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- Zhang, Guolong, et al. Show all 4 Authors
- Molecular Immunology 2014 v.57 pp. 171-180
- Plectranthus barbatus; adenosine monophosphate; adenylate cyclase; agonists; butyrates; chickens; cyclic AMP; disease resistance; drug therapy; explants; forskolin; gene expression; humans; immunomodulators; innate immunity; jejunum; macrophages; mitogen-activated protein kinase; peptides
- ... Host defense peptides (HDP) have both microbicidal and immunomodulatory properties. Specific induction of endogenous HDP synthesis has emerged as a novel approach to antimicrobial therapy. Cyclic adenosine monophosphate (cAMP) and butyrate have been implicated in HDP induction in humans. However, the role of cAMP signaling and the possible interactions between cAMP and butyrate in regulating HDP e ...
- Zhang, Guolong, et al. Show all 5 Authors
- Molecular Immunology 2014 v.59 pp. 55-63
- adaptive immunity; adjuvants; antibacterial properties; antibiotic resistance; cathelicidins; chemokine CCL2; chemokine CCL3; chemotaxis; chickens; drug therapy; immunoglobulin G; immunomodulators; innate immunity; interleukin-1beta; lipopolysaccharides; lymphocytes; macrophages; methicillin; methicillin-resistant Staphylococcus aureus; mice; monocytes; neutrophils; ovalbumin; peritoneum; vaccine development; vaccines
- ... Appropriate modulation of immunity is beneficial in antimicrobial therapy and vaccine development. Host defense peptides (HDPs) constitute critically important components of innate immunity with both antimicrobial and immune regulatory activities. We previously showed that a chicken HDP, namely fowlicidin-1(6-26), has potent antibacterial activities in vitro and in vivo. Here we further revealed t ...