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You searched for: Journal name Microbial pathogenesis Remove constraint Journal name: Microbial pathogenesis Publication year rev 7980-2020 Remove constraint Publication year rev: 7980-2020 Source 2020 v.138 Remove constraint Source: 2020 v.138
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1. Anti quorum sensing and anti virulence activity of tannic acid and it's potential to breach resistance in Salmonella enterica Typhi / Paratyphi A clinical isolates

Author:
Chandran Sivasankar; Nisha Kumari Jha; Ruchira Ghosh; Prathapkumar Halady Shetty
Source:
Microbial pathogenesis 2020 v.138 pp. 103813
ISSN:
0882-4010
Subject:
Fourier transform infrared spectroscopy; Salmonella enterica; amikacin; ampicillin; antibiotic resistance; azithromycin; bacterial motility; blood; chloramphenicol; ciprofloxacin; food pathogens; gentamicin; humans; hydrophobicity; peptides; phytochemicals; quorum sensing; screening; surfactants; tannins; therapeutics; typhoid fever; virulence
Abstract:
... Salmonella enterica Typhi and Paratyphi A are food borne pathogens causing typhoid, which is one of the most important food borne disease in the developing world. S. Typhi and S. Paratyphi A are of much concern as multi drug resistance has been on the rise. The current study is aimed to screen phytochemicals for anti quorum sensing (QS) activity against S. Typhi and S. Paratyphi A. Upon screening ...
DOI:
10.1016/j.micpath.2019.103813

2. Biochanin A protect against lipopolysaccharide-induced acute lung injury in mice by regulating TLR4/NF-κB and PPAR-γ pathway

Author:
Xiansheng Hu; Hongyu Qin; Yunpeng Li; Jingxian Li; Lianjun Fu; Musen Li; Cheng Jiang; Jinyan Yun; Zhihu Liu; Yao Feng; Yuxuan Yao; Baishuang Yin
Source:
Microbial pathogenesis 2020 v.138 pp. 103846
ISSN:
0882-4010
Subject:
Toll-like receptor 4; anti-inflammatory activity; biochanin A; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; lungs; mice; models; permeability; peroxisome proliferator-activated receptor gamma; protein content; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Acute lung injury (ALI) is a serious respiratory syndrome featured with uncontrolled inflammatory response. Biochanin A has been showed to possess and anti-inflammatory effect. This study intended to explore the suppression of biochanin A on lipopolysaccharide (LPS)-induced ALI in mice. Seven hours later LPS-induced ALI model established, the indexes including, pathological changes, MPO activity, ...
DOI:
10.1016/j.micpath.2019.103846

3. Biosynthesis of silver nanoparticles using red algae Portieria hornemannii and its antibacterial activity against fish pathogens

Author:
Roohi Fatima; Monisha Priya; Lavanya Indurthi; Vidya Radhakrishnan; Raja Sudhakaran
Source:
Microbial pathogenesis 2020 v.138 pp. 103780
ISSN:
0882-4010
Subject:
Fourier transform infrared spectroscopy; Rhodophyta; Vibrio alginolyticus; Vibrio anguillarum; Vibrio parahaemolyticus; X-ray diffraction; absorbance; antibacterial properties; antibiotics; biosynthesis; color; energy-dispersive X-ray analysis; fish; fish diseases; moieties; nanoparticles; nanosilver; pathogens; scanning electron microscopy; silver; transmission electron microscopy; zeta potential
Abstract:
... In the present study, red algae Portieria hornemannii was scrutinized for the productive synthesis of silver nanoparticles. These biosynthesized nanoparticles were characterized by visible color change and ultraviolet visible spectrophotometry that indicated the formation of nanoparticles at the absorbance of 418 nm. Fourier transforms infrared spectroscopy, X-ray Diffraction analysis was further ...
DOI:
10.1016/j.micpath.2019.103780

