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- Wang, A. Hongjun, et al. Show all 11 Authors
- Molecular cell 2013 v.51 pp. 5-19
- Drosophila; arginine; bone morphogenetic proteins; gene expression; ligands; methylation; methyltransferases; phosphorylation; phosphotransferases (kinases); signal transduction; transforming growth factor beta
- ... Kinase activation and substrate phosphorylation commonly form the backbone of signaling cascades. Bone morphogenetic proteins (BMPs), a subclass of TGF-β family ligands, induce activation of their signaling effectors, the Smads, through C-terminal phosphorylation by transmembrane receptor kinases. However, the slow kinetics of Smad activation in response to BMP suggests a preceding step in the ini ...
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