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You searched for: Journal Mammalian genome Remove constraint Journal: Mammalian genome Publication Year 2018 Remove constraint Publication Year: 2018 Source 2018 v.29 no.1-2 Remove constraint Source: 2018 v.29 no.1-2
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1. Advancing chemical risk assessment decision-making with population variability data: challenges and opportunities

Author:
Chiu, Weihsueh A.; Rusyn, Ivan
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 182-189
ISSN:
0938-8990
Subject:
at-risk population; case studies; chemical risk assessment; chromosome mapping; decision making; dose response; genome; hazard identification; human cell lines; human health; humans; mice; risk assessment process; statistical models; toxicity; toxicology
Abstract:
... Characterizing population variability, including identifying susceptible populations and quantifying their increased susceptibility, is an important aspect of chemical risk assessment, but one that is challenging with traditional experimental models and risk assessment methods. New models and methods to address population variability can be used to advance the human health assessments of chemicals ...
DOI:
10.1007/s00335-017-9731-6
PubMed:
29299621
PubMed Central:
PMC5849521

2. Genetic differences in the aryl hydrocarbon receptor and CYP1A2 affect sensitivity to developmental polychlorinated biphenyl exposure in mice: relevance to studies of human neurological disorders

Author:
Klinefelter, Kelsey; Hooven, Molly Kromme; Bates, Chloe; Colter, Breann T.; Dailey, Alexandra; Infante, Smitha Krishnan; Kania-Korwel, Izabela; Lehmler, Hans-Joachim; López-Juárez, Alejandro; Ludwig, Clare Pickering; Curran, Christine Perdan
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 112-127
ISSN:
0938-8990
Subject:
Parkinson disease; adults; bioaccumulation; cerebellum; children; cognition; cytochrome P-450; gene expression; gene expression regulation; genetic variation; genotype; histology; human health; humans; liver; metabolites; mice; neurotoxicity; persistent organic pollutants; pharmacokinetics; polychlorinated biphenyls; pups; risk factors; spleen; thymus gland; thyroxine; tyrosine 3-monooxygenase
Abstract:
... Polychlorinated biphenyls (PCBs) are persistent organic pollutants that remain a human health concern with newly discovered sources of contamination and ongoing bioaccumulation and biomagnification. Children exposed during early brain development are at highest risk of neurological deficits, but highly exposed adults reportedly have an increased risk of Parkinson’s disease. Our previous studies fo ...
DOI:
10.1007/s00335-017-9728-1
PubMed:
29197979
PubMed Central:
PMC6425730

3. Genetic variation in sensitivity to estrogens and breast cancer risk

Author:
Jerry, D. Joseph; Shull, James D.; Hadsell, Darryl L.; Rijnkels, Monique; Dunphy, Karen A.; Schneider, Sallie S.; Vandenberg, Laura N.; Majhi, Prabin Dhangada; Byrne, Celia; Trentham-Dietz, Amy
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 24-37
ISSN:
0938-8990
Subject:
agonists; animal tissues; breast neoplasms; diethylstilbestrol; estradiol; genetic variation; genome; humans; loci; mammary development; mammary glands; mammary neoplasms (animal); mice; puberty; quantitative trait loci; risk; women; xenoestrogens
Abstract:
... Breast cancer risk is intimately intertwined with exposure to estrogens. While more than 160 breast cancer risk loci have been identified in humans, genetic interactions with estrogen exposure remain to be established. Strains of rodents exhibit striking differences in their responses to endogenous ovarian estrogens (primarily 17β-estradiol). Similar genetic variation has been observed for synthet ...
DOI:
10.1007/s00335-018-9741-z
PubMed:
29487996
PubMed Central:
PMC5936622
CHORUS:
10.1007/s00335-018-9741-z

4. Individual susceptibility to arsenic-induced diseases: the role of host genetics, nutritional status, and the gut microbiome

