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1. An endophytic strain of genus Paenibacillus isolated from the fruits of Noni (Morinda citrifolia L.) has antagonistic activity against a Noni's pathogenic strain of genus Aspergillus

Author:
Liu, Yang; Bai, Feirong; Li, Ting; Yan, Hai
Source:
Microbial pathogenesis 2018 v.125 pp. 158-163
ISSN:
0882-4010
Subject:
Aspergillus aculeatus; Morinda citrifolia; Paenibacillus polymyxa; biological control; endophytes; enzymes; fruits; fungi; genes; hosts; matrix-assisted laser desorption-ionization mass spectrometry; pathogens; phylogeny; ribosomal DNA; taxonomy; tubulin; virulent strains
Abstract:
... Endophytes are microbes capable of colonizing the tissues of healthy plants and subsequently establishing a harmonious relationship with their hosts. In this research, the endophytic strain Paenibacillus sp. NEB was isolated from fruits of healthy Noni (Morinda citrifolia L.). Strain NEB was identified as Paenibacillus polymyxa using MALDI-TOF Mass Spectrometry. Pathogenic fungal strain NP-1 was i ...
DOI:
10.1016/j.micpath.2018.09.018

2. A novel antigen of Mycobacterium tuberculosis and MPLA adjuvant co-entrapped into PLGA:DDA hybrid nanoparticles stimulates mucosal and systemic immunity

Author:
Khademi, Farzad; Derakhshan, Mohammad; Yousefi-Avarvand, Arshid; Najafi, Adel; Tafaghodi, Mohsen
Source:
Microbial pathogenesis 2018 v.125 pp. 507-513
ISSN:
0882-4010
Subject:
Mycobacterium tuberculosis; adjuvants; antibodies; antigens; blood serum; emulsions; enzyme-linked immunosorbent assay; evaporation; immune response; immunoglobulin A; immunoglobulin G; interferon-gamma; interleukin-17; interleukin-4; intranasal administration; mice; mucosal immunity; nanoparticles; nose; solvents; splenocytes; transforming growth factor beta; tuberculosis; vaccination; vaccines
Abstract:
... Due to initiation of Mycobacterium tuberculosis infection via the mucosal tissue of the respiratory tract, intranasal administration of new tuberculosis vaccines is highly regarded to enhance mucosal immunity. Our outline was evaluation of mucosal and systemic immune responses in BALB/c mice after nasal delivery of HspX/EsxS fused antigen of Mycobacterium tuberculosis along with MPLA adjuvant entr ...
DOI:
10.1016/j.micpath.2018.10.023

3. Antibacterial and anticancer potential of marine endophytic actinomycetes Streptomyces coeruleorubidus GRG 4 (KY457708) compound against colistin resistant uropathogens and A549 lung cancer cells

Author:
Rajivgandhi, Govindan; Muneeswaran, Thillaichidambaram; Maruthupandy, Muthuchamy; Ramakritinan, Chockalingam Muthiah; Saravanan, Kandasamy; Ravikumar, Vilwanathan; Manoharan, Natesan
Source:
Microbial pathogenesis 2018 v.125 pp. 325-335
ISSN:
0882-4010
Subject:
Fourier transform infrared spectroscopy; Klebsiella pneumoniae; Pseudomonas aeruginosa; Streptomyces coeruleorubidus; Vibrio fischeri; anticarcinogenic activity; apoptosis; bacteria; bioactive compounds; cell proliferation; cell walls; coasts; colistin; confocal laser scanning microscopy; cytotoxicity; endophytes; gas chromatography-mass spectrometry; high performance liquid chromatography; humans; inhibitory concentration 50; lung neoplasms; metabolites; minimum inhibitory concentration; moieties; neoplasm cells; phenotype; phthalates; scanning electron microscopes; scanning electron microscopy; India
Abstract:
... The aim of the current study is to identify bioactive compound from marine endophytic actinomycetes (MEA) isolated from Gulf of Mannar region, Southeast coast of India. Among the isolated actinomycetes, strain GRG 4 exhibited excellent ability to inhibit isolated colistin resistant (CR) Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumoniae (K. pneumoniae), which is a emerging threat to ...
DOI:
10.1016/j.micpath.2018.09.025

