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- Jamali, Shirin; Karimian, Mohammad; Nikzad, Hossein; Aftabi, Younes
- Molecular biology reports 2016 v.43 no.8 pp. 795-802
- case-control studies, etc ; Internet; alleles; blood sampling; chromosomes; genetic markers; genotype; histones; male fertility; men; polymerase chain reaction; promoter regions; protamines; restriction fragment length polymorphism; risk factors; single nucleotide polymorphism; spermatogenesis; spermatozoa; transcription factors; Show all 19 Subjects
- ... The genome condensation in the sperm head is resulted with replacing of histones by protamines during spermatogenesis. It is reported that defects in the protamine 1 (PRM1) and/or 2 (PRM2) genes cause male infertility. Located on chromosome 16 (16p13.2) these genes contain numerous unstudied single nucleotide polymorphisms. This study aimed to investigate the association of c.−190 C>A and g.298 G> ...