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- Asakawa, Haruhiko; Hiraoka, Yasushi; Haraguchi, Tokuko
- Micron 2014 v.61 pp. 53-61
- cell structures; electron microscopy; fluorescence microscopy; fluorescent proteins; image analysis; light microscopy; microbial genetics; molecular genetics; ultrastructure; yeasts
- ... Correlative light and electron microscopy (CLEM) is a method of imaging in which the same specimen is observed by both light microscopy and electron microscopy. Specifically, CLEM compares images obtained by light and electron microscopy and makes a correlation between them. After the advent of fluorescent proteins, CLEM was extended by combining electron microscopy with fluorescence microscopy to ...