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- Author:
- Lappas, Martha
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 74-83
- ISSN:
- 0303-7207
- Subject:
- adipose tissue; advanced glycation end products; caspase-1; free fatty acids; gestational diabetes; glucose; inflammation; insulin; insulin resistance; interleukin-1beta; palmitates; phosphorylation; protein synthesis; secretion; signal transduction; women
- Abstract:
- ... Gestational diabetes mellitus (GDM) is characterised by maternal peripheral insulin resistance, increased inflammation, and increasing levels of circulating free fatty acids (FFAs) and advanced glycation endproducts (AGEs). Caspase-1 is a key component of the inflammasome, which is activated upon cellular infection or stress to trigger the maturation IL-1β, a pro-inflammatory cytokine that mediate ...
- DOI:
- 10.1016/j.mce.2013.09.011
-
http://dx.doi.org/10.1016/j.mce.2013.09.011
- Author:
- Regueira, M.; Riera, M.F.; Galardo, M.N.; Pellizzari, E.H.; Cigorraga, S.B.; Meroni, S.B.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 271-281
- ISSN:
- 0303-7207
- Subject:
- Sertoli cells; carnitine palmitoyltransferase; fatty acids; genes; germ cells; lactic acid; messenger RNA; metabolism; peroxisome proliferator-activated receptors; pyruvate dehydrogenase (lipoamide); pyruvic acid; rats
- Abstract:
- ... The purpose of this study was to evaluate the existence of a possible simultaneous regulation of fatty acid (FA) metabolism and lactate production by PPAR α and PPAR β/δ activation in Sertoli cells (SC). SC cultures obtained from 20-day-old rats were incubated with WY14643 or GW0742—pharmacological activators of PPAR α and PPAR β/δ respectively. The fatty acid transporter CD36, carnitine palmitoyl ...
- DOI:
- 10.1016/j.mce.2013.10.006
-
http://dx.doi.org/10.1016/j.mce.2013.10.006
- Author:
- Beales, Ian L.P.; Garcia-Morales, Carla; Ogunwobi, Olorunseun O.; Mutungi, Gabriel
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 150-158
- ISSN:
- 0303-7207
- Subject:
- adenocarcinoma; adiponectin; apoptosis; leptin; neoplasm cells; non-specific protein-tyrosine kinase; obesity; secretion; signal transduction; transcription (genetics); tyrosine
- Abstract:
- ... Obesity is characterised by hyperleptinaemia and hypoadiponectinaemia and these metabolic abnormalities may contribute to the progression of several obesity-associated cancers including oesophageal adenocarcinoma (OAC). We have examined the effects of leptin and adiponectin on OE33 OAC cells. Leptin stimulated proliferation, invasion and migration and inhibited apoptosis in a STAT3-dependant manne ...
- DOI:
- 10.1016/j.mce.2013.08.013
-
http://dx.doi.org/10.1016/j.mce.2013.08.013
- Author:
- Jung, Tae Woo; Lee, So Young; Hong, Ho Cheol; Choi, Hae Yoon; Yoo, Hye Jin; Baik, Sei Hyun; Choi, Kyung Mook
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 66-73
- ISSN:
- 0303-7207
- Subject:
- AMP-activated protein kinase; Toll-like receptor 4; binding proteins; carrageenan; endoplasmic reticulum; hepatocytes; human cell lines; inflammation; insulin resistance; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; selenoproteins
- Abstract:
- ... Carrageenan (CGN) has been shown to cause inflammation through toll-like receptor 4, which may play an important role in insulin resistance and type 2 diabetes mellitus. Selenoprotein P (SeP) has recently been identified as a novel hepatokine that causes insulin resistance. Here, we report that treatment of HepG2 cells with CGN increased both CCAAT enhancer binding protein homologous protein (CHOP ...
- DOI:
- 10.1016/j.mce.2013.09.013
-
http://dx.doi.org/10.1016/j.mce.2013.09.013
- Author:
- Cheng, Shi-Bin; Dong, Jing; Pang, Yefei; LaRocca, Jessica; Hixon, Mary; Thomas, Peter; Filardo, Edward J.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 950-959
- ISSN:
- 0303-7207
- Subject:
- aldosterone; antagonists; epithelium; estrogens; estrus; humans; mice; mineralocorticoid receptors; plasma membrane; proestrus; proximal tubules; spironolactone; staining
- Abstract:
- ... Prior studies have linked renoprotective effects of estrogens to G-protein-coupled estrogen receptor-1 (GPER-1) and suggest that aldosterone may also activate GPER-1. Here, the role of GPER-1 in murine renal tissue was further evaluated by examining its anatomical distribution, subcellular distribution and steroid binding specificity. Dual immunofluorescent staining using position-specific markers ...
- DOI:
- 10.1016/j.mce.2013.11.005
-
http://dx.doi.org/10.1016/j.mce.2013.11.005
- Author:
- Gyires, Klára; Rónai, András Z.; Zádori, Zoltán S.; Tóth, Viktória E.; Németh, József; Szekeres, Mária; Hunyady, László
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 971-978
- ISSN:
- 0303-7207
- Subject:
- agonists; angiotensin II; atropine; cannabinoid receptors; cannabinoids; ethanol; knockout mutants; lipoprotein lipase; males; mice; rats; transcriptional activation
- Abstract:
- ... The aim of the present study was to analyze whether angiotensin II via the endocannabinoid system can induce gastric mucosal protection, since transactivation of cannabinoid CB1 receptors by angiotensin AT1 receptor in CHO cells was described. Experimental ulcer was induced by acidified ethanol given orally in male Wistar rats, CB1(+/+) wild type and CB1(−/−) knockout mice. The compounds were admi ...