4. Blocking cellular N-glycosylation suppresses human cytomegalovirus entry in human fibroblasts

Author:
Luping Zheng; Huifen Li; Li Fu; Sally Liu; Qiu Yan; Sean X. Leng
Source:
Microbial pathogenesis 2020 v.138 pp. 103776
ISSN:
0882-4010
Subject:
Human betaherpesvirus 5; epidermal growth factor; fibroblasts; flow cytometry; fluorescent antibody technique; glycoproteins; glycosylation; glycosyltransferases; humans; integrins; pathogenesis; peptide-N4-(N-acetyl-beta-glucosaminyl) asparagine amidase; receptors; therapeutics; tunicamycin
Abstract:
... N-glycosylation plays an important role in the pathogenesis of viral infections. However, the role of host cell N-glycosylation in human cytomegalovirus (hCMV) infection remains to be elucidated. In this study, we found that blocking or removal of cellular N-glycosylation by tunicamycin, peptide-N-glycosidase F (PNGase F) treatment, or N-acetylglucosaminyltransferase I (MGAT1) knockdown resulted i ...
DOI:
10.1016/j.micpath.2019.103776

5. Branchial bioenergetics dysfunction as a relevant pathophysiological mechanism in freshwater silver catfish (Rhamdia quelen) experimentally infected with Flavobacterium columnare

Author:
Matheus D. Baldissera; Carine F. Souza; Juliane B. Dias; Tatiane O. Da Silva; Guilherme C. Tavares; Gustavo M.R. Valladão; Aleksandro S. da Silva; Camila Marina Verdi; Roberto C.V. Santos; Marina Vencato; Marcelo L. da Veiga; Maria Izabel U.M. da Rocha; Mauro A. Cunha; Bernardo Baldisserotto
Source:
Microbial pathogenesis 2020 v.138 pp. 103817
ISSN:
0882-4010
Subject:
Flavobacterium columnare; Rhamdia quelen; adenosine triphosphate; adenylate kinase; aquaculture industry; bacteria; columnaris disease; creatine kinase; discoloration; energy metabolism; enzyme activity; etiological agents; financial economics; freshwater; freshwater fish; gills; homeostasis; lipid peroxidation; mitochondria; mortality; necrosis; pathogenesis; pyruvate kinase; reactive oxygen species; signs and symptoms (animals and humans); sodium; sodium-potassium-exchanging ATPase
Abstract:
... Flavobacterium columnare, the causative agent of columnaris disease, is a serious bacterial disease responsible for causing devastating mortality rates in several species of freshwater fish, leading to severe economic losses in the aquaculture industry. Notwithstanding the enormous impacts this disease can have, very little is known regarding the interaction between the host and bacterium in terms ...
DOI:
10.1016/j.micpath.2019.103817

6. Changes in cardiac and hepatic energetic metabolism in gerbils infected by Listeria monocytogenes

Author:
Antonise M. Jaguezeski; Carine F. Souza; Géssica Perin; Roger R. Gebert; Kelen R.A. Baldi; Teane M.A. Gomes; Matheus D. Baldissera; Cinthia M. Andrade; Lenita M. Stefani; Aleksandro S. Da Silva
Source:
Microbial pathogenesis 2020 v.138 pp. 103786
ISSN:
0882-4010
Subject:
Listeria monocytogenes; adenosinetriphosphatase; antioxidant activity; creatine kinase; energy metabolism; enzyme activity; euthanasia; free radicals; gerbils; heart; histopathology; lipid peroxidation; listeriosis; liver; mitochondria; models; pyruvate kinase; sodium; sodium-potassium-exchanging ATPase
Abstract:
... Energy metabolism is a sensitive indicator of cellular disorders. Therefore, the objective of this study was to investigate changes in cardiac and hepatic energy metabolism during listeriosis using an experimental model. We divided gerbils into two groups: Control (n = 11) and orally Infected (n = 12) with 5 × 10⁹ CFU/mL of Listeria monocytogenes. Euthanasia and sampling were performed on days 6 a ...
DOI:
10.1016/j.micpath.2019.103786

