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1. Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

Author:
Yuan, Huier; Hu, Yaqiu; Zhu, Yuzhang; Zhang, Yongneng; Luo, Chaohuan; Li, Zhi; Wen, Tengfei; Zhuang, Wanling; Zou, Jinfang; Hong, Liangli; Zhang, Xin; Hisatome, Ichiro; Yamamoto, Tetsuya; Cheng, Jidong
Source:
Molecular and Cellular Endocrinology 2017 v.443 pp. 138-145
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Western blotting; energy balance; glucose; glucose transporters; hyperuricemia; insulin; insulin resistance; metabolism; metformin; myocytes; reactive oxygen species; skeletal muscle; uric acid
Abstract:
... Hyperuricemia occurs together with abnormal glucose metabolism and insulin resistance. Skeletal muscle is an important organ of glucose uptake, disposal, and storage. Metformin activates adenosine monophosphate-activated protein kinase (AMPK) to regulate insulin signaling and promote the translocation of glucose transporter type 4 (GLUT4), thereby stimulating glucose uptake to maintain energy bala ...
DOI:
10.1016/j.mce.2016.12.025

2. Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation

Author:
Mancini, Sarah J.; White, Anna D.; Bijland, Silvia; Rutherford, Claire; Graham, Delyth; Richter, Erik A.; Viollet, Benoit; Touyz, Rhian M.; Palmer, Timothy M.; Salt, Ian P.
Source:
Molecular and Cellular Endocrinology 2017 v.440 pp. 44-56
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adipocytes; adipogenesis; adipose tissue; anti-inflammatory activity; chemokine CXCL10; inflammation; insulin resistance; interleukin-1beta; interleukin-6; metabolism; mice; mitogen-activated protein kinase; obesity; phosphorylation; secretion; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Inflammation of adipose tissue in obesity is associated with increased IL-1β, IL-6 and TNF-α secretion and proposed to contribute to insulin resistance. AMP-activated protein kinase (AMPK) regulates nutrient metabolism and is reported to have anti-inflammatory actions in adipose tissue, yet the mechanisms underlying this remain poorly characterised. The effect of AMPK activation on cytokine-stimul ...
DOI:
10.1016/j.mce.2016.11.010
PubMed:
27840174
PubMed Central:
PMC5228585

3. Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms

Author:
Chen, Suet Ching; Brooks, Rebecca; Houskeeper, Jessica; Bremner, Shaun K.; Dunlop, Julia; Viollet, Benoit; Logan, Pamela J.; Salt, Ian P.; Ahmed, S. Faisal; Yarwood, Stephen J.
Source:
Molecular and Cellular Endocrinology 2017 v.440 pp. 57-68
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adipocytes; adipogenesis; bone density; bone formation; bone marrow; fibroblasts; knockout mutants; lipids; metformin; noninsulin-dependent diabetes mellitus; people; risk; signal transduction; stem cells; transcription factors
Abstract:
... People with Type 2 diabetes mellitus (T2DM) have reduced bone mineral density and an increased risk of fractures due to altered mesenchymal stem cell (MSC) differentiation in the bone marrow. This leads to a shift in the balance of differentiation away from bone formation (osteogenesis) in favour of fat cell development (adipogenesis). The commonly used anti-diabetic drug, metformin, activates the ...
DOI:
10.1016/j.mce.2016.11.011
PubMed:
27856330
PubMed Central:
PMC5228588

4. Effects of metformin on cell growth and AMPK activity in pituitary adenoma cell cultures, focusing on the interaction with adenylyl cyclase activating signals

Author:
Faggi, Lara; Giustina, Andrea; Tulipano, Giovanni
Source:
Molecular and Cellular Endocrinology 2017
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adenoma; adenylate cyclase; cell culture; cell growth; drug therapy; forskolin; humans; membrane proteins; metformin; neoplasm cells; rats; receptors; signal transduction; somatoliberin
Abstract:
... For a few years we have been investigating AMP-activated protein kinase (AMPK) as a target for drug therapy of GH-secreting pituitary adenomas. Aim of this study was to investigate the direct effects of metformin, which causes AMPK activation in different cell types, on rat pituitary adenoma cell growth and on related cell signalling pathways. Our results suggest that metformin can exert a growth- ...
DOI:
10.1016/j.mce.2017.09.030

5. Isoalantolactone derivative promotes glucose utilization in skeletal muscle cells and increases energy expenditure in db/db mice via activating AMPK-dependent signaling