- DOI:
- 10.1016/j.mce.2013.10.002
-
http://dx.doi.org/10.1016/j.mce.2013.10.002
- Author:
- Munetsuna, Eiji; Kawanami, Rie; Nishikawa, Miyu; Ikeda, Shinnosuke; Nakabayashi, Sachie; Yasuda, Kaori; Ohta, Miho; Kamakura, Masaki; Ikushiro, Shinichi; Sakaki, Toshiyuki
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 960-970
- ISSN:
- 0303-7207
- Subject:
- 25-hydroxycholecalciferol; DNA microarrays; bioactive properties; cell culture; cell growth; gene expression; genes; humans; messenger RNA; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... 1α-Hydroxylation of 25-hydroxyvitamin D3 is believed to be essential for its biological effects. In this study, we evaluated the biological activity of 25(OH)D3 itself comparing with the effect of cell-derived 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). First, we measured the cell-derived 1α,25(OH)2D3 level in immortalized human prostate cell (PZ-HPV-7) using [3H]-25(OH)D3. The effects of the cell-d ...
- DOI:
- 10.1016/j.mce.2013.11.014
-
http://dx.doi.org/10.1016/j.mce.2013.11.014
- Author:
- Wang, Yue; Qu, Ye; Zhang, Xiao Lei; Xing, Jie; Niu, Xiu Long; Chen, Xiao; Li, Zong Min
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 791-803
- ISSN:
- 0303-7207
- Subject:
- animal ovaries; antagonists; autocrine signaling; estrogen receptors; gene overexpression; interleukin-6; neoplasm cells; ovarian neoplasms; patients; plasmids; steroid hormone receptors; tamoxifen; therapeutics
- Abstract:
- ... Although 40–60% of ovarian cancer (OVCA)s express estrogen receptor (ER)α, only a minor proportion of patients respond to anti-estrogen treatment with ER antagonist tamoxifen (TAM). The mechanism underlying TAM resistance in the course of OVCA progression is incompletely understood. However, interleukin-6 (IL-6) plays a critical role in the development and progression of OVCA. Here we explore an a ...
- DOI:
- 10.1016/j.mce.2013.10.029
-
http://dx.doi.org/10.1016/j.mce.2013.10.029
- Author:
- Dettling, Juliane; Franz, Christoph; Zimmermann, Ulrike; Lee, Sze Chim; Bress, Andreas; Brandt, Niels; Feil, Robert; Pfister, Markus; Engel, Jutta; Flamant, Frédéric; Rüttiger, Lukas; Knipper, Marlies
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 26-37
- ISSN:
- 0303-7207
- Subject:
- brain stem; deafness; hearing; mice; mutants; mutation; signal transduction; thyroid hormone receptors; thyroid hormones; transcription (genetics)
- Abstract:
- ... Thyroid hormone acts on gene transcription by binding to its nuclear receptors TRα1 and TRβ. Whereas global deletion of TRβ causes deafness, global TRα-deficient mice have normal hearing thresholds. Since the individual roles of the two receptors in cochlear hair cells are still unclear, we generated mice with a hair cell-specific mutation of TRα1 or deletion of TRβ using the Cre-loxP system. Hair ...
- DOI:
- 10.1016/j.mce.2013.08.025
-
http://dx.doi.org/10.1016/j.mce.2013.08.025
- Author:
- Landomiel, Flavie; Gallay, Nathalie; Jégot, Gwenhael; Tranchant, Thibaud; Durand, Guillaume; Bourquard, Thomas; Crépieux, Pascale; Poupon, Anne; Reiter, Eric
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 452-459
- ISSN:
- 0303-7207
- Subject:
- G-protein coupled receptors; antibodies; chemical structure; cyclic AMP; drugs; follicle-stimulating hormone; glycosylation; ligands; mutants; mutation; reproduction; signal transduction
- Abstract:
- ... Follicle-stimulating hormone (FSH) plays a crucial role in the control of reproduction by specifically binding to and activating a membrane receptor (FSHR) that belongs to the G protein-coupled receptor (GPCR) family. Similar to all GPCRs, FSHR activation mechanisms have generally been viewed as a two-state process connecting a unique FSH-bound active receptor to the Gs/cAMP pathway. Over the last ...
- DOI:
- 10.1016/j.mce.2013.09.035
-
http://dx.doi.org/10.1016/j.mce.2013.09.035
- Author:
- Palmieri, Carlo; Patten, Darren K.; Januszewski, Adam; Zucchini, Giorgia; Howell, Sacha J.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 695-723
- ISSN:
- 0303-7207
- Subject:
- adjuvants; aromatase; breast neoplasms; estrogen receptors; hormones; mammals; metastasis; postmenopause; survival rate; tamoxifen; therapeutics
- Abstract:
- ... Endocrine therapy forms a central modality in the treatment of estrogen receptor positive breast cancer. The routine use of 5years of adjuvant tamoxifen has improved survival rates for early breast cancer, and more recently has evolved in the postmenopausal setting to include aromatase inhibitors. The optimal duration of adjuvant endocrine therapy remains an active area of clinical study with rece ...
- DOI:
- 10.1016/j.mce.2013.08.001
-
http://dx.doi.org/10.1016/j.mce.2013.08.001
- Author:
- Poursharifi, Pegah; Lapointe, Marc; Fisette, Alexandre; Lu, Huiling; Roy, Christian; Munkonda, Mercedes Nancy; Fairlie, David P.; Cianflone, Katherine
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 325-333
- ISSN:
- 0303-7207
- Subject:
- acylation; adipocytes; adipose tissue; cytokines; dimerization; gene expression; immune response; insulin; ligands; messenger RNA; metabolism; phosphorylation; receptors; secretion; signal transduction; transcription factor NF-kappa B; triacylglycerols
- Abstract:
- ... Recent studies suggested that the immunometabolic receptors; C5aR and C5L2, constitutively self-associate into homo-/heterodimers and that acylation stimulating protein (ASP/C3adesArg) or C5a treatment of adipocytes increased their colocalization. The present study evaluates the C5aR contribution in adipocytes to the metabolic and immune responses elicited by ligand stimulation.The effects of C5a, ...