Author:
Chi, Liang; Gao, Bei; Tu, Pengcheng; Liu, Chih-Wei; Xue, Jingchuan; Lai, Yunjia; Ru, Hongyu; Lu, Kun
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 63-79
ISSN:
0938-8990
Subject:
DNA repair; arsenic; ascorbic acid; biotransformation; carcinogens; folic acid; genes; intestinal microorganisms; lifestyle; metabolism; nutritional status; oxidative stress; people; risk; stress response; toxicity
Abstract:
... Arsenic (As) contamination in water or food is a global issue affecting hundreds of millions of people. Although As is classified as a group 1 carcinogen and is associated with multiple diseases, the individual susceptibility to As-related diseases is highly variable, such that a proportion of people exposed to As have higher risks of developing related disorders. Many factors have been found to b ...
DOI:
10.1007/s00335-018-9736-9
PubMed:
29429126
PubMed Central:
PMC6191311

5. Inter-individual variation in adaptations to endurance and resistance exercise training: genetic approaches towards understanding a complex phenotype

Author:
Vellers, Heather L.; Kleeberger, Steven R.; Lightfoot, J. Timothy
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 48-62
ISSN:
0938-8990
Subject:
animal models; chronic diseases; genetic background; genetic factors; guidelines; humans; mice; mitochondrial genome; nuclear genome; phenotype; rats; strength training
Abstract:
... Exercise training which meets the recommendations set by the National Physical Activity Guidelines ensues a multitude of health benefits towards the prevention and treatment of various chronic diseases. However, not all individuals respond well to exercise training. That is, some individuals have no response, while others respond poorly. Genetic background is known to contribute to the inter-indiv ...
DOI:
10.1007/s00335-017-9732-5
PubMed:
29356897
PubMed Central:
PMC5851699

6. Inter-individual variation in health and disease associated with pulmonary infectious agents

Author:
Verhein, Kirsten C.; Vellers, Heather L.; Kleeberger, Steven R.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 38-47
ISSN:
0938-8990
Subject:
Mycobacterium tuberculosis; Streptococcus pneumoniae; animal models; disease severity; gender; genes; genetic background; genome-wide association study; human population; influenza; mice; morbidity; mortality; myocardial ischemia; nutrition; pathogens; single nucleotide polymorphism; socioeconomic status; stroke; vaccines; viruses
Abstract:
... Respiratory infectious diseases resulting from bacterial or viral pathogens such as Mycobacterium tuberculosis, Streptococcus pneumoniae, respiratory syncytial virus (RSV), or influenza, are major global public health concerns. Lower respiratory tract infections are leading causes of morbidity and mortality, only behind ischemic heart disease and stroke (GBD 2015 LRI Collaborators in Lancet Infect ...
DOI:
10.1007/s00335-018-9733-z
PubMed:
29353387
PubMed Central:
PMC5851710

7. Leveraging human genetic and adverse outcome pathway (AOP) data to inform susceptibility in human health risk assessment

Author:
Mortensen, Holly M.; Chamberlin, John; Joubert, Bonnie; Angrish, Michelle; Sipes, Nisha; Lee, Janice S.; Euling, Susan Y.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 190-204
ISSN:
0938-8990
Subject:
at-risk population; data collection; genetic variation; health effects assessments; human health; humans; issues and policy; toxic substances
Abstract:
... Estimation of susceptibility differences in human health risk assessment (HHRA) has been challenged by a lack of available susceptibility and variability data after exposure to a specific environmental chemical or pharmaceutical. With the increasingly large number of available data sources that contain polymorphism and other genetic data, human genetic variability that informs susceptibility can b ...
DOI:
10.1007/s00335-018-9738-7

8. Linking inter-individual variability to endocrine disruptors: insights for epigenetic inheritance

Author:
Latchney, Sarah E.; Fields, Ashley M.; Susiarjo, Martha
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 141-152
ISSN:
0938-8990
Subject:
DNA methylation; adverse effects; disease transmission; endocrine-disrupting chemicals; environmental exposure; epigenetics; germ cells; histones; humans; phenotype; rodents
Abstract:
... Endocrine disrupting chemicals (EDCs) can induce a myriad of adverse health effects. An area of active investigation is the multi- and transgenerational inheritance of EDC-induced adverse health effects referring to the transmission of phenotypes across multiple generations via the germline. The inheritance of EDC-induced adverse health effects across multiple generations can occur independent of ...
DOI:
10.1007/s00335-017-9729-0
PubMed:
29218402
PubMed Central:
PMC5849504

