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You searched for: Journal Microbial pathogenesis Remove constraint Journal: Microbial pathogenesis Publication Year 2021 Remove constraint Publication Year: 2021 Source 2021 v.154 Remove constraint Source: 2021 v.154
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1. A comparative investigation on the role and interaction of EsxA and EsxB in host immune response

Author:
Yi, Yuanyang; Wang, Hanqing; Su, Lingling; Wang, Hao; Zhang, Baojiang; Su, Yan
Source:
Microbial pathogenesis 2021 v.154 pp. 104843
ISSN:
0882-4010
Subject:
CD4-positive T-lymphocytes; Mycobacterium tuberculosis; Staphylococcus aureus; antibodies; bovine mastitis; immune response; immunoglobulin G; mice; pathogenesis; secretion; vaccination; virulence
Abstract:
... Staphylococcus aureus (S. aureus) is a frequent and major cause of bovine mastitis; it poses a tremendous economic burden to dairy industries of numerous countries. Early-secretion antigen-6 secretion system (ESS) has been viewed as an essential virulence and pathogenic factor of S. aureus. EsxA and EsxB are small acidic proteins secreted by ESS and identified as potential T-cell antigens of S. au ...
DOI:
10.1016/j.micpath.2021.104843

2. Alterations in the gut microbiota and metabolic profiles coincide with intestinal damage in mice with a bloodborne Candida albicans infection

Author:
Hu, Wanchao; Xu, Dan; Zhou, Ziyang; Zhu, Junfeng; Wang, Dan; Tang, Jianguo
Source:
Microbial pathogenesis 2021 v.154 pp. 104826
ISSN:
0882-4010
Subject:
; Candida albicans; Lachnospiraceae; Lactobacillus; Proteus; Roseburia; Ruminococcus; arachidonic acid; bile acids; bile secretion; candidemia; caudal vein; central venous catheters; drugs; eosin; genes; inflammation; intestinal microorganisms; intestinal mucosa; intravenous injection; metabolites; metabolomics; mice; morbidity; opportunistic pathogens; pathogenesis; permeability; probiotics; survival rate; tight junctions; weight loss
Abstract:
... Candida albicans is an opportunistic fungus that can threaten life especially in patients with candidemia. The morbidity and mortality of candidemia originating from a central venous catheter (CVC) and illicit intravenous drug use (IVDU) are increasing. However, the mechanism underlying the bloodborne C. albicans infection remains unclear. Herein, we evaluated the gut microbiome, metabolites and i ...
DOI:
10.1016/j.micpath.2021.104826

3. Analysis of microRNA expression profiles in human bronchial epithelial cells infected by Chlamydia psittaci

Author:
Liu, Luyao; Chen, Xi; Tang, Ting; Chen, Li; Huang, Qiaoling; Li, Zhongyu; Bai, Qinqin; Chen, Lili
Source:
Microbial pathogenesis 2021 v.154 pp. 104837
ISSN:
0882-4010
Subject:
Chlamydia; Chlamydophila psittaci; epithelium; gene expression; gene ontology; humans; microRNA; non-coding RNA; oxytocin; pathogenesis; pathogens; pneumonia; signal transduction; transcription (genetics); zoonoses
Abstract:
... Chlamydia psittaci is a pathogen of birds that can cause zoonotic disease in mammals including pneumonia in humans. MicroRNAs (miRNAs) are a class of small non-coding RNA fragments with a length of about 22 nt, which play an important role in regulating gene expression after transcription. Chlamydia infection can cause changes in host cell miRNA expression, but the potential biological function of ...
DOI:
10.1016/j.micpath.2021.104837

4. Antiviral activity of portulaca oleracea L. extracts against porcine epidemic diarrhea virus by partial suppression on myd88/NF-κb activation in vitro

Author:
Liu, Yueyue; Zhao, Lu; Xie, Yunhui; Chen, Zhi; Yang, Shifa; Yin, Bin; Li, Guiming; Guo, Huijun; Lin, Shuqian; Wu, Jiaqiang
Source:
Microbial pathogenesis 2021 v.154 pp. 104832
ISSN:
0882-4010
Subject:
Porcine epidemic diarrhea virus; Portulaca oleracea; Western blotting; adsorption; antiviral properties; cytokines; dose response; fluorescent antibody technique; intestines; pathogenesis; pork industry; protein synthesis; therapeutics
Abstract:
... Porcine epidemic diarrhea virus (PEDV), especially variants, causes a highly contagious enteric disease which could give rise to huge economic losses in the swine industry worldwide. Portulaca oleracea L. has been reported to regulate intestine disease and involved in viral infections. However, the underlying mechanisms of Portulaca oleracea L. extracts against PEDV have not been fully elucidated. ...
DOI:
10.1016/j.micpath.2021.104832