- DOI:
- 10.1016/j.mce.2013.10.019
-
http://dx.doi.org/10.1016/j.mce.2013.10.019
- Author:
- Cong, Binhai; Xu, Yongjun; Sheng, Hui; Zhu, Xiaoyan; Wang, Long; Zhao, Wei; Tang, Zhiping; Lu, Jianqiang; Ni, Xin
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 17-25
- ISSN:
- 0303-7207
- Subject:
- agonists; antagonists; cardiomyocytes; estradiol; estrogen receptors; hypoxia; mice; ovariectomy; rats
- Abstract:
- ... Estrogens have been suggested to exert cardioprotection through maintaining endogenous cardioprotective mechanisms. In the present study, we investigated whether estrogens protect cardiomyocytes against hypoxia/reoxygenation (H/R) via modulating urocortins (UCNs) and their receptor corticotrophin-releasing hormone receptor type 2 (CRHR2). We found that 17β-estradiol (E2) enhanced UCN cardioprotect ...
- DOI:
- 10.1016/j.mce.2013.09.002
-
http://dx.doi.org/10.1016/j.mce.2013.09.002
- Author:
- Beltramo, Massimiliano; Dardente, Hugues; Cayla, Xavier; Caraty, Alain
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 387-399
- ISSN:
- 0303-7207
- Subject:
- blood; breeding; females; gonadotropin-releasing hormone; hypothalamus; luteinizing hormone; neurons; proteins; rodents; secretion; signal transduction
- Abstract:
- ... The hypothalamus integrates endogenous and exogenous inputs to control the pituitary–gonadal axis. The ultimate hypothalamic influence on reproductive activity is mediated through timely secretion of GnRH in the portal blood, which modulates the release of gonadotropins from the pituitary. In this context neurons expressing the RF-amide neuropeptide kisspeptin present required features to fulfill ...
- DOI:
- 10.1016/j.mce.2013.10.015
-
http://dx.doi.org/10.1016/j.mce.2013.10.015
- Author:
- Ruscica, M.; Magni, P.; Steffani, L.; Gatto, F.; Albertelli, M.; Rametta, R.; Valenti, L.; Ameri, P.; Magnaghi, V.; Culler, M.D.; Minuto, F.; Ferone, D.; Arvigo, M.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 860-870
- ISSN:
- 0303-7207
- Subject:
- cell growth; cell membranes; cell proliferation; humans; microsatellite repeats; models; neoplasm cells; prostatic neoplasms; receptors; somatostatin
- Abstract:
- ... Somatostatin (SST) and SST receptors (SS1R, SS2R, SS3R, SS4R and SS5R) appear to play a significant role in the progression of human prostate cancer (PCa), which is associated with heterogeneity of SSRs expression and specific cell localization as we already demonstrated in the LNCaP cell line, an in vitro model of human androgen-dependent PCa. In this study, PC-3 and DU-145 human castration-resis ...
- DOI:
- 10.1016/j.mce.2013.10.027
-
http://dx.doi.org/10.1016/j.mce.2013.10.027
- Author:
- Magnani, Luca; Lupien, Mathieu
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 633-641
- ISSN:
- 0303-7207
- Subject:
- DNA; breast neoplasms; chromatin; epigenetics; estrogen receptors; growth factors
- Abstract:
- ... The oestrogen receptor alpha (ESR1) is a transcription factor that potentiates the response to diverse stimuli, including oestrogen and growth factors, in various tissue types. Its recruitment to the DNA is directly regulated by the chromatin landscape, inclusive of chromatin compaction and epigenetic modifications. In this review we discuss our current understanding of the interplay between ESR1 ...
- DOI:
- 10.1016/j.mce.2013.04.026
-
http://dx.doi.org/10.1016/j.mce.2013.04.026
- Author:
- Panis, C.; Herrera, A.C.S.A.; Aranome, A.M.F.; Victorino, V.J.; Michelleti, P.L.; Morimoto, H.K.; Cecchini, A.L.; Simão, A.N.C.; Cecchini, R.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 190-196
- ISSN:
- 0303-7207
- Subject:
- adiponectin; anti-inflammatory activity; antioxidants; breast neoplasms; correlation; cytokines; drug therapy; estrogen receptors; humans; inflammation; metastasis; obesity; oxidative stress; patients; prognosis; women
- Abstract:
- ... Adiponectin is a cytokine reported as a determinant of poor prognosis in women with breast cancer. However, because data regarding its role in breast cancer have been obtained primarily from studies employing overweight or obese women, the adiponectin profile in non-obese women is poorly understood. In this study, we determined adiponectin levels in plasma from non-obese women with breast cancer a ...
- DOI:
- 10.1016/j.mce.2013.09.030
-
http://dx.doi.org/10.1016/j.mce.2013.09.030
- Author:
- Feng, Chun-Wei; Bowles, Josephine; Koopman, Peter
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 488-497
- ISSN:
- 0303-7207
- Subject:
- adults; animal ovaries; females; genes; males; mammals; meiosis; neoplasms; oocytes; puberty; reproduction; retinoic acid; spermatozoa; testes
- Abstract:
- ... Germ cells are unique in undergoing meiosis to generate oocytes and sperm. In mammals, meiosis onset is before birth in females, or at puberty in males, and recent studies have uncovered several regulatory steps involved in initiating meiosis in each sex. Evidence suggests that retinoic acid (RA) induces expression of the critical pre-meiosis gene Stra8 in germ cells of the fetal ovary, pubertal t ...
