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- Takahashi, Yasuhiro, et al. Show all 9 Authors
- Life sciences 2013 v.93 no.25-26 pp. 986-993
- analgesia; analgesic effect; anesthesia; antagonists; central nervous system diseases; cognition; correlation; elderly; enzyme-linked immunosorbent assay; hippocampus; isoflurane; laparotomy; memory; morphine; pain; patients; peroxidase; rats; receptors
- ... AIMS: Pain may be associated with postoperative cognitive dysfunction (POCD); however, this relationship remains underinvestigated. Therefore, we examined the impact of postoperative pain on cognitive functions in aged animals. MAIN METHODS: Rats were allocated to the following groups: control (C), 1.2 % isoflurane for 2hours alone (I), I with laparotomy (IL), IL with analgesia using local ropivac ...