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You searched for: Journal Molecular Immunology Remove constraint Journal: Molecular Immunology Publication Year 2016 Remove constraint Publication Year: 2016 Source 2016 v.74 Remove constraint Source: 2016 v.74 Subject immunoglobulin E Remove constraint Subject: immunoglobulin E
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1. A single mouse monoclonal antibody, E58 modulates multiple IgE epitopes on group 1 cedar pollen allergens

Author:
Goldblum, Randall M.; Ning, Bo; Judy, Barbara M.; Holthauzen, Luis Marcelo F.; van Bavel, Julius; Kamijo, Atsushi; Midoro-Horiuti, Terumi
Source:
Molecular Immunology 2016 v.74 pp. 106-112
ISSN:
0161-5890
Subject:
Juniperus ashei; allergens; epitopes; hay fever; immunoglobulin E; mice; monoclonal antibodies; patients; pollen; therapeutics; France; Japan; United States
Abstract:
... We recently described a dominant role for conformational epitopes on the group 1 allergen of the mountain cedar (Juniperus ashei, Cupressaceae), Jun a 1, in pollen hypersensitivity in South Central U.S.A. Since these epitopes are surface exposed and are likely to be flexible, they may be susceptible to molecular or physical perturbations. This may make Jun a 1 a potential target for new forms of t ...
DOI:
10.1016/j.molimm.2016.04.006
PubMed:
27174188
PubMed Central:
PMC4899245

2. Identification of the major allergenic epitopes of Eriocheir sinensis roe hemocyanin: A novel tool for food allergy diagnoses

Author:
Zhang, Yingying; Zhu, Lina; Li, Shaoshen; Zhang, Jiayi; She, Tiantian; Yan, Juanjuan; Bian, Ying; Li, Huiqiang
Source:
Molecular Immunology 2016 v.74 pp. 125-132
ISSN:
0161-5890
Subject:
Eriocheir sinensis; Escherichia coli; allergenicity; allergens; antibodies; bioinformatics; crab meat; crabs; dose response; enzyme-linked immunosorbent assay; food allergies; hemocyanin; immunoblotting; immunodominant epitopes; immunoglobulin E; patients; polyacrylamide gel electrophoresis; prediction; recombinant fusion proteins; China
Abstract:
... Crab meat and roe are highly nutritious delicacies in China. While extensive research has been conducted for allergens derived from crab-meat, data relevant to the allergenic potential of crab roe derived proteins, of which hemocyanin is a principal contender, are almost entirely absent. Using bioinformatics prediction and IgE-binding assays, the three principal immunodominant epitopes of hemocyan ...
DOI:
10.1016/j.molimm.2016.05.003

3. Longitudinal profiles of serum specific IgE and IgG4 to Dermatophagoides pteronyssinus allergen and its major components during allergen immunotherapy in a cohort of southern Chinese children

Author:
Zeng, Guangqiao; Zheng, Peiyan; Luo, Wenting; Huang, Huimin; Wei, Nili; Sun, Baoqing
Source:
Molecular Immunology 2016 v.74 pp. 1-9
ISSN:
0161-5890
Subject:
Chinese people; Dermatophagoides pteronyssinus; allergens; blood serum; children; immunoglobulin E; immunoglobulin G; immunotherapy
Abstract:
... Longitudinal data on serum specific sIgE and sIgG4 to allergen component of Dermatophagoides pteronyssinus (Der p) during allergen immunotherapy (AIT) are limited in Chinese populations. We serially followed up serum sIgE and sIgG4 to Der p and its components (Der p 1 and 2) in 51 Der p-sensitized children receiving guideline-based medications alone and additional 36-month AIT. The the Der p 1 and ...
DOI:
10.1016/j.molimm.2016.04.005

4. Purification, characterization and allergenicity assessment of 26kDa protein, a major allergen from Cicer arietinum

Author:
Verma, Alok Kumar; Sharma, Akanksha; Kumar, Sandeep; Gupta, Rinkesh Kumar; Kumar, Dinesh; Gupta, Kriti; Giridhar, B.H.; Das, Mukul; Dwivedi, Premendra D.
Source:
Molecular Immunology 2016 v.74 pp. 113-124
ISSN:
0161-5890
Subject:
Cicer arietinum; GATA transcription factors; albumins; allergenicity; allergens; anion exchange chromatography; chickpeas; crude protein; crystal structure; dietary fiber; essential amino acids; fractionation; histamine; hypersensitivity; immunoglobulin E; in vitro studies; interleukin-13; interleukin-4; interleukin-5; intestines; mast cells; messenger RNA; mice; minerals; models; myeloperoxidase; patients; prostaglandins; protein kinase C; tandem mass spectrometry; vitamins
Abstract:
... Chickpea (CP), a legume of the family Fabaceae, is an important nutrient-rich food providing protein, essential amino acids, vitamins, dietary fibre, and minerals. Unfortunately, several IgE-binding proteins in CP have been detected that are responsible for allergic manifestations in sensitized population. Therefore, the prevalence of CP induced allergy prompted us towards purification, characteri ...
DOI:
10.1016/j.molimm.2016.05.002