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You searched for: Journal Microbial pathogenesis Remove constraint Journal: Microbial pathogenesis Publication Year 2020 Remove constraint Publication Year: 2020 Source 2020 v.138 Remove constraint Source: 2020 v.138
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1. Analysis of different signal peptides for the secretory production of Ama r 2 in gram-positive systems (Lactococcus lactis)

Author:
Vasiee, Alireza; Norouzi, Neda; Yazdi, Farideh Tabatabaee; Mortazavi, Seyed Ali; Sankian, Mojtaba; Mahmoudi, Mahmoud; Shahidi, Fakhri
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
Amaranthus retroflexus; Lactococcus lactis; allergens; computer software; databases; dextranase; disulfide bonds; hosts; hypersensitivity; immunotherapy; lactic acid bacteria; physicochemical properties; probiotics; recombinant proteins; secretion; signal peptide
Abstract:
... Prokaryotic systems have been considered the most affordable and simplest hosts which are being employed to express recombinant proteins such as allergens; nevertheless, without appropriate signal peptide (SP), these systems cannot be used for secretory proteins. Recently, a lot of effort has been put into assessing the potential of gram-positive strains such as lactic acid bacteria for new applic ...
DOI:
10.1016/j.micpath.2019.103819

2. Antimicrobial, anti-biofilm, and anti-proliferative activities of lipopeptide biosurfactant produced by Acinetobacter junii B6

Author:
Ohadi, Mandana; Forootanfar, Hamid; Dehghannoudeh, Gholamreza; Eslaminejad, Touba; Ameri, Atefeh; Shakibaie, Mojtaba; Adeli-Sardou, Mahboubeh
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
Acinetobacter junii; Candida utilis; Gram-negative bacteria; Proteus mirabilis; Pseudomonas aeruginosa; Staphylococcus aureus; antibacterial properties; biofilm; biosurfactants; cell lines; cytotoxicity; fungi; inhibitory concentration 50; lipopeptides; medicine; micelles; minimum inhibitory concentration
Abstract:
... Lipopeptide biosurfactants (LPBs) are amphiphilic compounds produced by microorganisms exhibiting various biological activities. The main aim of the present study was to assess the in vitro antimicrobial, anti-biofilm, and cytotoxic effects of LPB produced by Acinetobacter junii (AjL). We determined AjL minimum inhibitory concentration (MIC) against both Gram-positive and Gram-negative bacteria as ...
DOI:
10.1016/j.micpath.2019.103806

3. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV

Author:
Fu, Xiaozhe; Zhang, Lixi; Liu, Lihui; Lin, Qiang; Liang, Hongru; Niu, Yinjie; Huang, Zhibin; Li, Ningqiu
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
DNA; DNA viruses; annealing; cost effectiveness; detection; fish; inactivated vaccines; introns; messenger RNA; oligodeoxyribonucleotides; reverse transcriptase polymerase chain reaction; sequence analysis; temperature; transcription (genetics); transcriptomics; viruses
Abstract:
... The virus inactivation test is a critical skill in inactivated vaccine production. Active viruses produced viral mRNA in susceptible cells or the host can be used to infer whether a DNA virus is replicating by RT-PCR. But it is generally difficult to avoid genomic DNA contamination in the samples. However, the use of primers spanning an intron is an effective alternative for virus inactivation tes ...
DOI:
10.1016/j.micpath.2019.103822

4. OmpW is positively regulated by iron via Fur, and negatively regulated by SoxS contribution to oxidative stress resistance in Escherichia coli

Author:
Zhang, Pengfei; Ye, Zhicang; Ye, Chen; Zou, Haijie; Gao, Zhichao; Pan, Jianyi
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
Escherichia coli; bacteria; environmental factors; immune response; infectious diseases; iron; mutants; outer membrane proteins; oxidative stress; pathogens; stress tolerance; transcription factors; virulence
Abstract:
... Iron plays a central role at the interface of pathogen and host. The ability to sequester iron from a host not only reduces host immune defenses but also promotes pathogen virulence, leading to the occurrence of infectious disease. Recently, outer membrane protein OmpW was shown to protect bacteria against harsh environmental conditions and to play a role in infectious disease. The expression of t ...
DOI:
10.1016/j.micpath.2019.103808

5. Pharmacokinetic and pharmacodynamic profiling of four antimicrobials against Acinetobacter baumannii infection

Author:
Zhu, Wan; Chu, Yunzhuo; Zhang, Jingping; Xian, Wei; Xu, Xueying; Liu, Hongbo
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
Acinetobacter baumannii; cefoperazone; colistin; drugs; imipenem; induced resistance; monitoring; patients; pharmacodynamics; pharmacokinetics; probability; sulbactam; sulfonates; therapeutics; tigecycline; China
Abstract:
... The aim of this study was to evaluate common antimicrobial regimens used in eradicating Acinetobacter baumannii in Shenyang, China.Monte Carlo simulation was conducted to estimate the probability target attainment (PTA) and cumulative fraction of response (CFR) for imipenem, cefoperazone/sulbactam (2:1), tigecycline and colistin methanesulfonate.For the results of PTAs, imipenem following administ ...
DOI:
10.1016/j.micpath.2019.103809

6. Quercetin a major biomarker of Psidium guajava L. inhibits SepA protease activity of Shigella flexneri in treatment of infectious diarrhoea

Author:
Hirudkar, Jayshri R.; Parmar, Komal M.; Prasad, Rupali S.; Sinha, Saurabh K.; Jogi, Mohit S.; Itankar, Prakash R.; Prasad, Satyendra K.
Source:
Microbial pathogenesis 2020 v.138
ISSN:
0882-4010
Subject:
Psidium guajava; Shigella flexneri; antidiarrheal effect; antioxidant activity; antioxidants; biomarkers; blood composition; colon; computer simulation; crystal structure; diarrhea; electrolytes; enzyme activity; epithelium; gastrointestinal diseases; histopathology; interleukin-6; leaf extracts; leaves; medicinal plants; models; quercetin; rats; small intestine; sodium; sodium-potassium-exchanging ATPase; tumor necrosis factor-alpha; water content
Abstract:
... The leaves of the plant Psidium guajava L. (Myrtaceae) has been traditionally used in treatment of various gastrointestinal disorders including diarrhoea and have also been reported for its potent antidiarrhoeal activity on various chemical induced diarrhoea models. The objective of our present study was to evaluate the potency of the leaf extract of the plant Psidium guajava (PGE) along with its ...
DOI:
10.1016/j.micpath.2019.103807