Author:
Arha, Deepti; Ramakrishna, E.; Gupta, Anand P.; Rai, Amit K.; Sharma, Aditya; Ahmad, Ishbal; Riyazuddin, Mohammed; Gayen, Jiaur R.; Maurya, Rakesh; Tamrakar, Akhilesh K.
Source:
Molecular and Cellular Endocrinology 2017
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Inula racemosa; acetyl-CoA carboxylase; bioactive compounds; bioactive properties; blood glucose; body mass index; chemical derivatives; energy expenditure; gene expression regulation; glucose; glucose tolerance; glucose transporters; liver; mice; mitochondria; myocytes; noninsulin-dependent diabetes mellitus; rats; roots; skeletal muscle; sterols; transcription (genetics); transcription factors
Abstract:
... Augmenting glucose utilization and energy expenditure in skeletal muscle via AMP-activated protein kinase (AMPK) is an imperative mechanism for the management of type 2 diabetes. Chemical derivatives (2a-2h, 3, 4a-4d, 5) of the isoalantolactone (K007), a bioactive molecule from roots of Inula racemosa were synthesized to optimize the bioactivity profile to stimulate glucose utilization in skeletal ...
DOI:
10.1016/j.mce.2017.07.015

6. Estrogen receptor beta signals to inhibition of cardiac fibrosis

Author:
Pedram, Ali; Razandi, Mahnaz; Narayanan, Ramesh; Levin, Ellis R.
Source:
Molecular and Cellular Endocrinology 2016 v.434 pp. 57-68
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; agonists; angiotensin II; cAMP-dependent protein kinase; estrogen receptors; fibroblasts; fibrosis; hypertrophy; metalloproteinases; mice; rats; transforming growth factor beta
Abstract:
... Cardiac fibrosis evolves from the cardiac hypertrophic state. In this respect, estrogen and estrogen receptor beta (ERβ) inhibit the effects of cardiac hypertrophic peptides that also stimulate fibrosis. Here we determine details of the anti-fibrotic functions of ERβ. In acutely isolated rat cardiac fibroblasts. E2 or a specific ERβ agonist (βLGND2) blocked angiotensin II (AngII) signaling to fibr ...
DOI:
10.1016/j.mce.2016.06.018

7. Specific deletion of AMP-activated protein kinase (α1AMPK) in mouse Sertoli cells modifies germ cell quality

Author:
Bertoldo, Michael J.; Guibert, Edith; Faure, Melanie; Guillou, Florian; Ramé, Christelle; Nadal-Desbarats, Lydie; Foretz, Marc; Viollet, Benoit; Dupont, Joëlle; Froment, Pascal
Source:
Molecular and Cellular Endocrinology 2016 v.423 pp. 96-112
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Sertoli cells; adenosine triphosphate; cytochrome c; droplets; energy; energy metabolism; genes; head; homeostasis; lactic acid; lipids; litter size; male fertility; males; mice; mitochondria; protein subunits; spermatozoa
Abstract:
... The AMP-activated protein kinase (AMPK) is an important regulator of cellular energy homeostasis which plays a role in fertility. Complete disruption of the AMPK catalytic subunit α1 gene (α1AMPK KO) in male mice results in a decrease in litter size which is associated with the production of altered sperm morphology and motility. Because of the importance of Sertoli cells in the formation of germ ...
DOI:
10.1016/j.mce.2016.01.001

8. C1q/TNF-related protein-9 inhibits cytokine-induced vascular inflammation and leukocyte adhesiveness via AMP-activated protein kinase activation in endothelial cells

Author:
Jung, Chang Hee; Lee, Min Jung; Kang, Yu Mi; Lee, Yoo La; Seol, So Mi; Yoon, Hae Kyeong; Kang, Sang-Wook; Lee, Woo Je; Park, Joong-Yeol
Source:
Molecular and Cellular Endocrinology 2016 v.419 pp. 235-243
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; acetyl-CoA carboxylase; adhesion; adiponectin; cardioprotective effect; cell adhesion; chemokine CCL2; endothelial cells; genes; humans; inflammation; monocytes; phosphorylation; small interfering RNA; transcription factor NF-kappa B; transfection; tumor necrosis factor-alpha
Abstract:
... Although recent studies have reported cardioprotective effects of C1q/TNF-related protein 9 (CTRP9), the closet adiponectin paralog, its role on cytokine-induced endothelial inflammation is unknown. We investigated whether CTRP9 prevented inflammatory cytokine-induced nuclear factor-kappa B (NF-κB) activation and inhibited the expression of adhesion molecules and a chemokine in the vascular endoth ...
DOI:
10.1016/j.mce.2015.10.023

9. Orexins (hypocretins) and energy balance: More than feeding

Author:
Fernø, Johan; Señarís, Rosa; Diéguez, Carlos; Tena-Sempere, Manuel; López, Miguel
Source:
Molecular and Cellular Endocrinology 2015 v.418 pp. 17-26
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; brown adipose tissue; endoplasmic reticulum; energy expenditure; heat production; neuropeptides; pain; sleep
Abstract:
... Initially implicated in the regulation of feeding, orexins/hypocretins are now acknowledged to play a major role in the control of a wide variety of biological processes, such as sleep, energy expenditure, pain, cardiovascular function and neuroendocrine regulation, a feature that makes them one of the most pleiotropic families of hypothalamic neuropeptides. While the orexigenic effect of orexins ...
DOI:
10.1016/j.mce.2015.07.022

