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1. Generation of ENU-Induced Mouse Mutants with Hypocholesterolemia: Novel Tools for Dissecting Plasma Lipoprotein Homeostasis

Author:
Aigner, Bernhard; Rathkolb, Birgit; Mohr, Manuela; Klempt, Martina; Hrabé de Angelis, Martin; Wolf, Eckhard
Source:
Lipids 2007 v.42 no.8 pp. 731-737
ISSN:
0024-4201
Subject:
high density lipoprotein; dominant genes; alleles; hypocholesterolemia; triacylglycerols; human health; mice; cholesterol; low density lipoprotein; recessive genes; mutants; homeostasis; blood plasma; phenotypic variation; animal disease models
Abstract:
... Pathologic plasma lipoprotein cholesterol levels play a key role in the development and pathogenesis of human atherosclerotic cardiovascular diseases. Plasma cholesterol homeostasis is regulated by genetic predispositions and environmental factors. Animal models showing aberrant plasma cholesterol levels are used for the identification and analysis of novel causative genes. Here, we searched for i ...
DOI:
10.1007/s11745-007-3075-z
PubMed:
17554576

2. Moderate Dietary Intake of Myristic and Alpha-Linolenic Acids Increases Lecithin-Cholesterol Acyltransferase Activity in Humans

Author:
Vaysse-Boué, Carole; Dabadie, Henry; Peuchant, Evelyne; Le Ruyet, Pascale; Mendy, François; Gin, Henry; Combe, Nicole
Source:
Lipids 2007 v.42 no.8 pp. 717-722
ISSN:
0024-4201
Subject:
high density lipoprotein; myristic acid; blood lipids; dietary fat; linolenic acid; blood proteins; phosphatidylcholine-choline acyltransferase; human nutrition; blood plasma; dietary supplements; enzyme activity
Abstract:
... Cholesterol removal from tissues into HDL depends on the activity of lecithin-cholesterol acyltransferase (LCAT; E.C. 2.3.1.43) that is associated with lower cardiovascular diseases risk. HDL cholesterol concentration and LCAT activity can be modulated by dietary fatty acids. Original data with substrate models have shown a positive effect of myristic acid (MA) on the esterification rate of choles ...
DOI:
10.1007/s11745-007-3074-0
PubMed:
17564735