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- Yang, Chih-Hao, et al. Show all 9 Authors
- Marine drugs 2019 v.17 no.6
- Chondrostereum; IKappaB kinase; animal models; edema; endotoxemia; gelatinase B; hippocampus; humans; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; macrophages; marine fungi; messenger RNA; mitogen-activated protein kinase; monocytes; phosphorylation; sepsis (infection); tumor necrosis factor-alpha
- ... Activated human monocytes/macrophages, which increase the levels of matrix metalloproteinases (MMPs) and pro-inflammatory cytokines, are the essential mechanisms for the progression of sepsis. In the present study, we determined the functions and mechanisms of hirsutanolA (HA), which is isolated from the red alga-derived marine fungus Chondrostereum sp. NTOU4196, on the production of pro-inflammat ...