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Mammalian genome
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2018
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2018 v.29 no.1-2
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- Author:
- Chiu, Weihsueh A.; Rusyn, Ivan
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 182-189
- ISSN:
- 0938-8990
- Subject:
- at-risk population; case studies; chemical risk assessment; chromosome mapping; decision making; dose response; genome; hazard identification; human cell lines; human health; humans; mice; risk assessment process; statistical models; toxicity; toxicology
- Abstract:
- ... Characterizing population variability, including identifying susceptible populations and quantifying their increased susceptibility, is an important aspect of chemical risk assessment, but one that is challenging with traditional experimental models and risk assessment methods. New models and methods to address population variability can be used to advance the human health assessments of chemicals ...
- DOI:
- 10.1007/s00335-017-9731-6
- PubMed:
- 29299621
- PubMed Central:
- PMC5849521
- https://dx.doi.org/10.1007/s00335-017-9731-6
- Author:
- Klinefelter, Kelsey; Hooven, Molly Kromme; Bates, Chloe; Colter, Breann T.; Dailey, Alexandra; Infante, Smitha Krishnan; Kania-Korwel, Izabela; Lehmler, Hans-Joachim; López-Juárez, Alejandro; Ludwig, Clare Pickering; Curran, Christine Perdan
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 112-127
- ISSN:
- 0938-8990
- Subject:
- Parkinson disease; adults; bioaccumulation; cerebellum; children; cognition; cytochrome P-450; gene expression; gene expression regulation; genetic variation; genotype; histology; human health; humans; liver; metabolites; mice; neurotoxicity; persistent organic pollutants; pharmacokinetics; polychlorinated biphenyls; pups; risk factors; spleen; thymus gland; thyroxine; tyrosine 3-monooxygenase
- Abstract:
- ... Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human health concern with newly discovered sources of contamination and ongoing bioaccumulation and biomagnification. Children exposed during early brain development are at highest risk of neurological deficits, but highly exposed adults reportedly have an increased risk of Parkinson’s disease. Our previous studies fo ...
- DOI:
- 10.1007/s00335-017-9728-1
- PubMed:
- 29197979
- PubMed Central:
- PMC6425730
- https://dx.doi.org/10.1007/s00335-017-9728-1
- Author:
- Jerry, D. Joseph; Shull, James D.; Hadsell, Darryl L.; Rijnkels, Monique; Dunphy, Karen A.; Schneider, Sallie S.; Vandenberg, Laura N.; Majhi, Prabin Dhangada; Byrne, Celia; Trentham-Dietz, Amy
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 24-37
- ISSN:
- 0938-8990
- Subject:
- agonists; animal tissues; breast neoplasms; diethylstilbestrol; estradiol; genetic variation; genome; humans; loci; mammary development; mammary glands; mammary neoplasms (animal); mice; puberty; quantitative trait loci; risk; women; xenoestrogens
- Abstract:
- ... Breast cancer risk is intimately intertwined with exposure to estrogens. While more than 160 breast cancer risk loci have been identified in humans, genetic interactions with estrogen exposure remain to be established. Strains of rodents exhibit striking differences in their responses to endogenous ovarian estrogens (primarily 17β-estradiol). Similar genetic variation has been observed for synthet ...
- DOI:
- 10.1007/s00335-018-9741-z
- PubMed:
- 29487996
- PubMed Central:
- PMC5936622
- CHORUS:
- 10.1007/s00335-018-9741-z
- https://dx.doi.org/10.1007/s00335-018-9741-z
- Author:
- Chi, Liang; Gao, Bei; Tu, Pengcheng; Liu, Chih-Wei; Xue, Jingchuan; Lai, Yunjia; Ru, Hongyu; Lu, Kun
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 63-79
- ISSN:
- 0938-8990
- Subject:
- DNA repair; arsenic; ascorbic acid; biotransformation; carcinogens; folic acid; genes; intestinal microorganisms; lifestyle; metabolism; nutritional status; oxidative stress; people; risk; stress response; toxicity
- Abstract:
- ... Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to b ...
- DOI:
- 10.1007/s00335-018-9736-9
- PubMed:
- 29429126
- PubMed Central:
- PMC6191311
- https://dx.doi.org/10.1007/s00335-018-9736-9
- Author:
- Vellers, Heather L.; Kleeberger, Steven R.; Lightfoot, J. Timothy
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 48-62
- ISSN:
- 0938-8990
- Subject:
- animal models; chronic diseases; genetic background; genetic factors; guidelines; humans; mice; mitochondrial genome; nuclear genome; phenotype; rats; strength training
- Abstract:
- ... Exercise training which meets the recommendations set by the National Physical Activity Guidelines ensues a multitude of health benefits towards the prevention and treatment of various chronic diseases. However, not all individuals respond well to exercise training. That is, some individuals have no response, while others respond poorly. Genetic background is known to contribute to the inter-indiv ...
