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- Sanidas, Ioannis; Morris, Robert; Fella, Katerina A.; Rumde, Purva H.; Boukhali, Myriam; Tai, Eric C.; Ting, David T.; Lawrence, Michael S.; Haas, Wilhelm; Dyson, Nicholas J.
- Molecular cell 2019
- cell cycle; genes; neoplasms; oxidative phosphorylation; oxygen consumption; proteins; proteomics; transcription (genetics)
- ... Hyper-phosphorylation of RB controls its interaction with E2F and inhibits its tumor suppressor properties. However, during G1 active RB can be mono-phosphorylated on any one of 14 CDK phosphorylation sites. Here, we used quantitative proteomics to profile protein complexes formed by each mono-phosphorylated RB isoform (mP-RB) and identified the associated transcriptional outputs. The results show ...