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- Pinto, Yishay; Levanon, Erez Y.
- Methods 2019 v.156 pp. 25-31
- RNA editing; adenosine deaminase; computational methodology; double-stranded RNA; genome; genomics; immune system; loci; messenger RNA; researchers; sequence analysis; transcriptome
- ... Adenosine deaminases that act on RNA (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing in double-stranded RNA. Such editing is important for protection against false activation of the immune system, but also confers plasticity on the transcriptome by generating several versions of a transcript from a single genomic locus. Recently, great efforts were made in developing computational metho ...
- Montiel-Gonzalez, Maria Fernanda; Diaz Quiroz, Juan Felipe; Rosenthal, Joshua J.C.
- Methods 2019 v.156 pp. 16-24
- RNA editing; active sites; adenosine deaminase; amino acid sequences; antisense RNA; catalytic activity; gene editing; inosine; messenger RNA; mutation; nucleases; oligonucleotides; therapeutics
- ... Adenosine Deaminases that Act on RNA (ADARs) are a group of enzymes that catalyze the conversion of adenosines (A’s) to inosines (I’s) in a process known as RNA editing. Though ADARs can act on different types of RNA, editing events in coding regions of mRNA are of particular interest as I’s base pair like guanosines (G’s). Thus, every A-to-I change catalyzed by ADAR is read as an A-to-G change du ...