- DOI:
- 10.1016/j.mce.2013.09.026
-
http://dx.doi.org/10.1016/j.mce.2013.09.026
- Author:
- Wang, Ying; Liu, Dan; Zhao, Huan; Jiang, Huixing; Luo, Chen; Wang, Min; Yin, Hongping
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 979-988
- ISSN:
- 0303-7207
- Subject:
- Ophiocordyceps sinensis; cell proliferation; dose response; humans; mitogen-activated protein kinase; platelet-derived growth factor; polysaccharides; renal failure; signal transduction; transforming growth factor beta 1
- Abstract:
- ... CPS-2, a Cordyceps sinensis polysaccharide, has been demonstrated to have significant therapeutic activity against chronic renal failure. However, little is known about the underlying molecular mechanism. In this study, we found that CPS-2 could inhibit PDGF-BB-induced human mesangial cells (HMCs) proliferation in a dose-dependent manner. In addition, CPS-2 notably suppressed the expression of α-S ...
- DOI:
- 10.1016/j.mce.2013.11.018
-
http://dx.doi.org/10.1016/j.mce.2013.11.018
- Author:
- Li, Hong; Gao, Si; Ye, Jiantao; Feng, Xiaojun; Cai, Yi; Liu, Zhiping; Lu, Jing; Li, Qin; Huang, Xiaoyang; Chen, Shaorui; Liu, Peiqing
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 998-1006
- ISSN:
- 0303-7207
- Subject:
- RNA interference; T-lymphocytes; cardiomyocytes; cyclosporine; endothelins; gene expression; genes; heart failure; hypertrophy; messenger RNA; promoter regions; prostaglandin synthase; rats; surface area; transcription (genetics)
- Abstract:
- ... Endothelin-1 (ET-1) is a critical molecule that involved in heart failure. It has been proved that ET-1 stimulation results in cardiac hypertrophy both in vitro and in vivo, but the mechanisms underlying remain largely unknown. In this study, we reported that cyclooxygenase-2 (COX-2) might be an important mediator of hypertrophic responses to ET-1 stimulation. In the cultured rat neonatal cardiomy ...
- DOI:
- 10.1016/j.mce.2013.11.012
-
http://dx.doi.org/10.1016/j.mce.2013.11.012
- Author:
- Biver, Emmanuel; Thouverey, Cyril; Magne, David; Caverzasio, Joseph
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 120-130
- ISSN:
- 0303-7207
- Subject:
- alkaline phosphatase; bone formation; calcification; fibroblast growth factor receptors; fibroblast growth factors; humans; mitogen-activated protein kinase; receptors; signal transduction; stem cells; tyrosine
- Abstract:
- ... Bone morphogenic proteins (BMPs) promote mesenchymal stem cell (MSC) osteogenic differentiation, whereas platelet derived growth factor (PDGF) and fibroblast growth factor (FGF) activate their proliferation through receptors tyrosine kinase (RTK). The effects of PDGF or FGF receptor signaling pathway on BMP2-induced osteoblastic differentiation was investigated in human MSC (HMSC). Inhibition of P ...
- DOI:
- 10.1016/j.mce.2013.09.018
-
http://dx.doi.org/10.1016/j.mce.2013.09.018
- Author:
- Chen, Li; Lei, Kaiyu; Malawana, Johann; Yulia, Angela; Sooranna, Suren R.; Bennett, Phillip R.; Liang, Zhiqing; Grammatopoulos, Dimitri; Johnson, Mark R.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 334-343
- ISSN:
- 0303-7207
- Subject:
- cyclic AMP; endometrium; forskolin; humans; pregnancy; progesterone; progesterone receptors; transcription factor NF-kappa B; uterine neoplasms
- Abstract:
- ... Cyclic AMP (cAMP) has been shown to promote progesterone and glucocorticoid action in a variety of cellular settings. In this study, we have used human myometrial cells to investigate whether cAMP potentiates the ability of progesterone to repress IL-1β-driven COX-2 expression. We found that forskolin enhanced progesterone-repression of IL-1β-driven COX-2 expression in association with delayed IL- ...
- DOI:
- 10.1016/j.mce.2013.10.018
-
http://dx.doi.org/10.1016/j.mce.2013.10.018
- Author:
- Chin, Andrew R.; Wang, Shizhen Emily
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 598-602
- ISSN:
- 0303-7207
- Subject:
- breast neoplasms; chemokine CCL2; disease course; drug therapy; drugs; interleukin-6; interleukin-8; mechanism of action; models; neoplasm cells; patients; radiotherapy; stem cells; transforming growth factor beta
- Abstract:
- ... There is increasing evidence for the cancer stem cell model in which a subset of cancer cells possessing stem cell properties, referred to as tumor-initiating or cancer stem-like cells (CSCs), play crucial roles in multiple aspects of cancer. Recent studies have started to characterize the crucial role of various cytokines in the tumor microenvironment in regulating the fate of CSCs. In this revie ...
- DOI:
- 10.1016/j.mce.2013.03.024
-
http://dx.doi.org/10.1016/j.mce.2013.03.024
- Author:
- Germano, Antonina; Rapa, Ida; Volante, Marco; Lo Buono, Nicola; Carturan, Sonia; Berruti, Alfredo; Terzolo, Massimo; Papotti, Mauro
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 1-7
- ISSN:
- 0303-7207
- Subject:
- apoptosis; cytotoxicity; genes; interphase; mitotane; neoplasm cells
- Abstract:
- ... We aimed at investigating in vitro the cytotoxic activity (determined using WST-1, apoptosis and cell cycle assays) of gemcitabine, alone or in combination with mitotane, in mitotane-sensitive H295R and mitotane-insensitive SW-13 cells. Results of these experiments were compared with drug-induced modulation of RRM1 gene, the specific target of gemcitabine. In H295R cells, mitotane and gemcitabine ...
