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You searched for: Journal Molecular Immunology Remove constraint Journal: Molecular Immunology Publication Year 2016 Remove constraint Publication Year: 2016 Source 2016 Remove constraint Source: 2016
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1. Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Author:
Chu, Edward P.F.; Elso, Colleen M.; Pollock, Abigail H.; Alsayb, May A.; Mackin, Leanne; Thomas, Helen E.; Kay, Thomas W.H.; Silveira, Pablo A.; Mansell, Ashley S.; Gaus, Katharina; Brodnicki, Thomas C.
Source:
Molecular Immunology 2016
ISSN:
0161-5890
Subject:
autoimmune diseases; autoimmunity; disease resistance; lipid composition; lymphocyte proliferation; lymphocytes; macrophages; mice; phosphatidylserines; plasma membrane; serine; sphingolipids; viability
Abstract:
... During immune cell activation, serine-derived lipids such as phosphatidylserine and sphingolipids contribute to the formation of protein signaling complexes within the plasma membrane. Altering lipid composition in the cell membrane can subsequently affect immune cell function and the development of autoimmune disease. Serine incorporator 1 (SERINC1) is a putative carrier protein that facilitates ...
DOI:
10.1016/j.molimm.2016.12.007

2. Intercellular communication for innate immunity

Author:
Nguyen, Tan A.; Pang, Ken C.; Masters, Seth L.
Source:
Molecular Immunology 2016
ISSN:
0161-5890
Subject:
DNA; RNA; bacteria; cell communication; chemokines; coevolution; immune system; innate immunity; microbial detection; pathogens; receptors; viruses
Abstract:
... An effective innate immune response relies on the detection of pathogen associated molecular patterns (PAMPs) by various host pattern recognition receptors (PRRs) that result in the production of pro-inflammatory cytokines and chemokines. Viruses and bacteria have co-evolved with the immune system and developed multiple strategies to usurp or circumvent host machinery and blunt the innate immune r ...
DOI:
10.1016/j.molimm.2016.10.002

3. Maspin Inhibits Macrophage Phagocytosis and Enhances Inflammatory Cytokine Production via Activation of NF-κB Signaling

Author:
Wang, Yimeng; Sun, Luguo; Song, Zhenbo; Wang, Danfeng; Bao, Yongli; Li, Yuxin
Source:
Molecular Immunology 2016
ISSN:
0161-5890
Subject:
immunomodulation; secretion; interferon-gamma; Western blotting; phagocytosis; interleukin-12; neoplasms; coculture; macrophages; enzyme-linked immunosorbent assay; transforming growth factor beta; interleukin-10; apoptosis; transcription factor NF-kappa B; serine proteinases; mice; tumor necrosis factor-alpha; interleukin-1beta; interleukin-6; therapeutics; Saccharomyces cerevisiae; inducible nitric oxide synthase; proteinase inhibitors; angiogenesis
Abstract:
... Maspin (mammary serine protease inhibitor) is a non-inhibitory member of the serine protease inhibitor superfamily and a tumor suppressor in several cancers due to its ability to inhibit cell invasion, angiogenesis, and promote apoptosis. However, its immunomodulatory function remains largely unexplored. Thus, we explored the potential link between Maspin and macrophage function, first evaluating ...
DOI:
10.1016/j.molimm.2016.12.021

4. Transcriptional regulation of inflammasome-associated pattern recognition receptors, and the relevance to disease pathogenesis

Author:
Deswaerte, Virginie; Ruwanpura, Saleela M.; Jenkins, Brendan J.
Source:
Molecular Immunology 2016
ISSN:
0161-5890
Subject:
apoptosis; autophagy; bacteria; cardiovascular diseases; caspase-1; cigarettes; fungi; genes; immunologic receptors; inflammation; interleukin-18; metabolic syndrome; metabolism; neoplasms; pathogenesis; pollution; transcription (genetics); viruses
Abstract:
... Over the last decade it has emerged that inflammasome complexes provide a pivotal platform for the host innate immune system to respond to exogenous infectious microbes (viruses, bacteria, fungi) and non-infectious environmental agents (cigarette smoke, pollution), as well as endogenous “danger” signals. Upon the canonical activation of inflammasomes, a key effector function is to catalyze, via ca ...
DOI:
10.1016/j.molimm.2016.09.023