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1. Alterations in metabolic pathways in gastric epithelial cells infected with Helicobacter pylori

Author:
Matsunaga, Shinsuke; Nishiumi, Shin; Tagawa, Ryoma; Yoshida, Masaru
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Helicobacter pylori; amino acid metabolism; aspartate-ammonia ligase; bacteria; epithelial cells; gastric mucosa; glycolysis; humans; isocitrate dehydrogenase; metabolites; neoplasm cells; pathogens; signal transduction; tricarboxylic acid cycle; virulence
Abstract:
... Helicobacter pylori (H. pylori), which is a spiral-shaped Gram-negative microaerobic bacterium, is a causative pathogen. The entry of H. pylori into gastric epithelial cells involves various host signal transduction events, and its virulence factors can also cause a variety of biological responses. In this study, AGS human gastric carcinoma cells were infected with CagA-positive H. pylori strain A ...
DOI:
10.1016/j.micpath.2018.08.033

2. Antigenic potential of a recombinant polyvalent DNA vaccine against pathogenic leptospiral infection

Author:
Bashiru, Garba; Bahaman, Abdul Rani; Zakaria, Zunita; Bejo, Siti Khairani; Mutalib, Abdul Rahim; Faruku, Bande; Suleiman, Nasiru
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
DNA; Leptospira; animals; cross immunity; epitopes; genes; hosts; immunization; leptospirosis; neutralizing antibodies; recombinant vaccines; serotypes; subtropics
Abstract:
... Leptospirosis is a serious epidemic disease caused by pathogenic Leptospira species. The disease is endemic in most tropical and sub-tropical regions of the world. Currently, there is no effective polyvalent vaccine for prevention against most of the circulating serovars. Moreover, development of an efficient leptospiral vaccine capable of stimulating cross-protective immune responses against a wi ...
DOI:
10.1016/j.micpath.2018.08.028

3. Antimicrobial potential of Alpinia purpurata lectin (ApuL): Growth inhibitory action, synergistic effects in combination with antibiotics, and antibiofilm activity

Author:
Ferreira, Gustavo Ramos Salles; Brito, Jéssica de Santana; Procópio, Thamara Figueiredo; Santos, Nataly Diniz de Lima; de Lima, Bárbara José Rocha Cardoso; Coelho, Luana Cassandra Breitenbach Barroso; Navarro, Daniela Maria do Amaral Ferraz; Paiva, Patrícia Maria Guedes; Soares, Tatiana; de Moura, Maiara Celine; Napoleão, Thiago Henrique
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Alpinia purpurata; Candida albicans; Candida parapsilosis; Pseudomonas aeruginosa; Staphylococcus aureus; abnormal development; animal pathogens; antibacterial properties; antibiotics; antifungal properties; biofilm; humans; lectins; minimum inhibitory concentration; multiple drug resistance; propidium; staining; synergism; viability
Abstract:
... The Alpinia purpurata inflorescence contains a lectin (ApuL), which has immunomodulatory activities on human cells. In the present work, it was evaluated the antibacterial and antifungal effects of ApuL against human pathogens. ApuL showed bacteriostatic activity against non-resistant (UFPEDA-02) and an oxacillin-resistant isolate (UFPEDA-672) of Staphylococcus aureus with minimal inhibitory conce ...
DOI:
10.1016/j.micpath.2018.08.027

4. Biofilm formation in erythromycin-resistant Staphylococcus aureus and the relationship with antimicrobial susceptibility and molecular characteristics

Author:
Sun, Xiang; Lin, Zhi-wei; Hu, Xiao-xiong; Yao, Wei-ming; Bai, Bing; Wang, Hong-yan; Li, Duo-yun; Chen, Zhong; Cheng, Hang; Pan, Wei-guang; Deng, Ming-gui; Xu, Guang-jian; Tu, Hao-peng; Chen, Jun-wen; Deng, Qi-wen; Yu, Zhi-jian; Zheng, Jin-xin
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
antibiotic resistance; biofilm; ciprofloxacin; clindamycin; erythromycin; essential genes; gentamicin; gentian violet; methicillin; methicillin-resistant Staphylococcus aureus; multilocus sequence typing; polymerase chain reaction; resistance genes; staining; China
Abstract:
... In this study, we aimed to investigate biofilm formation characteristics in clinical Staphylococcus aureus (S. aureus) isolates with erythromycin (ERY) resistance from China and further analyze their correlations with antimicrobial susceptibility and molecular characteristics.ology A total of 276 clinical isolates of ERY-resistant S. aureus, including 142 methicillin-resistant S. aureus (MRSA) str ...
DOI:
10.1016/j.micpath.2018.08.021