7. Cloning, expression and nanodiscs assemble of recombinant HIV-1 gp41

Author:
Mostafa A. Elbahnasawy; Mohamed M.S. Farag; Mohamed T. Mansour; Abbas A. El-Ghamery
Source:
Microbial pathogenesis 2020 v.138 pp. 103824
ISSN:
0882-4010
Subject:
Escherichia coli; Human immunodeficiency virus 1; amino acids; cell membranes; epitopes; genetic vectors; hydrophobicity; lipids; membrane proteins; molecular weight; plasmids; protein synthesis; vaccine development
Abstract:
... Structural studies of membrane proteins have been hurdled by their difficulty for expression in heterogeneous expression systems due to their intrinsically strong hydrophobicity and requirements for association with other cellular membranes. This study aims to design a construct for expression of membrane proteins. Because of its outstanding interest in HIV-1 vaccine design, transmembrane gp41 ami ...
DOI:
10.1016/j.micpath.2019.103824

8. Duckling short beak and dwarfism syndrome virus infection activates host innate immune response involving both DNA and RNA sensors

Author:
Shilong Chen; Tiehui Fang; Shifeng Xiao; Fengqiang Lin; Xiaoxia Cheng; Shao Wang; Xiaoli Zhu; Xiuqin Chen; Min Zheng; Muhammad Munir; Meiqing Huang; Fusong Yu; Shaoying Chen
Source:
Microbial pathogenesis 2020 v.138 pp. 103816
ISSN:
0882-4010
Subject:
Anseriform dependoparvovirus 1; Toll-like receptor 1; Toll-like receptor 2; Toll-like receptor 3; Toll-like receptor 4; Toll-like receptor 5; Toll-like receptor 7; beak; bird diseases; double-stranded RNA; ducklings; dwarfing; fibroblasts; gene expression; gene expression regulation; genes; genomics; immune response; industry; innate immunity; interferon-beta; messenger RNA; pathogen-associated molecular patterns; pathogenesis; single-stranded DNA; viruses; waterfowl
Abstract:
... Duckling short beak and dwarfism syndrome virus (SBDSV), a newly identified goose parvovirus, causes devastating disease in domestic waterfowl and considerable economic losses to Chinese waterfowl industry. The molecular pathogenesis of SBDSV infection, nature and dynamics of host immune responses against SBDSV infection remained elusive. In this study, we systematically explored the relative mRNA ...
DOI:
10.1016/j.micpath.2019.103816

9. Effects of probiotics on cecal microbiome profile altered by duck Escherichia coli 17 infection in Cherry Valley ducks

Author:
Shuiqin Shi; Zhao Qi; Wen Jiang; Suopei Quan; Tingting Sheng; Jian Tu; Yin Shao; Kezong Qi
Source:
Microbial pathogenesis 2020 v.138 pp. 103849
ISSN:
0882-4010
Subject:
Escherichia coli; Lactobacillus casei; Lactobacillus rhamnosus; bird diseases; ducks; dysbiosis; genes; intestinal microorganisms; intestines; lactic acid bacteria; microbiome; pathogens; poultry industry; probiotics; ribosomal RNA; sequence analysis
Abstract:
... Avian colibacillosis is one of the most serious infectious bacterial diseases that endanger the modern poultry industry. Lactobacillus is believed to inhibit intestinal pathogens and maintain a healthy gut microbiota. This study aimed to investigate Lactobacillus supplementation in Cherry Valley ducks to prevent the intestinal flora dysbiosis caused by Duck Escherichia coli 17. One hundred and twe ...
DOI:
10.1016/j.micpath.2019.103849

10. Establishment of a brain cell line obtained from hybrids of Channa argus ×Channa maculata for the detection of tilapia lake virus

Author:
Yingying Wang; Zhili Li; Qing Wang; Weiwei Zeng; Yingying Li; Jiyuan Yin; Sven M. Bergmann; Xinping Zhu
Source:
Microbial pathogenesis 2020 v.138 pp. 103810
ISSN:
0882-4010
Subject:
Channa argus; Tilapia lake virus; brain; cell lines; chromosome number; collagenase; cytogenetic analysis; electron microscopy; epithelium; females; fetal bovine serum; fluorescent antibody technique; hybrids; males; pathogenesis; trypsin; virus replication
Abstract:
... A brain cell line (CAMB) derived from hybrid snakehead (Channa argus (♂) × Channa maculata (♀)) was established by trypsin and collagenase combined digestion. The culturing conditions and cell biological characteristics were systematically studied. For growth of the cells, M199 medium containing 10% fetal bovine serum was used and at 27 °C incubated. Based on morphological analysis, CAMB cells wer ...
DOI:
10.1016/j.micpath.2019.103810