4. Antifungal, antibacterial, antibiofilm and colorimetric sensing of toxic metals activities of eco friendly, economical synthesized Ag/AgCl nanoparticles using Malva Sylvestris leaf extracts

Author:
Feizi, Sholeh; Taghipour, Elham; Ghadam, Parinaz; Mohammadi, Parisa
Source:
Microbial pathogenesis 2018 v.125 pp. 33-42
ISSN:
0882-4010
Subject:
Candida glabrata; Candida parapsilosis; Malva sylvestris; Pseudomonas aeruginosa; antifungal properties; bacteria; biofilm; carbohydrates; colorimetry; drug resistance; industry; lead; leaf extracts; leaves; medicine; mercury; nanoparticles; nanosilver; phenolic compounds; silver; silver chloride; toxicity; water pollution
Abstract:
... Silver nanoparticles, one of the most popular nanomaterials, are used extensively in medicine and industries. The present study biosynthesized spherical Ag/AgCl nanoparticles with a size range of 10–50 nm in less than 5 min. The synthesis was performed in a single step, in a low-cost and eco-friendly manner, from the aqueous extract of Malva Sylvestris leaves. The aqueous extract had a large numbe ...
DOI:
10.1016/j.micpath.2018.08.054

5. Antioxidant and immunostimulatory effect of potential probiotic Lactobacillus paraplantarum SC61 isolated from Korean traditional fermented food, jangajji

Author:
Son, Sung-Ho; Yang, Seo-Jin; Jeon, Hye-Lin; Yu, Hyung-Seok; Lee, Na-Kyoung; Park, Young-Seo; Paik, Hyun-Dong
Source:
Microbial pathogenesis 2018 v.125 pp. 486-492
ISSN:
0882-4010
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lactobacillus paraplantarum; Lactobacillus rhamnosus; Leuconostoc citreum; Pediococcus pentosaceus; antibiotic resistance; antioxidant activity; beta-carotene; beta-glucuronidase; bile; bleaching; fermented foods; gene expression; immunostimulants; inducible nitric oxide synthase; interleukin-1beta; interleukin-6; intestines; messenger RNA; nitric oxide; probiotics; stomach; superoxide anion; tumor necrosis factor-alpha
Abstract:
... This study aimed to isolate and demonstrate their antioxidant and immunostimulatory activities of potential probiotics. The isolated strains, S. Pum19, SC28, and SC61 showed potential probiotic properties including stability in artificial gastric and bile conditions, non-production of β-glucuronidase, suitable antibiotic susceptibility, and attachment to intestinal cells. S. Pum19, SC28, and SC61 ...
DOI:
10.1016/j.micpath.2018.10.018

6. Antiquorum sensing and biofilm potential of 5- Hydroxymethylfurfural against Gram positive pathogens

Author:
Vijayakumar, Karuppiah; Ramanathan, Thiruganasambandam
Source:
Microbial pathogenesis 2018 v.125 pp. 48-50
ISSN:
0882-4010
Subject:
Chromobacterium violaceum; Staphylococcus aureus; Staphylococcus epidermidis; Staphylococcus mutans; Streptococcus mutans; Streptococcus pyogenes; biofilm; confocal microscopy; hydroxymethylfurfural; pathogens; quorum sensing; violacein
Abstract:
... The present investigates the antiquorum sensing and biofilm inhibitory potential of 5 – hydroxymethylfurfural against Chromobacterium violaceum, Streptococcus pyogenes, Streptococcus mutans, Staphylococcus aureus and Staphylococcus epidermidis. 5HMF inhibits the quorum sensing mediated violacein pigment production by 87% at 100 μg/ml concentration. A 100 μg/ml concentration of the compound inhibit ...
DOI:
10.1016/j.micpath.2018.09.008

7. Bacterial respiratory tract inflammation in neonatal rat model is attenuated by benzofuran through inhibition of GATA3