5. Body fat modulated activity of Gallus gallus domesticus Linnaeus (1758) and Meleagris gallopavo Linnaeus (1758) in association with antibiotics against bacteria of veterinary interest

Author:
de Queiroz Dias, Diógenes; Sales, Débora Lima; Andrade, Jacqueline Cosmo; Pereira da Silva, Ana Raquel; Tintino, Saulo Relison; Datiane de Morais Oliveira-Tintino, Cícera; de Araújo Delmondes, Gyllyandeson; Gadelha Rocha, Marcos Fábio; Martins da Costa, José Galberto; Romeu da Nóbrega Alves, Rômulo; Ferreira, Felipe Silva; Melo Coutinho, Henrique Douglas; de Oliveira Almeida, Waltécio
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Meleagris gallopavo; amikacin; amoxicillin; antibacterial properties; bacteria; chemical composition; chickens; fatty acid methyl esters; hexane; linoleic acid; minimum inhibitory concentration; norfloxacin; oils; oleic acid; oxytetracycline; saturated fatty acids; solvents; synergism; Brazil
Abstract:
... In the Northeast of Brazil, ethnoveterinary studies have shown that the body fat from Gallus gallus domesticus and Meleagris gallopavo are used for diseases that affect domestic animals. The objective of this study was to identify the chemical composition and to evaluate the antibacterial activity of the Gallus gallus domesticus (OFGG) and Meleagris gallopavo (OFMG) fixed oils in isolation and in ...
DOI:
10.1016/j.micpath.2018.08.029

6. Candida species biotypes in the oral cavity of infants and children with orofacial clefts under surgical rehabilitation

Author:
Júnior da Silva, Jeferson; da Silva, Thaísla Andrielli; de Almeida, Hudson; Rodrigues Netto, Manoel Francisco; Cerdeira, Claudio Daniel; Höfling, José Francisco; Gomes Boriollo, Marcelo Fabiano
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Candida; DNA; amphotericin B; biotypes; children; cultural behavior; culture media; electrophoresis; extracellular enzymes; females; fluconazole; infants; infectious diseases; males; mouth; nucleotide sequences; nystatin; patients; polyenes; polymerase chain reaction; risk factors; surgery; virulence
Abstract:
... Patients with orofacial clefts present various risk factors for oral infectious diseases, resulting from anatomical and physiological changes and those resulting from rehabilitating therapeutic interventions. The incidence of Candida species in groups of babies and children with orofacial clefts, during pre- and post-operative periods and until return to first consultation, and the profiles for an ...
DOI:
10.1016/j.micpath.2018.08.042

7. Chemical composition, antibacterial, antioxidant and cytotoxic evaluation of the essential oil from pistachio (Pistacia khinjuk) hull

Author:
Taghizadeh, Seyedeh Faezeh; Davarynejad, Gholamhossein; Asili, Javad; Riahi-Zanjani, Bamdad; Nemati, Seyed Hossein; Karimi, Gholamreza
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
2,2-diphenyl-1-picrylhydrazyl; Pistacia khinjuk; Staphylococcus aureus; antioxidant activity; antioxidants; bacteria; bleaching; cell lines; chemical composition; cytotoxicity; essential oils; gas chromatography-mass spectrometry; inhibitory concentration 50; minimum inhibitory concentration; oils; pistachios
Abstract:
... Chemical composition, antibacterial, antioxidant and cytotoxic activities of (Pistacia khinjuk) hull essential oil (EO) were evaluated in this study. The EO was isolated and analyzed by gas chromatography-mass spectrometry. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) were determined using 6 strains of Gram-positive and negative bacteria. DPPH radical ...
DOI:
10.1016/j.micpath.2018.08.039

8. Clinical responses in cows vaccinated with a developed prototype killed Staphylococcus aureus mastitis vaccine

Author:
Hambali, I.U.; Bhutto, K.R.; Jesse, F.F.A.; Lawan, A.; Odhah, M.N.; Wahid, A.H.; Azmi, M.L. Mohd; Zakaria, Z.; Arsalan, M.; Muhammad, N.A.; Jefri, M.N.
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Staphylococcus aureus; adjuvants; algae; aluminum; bacteria; cows; fungi; heart rate; leukocytes; mastitis; potassium sulfate; prototypes; respiratory rate; temperature; udders; vaccination; vaccines; viruses
Abstract:
... Mastitis is an inflammatory condition of the udder that occurs as a result of the release of leucocytes into the udder in a response to bacterial invasion. The major causes of mastitis are an array of gram positive and negative bacteria, however, algae, virus, fungi, mechanical or thermal injury to the gland have also been identified as possible causes. Mastitis vaccines are yet to be developed us ...
DOI:
10.1016/j.micpath.2018.08.017