11. Evaluation of hematogenous spread and ascending infection in the pathogenesis of acute pyelonephritis due to group B streptococcus in mice

Author:
Matthew J. Sullivan; Glen C. Ulett
Source:
Microbial pathogenesis 2020 v.138 pp. 103796
ISSN:
0882-4010
Subject:
Streptococcus agalactiae; T-lymphocytes; adults; bacteremia; bacteria; bladder; cystitis; eosin; females; heart; histopathology; inoculum; kidneys; liver; macrophages; mast cells; mice; models; neutrophils; pathogenesis; pyelonephritis; serotypes; spleen
Abstract:
... Group B streptococcus (GBS) causes pyelonephritis in adults but the mechanisms of infection by which GBS infects the kidneys in vivo are unknown. We investigated GBS infection of the kidneys in mice following experimental challenge via the hematogenous route (transient bacteremia model) or transurethral route (bladder infection and cystitis model). Adult female mice were examined for bacterial dis ...
DOI:
10.1016/j.micpath.2019.103796

12. Identification of intron in ORF003 gene and its application for inactivation test of ISKNV

Author:
Xiaozhe Fu; Lixi Zhang; Lihui Liu; Qiang Lin; Hongru Liang; Yinjie Niu; Zhibin Huang; Ningqiu Li
Source:
Microbial pathogenesis 2020 v.138 pp. 103822
ISSN:
0882-4010
Subject:
DNA; DNA viruses; annealing; cost effectiveness; detection; fish; inactivated vaccines; introns; messenger RNA; oligodeoxyribonucleotides; reverse transcriptase polymerase chain reaction; sequence analysis; temperature; transcription (genetics); transcriptomics; viruses
Abstract:
... The virus inactivation test is a critical skill in inactivated vaccine production. Active viruses produced viral mRNA in susceptible cells or the host can be used to infer whether a DNA virus is replicating by RT-PCR. But it is generally difficult to avoid genomic DNA contamination in the samples. However, the use of primers spanning an intron is an effective alternative for virus inactivation tes ...
DOI:
10.1016/j.micpath.2019.103822

13. Immunization with proline rich region of pneumococcal surface protein A has no role in protection against Streptococcus pneumoniae serotype 19F

Author:
Michael M. Girgis; Abeer M. Abd El-Aziz; Ramadan Hassan; Youssif M. Ali
Source:
Microbial pathogenesis 2020 v.138 pp. 103761
ISSN:
0882-4010
Subject:
Streptococcus pneumoniae; animal models; immunization; lethal dose; mice; polyclonal antibodies; proline; rabbits; serotypes; surface proteins; vaccines; virulence
Abstract:
... Pneumococcal surface protein A (PspA) is one of the major virulence factors expressed by almost all pneumococcal serotypes and was suggested to be a promising universal vaccine candidate for all pneumococcal sero-groups. Here, we expressed and purified the proline-rich region (PR) of PspA and tested it as a recombinant vaccine against infection caused by a clinical isolate (SP₁₉) of Streptococcus ...
DOI:
10.1016/j.micpath.2019.103761

14. Immunohistochemical and molecular detection of natural cases of bovine rotavirus and coronavirus infection causing enteritis in dairy calves

