Jump to Main Content
- Rodriguez-Meira, Alba; Buck, Gemma; Clark, Sally-Ann; Povinelli, Benjamin J.; Alcolea, Veronica; Louka, Eleni; McGowan, Simon; Hamblin, Angela; Sousos, Nikolaos; Barkas, Nikolaos; Giustacchini, Alice; Psaila, Bethan; Jacobsen, Sten Eirik W.; Thongjuea, Supat; Mead, Adam J.
- Molecular cell 2019
- DNA; genomics; mutants; mutation; mutational analysis; neoplasm cells; neoplasms; stem cells; tissues; transcription (genetics)
- ... Single-cell RNA sequencing (scRNA-seq) has emerged as a powerful tool for resolving transcriptional heterogeneity. However, its application to studying cancerous tissues is currently hampered by the lack of coverage across key mutation hotspots in the vast majority of cells; this lack of coverage prevents the correlation of genetic and transcriptional readouts from the same single cell. To overcom ...