5. Autoinducer N-(3-oxododecanoyl)-l-homoserine lactone induces calcium and reactive oxygen species-mediated mitochondrial damage and apoptosis in blood platelets

Author:
Yadav, Vivek Kumar; Singh, Pradeep Kumar; Sharma, Deepmala; Pandey, Himanshu; Singh, Sunil Kumar; Agarwal, Vishnu
Source:
Microbial pathogenesis 2021 v.154 pp. 104792
ISSN:
0882-4010
Subject:
Pseudomonas aeruginosa; apoptosis; blood platelets; calcium; chelating agents; homoserine; humans; lactones; membrane potential; mitochondria; oxygen; pathogenesis; permeability; phosphatidylserines; platelet aggregation; virulence
Abstract:
... Acylated homoserine lactones (AHL) such as N-(3-oxododecanoyl)-l-homoserine lactone (3-oxo-C₁₂ HSL) and N-butyryl-l-homoserine lactone (C₄ HSL) are the most common autoinducer molecules in Pseudomonas aeruginosa. These AHL molecules not only regulate the expression of virulence factors but also have been shown to interfere with the host cell and modulate its functions. Recently, we reported that 3 ...
DOI:
10.1016/j.micpath.2021.104792

6. CoGRIM19 is required for invasive hyphal growth of Colletotrichum orbiculare inside epidermal cells of cucumber cotyledons

Author:
Harata, Ken; Shinonaga, Hayato; Nishiyama, Yuudai; Okuno, Tetsuro
Source:
Microbial pathogenesis 2021 v.154 pp. 104847
ISSN:
0882-4010
Subject:
Colletotrichum orbiculare; NADH dehydrogenase (ubiquinone); anthracnose; appressoria; cellulose; cucumbers; fluorescence; fungi; genes; host plants; hyphae; mutants; pathogenesis; pathogenicity; pathogens
Abstract:
... Colletotrichum orbiculare, an anthracnose disease fungus of cucurbit plants, extends penetration hyphae inside the epidermal cells of host plants. Unlike vegetative hyphae formed on a nutrient rich medium, this pathogen initially develops biotrophic penetration hyphae, which acquire nutrient resources from living host cells and secret effector proteins to suppress host defense responses. Subsequen ...
DOI:
10.1016/j.micpath.2021.104847

7. Comparative analysis of the vaginal microbiome of Chinese women with Trichomonas vaginalis and mixed infection

Author:
Li, Ting; Liu, Zhaohui; Zhang, Zhan; Bai, Huihui; Zong, Xiaonan; Wang, Fengjuan; Fan, Linyuan
Source:
Microbial pathogenesis 2021 v.154 pp. 104790
ISSN:
0882-4010
Subject:
Anaerococcus; Dialister; Mycoplasma; Peptoniphilus; Peptostreptococcus; Prevotella; Streptococcus; Trichomonas vaginalis; bacteria; bacterial communities; community structure; complications (disease); gene expression; metagenomics; microbiome; mixed infection; pathogenesis; probiotics
Abstract:
... The high prevalence and serious long-term sequelae of Trichomonas vaginalis (TV) infection worldwide is of a particular concern; however, data regarding the differences in the composition of the vaginal microbiome in cases of single TV infection or mixed infections (i.e., presence of TV and bacterial vaginosis) are scarce. We employed metagenomic sequencing analyses to study gene expression in the ...
DOI:
10.1016/j.micpath.2021.104790

8. Comparison of superantigens and attachment factors genes of Staphylococcus aureus in clinical isolates and nasal colonizers in the same patients

Author:
Sharabiani, Hamideh Richi; Sadeghi, Javid; Pirzade, Tahere; Rezaee, Mohammad Ahangarzadeh; Ghotaslou, Reza; Laghousi, Delara; Sefidan, Fateme Yeghane; Kafil, Hossein Samadi; Nikbakht, Mojtaba; Mazraeh, Fariba Naeimi; Hematyar, Yalda
Source:
Microbial pathogenesis 2021 v.154 pp. 104860
ISSN:
0882-4010
Subject:
Staphylococcus aureus; adhesion; antibiotic resistance; biofilm; cell adhesion molecules; cross infection; enterotoxins; epidemiology; erythromycin; linezolid; multiple drug resistance; nose; pathogenesis; pathogens; polymerase chain reaction; superantigens; vancomycin
Abstract:
... Staphylococcus aureus (S. aureus) is a bacterial pathogen can cause a wide range of nosocomial infections. Nasal colonization by S.aureus plays important role both in the epidemiology and pathogenesis of infection.The purpose of this study was to investigate the association of clinical isolates and nasal colonizers of S. aureus in the same patients by molecular methods, and their antibiotic suscep ...
DOI:
10.1016/j.micpath.2021.104860

