification, endochondral ossification and bone remodeling, as well as specific cells, such as mesenchymal cells, osteoblasts, osteoclasts, chondrocytes, etc. Growing evidences sug ...
DOI:
10.1016/j.lfs.2020.117636

15. The comprehensive upstream transcription and downstream targeting regulation network of miRNAs reveal potential diagnostic roles in gastric cancer

Author:
Zhang, Cheng; Zhang, Chun-Dong; Liang, Yu; Wu, Kun-Zhe; Pei, Jun-Peng; Dai, Dong-Qiu
Source:
Life sciences 2020 v.253 pp. 117741
ISSN:
0024-3205
Subject:
carcinogenesis; gene expression regulation; gene interaction; genes; messenger RNA; microRNA; patients; stomach neoplasms; tissues; transcription (genetics); vascular endothelial growth factors
Abstract:
... Evidence has shown that miRNAs can be regulated by multiple mechanisms and can participate in tumorigenesis and progression through binding to 3′-UTRs of target mRNAs. The present study identified differentially expressed miRNAs, mRNAs, and TFs by analyzing miRNA-Seq and mRNA-Seq data to construct a TFs/miRNAs/mRNAs regulation network for GC. We found five miRNAs (miR-18a-5p, miR-21-5p, miR-96-5p, ...
DOI:
10.1016/j.lfs.2020.117741

16. Combination therapy with liposomal doxorubicin and liposomal vaccine containing E75, an HER-2/neu-derived peptide, reduces myeloid-derived suppressor cells and improved tumor therapy

Author:
Zamani, Parvin; Navashenaq, Jamshid Gholizadeh; Teymouri, Manouchehr; Karimi, Maryam; Mashreghi, Mohammad; Jaafari, Mahmoud Reza
Source:
Life sciences 2020 v.252 pp. 117646
ISSN:
0024-3205
Subject:
CD4-positive T-lymphocytes; breasts; doxorubicin; drug therapy; erbB-2 receptor; genes; humans; immunosuppression; immunotherapy; inducible nitric oxide synthase; interferon-gamma; mice; neoplasm progression; neoplasms; peptides; reactive oxygen species; splenocytes; suppressor cells; vaccines
Abstract:
... Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells causing resistance to immunotherapies in cancer tumors. In the current study, various immunogenic and therapeutic features of the combination therapies with non-liposomal Doxorubicin (Dox) and the E75 immunogenic peptide (Pep), derived from the human epidermal receptor-2 (HER-2), are investigated in parallel with their liposomal ...
DOI:
10.1016/j.lfs.2020.117646

17. Cystathionine gamma-lyase/H2S system suppresses hepatic acetyl-CoA accumulation and nonalcoholic fatty liver disease in mice

Author:
Ali, Amr; Zhang, Yanjie; Fu, Ming; Pei, Yanxi; Wu, Lingyun; Wang, Rui; Yang, Guangdong
Source:
Life sciences 2020 v.252 pp. 117661
ISSN:
0024-3205
Subject:
Western blotting; acetyl coenzyme A; animal diseases; animal models; carcinoma; cystathionine; cystathionine gamma-lyase; cysteine; diet; fatty liver; fibrosis; free fatty acids; gene expression; genes; glucose; homeostasis; human diseases; hydrogen sulfide; inflammation; ingestion; knockout mutants; lipids; lipogenesis; liver; messenger RNA; mice; neoplasm cells; quantitative polymerase chain reaction; tissues
Abstract:
... Hydrogen sulfide (H₂S) as a novel gasotransmitter can be endogenously produced in liver by cystathionine gamma-lyase (CSE). The dysfunctions of CSE/H₂S system have been linked to various liver diseases. Acetyl-CoA is the key intermediate from the metabolism of lipid. This study examined the roles of H₂S in hepatic acetyl-CoA and lipid metabolism.Both in vitro cell model and in vivo animal model of ...
DOI:
10.1016/j.lfs.2020.117661

18. High-altitude chronic hypoxia ameliorates obesity-induced non-alcoholic fatty liver disease in mice by regulating mitochondrial and AMPK signaling

Author:
Song, Kang; Zhang, Yifan; Ga, Qin; Bai, Zhenzhong; Ge, Ri-Li
Source:
Life sciences 2020 v.252 pp. 117633
ISSN:
0024-3205
Subject:
AMP-activated protein kinase; acetyl coenzyme A; altitude; animal diseases; carnitine palmitoyltransferase; fatty acids; fatty liver; genes; high fat diet; hypoxia; liver; lung function; mice; mitochondria; mitochondrial DNA; obesity; protective effect; reactive oxygen species; sterols
Abstract:
... High-fat intake induces obesity and non-alcoholic fatty liver disease (NAFLD). However, high-altitude chronic hypoxia might alleviate NAFLD progression through improved mitochondrial function and AMP-activated protein kinase (AMPK) signaling. We hypothesized that high-altitude chronic hypoxia would have protective effects against NAFLD development.C57BL/6J mice were randomly divided into control ( ...
DOI:
10.1016/j.lfs.2020.117633

19. JAK/STAT signaling is involved in IL-35-induced inhibition of hepatitis B virus antigen-specific cytotoxic T cell exhaustion in chronic hepatitis B

Author:
Dong, Yuejiao; Li, Xuefen; Yu, Yanying; Lv, Feifei; Chen, Yu
Source:
Life sciences 2020 v.252 pp. 117663
ISSN:
0024-3205
Subject:
DNA; Hepatitis B virus; T-lymphocytes; automation; blood serum; chronic hepatitis B; cytotoxicity; flow cytometry; genes; immunotherapy; interferon-gamma; interleukin-12; lymphocyte proliferation; non-specific protein-tyrosine kinase; protein content; quantitative polymerase chain reaction; receptors; reverse transcriptase polymerase chain reaction; signal transduction; transactivators
Abstract:
... Interleukin-35 (IL-35) is a new member of the interleukin-12 family and is composed of the P35 and EB virus-inducible gene 3 subunits. The aims of this study were to examine the roles of IL-35 in the exhaustion of HBV-specific CTLs, as little as known on the subject.The relative levels of serum HBV markers were detected using automated biochemical techniques. The HBV DNA copies were measured by RT ...
DOI:
10.1016/j.lfs.2020.117663

20. Polyphyllin I attenuates pressure over-load induced cardiac hypertrophy via inhibition of Wnt/β-catenin signaling pathway

Author:
Li, Qing; Jiang, Wei; Wan, Zhaofei; Ni, Yajuan; Lei, Lei; Wei, Jin
Source:
Life sciences 2020 v.252 pp. 117624
ISSN:
0024-3205
Subject:
angiotensin II; antineoplastic activity; beta catenin; biomarkers; cardiac output; cardiomyocytes; cyclins; drugs; echocardiography; fibrosis; genes; histology; hypertrophy; males; medicinal plants; mice; mortality; pathogenesis; phosphorylation; protein synthesis; risk factors; signal transduction; surgery; tau-protein kinase
Abstract:
... Cardiac hypertrophy is one of most important risk factors for cardiovascular mortality. Activation of Wnt/β-catenin signaling pathway is acknowledged to be an important mechanism for pathogenesis of cardiac hypertrophy. Polyphyllin I (PPI), a component in the traditional Chinese medicinal herb, has shown anticancer effect partially via interruption of Wnt/β-catenin signaling pathway. Our aim was t ...
DOI:
10.1016/j.lfs.2020.117624