9. Population-based dose–response analysis of liver transcriptional response to trichloroethylene in mouse

Author:
Venkatratnam, Abhishek; House, John S.; Konganti, Kranti; McKenney, Connor; Threadgill, David W.; Chiu, Weihsueh A.; Aylor, David L.; Wright, Fred A.; Rusyn, Ivan
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 168-181
ISSN:
0938-8990
Subject:
adverse effects; cell lines; chromosome mapping; dose response; fatty acids; gene expression; genes; genetic background; genetic traits; liver; metabolites; mice; models; neoplasms; toxicity; toxicology; transcription (genetics); transcriptomics; trichloroacetic acid; trichloroethylene
Abstract:
... Studies of gene expression are common in toxicology and provide important clues to mechanistic understanding of adverse effects of chemicals. Most prior studies have been performed in a single strain or cell line; however, gene expression is heavily influenced by the genetic background, and these genotype-expression differences may be key drivers of inter-individual variation in response to chemic ...
DOI:
10.1007/s00335-018-9734-y
PubMed:
29353386
PubMed Central:
PMC6094947

10. Population genetic diversity in zebrafish lines

Author:
Balik-Meisner, Michele; Truong, Lisa; Scholl, Elizabeth H.; Tanguay, Robert L.; Reif, David M.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 90-100
ISSN:
0938-8990
Subject:
Danio rerio; alleles; databases; disease resistance; early development; experimental design; gene frequency; genetic variation; humans; mice; models; sequence analysis; single nucleotide polymorphism
Abstract:
... Toxicological and pharmacological researchers have seized upon the many benefits of zebrafish, including the short generation time, well-characterized development, and early maturation as clear embryos. A major difference from many model organisms is that standard husbandry practices in zebrafish are designed to maintain population diversity. While this diversity is attractive for translational ap ...
DOI:
10.1007/s00335-018-9735-x
PubMed:
29368091
PubMed Central:
PMC5851690

11. Quantitative trait mapping in Diversity Outbred mice identifies two genomic regions associated with heart size

Author:
Shorter, John R.; Huang, Wei; Beak, Ju Youn; Hua, Kunjie; Gatti, Daniel M.; de Villena, Fernando Pardo-Manuel; Pomp, Daniel; Jensen, Brian C.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 80-89
ISSN:
0938-8990
Subject:
cholesterol; collagen; females; fibrosis; genomics; haplotypes; heart; high protein diet; hypertrophy; insulin; mice; phenotypic variation; quantitative trait loci; quantitative traits; risk factors; single nucleotide polymorphism; triacylglycerols
Abstract:
... Heart size is an important factor in cardiac health and disease. In particular, increased heart weight is predictive of adverse cardiovascular outcomes in multiple large community-based studies. We use two cohorts of Diversity Outbred (DO) mice to investigate the role of genetics, sex, age, and diet on heart size. DO mice (n = 289) of both sexes from generation 10 were fed a standard chow diet, an ...
DOI:
10.1007/s00335-017-9730-7
PubMed:
29279960
PubMed Central:
PMC6340297

12. Screening for gene–environment (G×E) interaction using omics data from exposed individuals: an application to gene-arsenic interaction

