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- Isupov, Michail N., et al. Show all 6 Authors
- Molecular and biochemical parasitology 2008 v.161 no.1 pp. 44-48
- Fasciola hepatica; active sites; crystal structure; cysteine; disulfide bonds; hosts; humans; oxidation; protein structure
- ... The Fasciola hepatica thioredoxin protein structure has been determined to 1.45Å resolution. This is the first example of a single crystal structure to show the active site cysteine residues in both the reduced and disulfide oxidised form. Consistent with this observation the process of oxidation appears to require very little rearrangement of the surrounding protein structure. The F. hepatica thi ...