9. Contribution of STAT3 to the pathogenesis of COVID-19

Author:
Jafarzadeh, Abdollah; Nemati, Maryam; Jafarzadeh, Sara
Source:
Microbial pathogenesis 2021 v.154 pp. 104836
ISSN:
0882-4010
Subject:
COVID-19 infection; adaptive immunity; cell death; chemokines; cytoplasm; interferons; macrophages; pathogenesis; pulmonary fibrosis; signal transduction; thrombosis; transcription factors; virus replication
Abstract:
... Hyper-inflammatory responses, lymphopenia, unbalanced immune responses, cytokine storm, large viral replication and massive cell death play fundamental roles in the pathogenesis of COVID-19. Extreme production of many kinds of pro-inflammatory cytokines and chemokines occur in severe COVID-19 that called cytokine storm. Signal transducer and activator of transcription-3 (STAT-3) present in the cyt ...
DOI:
10.1016/j.micpath.2021.104836

10. Cucullanus bulbosus (Lane, 1916) Barreto, 1918 (Nematoda, Cucullanidae) from the common ponyfish Leiognathus equulus (Leiognathidae): Morphology and molecular study

Author:
Al-Hoshani, Nawal; Al-Quraishy, Saleh; Murshed, Mutee; Aljawdah, Hossam M.A.; Mares, Mohammed M.; Alghamdi, Jawahir; Al-Shaebi, Esam M.; Dkhil, Mohamed A.; Abdel-Gaber, Rewaida
Source:
Microbial pathogenesis 2021 v.154 pp. 104821
ISSN:
0882-4010
Subject:
Leiognathus equulus; Nematoda; body length; esophagus; genes; male reproductive system; marine fish; parasites; pathogenesis; phylogeny; Red Sea; Saudi Arabia
Abstract:
... The common ponyfish Leiognathus equulus is a marine fish species with very high commercial value. Little information is available about its parasitic infections. Based on light and scanning electron microscopy, as well as sequencing and analysis of the partial regions of the ITS-1, 18S rRNA, COX1 genes, were employed for the systematic evaluation of a nematode parasite, which it first isolated fro ...
DOI:
10.1016/j.micpath.2021.104821

11. Defining chaperone-usher fimbriae repertoire in Serratia marcescens

Author:
González-Montalvo, Martín A.; Tavares-Carreón, Faviola; González, Gloria M.; Villanueva-Lozano, Hiram; García-Romero, Inmaculada; Zomosa-Signoret, Viviana C.; Valvano, Miguel A.; Andrade, Angel
Source:
Microbial pathogenesis 2021 v.154 pp. 104857
ISSN:
0882-4010
Subject:
Serratia marcescens; adhesion; animal pathogens; biofilm; fimbriae; operon; organelles; pathogenesis; phylogeny; transcription (genetics)
Abstract:
... Chaperone-usher (CU) fimbriae are surface organelles particularly prevalent among the Enterobacteriaceae. Mainly associated to their adhesive properties, CU fimbriae play key roles in biofilm formation and host cell interactions. Little is known about the fimbriome composition of the opportunistic human pathogen Serratia marcescens. Here, by using a search based on consensus fimbrial usher protein ...
DOI:
10.1016/j.micpath.2021.104857

12. Development of CRISPR-Cas9 genome editing system in Talaromyces marneffei

Author:
Zhang, Xiangmei; Hu, Xueyan; jan, Saad; Rasheed, Syed Majid; Zhang, Yun; Du, Minghao; Yang, Ence
Source:
Microbial pathogenesis 2021 v.154 pp. 104822
ISSN:
0882-4010
Subject:
CRISPR-Cas systems; Talaromyces; genes; mutation rate; mycelium; pathogenesis; pathogenicity; phenotype; protoplasts; yeasts; South East Asia
Abstract:
... Talaromyces marneffei is an important pathogenic thermally dimorphic fungus causing systemic talaromycosis mainly prevalent in Southeast Asia. The dimorphic transition between mycelium and yeast is considered crucial for the pathogenicity of T. marneffei. However, the lack of genetic toolbox has been a major impediment for understanding its pathogenicity. Here a CRISPR-Cas9 system was developed to ...
DOI:
10.1016/j.micpath.2021.104822