9. Decidual macrophage M1 polarization contributes to adverse pregnancy induced by Toxoplasma gondii PRU strain infection

Author:
Liu, Xianbing; Jiang, Mengqi; Ren, Liqin; Zhang, Aihong; Zhao, Mingdong; Zhang, Haixia; Jiang, Yuzhu; Hu, Xuemei
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Toxoplasma gondii; animal models; immunosuppression; inducible nitric oxide synthase; interleukin-12; macrophages; mice; phenotype; placenta; pre-eclampsia; pregnancy outcome; tumor necrosis factor-alpha
Abstract:
... Recent evidence indicates that macrophages at the maternal–fetal interface adapt to a phenotype characterized by alternative activation (M2 polarization) and exhibit immunosuppressive functions that favor the maintenance of pregnancy. The bias of M2 decidual macrophages toward M1 has been clinically linked to pregnancy-related complications, such as preeclampsia, and preterm delivery. The aim of t ...
DOI:
10.1016/j.micpath.2018.08.043

10. Ferulic acid derivative inhibits NorA efflux and in combination with ciprofloxacin curtails growth of MRSA in vitro and in vivo

Author:
Sundarmoorthy, Niranjana Sri; Mithra, Karthik; Ganesh, Jayasankari Senthil; Makala, Himesh; Lotha, Robert; Bhanuvalli, Shamprasad R.; Ulaganathan, Venkatasubramanian; Thirunaukarasu, Vaidehi; Sivasubramanian, Aravind; Nagarajan, Saisubramanian
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Danio rerio; acetates; adjuvants; animal models; ciprofloxacin; ferulic acid; methicillin-resistant Staphylococcus aureus; molecular models; muscle tissues; prediction; reserpine; transporters
Abstract:
... A series of ferulic acid (FA) derivatives were synthesized and evaluated for its ability to inhibit NorA efflux in methicillin resistant Staphylococcus aureus (MRSA), by in silico docking analysis. Based on prediction from glide scores and ability to reduce EtBr MIC, two of the ten derivatives S3- [4-((E)-2-(diethylcarbamoyl)vinyl)-2-methoxyphenyl acetate] and S6- [(E)-methyl 3-(4-((p-tolylcarbamo ...
DOI:
10.1016/j.micpath.2018.08.022

11. Fructose-1,6-bisphosphate aldolase of Mycoplasma bovis is a plasminogen-binding adhesin

Author:
Gao, Xiang; Bao, Shijun; Xing, Xiaoyong; Fu, Xiaoping; Zhang, Yi; Xue, Huiwen; Wen, Fengqin; Wei, Yanming
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Escherichia coli; Mycoplasma bovis; NAD (coenzyme); adhesins; adhesion; antibodies; bacteria; bacterial adhesion; blood serum; cattle; cattle industry; cell membranes; complement; cytoplasm; dose response; electrophoresis; enzyme activity; enzyme-linked immunosorbent assay; financial economics; fluorescence microscopy; fluorescent antibody technique; fructose-bisphosphate aldolase; genes; genetic vectors; glycolysis; lungs; plasmids; plasminogen; polymerase chain reaction; rabbits
Abstract:
... Mycoplasma bovis is an extremely small cell wall-deficient pathogenic bacterium in the genus Mycoplasma that causes serious economic losses to the cattle industry worldwide. Fructose-1,6-bisphosphate aldolase (FBA), a key enzyme in the glycolytic pathway, is a multifunctional protein in several pathogenic bacterial species, but its role in M. bovis remains unknown. Herein, the FBA gene of the M. b ...
DOI:
10.1016/j.micpath.2018.08.032

12. Gamma-irradiation-killed Streptococcus pneumoniae potently induces the expression of IL-6 and IL-8 in human bronchial epithelial cells

