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You searched for: Subject "vasoactive intestinal peptide receptors" Remove constraint Subject: "vasoactive intestinal peptide receptors" Journal Molecular and cellular endocrinology Remove constraint Journal: Molecular and cellular endocrinology Subject vasoactive intestinal peptide receptors Remove constraint Subject: vasoactive intestinal peptide receptors
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1. RNA interference-directed silencing of VPAC₁ receptor inhibits VIP effects on both EGFR and HER2 transactivation and VEGF secretion in human breast cancer cells

Author:
Valdehita, Ana; Carmena, María J.; Bajo, Ana M.; Prieto, Juan C.
Source:
Molecular and cellular endocrinology 2012 v.348 no.1 pp. 241-246
ISSN:
0303-7207
Subject:
vasoactive intestinal peptide receptors,   etc   ; RNA interference; antagonists; breast neoplasms; epidermal growth factor receptors; erbB-2 receptor; humans; neoplasm cells; secretion; small interfering RNA; transcriptional activation; transfection; tyrosine; vascular endothelial growth factors; vasoactive intestinal peptide;     Show all 15 Subjects
Abstract:
... We used small-interference RNA (siRNA) to explore the mechanisms of some vasoactive intestinal peptide (VIP) actions on human breast cancer cells. Transfection of estrogen-dependent (T47D) and estrogen-independent (MDA-MB-468) breast cancer cells with VPAC₁-receptor siRNA completely abolished VIP stimulatory effect on secretion of the main angiogenic factor, vascular endothelial growth factor (VEG ...
DOI:
10.1016/j.mce.2011.08.031