10. Ketogenic diet delays the phase of circadian rhythms and does not affect AMP-activated protein kinase (AMPK) in mouse liver

Author:
Genzer, Yoni; Dadon, Maayan; Burg, Chen; Chapnik, Nava; Froy, Oren
Source:
Molecular and Cellular Endocrinology 2015 v.417 pp. 124-130
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; blood glucose; brain; circadian rhythm; epilepsy; gene expression; gene expression regulation; genes; gluconeogenesis; glucose; insulin; ketogenic diet; liver; locomotion; low fat diet; mice; satiety; weight loss
Abstract:
... Ketogenic diet (KD) is used for weight loss or to treat epilepsy. KD leads to liver AMP-activated protein kinase (AMPK) activation, which would be expected to inhibit gluconeogenesis. However, KD leads to increased hepatic glucose output. As AMPK and its active phosphorylated form (pAMPK) show circadian oscillation, this discrepancy could stem from wrong-time-of-day sampling. The effect of KD was ...
DOI:
10.1016/j.mce.2015.09.012

11. AMP-activated protein kinase suppresses the expression of LXR/SREBP-1 signaling-induced ANGPTL8 in HepG2 cells

Author:
Lee, Jinmi; Hong, Seok-Woo; Park, Se Eun; Rhee, Eun-Jung; Park, Cheol-Young; Oh, Ki-Won; Park, Sung-Woo; Lee, Won-Young
Source:
Molecular and Cellular Endocrinology 2015 v.414 pp. 148-155
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; blood serum; diabetes; gene expression; human cell lines; messenger RNA; metformin; obesity; palmitic acid; phosphorylation; small interfering RNA; triacylglycerols; tunicamycin
Abstract:
... ANGPTL8 is a liver-derived secretory protein that leads to elevated serum triglyceride and the level of circulating ANGPTL8 is strongly associated with obesity and diabetes. Here we investigated the mechanisms of activation and inhibition of ANGPTL8 expression in hepatocytes.The expression of ANGPTL8 was significantly increased in HepG2 cells exposed to palmitic acid, tunicamycin, or T0901317, and ...
DOI:
10.1016/j.mce.2015.07.031

12. Role of the AMP kinase in cytokine-induced human EndoC-βH1 cell death

Author:
Fred, Rikard G.; Kappe, Camilla; Ameur, Adam; Cen, Jing; Bergsten, Peter; Ravassard, Phillippe; Scharfmann, Raphael; Welsh, Nils
Source:
Molecular and Cellular Endocrinology 2015 v.414 pp. 53-63
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adenosine triphosphate; cell death; cell respiration; humans; inducible nitric oxide synthase; interferon-gamma; interleukin-1beta; islets of Langerhans; mitogen-activated protein kinase; models; transcription factor NF-kappa B
Abstract:
... The aim of the present investigation was to delineate cytokine-induced signaling and death using the EndoC-βH1 cells as a model for primary human beta-cells. The cytokines IL-1β and IFN-γ induced a rapid and transient activation of NF-κB, STAT-1, ERK, JNK and eIF-2α signaling. The EndoC-βH1 cells died rapidly when exposed to IL-1β + IFN-γ, and this occurred also in the presence of the actinomycin ...
DOI:
10.1016/j.mce.2015.07.015

13. Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK

Author:
Guo, Shuang; Yao, Qing; Ke, Zhiqiang; Chen, Hongguang; Wu, Jiliang; Liu, Chao
Source:
Molecular and Cellular Endocrinology 2015 v.412 pp. 85-94
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; NAD(P)H oxidase (H2O2-forming); antioxidant activity; apoptosis; cardiomyocytes; cardiomyopathy; catalase; cell viability; enzyme activity; glucose; hyperglycemia; lipid peroxidation; oxidative stress; pathogenesis; phosphorylation; polyphenols; pro-apoptotic proteins; protective effect; rats; reactive oxygen species; resveratrol; signal transduction; superoxide dismutase
Abstract:
... Diabetic cardiomyopathy (DCM) suggests a direct cellular insult to myocardium. Hyperglycemia-induced oxidative stress and apoptosis have been implicated in the pathogenesis of DCM. NADPH oxidase is a major source of reactive oxygen species (ROS) generation in cardiomyocytes. Resveratrol, a naturally occurring polyphenol, has shown beneficial effects on some cardiovascular complications associated ...
DOI:
10.1016/j.mce.2015.05.034

14. Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway

Author:
Shi, Linying; Zhang, Ting; Liang, Xinyu; Hu, Qin; Huang, Juan; Zhou, Yong; Chen, Mingliang; Zhang, Qianyong; Zhu, Jundong; Mi, Mantian
Source:
Molecular and Cellular Endocrinology 2015 v.409 pp. 92-102
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; autophagy; flavonoids; gene expression regulation; genes; glucose; hepatoprotective effect; in vitro studies; in vivo studies; insulin receptors; insulin resistance; myotubes; noninsulin-dependent diabetes mellitus; pathogenesis; rats; signal transduction; skeletal muscle; small interfering RNA
Abstract:
... Skeletal muscle insulin resistance (SMIR) plays an important role in the pathogenesis of type 2 diabetes. Dihydromyricetin (DHM), a natural flavonoid, exerts various bioactivities including anti-oxidative and hepatoprotective effects. Herein, we intended to determine the effect of DHM on SMIR and the underlying mechanisms. We found that DHM increased the expression of phosphorylated insulin recept ...
DOI:
10.1016/j.mce.2015.03.009

15. The dipeptidyl peptidase-IV inhibitor inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanisms

Author:
Hwang, Hwan-Jin; Chung, Hye Soo; Jung, Tae Woo; Ryu, Ja Young; Hong, Ho Cheol; Seo, Ji A.; Kim, Sin Gon; Kim, Nan Hee; Choi, Kyung Mook; Choi, Dong Seop; Baik, Sei Hyun; Yoo, Hye Jin
Source:
Molecular and Cellular Endocrinology 2015 v.405 pp. 25-34
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Western blotting; adhesion; anti-inflammatory activity; atherosclerosis; chemokine CCL2; dipeptidyl-peptidase IV; dose response; endothelium; enzyme inhibitors; foam cells; glycemic effect; human umbilical vein endothelial cells; interleukin-1beta; interleukin-6; lipopolysaccharides; low density lipoprotein; mitogen-activated protein kinase; phosphorylation; protective effect; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Recently, dipeptidyl peptidase-IV (DPP-IV) inhibitor, a major anti-hyperglycemic agent, has received substantial attention as a possible therapeutic target for inflammatory diseases such as atherosclerosis. However, the direct molecular mechanisms through which DPP-IV inhibitor mediates anti-inflammatory effects in vascular endothelial cells have not been clarified. The effects of the DPP-IV inhib ...
DOI:
10.1016/j.mce.2015.01.025

16. X-3, a mangiferin derivative, stimulates AMP-activated protein kinase and reduces hyperglycemia and obesity in db/db mice

Author:
Han, Jun; Yi, Jia; Liang, Fengying; Jiang, Bo; Xiao, Ying; Gao, Shouhong; Yang, Na; Hu, Honggang; Xie, Wei-Fen; Chen, Wansheng
Source:
Molecular and Cellular Endocrinology 2015 v.405 pp. 63-73
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; acetyl-CoA carboxylase; acute toxicity; adipose tissue; blood glucose; death; glucose; hyperglycemia; hypothalamus; islets of Langerhans; liver; mechanism of action; metformin; mice; muscles; noninsulin-dependent diabetes mellitus; obesity; phosphorylation; toxicity testing; triacylglycerols
Abstract:
... Diabetes mellitus is a major health concern, affecting nearly 10% of the population. Here we describe a potential novel therapeutic agent for this disease, X-3, a derivative of mangiferin. Therapeutic administration of X-3 significantly and dose-dependently reduced plasma glucose and triglycerides in db/db mice following 8 week-treatments. Treatment with X-3 dose-dependently increased the number o ...
DOI:
10.1016/j.mce.2015.02.008

17. Acute leptin exposure reduces megalin expression and upregulates TGFβ1 in cultured renal proximal tubule cells

Author:
Briffa, Jessica F.; Grinfeld, Esther; Mathai, Michael L.; Poronnik, Phillip; McAinch, Andrew J.; Hryciw, Deanne H.
Source:
Molecular and Cellular Endocrinology 2015 v.401 pp. 25-34
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Western blotting; albumins; albuminuria; kidney diseases; kidneys; leptin; obesity; opossums; secretion; transforming growth factor beta 1
Abstract:
... Increased leptin concentrations observed in obesity can lead to proteinuria, suggesting that leptin may play a role in obesity-related kidney disease. Obesity reduces activation of AMP-activated protein kinase (AMPK) and increases transforming growth factor-β1 (TGF-β1) expression in the kidney, leading to albuminuria. Thus we investigated if elevated leptin altered AMPK and TGF-β1 signaling in pro ...
DOI:
10.1016/j.mce.2014.11.024

18. Essential roles of insulin, AMPK signaling and lysyl and prolyl hydroxylases in the biosynthesis and multimerization of adiponectin