Author:
Jwa, Min Yong; Ko, Eun Byeol; Kim, Hyun Young; Kim, Sun Kyung; Jeong, Soyoung; Seo, Ho Seong; Yun, Cheol-Heui; Han, Seung Hyun
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Streptococcus pneumoniae; Toll-like receptor 2; cost effectiveness; epithelial cells; epithelium; formalin; heat; human cell lines; humans; immunogenicity; immunostimulants; innate immunity; interleukin-6; interleukin-8; meningitis; messenger RNA; mitogen-activated protein kinase; otitis media; pathogens; pneumonia; polysaccharides; protein content; vaccines
Abstract:
... Streptococcus pneumoniae is a major respiratory pathogen that can cause pneumonia, meningitis, and otitis media. Although capsular polysaccharide-based vaccines are commercially available, there is a need for broad-spectrum, serotype-independent, and cost-effective vaccines. Recently, an intranasal vaccine formulated with gamma-irradiated nonencapsulated S. pneumoniae whole cells has been develope ...
DOI:
10.1016/j.micpath.2018.08.015

13. Gut microbiome: Microflora association with obesity and obesity-related comorbidities

Author:
Lone, Jameel Barkat; Koh, Wee Yin; Parray, Hilal A.; Paek, Woon K.; Lim, Jeongheui; Rather, Irfan A.; Jan, Arif Tasleem
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
comorbidity; diet; energy; etiology; genetic factors; intestinal microorganisms; lifestyle; obesity; people; therapeutics
Abstract:
... Obesity and obesity-related comorbidities have transformed into a global epidemic. The number of people suffering from obesity has increased dramatically within the past few decades. This rise in obesity cannot alone be explained by genetic factors; however, diet, environment, lifestyle, and presence of other diseases undoubtedly contribute towards obesity etiology. Nevertheless, evidence suggests ...
DOI:
10.1016/j.micpath.2018.08.036

14. Langerin (CD207)-positive cells in leprosy: Possible implications for pathogenesis of the disease with special emphasis on dermal immunoreactivity

Author:
Hirai, Kelly Emi; Silva, Luciana Mota; de Sousa, Jorge Rodrigues; de Souza, Juarez; Dias, Leônidas Braga; Oliveira Carneiro, Francisca Regina; de Souza Aarão, Tinara Leila; Quaresma, Juarez Antonio Simões
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Mycobacterium leprae; antigens; dendritic cells; immune response; leprosy; pathogenesis; patients; skin lesions
Abstract:
... Leprosy is a disease caused by Mycobacterium leprae, which is characterized by two distinct poles, the tuberculoid pole and the lepromatous pole, depending on the immune response to the bacillus. Langerin-positive cells are dendritic cells that appear to play an essential role in the development of the disease. These cells are specialized in the processing and presentation of antigens, exerting an ...
DOI:
10.1016/j.micpath.2018.08.020

15. Molecular epidemiology of methicillin-susceptible Staphylococcus aureus (MSSA) isolated from milk of cows with subclinical mastitis

Author:
Bonsaglia, E.R.; Silva, N.C.C.; Rossi, B.F.; Camargo, C.H.; Dantas, S.T.A.; Langoni, H.; Guimarães, F.F.; Lima, F.S.; Fitzgerald, J.R.; Fernandes, A.; Rall, V.L.M.
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Staphylococcus aureus; bovine mastitis; clindamycin; clones; cows; dairy herds; enterotoxins; erythromycin; farms; genes; milk; molecular epidemiology; multilocus sequence typing; phenotype; polymerase chain reaction; pulsed-field gel electrophoresis; septic shock; streptomycin; swine; Brazil
Abstract:
... Bovine mastitis has been a concern for dairy herd for decades. The adaptation capacity of one of the main species responsible for this disease, Staphylococcus aureus (S. aureus), plays a pivotal role in this issue. The aim of this study was to establish a molecular and phenotypic profile of 285 S. aureus strains isolated from milk of subclinical mastitis cows from 18 different farms in São Paulo S ...
DOI:
10.1016/j.micpath.2018.08.031

16. Moonlighting proteins induce protection in a mouse model against Candida species

Author:
Medrano-Díaz, César Luis; Vega-González, Arturo; Ruiz-Baca, Estela; Moreno, Abel; Cuéllar-Cruz, Mayra
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Candida albicans; Candida glabrata; animal models; biofilm; candidiasis; cell walls; fructose-bisphosphate aldolase; humans; immunity; kidneys; liver; medical equipment; mice; oxidative stress; pathogens; patients; phosphoglycerate kinase; pyruvate kinase; reactive oxygen species; recombinant proteins; spleen; structural proteins; vaccines; virulence; yeasts
Abstract:
... In recent years, C. albicans and C. glabrata have been identified as the main cause of candidemia and invasive candidiasis in hospitalized and immunocompromised patients. In order to colonize the human host, these fungi express several virulence factors such as the response to oxidative stress and the formation of biofilms. In the expression of these virulence factors, the cell wall of C. albicans ...
DOI:
10.1016/j.micpath.2018.08.024