- DOI:
- 10.1016/j.mce.2013.08.023
-
http://dx.doi.org/10.1016/j.mce.2013.08.023
- Author:
- Wang, Bin; Qin, Chaobin; Zhang, Cong; Jia, Jirong; Sun, Caiyun; Li, Wensheng
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 851-859
- ISSN:
- 0303-7207
- Subject:
- Epinephelus coioides; cAMP-dependent protein kinase; cyclic AMP; cyclic GMP; forskolin; nitric oxide; protein kinase C; secretion; signal transduction; somatoliberin; somatostatin; somatotropin
- Abstract:
- ... Somatostatin is the most effective inhibitor of GH release, and GHRH was recently identified as one of the primary GH-releasing factors in teleosts. In this study, we analyzed the possible intracellular transduction pathways that are involved in the mechanisms induced by SRIF and GHRH to regulate GH release. Using a pharmacological approach, the blockade of the PLC/IP/PKC pathway reversed the SRIF ...
- DOI:
- 10.1016/j.mce.2013.10.025
-
http://dx.doi.org/10.1016/j.mce.2013.10.025
- Author:
- Lucas, Thaís F.G.; Lazari, Maria Fatima M.; Porto, Catarina S.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 84-96
- ISSN:
- 0303-7207
- Subject:
- GATA transcription factors; Sertoli cells; agonists; cell cycle; cell differentiation; cell proliferation; estradiol; estrogen receptors; phosphatidylinositol 3-kinase; rats; thymidine; transcription factor NF-kappa B
- Abstract:
- ... The aim of the present study was to investigate the role of each estrogen receptors on the regulation of proteins involved with proliferation and differentiation of Sertoli cells from 15-day-old rats. Activation of ESR1 by 17β-estradiol (E2) and ESR1-selective agonist PPT increased CCND1 expression, and this effect was dependent on NF-kB activation. E2 and the ESR2-selective agonist DPN, but not P ...
- DOI:
- 10.1016/j.mce.2013.09.015
-
http://dx.doi.org/10.1016/j.mce.2013.09.015
- Author:
- Li, Qiang; Su, Zhipeng; Liu, Jie; Cai, Lin; Lu, Jianglong; Lin, Shaojian; Xiong, Zhengkun; Li, Weiqiang; Zheng, Weiming; Wu, Jinsen; Zhuge, Qichuan; Wu, Zhebao
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 377-384
- ISSN:
- 0303-7207
- Subject:
- adenoma; agonists; bromocriptine; caspase-3; cell growth; cell viability; dopamine; dopamine receptors; mice; rats; transfection; vector control
- Abstract:
- ... Bromocriptine, a dopamine agonist (DA), has been used in the treatment of prolactinomas. Recent studies have indicated that dopamine 2 receptor short isoform (D2S) may play an important role in suppressing PRL synthesis and prolactinoma cell growth under DA treatment. In the current study, we investigated the role of D2S in the therapeutic action of bromocriptine in GH3 using both in vitro and in ...
- DOI:
- 10.1016/j.mce.2013.10.021
-
http://dx.doi.org/10.1016/j.mce.2013.10.021
- Author:
- Kararigas, Georgios; Nguyen, Ba Tiep; Jarry, Hubertus
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 909-914
- ISSN:
- 0303-7207
- Subject:
- body weight; diet; estradiol; estrogen receptors; genes; heart; mice; ovariectomy; uterus
- Abstract:
- ... The modulation of cardiac growth by estrogen in healthy mice is not completely understood. The aim was to investigate the effects of estrogen on cardiac growth in healthy mice lacking either estrogen receptor (ER) α or β. Wild-type (WT), ERα knockout (ERKO) and ERβ knockout (BERKO) 2-month-old mice were ovariectomized and randomly assigned to groups receiving an estradiol (E2)-containing or soy-fr ...
- DOI:
- 10.1016/j.mce.2013.11.011
-
http://dx.doi.org/10.1016/j.mce.2013.11.011
- Author:
- Haldosén, Lars-Arne; Zhao, Chunyan; Dahlman-Wright, Karin
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 665-672
- ISSN:
- 0303-7207
- Subject:
- agonists; animal models; antibodies; breast neoplasms; estrogen receptors; humans; mammary development; tissues
- Abstract:
- ... Estrogen is essential for growth and development of the mammary glands and has been associated with the promotion and growth of breast cancer and in line with this, most human breast cancers are initially estrogen-dependent and undergo regression when deprived of their supporting hormone. Estrogen exerts many of its effects via two nuclear estrogen receptors (ERs), ERα and ERβ. The discovery of a ...
- DOI:
- 10.1016/j.mce.2013.08.005
-
http://dx.doi.org/10.1016/j.mce.2013.08.005
- Author:
- Liu, Mei Hui; Cheung, Edwin
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 624-632
- ISSN:
- 0303-7207
- Subject:
- breast neoplasms; chromatin; genes; neoplasm cells; transcription (genetics)
- Abstract:
- ... Estrogen induces the binding of ERα to thousands of locations in the breast cancer genome, preferring intergenic and distal regions rather than near the promoters of estrogen-regulated genes. With recent technological innovations in mapping and characterization of global chromatin organization, evidence now indicates ERα mediates long-range chromatin interactions to control gene transcription. The ...
- DOI:
- 10.1016/j.mce.2013.09.019
-
http://dx.doi.org/10.1016/j.mce.2013.09.019
- Author:
- Becquet, Denis; Boyer, Bénédicte; Rasolonjanahary, Ramahefarizo; Brue, Thierry; Guillen, Séverine; Moreno, Mathias; Franc, Jean-Louis; François-Bellan, Anne-Marie
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 888-898
- ISSN:
- 0303-7207
- Subject:
- DNA microarrays; circadian rhythm; equations; genes; mice; mutants; physiology; prolactin; rats
- Abstract:
- ... In primary cultures of rat pituitary cells and in a pituitary sommatolactotroph cell line (GH4C1), endogenous core-clock- as well as hormone-genes such as prolactin displayed a rhythmic expression pattern, fitted by a sinusoidal equation in which the period value was close to the circadian one. This is consistent with the presence of a functional circadian oscillator in pituitary cells whose impor ...