Author:
Shailendra Singh; Rajendra Singh; K.P. Singh; V. Singh; Y.P.S. Malik; Bhupesh Kamdi; Rahul Singh; Gayatri Kashyap
Source:
Microbial pathogenesis 2020 v.138 pp. 103814
ISSN:
0882-4010
Subject:
Bovine coronavirus; Peyer's patches; Rotavirus; beef cattle; cattle diseases; colon; dairy calves; diarrhea; enteritis; histopathology; ileum; immunohistochemistry; jejunum; lymph nodes; lymphocytes; macrophages; pathogens; reverse transcriptase polymerase chain reaction; risk factors; villi; viral antigens; India
Abstract:
... Bovine rotavirus (BRoV) and bovine coronavirus (BCoV) are major enteric viral pathogens responsible for calve diarrhoea. They are widespread both in dairy and beef cattle throughout the world and causing huge economic losses. The diagnosis of these agents is very difficult due to non-specific nature of lesions and the involvement of some intrinsic and extrinsic risk factors. We performed postmorte ...
DOI:
10.1016/j.micpath.2019.103814
PubMed:
31639467
PubMed Central:
PMC7127329

15. Impacts of Escherichia coli infection in young breeder chicks on the animal behavior and cerebral activity of purinergic and cholinergic enzymes involved in the regulation of molecules with neurotransmitter and neuromodulator function

Author:
Gilneia da Rosa; Davi F. Alba; Anielen D. Silva; Vanessa V. Miron; Vera Maria Morsch; Marcel M. Boiago; Lenita M. Stefani; Matheus M. Baldissera; Marcos T. Lopes; Ricardo E. Mendes; Aleksandro S. da Silva
Source:
Microbial pathogenesis 2020 v.138 pp. 103787
ISSN:
0882-4010
Subject:
adenosine; adenosine deaminase; immunomodulation; adenosine monophosphate; chicks; juveniles; acetylcholinesterase; acetylcholine; cerebral cortex; neurotransmitters; pathogenesis; Escherichia coli; adenosine triphosphate; hydrolysis; enzyme activity; culture media; histopathology; pericarditis; adenosine diphosphate; deamination; poultry diseases; bacteria
Abstract:
... The objective of this study was to evaluate if infection by Escherichia coli in juvenile breeder chicks alters the activity of enzymes involved in neurotransmission and cerebral immunomodulation, including acetylcholinesterase (AChE), nucleoside triphosphate diphosphohydrolase (NTPDase), 5′-nucleotidase (5′NT) and adenosine deaminase (ADA), as well as their effects on the pathogenesis of the disea ...
DOI:
10.1016/j.micpath.2019.103787

16. Mapping a highly conserved linear neutralizing epitope at the N-terminus of the gD glycoprotein of bovine herpesvirus type I using a monoclonal antibody

Author:
Hongbo Ni; Xiao-Xue Jia; Jun Wang; Xuhua Ran; Xiaobo Wen
Source:
Microbial pathogenesis 2020 v.138 pp. 103815
ISSN:
0882-4010
Subject:
Bovine alphaherpesvirus 1; amino acid sequences; animal models; cattle; cattle diseases; cattle industry; diagnostic techniques; epitopes; financial economics; glutathione transferase; glycoproteins; herpes simplex; immune response; kidney cells; mice; monoclonal antibodies; neutralization; pathogenesis; prototypes; recombinant proteins; vaccination; vaccine development; vaccines; viruses
Abstract:
... Bovine herpesvirus type 1 (BoHV-1), a member of the Alphaherpesvirinae subfamily, causes significant economic losses to the cattle industry worldwide. Envelope glycoprotein D (gD) of BoHV-1 plays an essential role in the viral entry into permissive cells and possibly cooperates with other envelope glycoproteins. The herpesvirus gD induces a protective immune response against diseases in cattle or ...
DOI:
10.1016/j.micpath.2019.103815

17. Molecular mimicry between Larrea divaricata Cav. plant and a reference strain of Pseudomonas aeruginosa

Author:
Florencia Fátima Ferramola; Silvia del Valle Dávila; Corina Verónica Sasso; María Aída Mattar Domínguez
Source:
Microbial pathogenesis 2020 v.138 pp. 103818
ISSN:
0882-4010
Subject:
Gram-negative bacteria; Larrea divaricata; Pseudomonas aeruginosa; World Health Organization; antibiotic resistance; antibiotics; antibodies; cross infection; cross reaction; epitopes; molecular mimicry; neutralization; pathogenicity; proteins; secondary infection; shrubs; therapeutics; traditional medicine; vaccines
Abstract:
... Currently, the world health sector faces a big problem due to the increase of bacterial strains resistant to antibiotics. In 2017, the World Health Organization reported a list of resistant bacteria, among which Pseudomonas aeruginosa was present. This opportunistic pathogen is associated to nosocomial infections, and no effective vaccines against this bacterium have been found. Larrea divaricata ...
DOI:
10.1016/j.micpath.2019.103818