17. Paeoniflorin attenuates LPS-induced inflammation in nucleus pulposus cells via Nrf-2/HO-1/HMGB1/NF-κB pathway

Author:
Heng, Yin; Mao, Wu; Yong, Ma; Yang, Guo; Su, Qiuju; Wang, Jianwei
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; malondialdehyde; protein content; superoxide dismutase; tumor necrosis factor-alpha
Abstract:
... This study was to investigate the effects of paeoniflorin (PA) on lipopolysaccharides (LPS)-induced nucleus pulposus cells. Our results demonstrated that PA significantly reduced lipopolysaccharides (LPS) induced inflammatory factors including interleukin-1β (IL-1β), tumor necrosis Factor-α (TNF-α) and interleukin-6 (IL-6) in nucleus pulposus cells. PA also decreased of malondialdehyde (MDA) and i ...
DOI:
10.1016/j.micpath.2018.08.009

18. Peptides as adjuvants for ampicillin and oxacillin against methicillin-resistant Staphylococcus aureus (MRSA)

Author:
Rishi, Praveen; Vij, Shania; Maurya, Indresh Kumar; Kaur, Ujjwal Jit; Bharati, Sanjay; Tewari, Rupinder
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
adjuvants; ampicillin; antibiotic resistance; antimicrobial properties; confocal microscopy; dielectric spectroscopy; ethidium; flow cytometry; mechanism of action; methicillin; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; multiple drug resistance; oxacillin; pathogens; peptides; proteins; scanning electron microscopy; screening
Abstract:
... Fast emerging antibiotic resistance in pathogens requires special attention for strengthening the reservoir of antimicrobial compounds. In view of this, several peptides with known antimicrobial activities have been reported to enhance the efficacy of antibiotics against multidrug resistant (MDR) pathogens. In the present study, potential of peptides having distinct mechanism of action, if any, wa ...
DOI:
10.1016/j.micpath.2018.08.023

19. Porphyromonas gingivalis induces exacerbated periodontal disease during pregnancy

Author:
Duan, Xingyu; Hays, Aislinn; Zhou, Wei; Sileewa, Nawar; Upadhyayula, Satya; Wang, Huizhi; Liang, Shuang
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Porphyromonas gingivalis; animal models; bone resorption; cytokines; inflammation; mice; microbial load; periodontal diseases; pregnancy; pregnant women; quantitative polymerase chain reaction
Abstract:
... Although pregnant women are prone to gingival inflammation, its mechanism remains unclear. Animal models are ideal for investigating immunological mechanisms in the periodontal disease. A murine model for ligature-induced periodontal disease has been modified and utilized to determine the susceptibility to periodontal inflammation and tissue damage in pregnant mice. Expression of different inflamm ...
DOI:
10.1016/j.micpath.2018.08.019
PubMed:
30118804
PubMed Central:
PMC6365183

20. Preparation and evaluation of chitosan nanoparticles containing CtxB antigen against Vibrio cholera

Author:
Tabrizi, Niloufar Mirzaee; Amani, Jafar; Ebrahimzadeh, Mohammad; Nazarian, Shahram; Kazemi, Rohoallah; Almasian, Pegah
Source:
Microbial pathogenesis 2018
ISSN:
0882-4010
Subject:
Gram-negative bacteria; Vibrio cholerae; Western blotting; antigens; blood serum; chitosan; cholera; diarrhea; enzyme-linked immunosorbent assay; ileum; immune response; immunogenicity; immunoglobulin A; immunoglobulin G; mice; nanoparticles; neutralization; polyacrylamide gel electrophoresis; rabbits; vaccines
Abstract:
... Vibrio cholera is a Gram-negative pathogen that causes diarrheal disease. The B subunit of Chlora toxin (CtxB) is one of the most important antigens of Vibrio cholera in which mediates the attachment of the bacteria to target cells. The aim of this study was to prepare chitosan nanoparticles containing CtxB and evaluate the effect of the antigen entrapment on the immunogenicity of this antigen.For ...
DOI:
10.1016/j.micpath.2018.08.037