- DOI:
- 10.1007/s00335-017-9732-5
- PubMed:
- 29356897
- PubMed Central:
- PMC5851699
- https://dx.doi.org/10.1007/s00335-017-9732-5
- Author:
- Verhein, Kirsten C.; Vellers, Heather L.; Kleeberger, Steven R.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 38-47
- ISSN:
- 0938-8990
- Subject:
- Mycobacterium tuberculosis; Streptococcus pneumoniae; animal models; disease severity; gender; genes; genetic background; genome-wide association study; human population; influenza; mice; morbidity; mortality; myocardial ischemia; nutrition; pathogens; single nucleotide polymorphism; socioeconomic status; stroke; vaccines; viruses
- Abstract:
- ... Respiratory infectious diseases resulting from bacterial or viral pathogens such as Mycobacterium tuberculosis, Streptococcus pneumoniae, respiratory syncytial virus (RSV), or influenza, are major global public health concerns. Lower respiratory tract infections are leading causes of morbidity and mortality, only behind ischemic heart disease and stroke (GBD 2015 LRI Collaborators in Lancet Infect ...
- DOI:
- 10.1007/s00335-018-9733-z
- PubMed:
- 29353387
- PubMed Central:
- PMC5851710
- https://dx.doi.org/10.1007/s00335-018-9733-z
- Author:
- Mortensen, Holly M.; Chamberlin, John; Joubert, Bonnie; Angrish, Michelle; Sipes, Nisha; Lee, Janice S.; Euling, Susan Y.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 190-204
- ISSN:
- 0938-8990
- Subject:
- at-risk population; data collection; genetic variation; health effects assessments; human health; humans; issues and policy; toxic substances
- Abstract:
- ... Estimation of susceptibility differences in human health risk assessment (HHRA) has been challenged by a lack of available susceptibility and variability data after exposure to a specific environmental chemical or pharmaceutical. With the increasingly large number of available data sources that contain polymorphism and other genetic data, human genetic variability that informs susceptibility can b ...
- DOI:
- 10.1007/s00335-018-9738-7
- https://dx.doi.org/10.1007/s00335-018-9738-7
8. Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance
- Author:
- Latchney, Sarah E.; Fields, Ashley M.; Susiarjo, Martha
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 141-152
- ISSN:
- 0938-8990
- Subject:
- DNA methylation; adverse effects; disease transmission; endocrine-disrupting chemicals; environmental exposure; epigenetics; germ cells; histones; humans; phenotype; rodents
- Abstract:
- ... Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of ...
- DOI:
- 10.1007/s00335-017-9729-0
- PubMed:
- 29218402
- PubMed Central:
- PMC5849504
- https://dx.doi.org/10.1007/s00335-017-9729-0
- Author:
- Venkatratnam, Abhishek; House, John S.; Konganti, Kranti; McKenney, Connor; Threadgill, David W.; Chiu, Weihsueh A.; Aylor, David L.; Wright, Fred A.; Rusyn, Ivan
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 168-181
- ISSN:
- 0938-8990
- Subject:
- adverse effects; cell lines; chromosome mapping; dose response; fatty acids; gene expression; genes; genetic background; genetic traits; liver; metabolites; mice; models; neoplasms; toxicity; toxicology; transcription (genetics); transcriptomics; trichloroacetic acid; trichloroethylene
- Abstract:
- ... Studies of gene expression are common in toxicology and provide important clues to mechanistic understanding of adverse effects of chemicals. Most prior studies have been performed in a single strain or cell line; however, gene expression is heavily influenced by the genetic background, and these genotype-expression differences may be key drivers of inter-individual variation in response to chemic ...
- DOI:
- 10.1007/s00335-018-9734-y
- PubMed:
- 29353386
- PubMed Central:
- PMC6094947
- https://dx.doi.org/10.1007/s00335-018-9734-y
- Author:
- Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H.; Tanguay, Robert L.; Reif, David M.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 90-100
- ISSN:
- 0938-8990
- Subject:
- Danio rerio; alleles; databases; disease resistance; early development; experimental design; gene frequency; genetic variation; humans; mice; models; sequence analysis; single nucleotide polymorphism
- Abstract:
- ... Toxicological and pharmacological researchers have seized upon the many benefits of zebrafish, including the short generation time, well-characterized development, and early maturation as clear embryos. A major difference from many model organisms is that standard husbandry practices in zebrafish are designed to maintain population diversity. While this diversity is attractive for translational ap ...