Author:
Argos, Maria; Tong, Lin; Roy, Shantanu; Sabarinathan, Mekala; Ahmed, Alauddin; Islam, Md. Tariqul; Islam, Tariqul; Rakibuz-Zaman, Muhammad; Sarwar, Golam; Shahriar, Hasan; Rahman, Mahfuzar; Yunus, Md.; Graziano, Joseph H.; Jasmine, Farzana; Kibriya, Muhammad G.; Zhou, Xiang; Ahsan, Habibul; Pierce, Brandon L.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 101-111
ISSN:
0938-8990
Subject:
DNA methylation; arsenic; cohort studies; environmental exposure; etiology; gene expression; genetic variation; genotype-environment interaction; phenotype; screening; single nucleotide polymorphism; skin lesions; statistical analysis; toxicity; Bangladesh
Abstract:
... Identifying gene–environment interactions is a central challenge in the quest to understand susceptibility to complex, multi-factorial diseases. Developing an understanding of how inter-individual variability in inherited genetic variation alters the effects of environmental exposures will enhance our knowledge of disease mechanisms and improve our ability to predict disease and target interventio ...
DOI:
10.1007/s00335-018-9737-8
PubMed:
29453499
PubMed Central:
PMC5908479

13. The road less traveled: from genotype to phenotype in flies and humans

Author:
Anholt, Robert R. H.; Mackay, Trudy F. C.
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 5-23
ISSN:
0938-8990
Subject:
DNA; Drosophila melanogaster; animal breeding; environmental factors; epistasis; evolutionary adaptation; gene regulatory networks; genetic background; genetic models; genetic variation; genome; genome-wide association study; human population; humans; life history; lifestyle; linkage disequilibrium; phenotype; phenotypic variation; rearing; sexual dimorphism; transcriptome
Abstract:
... Understanding how genomic variation gives rise to phenotypic variation is essential for elucidating mechanisms of adaptive evolution, plant and animal breeding, and precision medicine. However, identifying causal links between DNA sequence variants and variation in phenotypes is challenging in human populations, due to large blocks of linkage disequilibrium in the genome and heterogeneous developm ...
DOI:
10.1007/s00335-017-9722-7

14. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription

Author:
Israel, Jennifer W.; Chappell, Grace A.; Simon, Jeremy M.; Pott, Sebastian; Safi, Alexias; Lewis, Lauren; Cotney, Paul; Boulos, Hala S.; Bodnar, Wanda; Lieb, Jason D.; Crawford, Gregory E.; Furey, Terrence S.; Rusyn, Ivan
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 153-167
ISSN:
0938-8990
Subject:
DNA damage; acetylation; air; carcinogens; chromatin; epigenetics; gene expression; histones; immune system; inflammation; kidneys; liver; lungs; lysine; messenger RNA; metabolism; mice; mutagens; sequence analysis; transcription (genetics); transcriptome; xenobiotics
Abstract:
... Epigenetic effects of environmental chemicals are under intense investigation to fill existing knowledge gaps between environmental/occupational exposures and adverse health outcomes. Chromatin accessibility is one prominent mechanism of epigenetic control of transcription, and understanding of the chemical effects on both could inform the causal role of epigenetic alterations in disease mechanism ...
DOI:
10.1007/s00335-018-9739-6
PubMed:
29429127
PubMed Central:
PMC6095468

15. Voluntary exposure to a toxin: the genetic influence on ethanol consumption

Author:
Hoffman, Paula L.; Saba, Laura M.; Vanderlinden, Lauren A.; Tabakoff, Boris
Source:
Mammalian genome 2018 v.29 no.1-2 pp. 128-140
ISSN:
0938-8990
Subject:
alcohol drinking; brain; death; ethanol; gene regulatory networks; genes; genetic variance; genetic variation; genomics; humans; liver; microarray technology; phenotype; quantitative trait loci; rats; sequence analysis; signal transduction; transcription (genetics); transcriptome
Abstract:
... Ethyl alcohol is a toxin that, when consumed at high levels, produces organ damage and death. One way to prevent or ameliorate this damage in humans is to reduce the exposure of organs to alcohol by reducing alcohol ingestion. Both the propensity to consume large volumes of alcohol and the susceptibility of human organs to alcohol-induced damage exhibit a strong genetic influence. We have develope ...
DOI:
10.1007/s00335-017-9726-3
PubMed:
29196862
PubMed Central:
PMC5988204