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- Aigner, Bernhard; Rathkolb, Birgit; Mohr, Manuela; Klempt, Martina; Hrabé de Angelis, Martin; Wolf, Eckhard
- Lipids 2007 v.42 no.8 pp. 731-737
- mice; mutants; dominant genes; recessive genes; alleles; hypocholesterolemia; animal disease models; blood plasma; lipoproteins; cholesterol; high density lipoprotein; low density lipoprotein; triacylglycerols; homeostasis; phenotypic variation; human health
- ... Pathologic plasma lipoprotein cholesterol levels play a key role in the development and pathogenesis of human atherosclerotic cardiovascular diseases. Plasma cholesterol homeostasis is regulated by genetic predispositions and environmental factors. Animal models showing aberrant plasma cholesterol levels are used for the identification and analysis of novel causative genes. Here, we searched for i ...
- Vaysse-Boué, Carole; Dabadie, Henry; Peuchant, Evelyne; Le Ruyet, Pascale; Mendy, François; Gin, Henry; Combe, Nicole
- Lipids 2007 v.42 no.8 pp. 717-722
- dietary supplements; dietary fat; myristic acid; linolenic acid; blood plasma; blood lipids; blood proteins; lipoproteins; phosphatidylcholine-choline acyltransferase; enzyme activity; high density lipoprotein; human nutrition
- ... Cholesterol removal from tissues into HDL depends on the activity of lecithin-cholesterol acyltransferase (LCAT; E.C. 126.96.36.199) that is associated with lower cardiovascular diseases risk. HDL cholesterol concentration and LCAT activity can be modulated by dietary fatty acids. Original data with substrate models have shown a positive effect of myristic acid (MA) on the esterification rate of choles ...