- DOI:
- 10.1007/s00335-018-9735-x
- PubMed:
- 29368091
- PubMed Central:
- PMC5851690
- https://dx.doi.org/10.1007/s00335-018-9735-x
- Author:
- Shorter, John R.; Huang, Wei; Beak, Ju Youn; Hua, Kunjie; Gatti, Daniel M.; de Villena, Fernando Pardo-Manuel; Pomp, Daniel; Jensen, Brian C.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 80-89
- ISSN:
- 0938-8990
- Subject:
- cholesterol; collagen; females; fibrosis; genomics; haplotypes; heart; high protein diet; hypertrophy; insulin; mice; phenotypic variation; quantitative trait loci; quantitative traits; risk factors; single nucleotide polymorphism; triacylglycerols
- Abstract:
- ... Heart size is an important factor in cardiac health and disease. In particular, increased heart weight is predictive of adverse cardiovascular outcomes in multiple large community-based studies. We use two cohorts of Diversity Outbred (DO) mice to investigate the role of genetics, sex, age, and diet on heart size. DO mice (n = 289) of both sexes from generation 10 were fed a standard chow diet, an ...
- DOI:
- 10.1007/s00335-017-9730-7
- PubMed:
- 29279960
- PubMed Central:
- PMC6340297
- https://dx.doi.org/10.1007/s00335-017-9730-7
- Author:
- Argos, Maria; Tong, Lin; Roy, Shantanu; Sabarinathan, Mekala; Ahmed, Alauddin; Islam, Md. Tariqul; Islam, Tariqul; Rakibuz-Zaman, Muhammad; Sarwar, Golam; Shahriar, Hasan; Rahman, Mahfuzar; Yunus, Md.; Graziano, Joseph H.; Jasmine, Farzana; Kibriya, Muhammad G.; Zhou, Xiang; Ahsan, Habibul; Pierce, Brandon L.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 101-111
- ISSN:
- 0938-8990
- Subject:
- DNA methylation; arsenic; cohort studies; environmental exposure; etiology; gene expression; genetic variation; genotype-environment interaction; phenotype; screening; single nucleotide polymorphism; skin lesions; statistical analysis; toxicity; Bangladesh
- Abstract:
- ... Identifying gene–environment interactions is a central challenge in the quest to understand susceptibility to complex, multi-factorial diseases. Developing an understanding of how inter-individual variability in inherited genetic variation alters the effects of environmental exposures will enhance our knowledge of disease mechanisms and improve our ability to predict disease and target interventio ...
- DOI:
- 10.1007/s00335-018-9737-8
- PubMed:
- 29453499
- PubMed Central:
- PMC5908479
- https://dx.doi.org/10.1007/s00335-018-9737-8
- Author:
- Anholt, Robert R. H.; Mackay, Trudy F. C.
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 5-23
- ISSN:
- 0938-8990
- Subject:
- DNA; Drosophila melanogaster; animal breeding; environmental factors; epistasis; evolutionary adaptation; gene regulatory networks; genetic background; genetic models; genetic variation; genome; genome-wide association study; human population; humans; life history; lifestyle; linkage disequilibrium; phenotype; phenotypic variation; rearing; sexual dimorphism; transcriptome
- Abstract:
- ... Understanding how genomic variation gives rise to phenotypic variation is essential for elucidating mechanisms of adaptive evolution, plant and animal breeding, and precision medicine. However, identifying causal links between DNA sequence variants and variation in phenotypes is challenging in human populations, due to large blocks of linkage disequilibrium in the genome and heterogeneous developm ...
- DOI:
- 10.1007/s00335-017-9722-7
- https://dx.doi.org/10.1007/s00335-017-9722-7
- Author:
- Israel, Jennifer W.; Chappell, Grace A.; Simon, Jeremy M.; Pott, Sebastian; Safi, Alexias; Lewis, Lauren; Cotney, Paul; Boulos, Hala S.; Bodnar, Wanda; Lieb, Jason D.; Crawford, Gregory E.; Furey, Terrence S.; Rusyn, Ivan
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 153-167
- ISSN:
- 0938-8990
- Subject:
- DNA damage; acetylation; air; carcinogens; chromatin; epigenetics; gene expression; histones; immune system; inflammation; kidneys; liver; lungs; lysine; messenger RNA; metabolism; mice; mutagens; sequence analysis; transcription (genetics); transcriptome; xenobiotics
- Abstract:
- ... Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanism ...
- DOI:
- 10.1007/s00335-018-9739-6
- PubMed:
- 29429127
- PubMed Central:
- PMC6095468
- https://dx.doi.org/10.1007/s00335-018-9739-6
- Author:
- Hoffman, Paula L.; Saba, Laura M.; Vanderlinden, Lauren A.; Tabakoff, Boris
- Source:
- Mammalian genome 2018 v.29 no.1-2 pp. 128-140
- ISSN:
- 0938-8990
- Subject:
- alcohol drinking; brain; death; ethanol; gene regulatory networks; genes; genetic variance; genetic variation; genomics; humans; liver; microarray technology; phenotype; quantitative trait loci; rats; sequence analysis; signal transduction; transcription (genetics); transcriptome
- Abstract:
- ... Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organs to alcohol-induced damage exhibit a strong genetic influence. We have develope ...
- DOI:
- 10.1007/s00335-017-9726-3
- PubMed:
- 29196862
- PubMed Central:
- PMC5988204
- https://dx.doi.org/10.1007/s00335-017-9726-3