- DOI:
- 10.1016/j.mce.2013.11.004
-
http://dx.doi.org/10.1016/j.mce.2013.11.004
- Author:
- Ramirez, Maria Cecilia; Zubeldía-Brenner, Lautaro; Wargon, Victoria; Ornstein, Ana María; Becu-Villalobos, Damasia
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 825-834
- ISSN:
- 0303-7207
- Subject:
- adulthood; endocrine-disrupting chemicals; females; gene expression; genes; liver; males; masculinization; messenger RNA; methylation; mice; signal transduction; testosterone
- Abstract:
- ... Neonatal androgenization masculinizes the GH axis and thus may impact on liver gene regulation. Neonatal testosterone administration to female mice decreased (defeminized) female predominant GH-dependent liver gene expression (Hnf6, Adh1, Prlr, Cyp3a41) and did not modify male predominant genes (Cyp7b1, Cyp4a12, Slp). Female predominance of Cis mRNA, an inhibitor of episodic GH signaling pathway, ...
- DOI:
- 10.1016/j.mce.2013.11.003
-
http://dx.doi.org/10.1016/j.mce.2013.11.003
- Author:
- Pharo, Elizabeth A.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 871-880
- ISSN:
- 0303-7207
- Subject:
- Macropus eugenii; beta-lactoglobulin; cattle; colostrum; cortisol; dogs; early lactation; explants; genes; insulin; mammary glands; models; pregnancy; prolactin; repressor proteins; trypsin inhibitors
- Abstract:
- ... Marsupial ELP (early lactation protein) and its eutherian orthologue, CTI (colostrum trypsin inhibitor) are expressed in the mammary gland only for the first 100days postpartum (Phase 2A) in the tammar wallaby and during the bovine and canine colostrogenesis period 24–36h postpartum respectively. The factors which regulate temporal ELP and CTI expression are unknown. A tammar mammary gland explant ...
- DOI:
- 10.1016/j.mce.2013.10.030
-
http://dx.doi.org/10.1016/j.mce.2013.10.030
- Author:
- Zambrano, Elena; Guzmán, Carolina; Rodríguez-González, Guadalupe L.; Durand-Carbajal, Marta; Nathanielsz, Peter W.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 538-549
- ISSN:
- 0303-7207
- Subject:
- Primates; cardiovascular system; diabetes; females; fetal development; hypertension; males; obesity; phenotype; progeny; puberty; rats; reproductive performance; sheep
- Abstract:
- ... The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function. In rats, sheep and nonhuman primates, reproduc ...
- DOI:
- 10.1016/j.mce.2013.09.008
-
http://dx.doi.org/10.1016/j.mce.2013.09.008
- Author:
- Negahdar, Maria; Aukrust, Ingvild; Molnes, Janne; Solheim, Marie H.; Johansson, Bente B.; Sagen, Jørn V.; Dahl-Jørgensen, Knut; Kulkarni, Rohit N.; Søvik, Oddmund; Flatmark, Torgeir; Njølstad, Pål R.; Bjørkhaug, Lise
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 55-65
- ISSN:
- 0303-7207
- Subject:
- diabetes; enzyme activity; genes; glucokinase; hydrogen bonding; hyperglycemia; islets of Langerhans; mutants; mutation; oxygen; protein folding; proteolysis; trypsin
- Abstract:
- ... GCK-MODY, dominantly inherited mild hyperglycemia, is associated with more than 600 mutations in the glucokinase gene. Different molecular mechanisms have been shown to explain GCK-MODY. Here, we report a Pakistani family harboring the glucokinase mutation c.823C>T (p.R275C). The recombinant and in cellulo expressed mutant pancreatic enzyme revealed slightly increased enzyme activity (kcat) and no ...
- DOI:
- 10.1016/j.mce.2013.08.020
-
http://dx.doi.org/10.1016/j.mce.2013.08.020
- Author:
- Groop, Leif; Pociot, Flemming
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 726-739
- ISSN:
- 0303-7207
- Subject:
- blood vessels; exercise; eyes; genes; heart; heritability; hyperglycemia; insulin; insulin resistance; insulin secretion; insulin-dependent diabetes mellitus; islets of Langerhans; kidneys; nerve tissue; noninsulin-dependent diabetes mellitus; obesity; patients; risk; Europe
- Abstract:
- ... Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of different organs, especially the eyes, kidneys, nerves, heart, and blood vessels. Several pathogenic processes are involved in the development of diabetes ...
- DOI:
- 10.1016/j.mce.2013.04.002
-
http://dx.doi.org/10.1016/j.mce.2013.04.002
- Author:
- He, Chunyan; Murabito, Joanne M.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 767-779
- ISSN:
- 0303-7207
- Subject:
- genome-wide association study; heritability; loci; menarche; menopause; prediction; risk; translation (genetics)
- Abstract:
- ... Genome-wide association studies (GWAS) have been successful in uncovering genetic determinants of age at menarche and age at natural menopause. To date, more than 30 novel genetic loci have been identified in GWAS for age at menarche and 17 for age at natural menopause. These findings have stimulated a plethora of follow-up studies particularly with respect to the functional characterization of th ...
- DOI:
- 10.1016/j.mce.2012.05.003
-
http://dx.doi.org/10.1016/j.mce.2012.05.003
- Author:
- Fall, Tove; Ingelsson, Erik
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 740-757
- ISSN:
- 0303-7207
- Subject:
- appetite; body mass index; genes; genome-wide association study; metabolic syndrome; obesity; single nucleotide polymorphism; systematic review
- Abstract:
- ... Until just a few years ago, the genetic determinants of obesity and metabolic syndrome were largely unknown, with the exception of a few forms of monogenic extreme obesity. Since genome-wide association studies (GWAS) became available, large advances have been made. The first single nucleotide polymorphism robustly associated with increased body mass index (BMI) was in 2007 mapped to a gene with f ...