13. Development of monoclonal antibody against glycoprotein of hirame novirhabdovirus (HIRRV) with virus neutralizing activity

Author:
Tang, Xiaoqian; Cao, Jing; Zhang, Jialin; Xing, Jing; Sheng, Xiuzhen; Zhan, Wenbin
Source:
Microbial pathogenesis 2021 v.154 pp. 104868
ISSN:
0882-4010
Subject:
Escherichia coli; Hirame rhabdovirus; Western blotting; amino acid sequences; cytopathogenicity; enzyme-linked immunosorbent assay; fish industry; flounder; fluorescent antibody technique; glycoproteins; hybridomas; mass spectrometry; molecular weight; monoclonal antibodies; mortality; neutralization tests; pathogenesis; therapeutics; viruses; Asia; Europe
Abstract:
... Hirame rhabdovirus (HIRRV) is one of the most important viruses of fish, posing a great threat to the fish industry in Asia and Europe. The glycoprotein (G) of HIRRV is known to play important roles in virus attachment and entry, making it an ideal target for both diagnosis and therapy. In this study, a truncated G of HIRRV was expressed as a fusion protein in Escherichia coli. Using the recombina ...
DOI:
10.1016/j.micpath.2021.104868

14. Dirofilariosis caused by Dirofilaria immitis in the south of Kerman province, Iran

Author:
Naderi, Afsaneh; Sharifi, Iraj; Aflatoonian, Mohammad Reza; Mostafavi, Mahshid; Hakimi Parizi, Maryam; Mashayekhi, Jahangir; Mashayekhi, Mojtaba; Nikpour, Saeideh; Bamorovat, Mehdi
Source:
Microbial pathogenesis 2021 v.154 pp. 104863
ISSN:
0882-4010
Subject:
Dirofilaria immitis; blood; blood flow; descriptive studies; dirofilariasis; dogs; enzyme-linked immunosorbent assay; gender; microfilariae; pathogenesis; public health; questionnaires; therapeutics; Iran
Abstract:
... Dirofilariosis due to Dirofilaria immitis is endemic in various areas of Iran. Domestic dogs are the main reservoirs and represent a major potential infection source for the vector and humans.This study aimed to explore the prevalence of dirofilariosis due to D.immitis and its public health importance in domestic dogs in the Jiroft district, south of Kerman province, Iran, by serological and paras ...
DOI:
10.1016/j.micpath.2021.104863

15. Do entomopathogenic nematodes induce immune priming?

Author:
Texca Tatevari, Méndez-López; Jorge, Contreras-Garduño; Luis, Mendoza-Cuenca; Ricardo, Ramirez-Romero
Source:
Microbial pathogenesis 2021 v.154 pp. 104844
ISSN:
0882-4010
Subject:
; Nematoda; Tenebrio molitor; carbon dioxide; entomopathogenic nematodes; immune evasion; metabolism; pathogenesis; virulence; virulent strains
Abstract:
... Although the study of immune priming in insects is a growing area of research, its occurrence in various biological models has not been evaluated, and its mechanisms are poorly understood. Whether entomopathogenic nematodes (EPNs) can induce immune priming and what role their virulence might play in it has not been assessed. Here, we tested for the first time: 1) whether a nematode is capable of e ...
DOI:
10.1016/j.micpath.2021.104844

16. Effects of extracellular DNA on dual-species biofilm formed by Streptococcus mutans and Candida albicans

Author:
Guo, Haoran; Chen, Yitong; Guo, Wenjin; Chen, Jingyu
Source:
Microbial pathogenesis 2021 v.154 pp. 104838
ISSN:
0882-4010
Subject:
Candida albicans; Streptococcus mutans; adhesion; biofilm; cell viability; coculture; dental caries; dental plaque; drug resistance; environmental DNA; fungi; mycelium; pathogenesis; pathogens; polysaccharides
Abstract:
... Streptococcus mutans is the most important acid-producing pathogen that causes dental caries, while Candida albicans is an opportunistic fungal pathogen that is frequently detected in conjunction with heavy infection by S. mutans. Their interactions in dental plaque biofilms remain unclear. Extracellular DNA (eDNA) is found in oral biofilms, but its effects have not been thoroughly defined. In thi ...
DOI:
10.1016/j.micpath.2021.104838