18. Pharmacokinetic and pharmacodynamic profiling of four antimicrobials against Acinetobacter baumannii infection

Author:
Wan Zhu; Yunzhuo Chu; Jingping Zhang; Wei Xian; Xueying Xu; Hongbo Liu
Source:
Microbial pathogenesis 2020 v.138 pp. 103809
ISSN:
0882-4010
Subject:
Acinetobacter baumannii; cefoperazone; colistin; drugs; imipenem; induced resistance; monitoring; patients; pharmacodynamics; pharmacokinetics; probability; sulbactam; sulfonates; therapeutics; tigecycline; China
Abstract:
... The aim of this study was to evaluate common antimicrobial regimens used in eradicating Acinetobacter baumannii in Shenyang, China.Monte Carlo simulation was conducted to estimate the probability target attainment (PTA) and cumulative fraction of response (CFR) for imipenem, cefoperazone/sulbactam (2:1), tigecycline and colistin methanesulfonate.For the results of PTAs, imipenem following administ ...
DOI:
10.1016/j.micpath.2019.103809

19. Quercetin a major biomarker of Psidium guajava L. inhibits SepA protease activity of Shigella flexneri in treatment of infectious diarrhoea

Author:
Jayshri R. Hirudkar; Komal M. Parmar; Rupali S. Prasad; Saurabh K. Sinha; Mohit S. Jogi; Prakash R. Itankar; Satyendra K. Prasad
Source:
Microbial pathogenesis 2020 v.138 pp. 103807
ISSN:
0882-4010
Subject:
Psidium guajava; Shigella flexneri; antidiarrheal effect; antioxidant activity; antioxidants; biomarkers; blood composition; colon; computer simulation; crystal structure; diarrhea; electrolytes; enzyme activity; epithelium; gastrointestinal diseases; histopathology; interleukin-6; leaf extracts; leaves; medicinal plants; models; quercetin; rats; small intestine; sodium; sodium-potassium-exchanging ATPase; tumor necrosis factor-alpha; water content
Abstract:
... The leaves of the plant Psidium guajava L. (Myrtaceae) has been traditionally used in treatment of various gastrointestinal disorders including diarrhoea and have also been reported for its potent antidiarrhoeal activity on various chemical induced diarrhoea models. The objective of our present study was to evaluate the potency of the leaf extract of the plant Psidium guajava (PGE) along with its ...
DOI:
10.1016/j.micpath.2019.103807

20. Serological and molecular characterization of Leptospira kirschneri serogroup Grippotyphosa isolated from bovine in Brazil

Author:
Pollyanna M. Soares; Dayane O. Gomes; Fernando P. Macedo; Mayara M. Soares; Karla R. Lemes; Lauren H. Jaeger; Walter Lilenbaum; Anna M.C. Lima
Source:
Microbial pathogenesis 2020 v.138 pp. 103803
ISSN:
0882-4010
Subject:
Leptospira kirschneri; agglutination tests; bacteria; cattle; disease control; epidemiology; genotyping; herds; kidneys; leptospirosis; livestock breeding; males; serotypes; tandem repeat sequences; urine; zoonoses; Brazil
Abstract:
... Leptospirosis is a zoonotic disease caused by a bacterium of the genus Leptospira that affects domestic animals, including cattle. Despite of this importance in livestock, little is known about the epidemiology of leptospirosis in cattle in Brazil and other tropical countries. In this context, the objective of this study was to perform the culture of urine and kidney (n = 372 animals) of slaughter ...
DOI:
10.1016/j.micpath.2019.103803