Author:
Zhang, Lin; Li, Ming-Ming; Corcoran, Marie; Zhang, Shaoping; Cooper, Garth J.S.
Source:
Molecular and Cellular Endocrinology 2015 v.399 pp. 164-177
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adipocytes; adiponectin; adiponectin receptors; antibodies; bioactive properties; biosynthesis; genes; insulin; insulin receptors; insulin resistance; luteinizing hormone; mice; molecular weight; noninsulin-dependent diabetes mellitus; obesity; post-translational modification; secretion
Abstract:
... Post-translational modifications (PTMs) of the adiponectin molecule are essential for its full bioactivity, and defects in PTMs leading to its defective production and multimerization have been linked to the mechanisms of insulin resistance, obesity, and type-2 diabetes. Here we observed that, in differentiated 3T3-L1 adipocytes, decreased insulin signaling caused by blocking of insulin receptors ...
DOI:
10.1016/j.mce.2014.09.014

19. Glabridin induces glucose uptake via the AMP-activated protein kinase pathway in muscle cells

Author:
Sawada, Keisuke; Yamashita, Yoko; Zhang, Tianshun; Nakagawa, Kaku; Ashida, Hitoshi
Source:
Molecular and Cellular Endocrinology 2014 v.393 pp. 99-108
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; diabetes; dose response; glucose; glucose transporters; glycogen; hyperglycemia; isoflavones; lactic acid; licorice; metabolism; mice; myotubes; phosphatidylinositol 3-kinase; phosphorylation; plasma membrane; skeletal muscle; small interfering RNA; therapeutics
Abstract:
... The present study demonstrates that glabridin, a prenylated isoflavone in licorice, stimulates glucose uptake through the adenosine monophosphate-activated protein kinase (AMPK) pathway in L6 myotubes. Treatment with glabridin for 4h induced glucose uptake in a dose-dependent manner accompanied by the translocation of glucose transporter type 4 (GLUT4) to the plasma membrane. Glabridin needed at l ...
DOI:
10.1016/j.mce.2014.06.009

20. Partial hepatic resistance to IL-6-induced inflammation develops in type 2 diabetic mice, while the anti-inflammatory effect of AMPK is maintained

Author:
Cansby, Emmelie; Nerstedt, Annika; Amrutkar, Manoj; Durán, Esther Nuñez; Smith, Ulf; Mahlapuu, Margit
Source:
Molecular and Cellular Endocrinology 2014 v.393 pp. 143-151
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; agonists; animal disease models; anti-inflammatory activity; gene expression; hepatocytes; high fat diet; inflammation; insulin resistance; interleukin-6; liver; metformin; mice; noninsulin-dependent diabetes mellitus
Abstract:
... Interleukin-6 (IL-6) induces hepatic inflammation and insulin resistance, and therapeutic strategies to counteract the IL-6 action in liver are of high interest. In this study, we demonstrate that acute treatment with AMP-activated protein kinase (AMPK) agonists AICAR and metformin efficiently repressed IL-6-induced hepatic proinflammatory gene expression and activation of STAT3 in a mouse model o ...
DOI:
10.1016/j.mce.2014.06.014

21. Adiponectin regulates ACTH secretion and the HPAA in an AMPK-dependent manner in pituitary corticotroph cells

Author:
Chen, Maopei; Wang, Zhiquan; Zhan, Ming; Liu, Ruixin; Nie, Aifang; Wang, Jiqiu; Ning, Guang; Ma, Qinyun
Source:
Molecular and Cellular Endocrinology 2014 v.383 pp. 118-125
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adiponectin; adiponectin receptors; calcium; corticotropin; fluorescent antibody technique; humans; neoplasm cells; neoplasms; reverse transcriptase polymerase chain reaction; secretion
Abstract:
... It is known that adipokines can regulate the hypothalamic–pituitary–adrenal axis (HPAA). In this study, we confirmed that adiponectin regulates the HPAA by affecting pituitary corticotroph cells. Using RT-PCR and immunofluorescence, we determined that adiponectin receptors were expressed in pituitary corticotroph tumour cells (AtT-20 cells and human corticotroph tumours). Adiponectin stimulated ca ...
DOI:
10.1016/j.mce.2013.12.007

22. AMPK activator-mediated inhibition of endoplasmic reticulum stress ameliorates carrageenan-induced insulin resistance through the suppression of selenoprotein P in HepG2 hepatocytes

