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You searched for: Journal Molecular biology reports Remove constraint Journal: Molecular biology reports Source 2015 v.42 no.2 Remove constraint Source: 2015 v.42 no.2 Subject genes Remove constraint Subject: genes Subject messenger RNA Remove constraint Subject: messenger RNA
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1. Altered nuclear structure in myotonic dystrophy type 1-derived fibroblasts

Author:
Rodríguez, R.; Hernández-Hernández, O.; Magaña, J..J.; González-Ramírez, R.; García-López, E. S.; Cisneros, B.
Source:
Molecular biology reports 2015 v.42 no.2 pp. 479-488
ISSN:
0301-4851
Subject:
cell culture; cell nucleolus; fibroblasts; gene expression; genes; genetic disorders; messenger RNA; mutants; nuclear membrane; patients; proteins
Abstract:
... Myotonic dystrophy type 1 (DM1) is a multisystem genetic disorder caused by a triplet nucleotide repeat expansion in the 3′ untranslated region of the Dystrophia Myotonica-Protein Kinase (DMPK) gene. DMPK gene transcripts containing CUG expanded repeats accumulate in nuclear foci and ultimately cause altered splicing/gene expression of numerous secondary genes. The study of primary cell cultures d ...
DOI:
10.1007/s11033-014-3791-4
PubMed:
25307018

2. Cloning, characterization and expression of myostatin (growth differentiating factor-8) gene in broiler and layer chicken (Gallus gallus)

Author:
Bhattacharya, T. K.; Chatterjee, R. N.; Dushyanth, K.; Shukla, R.
Source:
Molecular biology reports 2015 v.42 no.2 pp. 319-327
ISSN:
0301-4851
Subject:
Escherichia coli; Gallus gallus; alanine; body weight; broiler chickens; complementary DNA; gene expression; gene expression regulation; genes; histidine; laying hens; leucine; messenger RNA; molecular cloning; muscles; myostatin; nucleotide sequences; nucleotides; phylogeny; proline; tyrosine; valine
Abstract:
... A study was conducted to characterize myostatin gene in broiler and layer chicken and to explore mRNA expression profile in these two varieties of chicken. The myostatin cDNAs of broiler and layer varieties were cloned and sequenced. The total length of the cDNA was 1128 bp. The differences of nucleotides between PB-1 broiler and IWI layer were C > 65 > T, C > 306 > T and C > 1094 > T while those ...
DOI:
10.1007/s11033-014-3753-x
PubMed:
25479731

3. FLT3 expression and IL10 promoter polymorphism in acute myeloid leukemia with RUNX1-RUNX1T1

Author:
Kim, Myungshin; Kim, Jiyeon; Kim, Jung Rok; Han, Eunhee; Park, Joonhong; Lim, Jihyang; Kim, Yonggoo; Han, Kyungja; Kim, Hee-Je; Min, Woo-Sung; Cho, Bin
Source:
Molecular biology reports 2015 v.42 no.2 pp. 451-456
ISSN:
0301-4851
Subject:
bone marrow; gene overexpression; genes; genotype; immunohistochemistry; interleukin-10; messenger RNA; myeloid leukemia; patients; quantitative polymerase chain reaction; remission
Abstract:
... We investigated the correlation between FLT3 expression and IL10 gene promoter polymorphism in acute myeloid leukemia with RUNX1-RUNX1T1 and their clinical significance. FLT3 mRNA expression was measured by real-time quantitative PCR (qPCR) and immunohistochemical staining (IHC) on bone marrow (BM) leukemic cells. IL10 gene promoter polymorphisms including rs1800896 (G-1082A), rs1800871 (C-819T), ...
DOI:
10.1007/s11033-014-3786-1
PubMed:
25287662

4. Screening aberrant methylation profile in esophageal squamous cell carcinoma for Kazakhs in Xinjiang area of China

Author:
Chen, Yan; Yin, Dong; Li, Lei; Deng, Yan-chao; Tian, Wei
Source:
Molecular biology reports 2015 v.42 no.2 pp. 457-464
ISSN:
0301-4851
Subject:
DNA; DNA methylation; apoptosis; bioinformatics; carbon; cell proliferation; gene expression; gene expression regulation; genes; humans; loci; messenger RNA; metabolism; nationalities and ethnic groups; screening; squamous cell carcinoma; China
Abstract:
... To screen the aberrant methylation genes in esophageal squamous cell carcinoma (ESCC) for Kazakh nationality in Xinjiang, and the aberrant DNA methylation genes pattern provides a clue for deeply study on ESCC mechanism. Illumina Human Methylation 450 K chip was used to screen the genome-wide methylation on six cancer tissues and six adjacent normal tissues of ESCC in Kazakh people. Meanwhile, mRN ...
DOI:
10.1007/s11033-014-3788-z
PubMed:
25304811

5. The CD8α gene in duck (Anatidae): cloning, characterization, and expression during viral infection

Author:
Xu, Qi; Chen, Yang; Zhao, Wen Ming; Huang, Zheng Yang; Duan, Xiu Jun; Tong, Yi Yu; Zhang, Yang; Li, Xiu; Chang, Guo Bin; Chen, Guo Hong
Source:
Molecular biology reports 2015 v.42 no.2 pp. 431-439
ISSN:
0301-4851
Subject:
Anas platyrhynchos; Cairina moschata; Duck hepatitis A virus; Muscovy; amino acids; cerebellum; cerebrum; complementary DNA; ducklings; gene expression regulation; genes; immune response; immunohistochemistry; kidneys; liver; messenger RNA; muscles; nucleotides; open reading frames; reverse transcriptase polymerase chain reaction; signal peptide; spleen
Abstract:
... Cluster of differentiation 8 alpha (CD8α) is critical for cell-mediated immune defense and T-cell development. Although CD8α sequences have been reported for several species, very little is known about CD8α in ducks. To elucidate the mechanisms involved in the innate and adaptive immune responses of ducks, we cloned CD8α coding sequences from domestic, Muscovy, Mallard, and Spotbill ducks using re ...
DOI:
10.1007/s11033-014-3784-3
PubMed:
25332128