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1. Calcitonin protects chondrocytes from lipopolysaccharide-induced apoptosis and inflammatory response through MAPK/Wnt/NF-κB pathways

Author:
Zhang, Lai-Bo; Man, Zhen-Tao; Li, Wei; Zhang, Wei; Wang, Xian-Quan; Sun, Shui
Source:
Molecular Immunology 2017 v.87 pp. 249-257
ISSN:
0161-5890
Subject:
apoptosis; bone morphogenetic proteins; calcitonin; cartilage; cell viability; chondrocytes; inflammation; lipopolysaccharides; mice; mitogen-activated protein kinase; nitric oxide; osteoarthritis; osteoporosis; secretion; small interfering RNA
Abstract:
... Calcitonin (CT) is an anti-absorbent, which has long been used for treatment of osteoporosis. However, little information is available about the effects of CT on osteoarthritis (OA). This study was mainly aimed to explore the effects of CT on the treatment of OA, as well as the underlying mechanisms. Chondrocytes were isolated from immature mice and then were incubated with lipopolysaccharide (LPS ...
DOI:
10.1016/j.molimm.2017.05.002

2. CD11b regulates antibody class switching via induction of AID

Author:
Park, Seohyun; Sim, Hyunsub; Kim, Hye-In; Jeong, Daecheol; Wu, Guang; Cho, Soo Young; Lee, Young Seek; Kwon, Hyung-Joo; Lee, Keunwook
Source:
Molecular Immunology 2017 v.87 pp. 47-59
ISSN:
0161-5890
Subject:
B-lymphocytes; IKappaB kinase; autoantibodies; cytidine deaminase; genetic variation; immunoglobulin G; immunoglobulin heavy chains; integrins; lupus erythematosus; mice; phosphorylation; risk factors; transcription factor NF-kappa B
Abstract:
... The integrin CD11b, which is encoded by the integrin subunit alpha M (ITGAM), is primarily expressed on the surface of innate immune cells. Genetic variations in ITGAM are among the strongest risk factors for systemic lupus erythematosus, an autoimmune disease characterized by the presence of autoantibodies. However, the regulatory function of CD11b in the antibody responses remains unclear. Here, ...
DOI:
10.1016/j.molimm.2017.04.005

3. Expression and splicing of Ikaros family members in murine and human thymocytes

Author:
Mitchell, Julie L.; Seng, Amara; Yankee, Thomas M.
Source:
Molecular Immunology 2017 v.87 pp. 1-11
ISSN:
0161-5890
Subject:
CD8-positive T-lymphocytes; DNA; alternative splicing; dimerization; humans; messenger RNA; mice; thymocytes; transcription (genetics); transcription factors
Abstract:
... The Ikaros family of transcription factors includes five highly homologous members that can homodimerize or heterodimerize in any combination. Dimerization is essential for their ability to bind DNA and function as transcription factors. Previous studies showed that eliminating the function of the entire family blocks lymphocyte development while deletion of individual family members has relativel ...
DOI:
10.1016/j.molimm.2017.03.014

4. Scaffold protein JLP mediates TCR-initiated CD4+T cell activation and CD154 expression

Author:
Yan, Qi; Yang, Cheng; Fu, Qiang; Chen, Zhaowei; Liu, Shan; Fu, Dou; Rahman, Rahmat N.; Nakazato, Ryota; Yoshioka, Katsuji; Kung, Sam K.P.; Ding, Guohua; Wang, Huiming
Source:
Molecular Immunology 2017 v.87 pp. 258-266
ISSN:
0161-5890
Subject:
CD4-positive T-lymphocytes; calcium; cell-mediated immunity; interleukin-2; ligands; lymph nodes; mice; mitogen-activated protein kinase; scaffolding proteins; signal transduction; spleen; thymus gland; tissues; transcription factor NF-kappa B
Abstract:
... CD4+ T-cell activation and its subsequent induction of CD154 (CD40 ligand, CD40L) expression are pivotal in shaping both the humoral and cellular immune responses. Scaffold protein JLP regulates signal transduction pathways and molecular trafficking inside cells, thus represents a critical component in maintaining cellular functions.Its role in regulating CD4+ T-cell activation and CD154 expressio ...
DOI:
10.1016/j.molimm.2017.05.006

5. TLR2 mediates autophagy through ERK signaling pathway in Mycoplasma gallisepticum-infected RAW264.7 cells

Author:
Lu, Ziyin; Xie, Daoyuan; Chen, Ying; Tian, Erjie; Muhammad, Ishfaq; Chen, Xueping; Miao, Yusong; Hu, Wanjun; Wu, Ziyong; Ni, Huili; Xin, Jiuqing; Li, Yuan; Li, Jichang
Source:
Molecular Immunology 2017 v.87 pp. 161-170
ISSN:
0161-5890
Subject:
Mycoplasma gallisepticum; Toll-like receptor 2; Western blotting; autophagy; chickens; electron microscopy; fluorescence microscopy; gene expression regulation; macrophages; mice; microorganisms; mitogen-activated protein kinase; pathogens; respiratory tract diseases; signal transduction; small interfering RNA
Abstract:
... Toll-like receptor 2 (TLR2) plays a crucial role in early innate immune response of host to various microorganisms. Mycoplasma gallisepticum (MG) is one of the major pathogen that can cause chronic respiratory diseases in chickens, but the molecular mechanism of MG infection still remained unclear. In this study, we examined the typical hallmarks of autophagy and multiple signaling pathways by wes ...
DOI:
10.1016/j.molimm.2017.04.013

6. TLR4 supports the expansion of FasL+CD5+CD1dhi regulatory B cells, which decreases in contact hypersensitivity

Author:
Wang, Keng; Tao, Lei; Su, Jianbing; Zhang, Yueyang; Zou, Binhua; Wang, Yiyuan; Zou, Min; Chen, Nana; Lei, Linsheng; Li, Xiaojuan
Source:
Molecular Immunology 2017 v.87 pp. 188-199
ISSN:
0161-5890
Subject:
B-lymphocytes; CD4-positive T-lymphocytes; Toll-like receptor 4; Toll-like receptor 9; antibodies; chemical elements; flow cytometry; hypersensitivity; immune response; interleukin-10; ligands; lipopolysaccharides; mice; secretion; splenocytes; transcription factor NF-kappa B
Abstract:
... Certain B cells termed as “regulatory B cells” (Bregs) can suppress the ongoing immune responses and a splenic CD5+CD1dhi Breg subset identified earlier was shown to exert its regulatory functions through secretion of IL-10. Though FasL expression is an alternative mechanism of immune suppression used by B cells, little is known about the FasL expressing CD5+CD1dhi Bregs. In this study, we isolate ...
DOI:
10.1016/j.molimm.2017.04.016