17. Effects of mancozeb on citrus rhizosphere bacterial community

Author:
Huang, Zhendong; Wang, Peng; Pu, Zhanxu; Lu, Lianming; Chen, Guoqing; Hu, Xiurong; Fayyaz, Amna; Gai, Yunpeng
Source:
Microbial pathogenesis 2021 v.154 pp. 104845
ISSN:
0882-4010
Subject:
Citrus; Nitrospirae; Proteobacteria; bacterial communities; fungicide application; fungicides; mancozeb; pathogenesis; rhizosphere; soil
Abstract:
... Multiple and consecutive application of fungicide might damage the rhizosphere bacterial community of citrus. In order to evaluated effect of mancozeb on the chemical properties of citrus-cultivated soil and the richness and diversity of rhizosphere bacterial community. The abundance response of rhizosphere bacterial groups without application or with application of 1.333 g mg⁻¹ mancozeb for 2, 4, ...
DOI:
10.1016/j.micpath.2021.104845

18. Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages

Author:
Ran, Shujun; Huang, Jing; Liu, Bin; Gu, Shensheng; Jiang, Wei; Liang, Jingping
Source:
Microbial pathogenesis 2021 v.154 pp. 104761
ISSN:
0882-4010
Subject:
Enterococcus faecalis; Western blotting; adenosine triphosphate; caspase-1; chronic diseases; enzyme-linked immunosorbent assay; granulation tissue; inflammasomes; inflammation; interleukin-1beta; lactate dehydrogenase; macrophages; melanoma; oligomerization; oxidation; pathogenesis; pathogenicity; periodontitis; pyroptosis; quantitative polymerase chain reaction; secretion; toxicity testing
Abstract:
... Enterococcus faecalis is the bacterial species closely related to persistent infection in root canals. Interleukin-1 beta (IL-1β) is the most commonly detected proinflammatory cytokine in periapical granulation tissue and plays a critical role in host defenses against microbial infection. The synthesis and secretion of IL-1β are mediated mainly by Toll-like receptors and inflammasome activation. T ...
DOI:
10.1016/j.micpath.2021.104761

19. Expression of virulence factors by Pseudomonas aeruginosa biofilm after bacteriophage infection

Author:
Oliveira, Viviane de Cássia; Steixner, Stephan; Nascimento, Cássio do; Pagnano, Valéria Oliveira; Silva-Lovato, Cláudia Helena; Paranhos, Helena de Freitas Oliveira; Wilflingseder, Doris; Coraça-Huber, Débora; Watanabe, Evandro
Source:
Microbial pathogenesis 2021 v.154 pp. 104834
ISSN:
0882-4010
Subject:
Pseudomonas aeruginosa; bacteriophages; biofilm; coculture; elastase; enzyme activity; pathogenesis; pyocyanin; stress response; transcription (genetics); virulence
Abstract:
... The use of bacteriophages for the treatment of bacterial infections has been extensively studied. Nonetheless, the stress response regarding bacteriophage infection and the expression of virulence factors of Pseudomonas aeruginosa after phage infection is poorly discussed. In this study, we evaluated biofilm formation capacity and expression of virulence factors of P. aeruginosa after bacteriophag ...
DOI:
10.1016/j.micpath.2021.104834

20. First description of natural concomitant infection of avian nephritis virus and infectious bronchitis virus reveals exacerbated inflammatory response and renal damage in broiler chicks

Author:
Munuswamy, Palanivelu; Ramakrishnan, Saravanan; Latheef, Shyma K.; Kappala, Deepthi; Mariappan, Asok Kumar; Kaore, Megha; Anbazhagan, Karthikeyan; Puvvala, Bhavani; Singh, Karam Pal; Dhama, Kuldeep
Source:
Microbial pathogenesis 2021 v.154 pp. 104830
ISSN:
0882-4010
Subject:
; Avastrovirus 2; Avian nephritis virus; Infectious bronchitis virus; RNA-directed RNA polymerase; genes; glycoproteins; histopathology; inflammation; interleukin-12; interleukin-13; interleukin-4; macrophages; mixed infection; necropsy; pathogenesis; viruses
Abstract:
... We describe the first report on spontaneous Avian Nephritis Virus (ANV) and Infectious Bronchitis Virus (IBV) concurrent infection in broiler chicks. On necropsy, the kidneys were found swollen with its parenchyma and ureters stuffed with urate flakes. Histopathologically, the renal tubular damage and inflammatory response were severe in concurrently infected birds compared to the cases infected o ...
DOI:
10.1016/j.micpath.2021.104830