Author:
Jung, Tae Woo; Lee, So Young; Hong, Ho Cheol; Choi, Hae Yoon; Yoo, Hye Jin; Baik, Sei Hyun; Choi, Kyung Mook
Source:
Molecular and Cellular Endocrinology 2014 v.382 pp. 66-73
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; Toll-like receptor 4; binding proteins; carrageenan; endoplasmic reticulum; hepatocytes; human cell lines; inflammation; insulin resistance; mitogen-activated protein kinase; noninsulin-dependent diabetes mellitus; selenoproteins
Abstract:
... Carrageenan (CGN) has been shown to cause inflammation through toll-like receptor 4, which may play an important role in insulin resistance and type 2 diabetes mellitus. Selenoprotein P (SeP) has recently been identified as a novel hepatokine that causes insulin resistance. Here, we report that treatment of HepG2 cells with CGN increased both CCAAT enhancer binding protein homologous protein (CHOP ...
DOI:
10.1016/j.mce.2013.09.013

23. Glucose sensing mechanisms in hypothalamic cell models: Glucose inhibition of AgRP synthesis and secretion

Author:
Chalmers, Jennifer A.; Jang, Janet J.; Belsham, Denise D.
Source:
Molecular and Cellular Endocrinology 2014 v.382 pp. 262-270
ISSN:
0303-7207
Subject:
2-deoxyglucose; AMP-activated protein kinase; cystic fibrosis; energy; gene expression; glucose; homeostasis; messenger RNA; models; neuronal nitric oxide synthase; neurons; neuropeptides; phosphorylation; secretion; taste receptors
Abstract:
... Glucose-sensing neurons play a role in energy homeostasis, yet how orexigenic neurons sense glucose remains unclear. As models of glucose-inhibited (GI) neurons, mHypoE-29/1 and mHypoA-NPY/GFP cells express the essential orexigenic neuropeptide AgRP and glucose sensing machinery. Exposure to increasing concentrations of glucose or the glucose analog 2-deoxyglucose (2-DG) results in a decrease in A ...
DOI:
10.1016/j.mce.2013.10.013

24. Hypothalamic AMPK activation blocks lipopolysaccharide inhibition of glucose production in mice liver

Author:
Santos, G.A.; Moura, R.F.; Vitorino, D.C.; Roman, E.A.F.R.; Torsoni, A.S.; Velloso, L.A.; Torsoni, M.A.
Source:
Molecular and Cellular Endocrinology 2013 v.381 pp. 88-96
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; blood glucose; blood serum; dephosphorylation; endotoxemia; fasting; food intake; glucose; glycemic control; homeostasis; hypoglycemia; interleukin-1beta; lipopolysaccharides; liver; mice; patients; phosphorylation; survival rate; tumor necrosis factor-alpha
Abstract:
... Endotoxic hypoglycaemia has an important role in the survival rates of septic patients. Previous studies have demonstrated that hypothalamic AMP-activated protein kinase (hyp-AMPK) activity is sufficient to modulate glucose homeostasis. However, the role of hyp-AMPK in hypoglycaemia associated with endotoxemia is unknown. The aims of this study were to examine hyp-AMPK dephosphorylation in lipopol ...
DOI:
10.1016/j.mce.2013.07.018

25. Glucose responsiveness in a novel adult-derived GnRH cell line, mHypoA-GnRH/GFP: Involvement of AMP-activated protein kinase

Author:
McFadden, Sean A.; Menchella, Jonathan A.; Chalmers, Jennifer A.; Centeno, Maria-Luisa; Belsham, Denise D.
Source:
Molecular and Cellular Endocrinology 2013 v.377 pp. 65-74
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; agonists; antagonists; energy; glucose; gonadotropin-releasing hormone; homeostasis; hypothalamus; messenger RNA; mice; models; neurons; secretion; transcription (genetics)
Abstract:
... Glucose regulates energy homeostasis and reproductive function within the hypothalamus. The underlying mechanisms responsible for glucose regulation of GnRH gene transcription were investigated using a novel murine immortalized, adult-derived hypothalamic cell line, mHypoA-GnRH/GFP. Analysis of GnRH mRNA synthesis and secretion following agonist treatment demonstrated that the mHypoA-GnRH/GFP cell ...
DOI:
10.1016/j.mce.2013.06.035

26. Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes

Author:
Yu, An; Zheng, Yu; Zhang, Rongrong; Huang, Jianfeng; Zhu, Zhoujie; Zhou, Ronghua; Jin, Dan; Yang, Zaiqing
Source:
Molecular and Cellular Endocrinology 2013 v.377 pp. 23-32
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; agonists; beta-galactosidase; genes; hepatocytes; hepatoma; human cell lines; humans; insulin resistance; mice; nicotinamide; phenotype; phosphorylation; resistin; resveratrol
Abstract:
... Resistin is a cysteine-rich secreted protein which significantly inhibits phosphorylation of AMP-activated protein kinase in both human and mouse hepatocytes. It has been demonstrated that resistin plays an important role in inducing hepatic insulin resistance. However, whether resistin has other unknown influences on hepatocytes still remains poorly studied. Here, we show that recombinant resisti ...
DOI:
10.1016/j.mce.2013.06.028