Author:
Aierken, Aibibai; Xu, Peiru
Source:
Microbial pathogenesis 2018 v.125 pp. 313-317
ISSN:
0882-4010
Subject:
GATA transcription factors; animal models; asthma; blood serum; enzyme-linked immunosorbent assay; immunoglobulin E; inflammation; interferon-gamma; interleukin-4; lungs; macrophages; mechanics; mice; neonates; rats; therapeutics
Abstract:
... The current study was aimed to investigate the effect of benzofuran on asthma neonatal rat model. Twenty-five neonatal rats were assigned into five groups; Normal control, untreated, 1 mg/kg, 8 mg/kg and 10 mg/kg treatment groups. Methacholine was administered orally to the rats of untreated and treatment groups. Animals in the normal control group were given PBS as a vehicle. FlexiVent system emp ...
DOI:
10.1016/j.micpath.2018.09.043

8. Candida auris: Epidemiology, risk factors, virulence, resistance, and therapeutic options

Author:
de Cássia Orlandi Sardi, Janaina; Silva, Diego Romário; Soares Mendes-Giannini, Maria José; Rosalen, Pedro Luiz
Source:
Microbial pathogenesis 2018 v.125 pp. 116-121
ISSN:
0882-4010
Subject:
Candida; antifungal agents; cross infection; death; ears; mortality; pathogens; patients; risk factors; therapeutics; virulence; Japan
Abstract:
... Candida auris emerged as a pathogen resistant to multiple antifungal and has been associated with nosocomial outbreaks with high transmission capacity between hospitalized individuals. C. auris was first described in 2009, after being isolated from the external ear canal discharge of a patient in Japan. The difficulty in identification, incorrect use of antifungal drugs, and treatment failure are ...
DOI:
10.1016/j.micpath.2018.09.014

9. Citrobacter freundii infection in silver catfish (Rhamdia quelen): Hematological and histological alterations

Author:
Bandeira Junior, Guerino; dos Santos, Alessandro Casale; Souza, Carine de Freitas; Baldissera, Matheus Dellaméa; Moreira, Karen Luise dos Santos; da Veiga, Marcelo Leite; da Rocha, Maria Izabel de Ugalde Marques; de Vargas, Agueda Palmira Castagna; da Cunha, Mauro Alves; Baldisserotto, Bernardo
Source:
Microbial pathogenesis 2018 v.125 pp. 276-280
ISSN:
0882-4010
Subject:
Citrobacter freundii; Rhamdia quelen; anemia; bacteria; bacterial infections; blood; fish; fish diseases; hematologic tests; hematology; histology; histopathology; kidneys; liver; mortality; neutropenia; pathogens; pathophysiology; protein depletion; spleen
Abstract:
... Citrobacter freundii is a fish pathogen known for its ability to cause injury and high mortality. There have been no studies reporting the effect of this bacterium on hematological parameters and internal organ histology in silver catfish (Rhamdia quelen). Therefore, the aim of this study is to evaluate the hematological and histopathological effects of an experimentally induced C. freundii infect ...
DOI:
10.1016/j.micpath.2018.09.038

10. Conserved epitopes in variants of amastin protein of Trypanosoma cruzi for vaccine design: A bioinformatics approach

Author:
Slathia, Parvez Singh; Sharma, Preeti
Source:
Microbial pathogenesis 2018 v.125 pp. 423-430
ISSN:
0882-4010
Subject:
Chagas disease; Trypanosoma cruzi; benznidazole; bioinformatics; databases; endemic diseases; epitopes; human population; parasites; surface proteins; vaccines; Australia; Europe; North America
Abstract:
... Chagas disease caused by protozoan parasite Trypanosoma cruzi is endemic disease in South and Central American countries but due to migrating human populations it has shown emergence in Europe, North America and Australia. With only two drugs, benznidazole and nifurtimox for its treatment there is need for newer therapies. In the current study, we have tried to analyse the potential of amastin, a ...
DOI:
10.1016/j.micpath.2018.10.006