- DOI:
- 10.1016/j.mce.2012.08.018
-
http://dx.doi.org/10.1016/j.mce.2012.08.018
- Author:
- Vandenput, Liesbeth; Ohlsson, Claes
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 758-766
- ISSN:
- 0303-7207
- Subject:
- blood serum; genome-wide association study; heritability; loci; neoplasms; noninsulin-dependent diabetes mellitus; prasterone; sex hormone-binding globulin; steroid hormones; testosterone
- Abstract:
- ... Even though the levels of circulating sex steroid hormones are to a large extent heritable, their genetic determinants are largely unknown. With the advent of genome-wide association studies (GWAS), much progress has been made and several genetic loci have been identified to be associated with serum levels of dehydroepiandrosterone sulfate, testosterone and sex hormone-binding globulin. The varian ...
- DOI:
- 10.1016/j.mce.2013.03.009
-
http://dx.doi.org/10.1016/j.mce.2013.03.009
- Author:
- Benko, Ann L.; Olsen, Nancy J.; Kovacs, William J.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 881-887
- ISSN:
- 0303-7207
- Subject:
- B-lymphocytes; antagonists; antibodies; cell viability; cytidine deaminase; dexamethasone; dose response; glucocorticoid receptors; glucocorticoids; humans; humoral immunity; immunoglobulin genes; interleukin-4; messenger RNA
- Abstract:
- ... We examined whether glucocorticoids could modulate the expression of activation-induced cytidine deaminase (AICDA), the principal regulator of the processes of immunoglobulin gene somatic hypermutation and class switch recombination in B lymphocytes. Treatment of human B cells with IL-4 and anti-CD40 antibody for 18–20h resulted in induction of expression of AICDA mRNA by over 10-fold. Dexamethaso ...
- DOI:
- 10.1016/j.mce.2013.11.001
-
http://dx.doi.org/10.1016/j.mce.2013.11.001
- Author:
- Chalmers, Jennifer A.; Jang, Janet J.; Belsham, Denise D.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 262-270
- ISSN:
- 0303-7207
- Subject:
- 2-deoxyglucose; AMP-activated protein kinase; cystic fibrosis; energy; gene expression; glucose; homeostasis; messenger RNA; models; neuronal nitric oxide synthase; neurons; neuropeptides; phosphorylation; secretion; taste receptors
- Abstract:
- ... Glucose-sensing neurons play a role in energy homeostasis, yet how orexigenic neurons sense glucose remains unclear. As models of glucose-inhibited (GI) neurons, mHypoE-29/1 and mHypoA-NPY/GFP cells express the essential orexigenic neuropeptide AgRP and glucose sensing machinery. Exposure to increasing concentrations of glucose or the glucose analog 2-deoxyglucose (2-DG) results in a decrease in A ...
- DOI:
- 10.1016/j.mce.2013.10.013
-
http://dx.doi.org/10.1016/j.mce.2013.10.013
- Author:
- Felizola, Saulo J.A.; Nakamura, Yasuhiro; Satoh, Fumitoshi; Morimoto, Ryo; Kikuchi, Kumi; Nakamura, Tomohiro; Hozawa, Atsushi; Wang, Lin; Onodera, Yoshiaki; Ise, Kazue; McNamara, Keely M.; Midorikawa, Sanae; Suzuki, Shinichi; Sasano, Hironobu
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 170-177
- ISSN:
- 0303-7207
- Subject:
- adenoma; adrenal cortex; agonists; aldosterone; angiotensin II; brain; cortisol; forskolin; glutamate receptors; glutamic acid; humans; immunohistochemistry; messenger RNA; neurotransmitters; quantitative polymerase chain reaction; rats; steroidogenesis; tissues
- Abstract:
- ... l-glutamate is a major excitatory neurotransmitter in the mammalian brain. Glutamate receptors have been reported in the rat adrenal cortex and in human aldosterone-producing adenomas (APA). However, details regarding the expression levels and functions of these receptors in human adrenocortical tissues remain unknown.The mRNA levels of glutamate receptors were evaluated by qPCR in: 12 normal adre ...
- DOI:
- 10.1016/j.mce.2013.09.025
-
http://dx.doi.org/10.1016/j.mce.2013.09.025
- Author:
- Gaujoux, Sébastien; Chanson, Philippe; Bertherat, Jérôme; Sauvanet, Alain; Ruszniewski, Philippe
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 344-345
- ISSN:
- 0303-7207
- Subject:
- cyclic AMP; lesions (animal); liver; pancreas; signal transduction
- Abstract:
- ... One of the key messages of recent Salpea and Stratakis work is to underline the clinical similarities shared by these syndromes that could be explained by a defect in the same signaling pathway, i.e. activation of the cAMP pathway. That being said, we would like to emphasize that hepatopancreato-biliary lesions are one additional feature shared both by Carney complex and McCune Albright syndrome. ...
- DOI:
- 10.1016/j.mce.2013.10.020
-
http://dx.doi.org/10.1016/j.mce.2013.10.020
- Author:
- Bae, Seung-Min; Lim, Whasun; Jeong, Wooyoung; Lee, Jin-Young; Kim, Jinyoung; Han, Jae Yong; Bazer, Fuller W.; Song, Gwonhwa
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 46-54
- ISSN:
- 0303-7207
- Subject:
- angiogenesis; animal ovaries; cadherins; carcinogenesis; diethylstilbestrol; embryogenesis; epithelial cells; epithelium; genes; hormonal regulation; laying hens; messenger RNA; metastasis; mice; microRNA; ovarian neoplasms; oviducts; signal transduction; uterus; women
- Abstract:
- ... Beta-catenin (CTNNB1) is a dual function molecule that acts as a key component of the cadherin complex and WNT signaling pathway. It has a crucial role in embryogenesis, tumorigenesis, angiogenesis and progression of metastasis. Recently, it has been suggested that the CTNNB1 complex is a major regulator of development of the mouse oviduct and uterus. However, little is known about the CTNNB1 gene ...