27. AMPK signaling pathway is rapidly activated by T3 and regulates the cardiomyocyte growth

Author:
Takano, Ana Paula Cremasco; Diniz, Gabriela Placoná; Barreto-Chaves, Maria Luiza Morais
Source:
Molecular and Cellular Endocrinology 2013 v.376 pp. 43-50
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; cardiomyocytes; hypertrophy; signal transduction; small interfering RNA; thyroid hormones; transcription (genetics)
Abstract:
... Previous studies have indicated that AMP-activated protein kinase (AMPK) plays a critical role in the control of cardiac hypertrophy mediated by different stimuli such as thyroid hormone (TH). Although the classical effects of TH mediating cardiac hypertrophy occur by transcriptional mechanisms, recent studies have identified other responses to TH, which are more rapid and take place in seconds or ...
DOI:
10.1016/j.mce.2013.05.024

28. Pharmacological activation of AMPK suppresses inflammatory response evoked by IL-6 signalling in mouse liver and in human hepatocytes

Author:
Nerstedt, Annika; Cansby, Emmelie; Amrutkar, Manoj; Smith, Ulf; Mahlapuu, Margit
Source:
Molecular and Cellular Endocrinology 2013 v.375 pp. 68-78
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; amyloid; blood serum; hepatocytes; hepatoma; humans; inflammation; insulin; interleukin-6; liver; mice; non-specific protein-tyrosine kinase; phosphorylation; protein-tyrosine-phosphatase; signal transduction; transcription factors
Abstract:
... Interleukin-6 (IL-6) induces inflammatory signalling in liver, leading to impaired insulin action in hepatocytes. In this study, we demonstrate that pharmacological activation of AMP-activated protein kinase (AMPK) represses IL-6-stimulated expression of proinflammatory markers serum amyloid A (Saa) as well as suppressor of cytokine signalling 3 (Socs3) in mouse liver. Further studies using the hu ...
DOI:
10.1016/j.mce.2013.05.013

29. Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Author:
Zhang, Yongneng; Yamamoto, Tetsuya; Hisatome, Ichiro; Li, Youfeng; Cheng, Weijie; Sun, Ning; Cai, Bozhi; Huang, Tianliang; Zhu, Yuzhang; Li, Zhi; Jing, Xubin; Zhou, Rui; Cheng, Jidong
Source:
Molecular and Cellular Endocrinology 2013 v.375 pp. 89-96
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; blood serum; glucose; hyperuricemia; insulin; insulin resistance; insulin secretion; islets of Langerhans; metabolism; mitogen-activated protein kinase; oxidative stress; rats; reactive oxygen species; signal transduction; uric acid
Abstract:
... Hyperuricaemia is a disorder of purine metabolism, and is strongly associated with insulin resistance and abnormal glucose metabolism. As the producer of insulin, pancreatic β cells might be affected by elevated serum uric acid levels and contribute to the disregulated glucose metabolism. In this study, we investigated the effect of high uric acid on rat pancreatic β cell function. Under high uric ...
DOI:
10.1016/j.mce.2013.04.027

30. Hyperglycemia is associated with enhanced gluconeogenesis in a rat model of permanent cerebral ischemia

Author:
Wang, Ya-Yu; Chen, Chun-Jung; Lin, Shih-Yi; Chuang, Yu-Han; Sheu, Wayne Huey-Herng; Tung, Kwong-Chung
Source:
Molecular and Cellular Endocrinology 2013 v.367 pp. 50-56
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; C-reactive protein; adiponectin; animal models; blood glucose; chemokine CCL2; cortisol; cyclic AMP; fasting; gene expression; glucagon; gluconeogenesis; glucose-6-phosphatase; hyperglycemia; insulin; insulin receptors; ischemia; liver; mitogen-activated protein kinase; phosphorylation; rats; resistin; serine; stroke; tyrosine
Abstract:
... Hyperglycemia is common after acute stroke. In the acute phase of stroke (within 24h), rats with permanent cerebral ischemia developed higher fasting blood glucose and insulin levels in association with up-regulation of hepatic gluconeogenic gene expression, including phosphoenolpyruvate carboxykinase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase. In addition, hepatic gluconeogenesis-ass ...
DOI:
10.1016/j.mce.2012.12.016

31. AMPK at the crossroads of circadian clocks and metabolism

Author:
Jordan, Sabine D.; Lamia, Katja A.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 163-169
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; brain; circadian rhythm; cryptochromes; glucose; insulin secretion; mammals; phosphorylation; post-translational modification; transcription factors; translation (genetics)
Abstract:
... Circadian clocks coordinate behavior and physiology with daily environmental cycles and thereby optimize the timing of metabolic processes such as glucose production and insulin secretion. Such circadian regulation of metabolism provides an adaptive advantage in diverse organisms. Mammalian clocks are primarily based on a transcription and translation feedback loop in which a heterodimeric complex ...
DOI:
10.1016/j.mce.2012.06.017
PubMed:
22750052
PubMed Central:
PMC3502724

32. AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity

Author:
O’Neill, Hayley M.; Holloway, Graham P.; Steinberg, Gregory R.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 135-151
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; biogenesis; exercise; fatty acid metabolism; glucose; homeostasis; insulin resistance; lipid peroxidation; muscles; noninsulin-dependent diabetes mellitus; obesity; skeletal muscle
Abstract:
... Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates ...
DOI:
10.1016/j.mce.2012.06.019

33. Emerging role of AMP-activated protein kinase in endocrine control of metabolism in the liver

Author:
Hasenour, Clinton M.; Berglund, Eric D.; Wasserman, David H.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 152-162
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; animal models; hormones; liver; metabolism
Abstract:
... This review summarizes the emerging role of AMP-activated protein kinase (AMPK) in mediating endocrine regulation of metabolic fluxes in the liver. There are a number of hormones which, when acting on the liver, alter AMPK activation. Here we describe those hormones associated with activation and de-activation of AMPK and the potential mechanisms for changes in AMPK activation state. The actions o ...
DOI:
10.1016/j.mce.2012.06.018
PubMed:
22796337
PubMed Central:
PMC3538936

34. Endocrine-related cancers and the role of AMPK

Author:
Brown, Kristy A.; Samarajeewa, Nirukshi U.; Simpson, Evan R.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 170-179
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; adipokines; animal ovaries; apoptosis; beta oxidation; breast neoplasms; cell cycle; cholesterol; colon; endometrium; energy; fatty acids; homeostasis; lipogenesis; metformin; neoplasm cells; obesity; prostatic neoplasms; risk factors; steroid hormones
Abstract:
... AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis involved in the regulation of a number of physiological processes including β-oxidation of fatty acids, lipogenesis, protein and cholesterol synthesis, as well as cell cycle inhibition and apoptosis. Important changes to these processes are known to occur in cancer due to changes in AMPK activity within cancer cells an ...
DOI:
10.1016/j.mce.2012.06.016

35. Exercise-induced AMPK activity in skeletal muscle: Role in glucose uptake and insulin sensitivity

Author:
Friedrichsen, Martin; Mortensen, Brynjulf; Pehmøller, Christian; Birk, Jesper B.; Wojtaszewski, Jørgen F.P.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 204-214
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; energy balance; exercise; glucose; glycogen; insulin; insulin resistance; protein metabolism; skeletal muscle
Abstract:
... The energy/fuel sensor 5′-AMP-activated protein kinase (AMPK) is viewed as a master regulator of cellular energy balance due to its many roles in glucose, lipid, and protein metabolism. In this review we focus on the regulation of AMPK activity in skeletal muscle and its involvement in glucose metabolism, including glucose transport and glycogen synthesis. In addition, we discuss the plausible int ...
DOI:
10.1016/j.mce.2012.06.013

36. Immunometabolism of AMPK in insulin resistance and atherosclerosis

Author:
Fullerton, Morgan D.; Steinberg, Gregory R.; Schertzer, Jonathan D.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 224-234
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; atherosclerosis; chronic diseases; energy; homeostasis; immune response; inflammation; insulin resistance; lipid peroxidation; noninsulin-dependent diabetes mellitus; obesity; serine; signal transduction; therapeutics; threonine
Abstract:
... Obesity leads to insulin resistance and atherosclerosis, which precede Type 2 diabetes and cardiovascular disease. Immunometabolism addresses how metabolic and inflammatory pathways converge to maintain health and a contemporary problem is determining how obesity-induced inflammation precipitates chronic diseases such as insulin resistance and atherosclerosis. AMP-activated protein kinase (AMPK) i ...
DOI:
10.1016/j.mce.2012.02.004

37. The role of AMP-activated protein kinase in regulating white adipose tissue metabolism

Author:
Ceddia, R.B.
Source:
Molecular and Cellular Endocrinology 2013 v.366 pp. 194-203
ISSN:
0303-7207
Subject:
AMP-activated protein kinase; acute effects; adenosine triphosphate; adipocytes; adiposity; biogenesis; cell differentiation; energy; gene expression; glucose; homeostasis; lipid metabolism; liver; metabolic diseases; muscles; obesity; white adipose tissue
Abstract:
... AMP-activated protein kinase (AMPK) is a heterotrimeric enzyme that plays a major role in the maintenance of energy homeostasis in various organs and tissues. When activated, AMPK can induce substrate catabolism and shut down energy-consuming anabolic pathways to increase intracellular ATP availability. Even though most of these effects have been described in muscle and liver, several studies have ...
DOI:
10.1016/j.mce.2012.06.014