11. Critical role of MAVS in the protection against Clostridium difficile-induced colitis

Author:
Zhang, Pingping; Mao, Ruitao; Lv, Zhi; Wang, Baoya; Su, Jianrong
Source:
Microbial pathogenesis 2018 v.125 pp. 306-312
ISSN:
0882-4010
Subject:
Clostridium difficile; antibiotics; bacteria; cecum; colitis; colon; enteropathogens; gene expression; histopathology; inflammation; innate immunity; interferon-beta; interleukin-1beta; interleukin-6; intestinal microorganisms; intestinal mucosa; mice; mortality; oral administration; tumor necrosis factor-alpha
Abstract:
... Clostridium difficile (C. difficile) is an opportunistic bacteria that flourishes in intestinal flora is altered by antibiotic use and can cause large intestinal colitis if left untreated. The mechanism of MAVS-mediated innate immune signaling in response to C. difficile infection remains unclear. This knowledge gap was addressed in the present research by administration of an antibiotic cocktail ...
DOI:
10.1016/j.micpath.2018.09.035

12. Detection of antibodies against Aggregatibacter actinomycetemcomitans in serum and saliva through ELISA in periodontally healthy individuals and individuals with chronic periodontitis

Author:
Gadekar, Nikita B.; Hosmani, Jagadish V.; Bhat, Kishore G.; Kotrashetti, Vijayalakshmi S.; Nayak, Ramakant S.; Babji, Deepa V.; Pattanshetty, Smita M.; Joshi, Vinayak M.; Bansode, Rani A.
Source:
Microbial pathogenesis 2018 v.125 pp. 438-442
ISSN:
0882-4010
Subject:
Actinobacillus actinomycetemcomitans; antibodies; aseptic conditions; blood serum; enzyme-linked immunosorbent assay; immunoglobulin A; immunoglobulin G; inflammation; monitoring; mouth; pathogens; patients; periodontitis; prognosis; saliva; screening; tissues
Abstract:
... Periodontitis is a persistent polymicrobial infection, which leads to chronic inflammation in the tooth supporting tissues. Aggregatibacter actinomycetemcomitans are normal commensals of oral cavity but are low in number in periodontally healthy subjects. They are one of the major pathogens aetiologically linked to periodontal disease. Plasma and salivary antibody measurement may be useful to supp ...
DOI:
10.1016/j.micpath.2018.10.007

13. Dynamics of expression of antibacterial and antioxidant defence genes in Indian major carp, Labeo rohita in response to Aeromonas hydrophila infection

Author:
Sharma, Arun; Paul, Anirban; Parida, Sonali; Pattanayak, Sabyasachi; Mohapatra, Amruta; Rajesh Kumar, Pasim; Sahoo, Manoj Kumar; Sundaray, Jitendra Kumar; Sahoo, Pramoda Kumar
Source:
Microbial pathogenesis 2018 v.125 pp. 108-115
ISSN:
0882-4010
Subject:
Aeromonas hydrophila; Labeo rohita; antioxidant activity; antioxidant genes; antioxidants; apolipoprotein A-I; bacteria; carp; catalase; gene expression regulation; glutathione peroxidase; hepcidin; inducible nitric oxide synthase; lysozyme; muscle tissues; muscles; oxygen; pathogens; superoxide dismutase
Abstract:
... Cells produce large number of antioxidant molecules to prevent reactive oxygen species-induced self-damage during microbial assault while generating simultaneously number of antimicrobial molecules to target the pathogen. The present study was aimed at looking into molecules involved in antibacterial and self-protection mechanism of a host Labeo rohita when challenged with a pathogenic bacterium A ...
DOI:
10.1016/j.micpath.2018.09.007

14. Effects of Christensenella minuta lipopolysaccharide on RAW 264.7 macrophages activation

Author:
Yang, Yingyin; Gu, Huawei; Sun, Qiuli; Wang, Jufang
Source:
Microbial pathogenesis 2018 v.125 pp. 411-417
ISSN:
0882-4010
Subject:
Escherichia coli; Gram-negative bacteria; agonists; biosynthesis; cell proliferation; cytokines; gastrointestinal system; genes; inflammation; lipopolysaccharides; macrophages; nitric oxide; nucleotide sequences; obesity; pathogens; phagocytosis; polyacrylamide gel electrophoresis; reactive oxygen species; signal transduction; toxicity; transcription factor NF-kappa B; virulence; weight loss
Abstract:
... Christensenella minuta (C. minuta) is a gram-negative gastrointestinal bacterium associated with weight loss. However, recent studies have shown that C. minuta might be a potential pathogen and thus limited its application in the control of obesity. Research into the genetic characteristics and pathogenicity of C. minuta remain elusive. As a major virulence factor of gram-negative bacteria, lipopo ...
DOI:
10.1016/j.micpath.2018.10.005

