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- Roed, Sarah Noerklit; Wismann, Pernille; Underwood, Christina Rye; Kulahin, Nikolaj; Iversen, Helle; Cappelen, Karen Arevad; Schäffer, Lauge; Lehtonen, Janne; Hecksher-Soerensen, Jacob; Secher, Anna; Mathiesen, Jesper Mosolff; Bräuner-Osborne, Hans; Whistler, Jennifer L.; Knudsen, Sanne Moeller; Waldhoer, Maria
- Molecular and Cellular Endocrinology 2014 v.382 pp. 938-949
- G-protein coupled receptors, etc ; blood glucose; cyclic AMP; drugs; glucagon-like peptide 1; humans; islets of Langerhans; mice; microscopy; secretin; Show all 10 Subjects
- ... The glucagon-like peptide-1 incretin receptor (GLP-1R) of family B G protein-coupled receptors (GPCRs) is a major drug target in type-2-diabetes due to its regulatory effect on post-prandial blood-glucose levels. The mechanism(s) controlling GLP-1R mediated signaling are far from fully understood. A fundamental mechanism controlling the signaling capacity of GPCRs is the post-endocytic trafficking ...
- Thompson, Aiysha; Kanamarlapudi, Venkateswarlu
- Molecular and Cellular Endocrinology 2015 v.413 pp. 66-77
- G-protein coupled receptors, etc ; cyclic AMP; drugs; glucagon-like peptide 1; humans; insulin secretion; mutation; noninsulin-dependent diabetes mellitus; plasma membrane; Show all 9 Subjects
- ... The glucagon-like peptide-1 (GLP-1) receptor (GLP-1R), an important drug target in the treatment of type 2 diabetes, is a G-protein coupled receptor (GPCR) that mediates insulin secretion by GLP-1. The N-terminus controls GLP-1R biosynthetic trafficking to the cell surface but the C-terminus involvement in that trafficking is unknown. The aim of this study was to identify distinct regions within t ...