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- Chen, Changming; Yan, Qiulong; Tao, Mengxing; Shi, Huaying; Han, Xiuyan; Jia, Liqiu; Huang, Yukun; Zhao, Lizhe; Wang, Chao; Ma, Xiaochi; Ma, Yufang
- Microbial pathogenesis 2019 v.131 pp. 218-226
- antibiotic resistance; bacteria; biofilm; biosynthesis; colorimetry; computer simulation; cysteine; drugs; enzyme activity; inhibitory concentration 50; methicillin; methicillin-resistant Staphylococcus aureus; models; pathogens; screening; serine O-acetyltransferase; site-directed mutagenesis; viability
- ... Methicillin-resistant Staphylococcus aureus (MRSA) is a major hospital-acquired infective pathogen that has developed resistance to many antibiotics. It is imperious to develop novel anti-MRSA drugs to control the emergence of drug resistance. The biosynthesis of cysteine in bacteria is catalyzed by CysE and CysK. CysE was predicted to be important for bacterial viability, it could be a potential ...
- Frutis-Murillo, Minerva; Sandoval-Carrillo, Marcelo Alejandro; Alva-Murillo, Nayeli; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E.
- Microbial pathogenesis 2019 v.131 pp. 15-21
- Staphylococcus aureus; adhesins; bacteria; bovine mastitis; cattle; cholecalciferol; epithelial cells; gene expression; gene expression regulation; genes; mammary glands; messenger RNA; octanoic acid; pathogens; phagocytes; sodium; sodium butyrate
- ... Staphylococcus aureus is a major pathogen of subclinical bovine mastitis that usually is chronic and recurrent, which has been related to its ability to internalize into bovine mammary epithelial cells (bMECs). Previously, we reported that short and medium fatty acids and cholecalciferol reduce S. aureus internalization into pretreated-bMECs with these molecules suggesting a role as immunomodulato ...