15. Effects of phytogenic feed additive based on thymol, carvacrol and cinnamic aldehyde on body weight, blood parameters and environmental bacteria in broilers chickens

Author:
Reis, João H.; Gebert, Roger R.; Barreta, Mauricio; Baldissera, Matheus D.; dos Santos, Ingrid D.; Wagner, Roger; Campigotto, Gabriela; Jaguezeski, Antonise M.; Gris, Anderson; de Lima, Jéssica L.F.; Mendes, Ricardo E.; Fracasso, Mateus; Boiago, Marcel M.; Stefani, Lenita M.; dos Santos, Daiane S.; Robazza, Weber S.; Da Silva, Aleksandro S.
Source:
Microbial pathogenesis 2018 v.125 pp. 168-176
ISSN:
0882-4010
Subject:
alanine transaminase; aldehydes; aspartate transaminase; bacitracin; bacteria; blood serum; body weight; breast meat; broiler chickens; carvacrol; cooking; diet; essential oils; fatty acid composition; feed additives; globulins; growth promotion; hemoglobin; immune response; intestines; leukocyte count; meat quality; plate count; protein content; thymol; villi; weight loss; zinc
Abstract:
... The aim of this study was to evaluate whether a phytogenic feed additive (PFA) based on essential oils such as carvacrol, thymol and cinnamic aldehyde, could be considered a replacement for antimicrobials used as growth promoters in broiler chickens, as well as to investigate its effect on total bacterial count, biochemical profiles, meat quality and meat fatty acid profile. A total of 240 broiler ...
DOI:
10.1016/j.micpath.2018.09.015

16. Emerging Candida species isolated from renal transplant recipients: Species distribution and susceptibility profiles

Author:
Diba, Kambiz; Makhdoomi, Khadijeh; Nasri, Elahe; Vaezi, Afsane; Javidnia, Javad; Gharabagh, Davood Jabbari; Jazani, Nima Hosseni; Reza Chavshin, Ali; Badiee, Parisa; Badali, Hamid; Fakhim, Hamed
Source:
Microbial pathogenesis 2018 v.125 pp. 240-245
ISSN:
0882-4010
Subject:
Candida albicans; Candida glabrata; Candida kefyr; Candida parapsilosis; Candida saitoana; Candida tropicalis; Clavispora lusitaniae; amphotericin B; biogeography; candidiasis; caspofungin; early diagnosis; fluconazole; itraconazole; kidney transplant; minimum inhibitory concentration; morbidity; mortality; patients; peritonitis; pneumonia; polymerase chain reaction; relapse; restriction fragment length polymorphism; urinary tract
Abstract:
... Candidiasis is a major challenge among renal transplant recipients (RTRs) worldwide and is associated with high morbidity and mortality rates. Fluconazole is the most commonly used agent for Candida infections. However, frequent relapse and treatment failure are still reported among patients affected with this infection. In the present study, Candida species obtained from RTRs were characterized b ...
DOI:
10.1016/j.micpath.2018.09.026

17. Endophytic entomopathogenic fungi enhance the growth of Phaseolus vulgaris L. (Fabaceae) and negatively affect the development and reproduction of Tetranychus urticae Koch (Acari: Tetranychidae)