- DOI:
- 10.1016/j.mce.2013.09.010
-
http://dx.doi.org/10.1016/j.mce.2013.09.010
- Author:
- Yamamura, Koki; Doi, Masao; Hayashi, Hida; Ota, Takumi; Murai, Iori; Hotta, Yunhong; Komatsu, Rie; Okamura, Hitoshi
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 131-138
- ISSN:
- 0303-7207
- Subject:
- Leydig cells; adrenal cortex; aldosterone; animal ovaries; antibodies; biosynthesis; corticosterone; enzymes; humans; immunohistochemistry; mice; pregnancy; progesterone; sebaceous glands; steroid hormones; steroidogenesis; testosterone; trophoblast
- Abstract:
- ... The enzyme 3β-hydroxysteroid dehydrogenase/isomerase (3β-HSD) is essential for the biosynthesis of all active steroid hormones, such as those secreted from the adrenal gland, testis, ovary, skin and placenta. The 3β-HSD enzymes exist in multiple isoforms in humans and rodents. To date, six different isoforms have been identified in the mouse, and these isoforms are speculated to play different rol ...
- DOI:
- 10.1016/j.mce.2013.09.014
-
http://dx.doi.org/10.1016/j.mce.2013.09.014
- Author:
- Mahajan, Muktar A.; Stanley, Frederick M.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 159-169
- ISSN:
- 0303-7207
- Subject:
- gene expression; histone deacetylase; insulin; messenger RNA; mutants; phosphorylation; prolactin; proteins; reverse transcriptase polymerase chain reaction; transcription (genetics); two hybrid system techniques; yeasts
- Abstract:
- ... Insulin increases prolactin gene expression in GH4 cells through phosphorylation of Elk-1 (Jacob and Stanley, 2001). We preformed a reverse two-hybrid screen using Elk-1-B42 as bait to identify proteins from GH4 cells that might serve as co-activators or co-repressors for insulin-increased prolactin gene expression. A number of the components of the TIP60/NuA4 complex interacted with Elk-1 suggest ...
- DOI:
- 10.1016/j.mce.2013.09.021
-
http://dx.doi.org/10.1016/j.mce.2013.09.021
- Author:
- Wang, Yong; Liang, Ning; Yao, Guidong; Tian, Hui; Zhai, Yiwen; Yin, Yimeng; Sun, Fei
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 804-813
- ISSN:
- 0303-7207
- Subject:
- Drosophila; epidermal growth factor; follicular development; gene expression; interleukin-6; messenger RNA; microarray technology; nerve growth factor; oocytes; ovarian follicles; ovulation; phosphorylation; prostaglandin synthase; protein secretion; protein synthesis; receptor protein-tyrosine kinase
- Abstract:
- ... Tyrosine kinase receptor A (TrkA), the high-affinity receptor of nerve growth factor (NGF), is known to play key roles in ovarian follicular development, such as assembly of early follicles and follicular ovulation. However, little is known about the roles of TrkA in cumulus oocyte complex (COC) expansion. In this study, we found that TrkA was abundant in large antral follicles and knockdown of Tr ...
- DOI:
- 10.1016/j.mce.2013.10.031
-
http://dx.doi.org/10.1016/j.mce.2013.10.031
- Author:
- Helsen, Christine; Claessens, Frank
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 97-106
- ISSN:
- 0303-7207
- Subject:
- DNA; crystal structure; ligands; peptides; receptors
- Abstract:
- ... While the structures of the DNA- and ligand-binding domains of many nuclear receptors have been determined in great detail; the mechanisms by which these domains interact and possibly ‘communicate’ is still under debate. The first crystal structures of receptor dimers bound to ligand, DNA and coactivator peptides provided new insights in this matter. The observed binding modes revealed exciting ne ...
- DOI:
- 10.1016/j.mce.2013.09.009
-
http://dx.doi.org/10.1016/j.mce.2013.09.009
- Author:
- Wang, Xinhui; Lei, Xin Gen; Wang, Jufang
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 8-16
- ISSN:
- 0303-7207
- Subject:
- adenosine diphosphate; adenosine triphosphate; calcium; etiology; hyperinsulinemia; insulin secretion; malondialdehyde; mice; noninsulin-dependent diabetes mellitus; phosphatidylinositol 3-kinase; signal transduction; small interfering RNA
- Abstract:
- ... Evidence showed strong relations between malondialdehyde (MDA) levels and different pathological stages of diabetes. Here, an explicit system with freshly isolated islets and precisely controlled MDA gradient was employed to investigate the physiological effect of MDA on GSIS. Promoter analysis, pathway mapping, Q-PCR profiling, and siRNA verification were performed to clarify the intracellular si ...
- DOI:
- 10.1016/j.mce.2013.09.003
-
http://dx.doi.org/10.1016/j.mce.2013.09.003
- Author:
- Sun, Caiyun; He, Mulan; Ko, Wendy K.W.; Wong, Anderson O.L.
- Source:
- Molecular and Cellular Endocrinology 2014 v.382 pp. 835-850
- ISSN:
- 0303-7207
- Subject:
- Ctenopharyngodon idella; adenylate cyclase; autocrine signaling; cAMP-dependent protein kinase; carp; cyclic AMP; gene expression; human chorionic gonadotropin; luteinizing hormone; luteinizing hormone receptors; mitogen-activated protein kinase; models; phosphatidylinositol 3-kinase; phosphorylation; secretion; somatotropin; transcription (genetics)
- Abstract:
- ... In our previous studies in grass carp pituitary cells, local production of luteinizing hormone (LH) was shown to induce growth hormone (GH) production and gene expression, which constitutes a major component of the “intrapituitary feedback loop” regulating GH secretion and synthesis via autocrine/paracrine interactions between gonadotrophs and somatotrophs in the carp pituitary. To further investi ...
- DOI:
- 10.1016/j.mce.2013.10.017
-
http://dx.doi.org/10.1016/j.mce.2013.10.017