Author:
Dash, Chandra Kanta; Bamisile, Bamisope Steve; Keppanan, Ravindran; Qasim, Muhammad; Lin, Yongwen; Islam, Saif Ul; Hussain, Mubasher; Wang, Liande
Source:
Microbial pathogenesis 2018 v.125 pp. 385-392
ISSN:
0882-4010
Subject:
Beauveria; Isaria; Lecanicillium; Phaseolus vulgaris; Tetranychus urticae; adults; beans; endophytes; entomopathogenic fungi; fecundity; females; growth promotion; host plants; integrated pest management; larval development; leaves; longevity; pests; phytophagous mites; plant growth; population growth; probability; roots; shoots; survival rate
Abstract:
... Entomopathogenic fungi (EPF) have primarily been applied as an inundative approach to manage pests. However, in recent decade multifunctional role of EPF have been documented which provide multiple benefits to host plants when colonized as an endophyte. In this study five fungal isolates from the genus Beauveria (three), Isaria (one) and Lecanicillium (one) were evaluated for their ability to colo ...
DOI:
10.1016/j.micpath.2018.09.044

18. Enhanced antimicrobial, antioxidant, in vivo antitumor and in vitro anticancer effects against breast cancer cell line by green synthesized un-doped SnO2 and Co-doped SnO2 nanoparticles from Clerodendrum inerme

Author:
Khan, Shakeel Ahmad; Kanwal, Sadia; Rizwan, Komal; Shahid, Sammia
Source:
Microbial pathogenesis 2018 v.125 pp. 366-384
ISSN:
0882-4010
Subject:
2,2-diphenyl-1-picrylhydrazyl; Aspergillus flavus; Aspergillus niger; Bacillus subtilis; Candida albicans; Clerodendrum inerme; Escherichia coli; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; breast neoplasms; carcinoma; cell lines; cobalt; combustion; confocal laser scanning microscopy; culture media; cytotoxicity; energy; energy-dispersive X-ray analysis; fungi; hemolysis; nanomedicine; nanoparticles; neoplasm cells; scanning electron microscopy; spectroscopy; tin dioxide; transmission electron microscopy
Abstract:
... A novel approach was employed for the synthesis of un-doped tinoxide and Cobalt-doped tinoxide (Co-doped SnO2) nanoparticles (NAPs) by using aqueous extract of Clerodendrum inerme with the help of eco-friendly superficial solution combustion method. Synthesized NAPs were characterized by different spectroscopic techniques and results from XRD, TEM, SEM, EDX and UV–Vis examines confirmed the succes ...
DOI:
10.1016/j.micpath.2018.09.041

19. Enterotoxigenic Escherichia coli infection promotes apoptosis in piglets

Author:
Xia, Yaoyao; Bin, Peng; Liu, Shaojuan; Chen, Shuai; Yin, Jie; Liu, Gang; Tang, Zhiyi; Ren, Wenkai
Source:
Microbial pathogenesis 2018 v.125 pp. 290-294
ISSN:
0882-4010
Subject:
apoptosis; caspase-8; caspase-9; diarrhea; enterotoxigenic Escherichia coli; humans; jejunum; pathogens; piglets
Abstract:
... Enterotoxigenic Escherichia coli (ETEC), as a universal pathogen, often causes diarrhea in animals and humans. However, whether ETEC infection induces apoptosis in host remains controversial. Herein, we use ETEC-infected piglet to investigate apoptosis in the jejunum. Apoptosis and the activation of capase-3 are observed in piglet jejunum after ETEC infection. Additionally, ETEC infection induces ...
DOI:
10.1016/j.micpath.2018.09.032

20. Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice

Author:
Liu, Aiyun; Shen, Yongbin; Du, Yaju; Chen, Jing; Pei, Fenghua; Fu, Weiran; Qiao, Jiutao
Source:
Microbial pathogenesis 2018 v.125 pp. 418-422
ISSN:
0882-4010
Subject:
Aesculus hippocastanum; alanine transaminase; animal models; antioxidant activity; aspartate transaminase; blood serum; heme oxygenase (biliverdin-producing); histology; interleukin-1beta; intraperitoneal injection; liver; liver neoplasms; malondialdehyde; mice; myeloperoxidase; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Liver injury is an important cause of serious liver disease and is characterized by inflammatory and oxidative responses. Esculin, a coumarinic derivative found in Aesculus hippocastanum L., has been shown to exhibit anti-inflammatory and anti-oxidative effects. Here, we investigated the effects and molecular mechanism of esculin on Lipopolysaccharide/D-Galactosamine (LPS/D-Gal)-induced acute live ...
DOI:
10.1016/j.micpath.2018.10.003